Michael Heuser

Michael Heuser

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Michael Heuser

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Allogeneic stem cell transplantation in patients with myelofibrosis harboring the MPL mutation.

Eur J Haematol 2019 Dec 16;103(6):552-557. Epub 2019 Sep 16.

Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1111/ejh.13318DOI Listing
December 2019

Monocytes reprogrammed with lentiviral vectors co-expressing GM-CSF, IFN-α2 and antigens for personalized immune therapy of acute leukemia pre- or post-stem cell transplantation.

Cancer Immunol Immunother 2019 Nov 18;68(11):1891-1899. Epub 2019 Oct 18.

Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany.

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http://dx.doi.org/10.1007/s00262-019-02406-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851032PMC
November 2019

The Actin Binding Protein Plastin-3 Is Involved in the Pathogenesis of Acute Myeloid Leukemia.

Cancers (Basel) 2019 Oct 26;11(11). Epub 2019 Oct 26.

Department of Oncology, Hematology and Bone Marrow Transplantation with Division of Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

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http://dx.doi.org/10.3390/cancers11111663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895973PMC
October 2019

Lipid nanoparticle-mediated siRNA delivery for safe targeting of human CML in vivo.

Ann Hematol 2019 Aug 18;98(8):1905-1918. Epub 2019 May 18.

Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg Strasse 1, 30625, Hannover, Germany.

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http://dx.doi.org/10.1007/s00277-019-03713-yDOI Listing
August 2019

MN1 is indispensable for MLL-rearranged acute myeloid leukemia.

Haematologica 2019 Aug 14. Epub 2019 Aug 14.

Hannover Medical School, Hannover, Germany;

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http://dx.doi.org/10.3324/haematol.2018.211201DOI Listing
August 2019

Emerging strategies to target the dysfunctional cohesin complex in cancer.

Expert Opin Ther Targets 2019 Jun 25;23(6):525-537. Epub 2019 Apr 25.

a Department of Hematology , Oncology, Hemostasis and Stem Cell Transplantation, Hannover Medical School , Hannover , Germany.

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http://dx.doi.org/10.1080/14728222.2019.1609943DOI Listing
June 2019

Message from the void: MRD analysis from ctDNA.

Blood 2019 06;133(25):2631-2633

Hannover Medical School.

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http://dx.doi.org/10.1182/blood-2019-04-901181DOI Listing
June 2019

ASXL1/EZH2 mutations promote clonal expansion of neoplastic HSC and impair erythropoiesis in PMF.

Leukemia 2019 01 15;33(1):99-109. Epub 2018 Jun 15.

Department for Stem Cell Transplantation, University Medical Center Hamburg - Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1038/s41375-018-0159-0DOI Listing
January 2019

How Precision Medicine Is Changing Acute Myeloid Leukemia Therapy.

Am Soc Clin Oncol Educ Book 2019 Jan 17;39:411-420. Epub 2019 May 17.

2 Northwestern University, Chicago, IL.

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http://dx.doi.org/10.1200/EDBK_238687DOI Listing
January 2019

Influenza and respiratory syncytial virus screening for the detection of asymptomatically infected patients in hematology and oncology.

GMS Hyg Infect Control 2018 24;13:Doc08. Epub 2018 Sep 24.

Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School (MHH), Hannover, Germany.

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http://dx.doi.org/10.3205/dgkh000314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234716PMC
September 2018

Epigenetics in myelodysplastic syndromes.

Semin Cancer Biol 2018 08 2;51:170-179. Epub 2017 Aug 2.

Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1016/j.semcancer.2017.07.009DOI Listing
August 2018

Endogenous Tumor Suppressor microRNA-193b: Therapeutic and Prognostic Value in Acute Myeloid Leukemia.

J Clin Oncol 2018 04 12;36(10):1007-1016. Epub 2018 Feb 12.

Raj Bhayadia, Razan Jammal, Stephan Emmrich, Jan Fiedler, Adrian Schwarzer, Michael Heuser, Michelle Ng, Dirk Heckl, and Thomas Thum, Hannover Medical School, Hannover; Raj Bhayadia, Michelle Ng, and Jan-Henning Klusmann, University of Halle, Halle; Kathrin Krowiorz, Arefeh Rouhi, Konstanze Döhner, Hartmut Döhner, and Florian Kuchenbauer, University Hospital of Ulm, Ulm; Nadine Haetscher, Susanne Wingert, Sabrina Bothur, and Michael A. Rieger, Goethe University Frankfurt, Frankfurt; Sabrina Bothur and Michael A. Rieger, German Cancer Consortium, and German Cancer Research Center, Heidelberg; Dirk Reinhardt, University Hospital Essen, Essen, Germany; Askar Obulkasim, C. Michel Zwaan, and Maarten Fornerod, Erasmus MC/Sophia Children's Hospital, Rotterdam; Marry van den Heuvel Eibrink, Prinses Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; Tobias Mätzig and R. Keith Humphries, Terry Fox Laboratory, Vancouver, Canada; and Thomas Thum, National Heart and Lung Institute, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1200/JCO.2017.75.2204DOI Listing
April 2018

Exploiting differential RNA splicing patterns: a potential new group of therapeutic targets in cancer.

Expert Opin Ther Targets 2018 02 20;22(2):107-121. Epub 2017 Dec 20.

a Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation , Hannover Medical School , Hannover , Germany.

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http://dx.doi.org/10.1080/14728222.2018.1417390DOI Listing
February 2018

Pyrimethamine as a Potent and Selective Inhibitor of Acute Myeloid Leukemia Identified by High-throughput Drug Screening.

Curr Cancer Drug Targets 2016 ;16(9):818-828

Department of Hematology, Hemostasis, Oncology and Stem cell Transplantation, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

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http://dx.doi.org/10.2174/1568009616666160617103301DOI Listing
October 2017

An optimized lentiviral vector system for conditional RNAi and efficient cloning of microRNA embedded short hairpin RNA libraries.

Biomaterials 2017 Sep 23;139:102-115. Epub 2017 May 23.

Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, 30625 Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2017.05.032DOI Listing
September 2017

Activation of TRKA receptor elicits mastocytosis in mice and is involved in the development of resistance to KIT-targeted therapy.

Oncotarget 2017 Sep 19;8(43):73871-73883. Epub 2017 May 19.

Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.18632/oncotarget.18027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650308PMC
September 2017

Therapy-related myeloid neoplasms.

Curr Opin Hematol 2017 03;24(2):152-158

Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1097/MOH.0000000000000316DOI Listing
March 2017

Therapeutic miR-21 Silencing Ameliorates Diabetic Kidney Disease in Mice.

Mol Ther 2017 01 4;25(1):165-180. Epub 2017 Jan 4.

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hanover Medical School, 30625 Hannover, Germany; Department of Nephrology, Hanover Medical School, 30625 Hannover, Germany; Division of Nephrology, University Hospital Zürich, 8091 Zürich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2016.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363308PMC
January 2017

MicroRNA-155 is upregulated in MLL-rearranged AML but its absence does not affect leukemia development.

Exp Hematol 2016 Dec 13;44(12):1166-1171. Epub 2016 Sep 13.

Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2016.08.012DOI Listing
December 2016

Therapy-related myeloid neoplasms: does knowing the origin help to guide treatment?

Authors:
Michael Heuser

Hematology Am Soc Hematol Educ Program 2016 Dec;2016(1):24-32

Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1182/asheducation-2016.1.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142514PMC
December 2016

A Roadmap and Cost Implications of Establishing Comprehensive Cancer Care Using a Teleradiotherapy Network in a Group of Sub-Saharan African Countries With No Access to Radiation Therapy.

Int J Radiat Oncol Biol Phys 2016 08 29;95(5):1334-1343. Epub 2016 Mar 29.

Center for Radiation Oncology, KSA-KSB, Kantonsspital Aarau, Aarau, Switzerland; Department of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.ijrobp.2016.03.030DOI Listing
August 2016

RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells.

Cancer Cell 2016 07;30(1):75-91

III. Medical Department for Hematology and Oncology, Klinikum rechts der Isar, Technische Universität München, 81675 München, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.06.002DOI Listing
July 2016

Genomic Classification and Prognosis in Acute Myeloid Leukemia.

N Engl J Med 2016 Jun;374(23):2209-2221

Cancer Genome Project, Wellcome Trust Sanger Institute (E.P., M.G., N.D.R., N.B., G.G., P.V.L., I.M., L.M., S.M., S.O., K.R., D.R.J., J.W.T., A.P.B., P.J.C.), and the European Bioinformatics Institute, European Molecular Biology Laboratory (EMBL-EBI) (M.G.), Hinxton, the Centre for Evolution and Cancer, Institute of Cancer Research, London (N.E.P., M.F.G.), and the Department of Haematology, University of Cambridge, Cambridge (N.B.) - all in the United Kingdom; the Departments of Epidemiology and Biostatistics and Cancer Biology, the Center for Molecular Oncology and the Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York (E.P.); the Department of Internal Medicine III, Ulm University, Ulm (L.B., V.I.G., P.P., K.D., R.F.S., H.D.), and the Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover (M.H., F.T., A.G.) - both in Germany; the Division of Hematology, Fondazione IRCCS, Istituto Nazionale dei Tumori, and Department of Oncology and Onco-Hematology, University of Milan, Milan (N.B.); the Department of Human Genetics, University of Leuven, Leuven, Belgium (P.V.L.); and the Department of Pathology, University of Otago, Christchurch, New Zealand (P.G., P.J.C.).

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http://dx.doi.org/10.1056/NEJMoa1516192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979995PMC
June 2016

miR-21 promotes fibrosis in an acute cardiac allograft transplantation model.

Cardiovasc Res 2016 May 9;110(2):215-26. Epub 2016 Feb 9.

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), OE 8886, Hannover Medical School, Carl-Neuberg Strasse 1, 30625 Hannover, Germany REBIRTH Excellence Cluster, Hannover Medical School, Hannover, Germany National Heart and Lung Institute, Imperial College London, London, UK

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http://dx.doi.org/10.1093/cvr/cvw030DOI Listing
May 2016

Clonal Hematopoiesis of Indeterminate Potential.

Dtsch Arztebl Int 2016 May;113(18):317-22

Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School.

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http://dx.doi.org/10.3238/arztebl.2016.0317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961884PMC
May 2016

Oxaliplatin pharmacokinetics on hemodialysis in a patient with diffuse large B cell lymphoma.

Ann Hematol 2016 Mar 5;95(4):649-50. Epub 2016 Feb 5.

Division of Nephrology and Hypertension, Department of Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

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http://dx.doi.org/10.1007/s00277-016-2607-0DOI Listing
March 2016

Enigmas of IDH mutations in hematology/oncology.

Exp Hematol 2015 Aug 30;43(8):685-97. Epub 2015 May 30.

Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1016/j.exphem.2015.05.005DOI Listing
August 2015

How I treat refractory and early relapsed acute myeloid leukemia.

Blood 2015 Jul 7;126(3):319-27. Epub 2015 Apr 7.

Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany; and.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2014-10-55
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http://dx.doi.org/10.1182/blood-2014-10-551911DOI Listing
July 2015

Modeling de novo leukemogenesis from human cord blood with MN1 and NUP98HOXD13.

Blood 2014 Dec 22;124(24):3608-12. Epub 2014 Oct 22.

Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1182/blood-2014-04-564666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256911PMC
December 2014

TET2 mutations in cytogenetically normal acute myeloid leukemia: clinical implications and evolutionary patterns.

Genes Chromosomes Cancer 2014 Oct 5;53(10):824-32. Epub 2014 Jun 5.

INSERM U985, Institut Gustave Roussy, Villejuif, France; Department of Hematology, Oncology, and Tumor Immunology, Charité, Berlin, Germany.

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http://dx.doi.org/10.1002/gcc.22191DOI Listing
October 2014

Lack of noncanonical RAS mutations in cytogenetically normal acute myeloid leukemia.

Ann Hematol 2014 Jun 16;93(6):977-82. Epub 2014 Apr 16.

Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1007/s00277-014-2061-9DOI Listing
June 2014

All-in-One inducible lentiviral vector systems based on drug controlled FLP recombinase.

Biomaterials 2014 May 14;35(14):4345-56. Epub 2014 Feb 14.

Institute of Experimental Hematology, Hannover Medical School, Germany; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2014.01.057DOI Listing
May 2014

Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma.

Blood 2013 Oct 27;122(14):2443-52. Epub 2013 Aug 27.

Department of Hematology, Oncology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Tumorzentrum, University Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;

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http://dx.doi.org/10.1182/blood-2013-03-491431DOI Listing
October 2013

Monitoring dendritic cell and cytokine biomarkers during remission prior to relapse in patients with FLT3-ITD acute myeloid leukemia.

Ann Hematol 2013 Aug 25;92(8):1079-90. Epub 2013 Apr 25.

Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH), OE 6860, Carl-Neuberg Strasse 1, Hannover, Germany.

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http://dx.doi.org/10.1007/s00277-013-1744-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701796PMC
August 2013

Acute leukemias of ambiguous lineage in adults: molecular and clinical characterization.

Ann Hematol 2013 Jun 15;92(6):747-58. Epub 2013 Feb 15.

Department of Hematology, Oncology and Tumor Immunology, Charité University Hospital Berlin, Hindenburgdamm 30, 12203, Campus Benjamin Franklin, Berlin, Germany.

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http://dx.doi.org/10.1007/s00277-013-1694-4DOI Listing
June 2013

Prognostic significance of expression levels of stem cell regulators MSI2 and NUMB in acute myeloid leukemia.

Ann Hematol 2013 Mar 12;92(3):315-23. Epub 2012 Dec 12.

Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany.

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http://dx.doi.org/10.1007/s00277-012-1637-5DOI Listing
March 2013

Next-generation sequencing for minimal residual disease monitoring in acute myeloid leukemia patients with FLT3-ITD or NPM1 mutations.

Genes Chromosomes Cancer 2012 Jul 27;51(7):689-95. Epub 2012 Mar 27.

Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1002/gcc.21955DOI Listing
July 2012