Publications by authors named "Michael Hershfield"

88Publications

A Case with Purine Nucleoside Phosphorylase Deficiency Suffering from Late-Onset Systemic Lupus Erythematosus and Lymphoma.

J Clin Immunol 2020 Aug 8;40(6):833-839. Epub 2020 Jun 8.

College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.

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http://dx.doi.org/10.1007/s10875-020-00800-yDOI Listing
August 2020

Morbidity in an adenosine deaminase-deficient patient during 27 years of enzyme replacement therapy.

Clin Immunol 2020 02 5;211:108321. Epub 2019 Dec 5.

Division of Immunology and Allergy, Department of Pediatrics, Hospital for Sick Children, Toronto, ON, Canada; University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2019.108321DOI Listing
February 2020

Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout.

Ann Rheum Dis 2019 11 9;78(11):1592-1600. Epub 2019 Sep 9.

Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1136/annrheumdis-2019-215933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288724PMC
November 2019

Deficiency of adenosine deaminase 2: a case series revealing clinical manifestations, genotypes and treatment outcomes from Turkey.

Rheumatology (Oxford) 2020 01;59(1):254-256

Department of Pediatric Rheumatology, Cukurova University Faculty of Medicine, Adana, Turkey.

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http://dx.doi.org/10.1093/rheumatology/kez260DOI Listing
January 2020

Anti-PEG Antibodies Inhibit the Anticoagulant Activity of PEGylated Aptamers.

Cell Chem Biol 2019 05 28;26(5):634-644.e3. Epub 2019 Feb 28.

Department of Molecular Genetics and Microbiology Graduate Program, Duke University, Durham, NC, USA; Department of Surgery, Duke University, Durham, NC, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24519456193003
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http://dx.doi.org/10.1016/j.chembiol.2019.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707742PMC
May 2019

Childhood Hodgkin Lymphoma: Think DADA2.

J Clin Immunol 2019 01 14;39(1):26-29. Epub 2019 Jan 14.

Department of Pediatrics, Department of Microbiology and Immunology, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1007/s10875-019-0590-7DOI Listing
January 2019

Human adenosine deaminase 2 deficiency: A multi-faceted inborn error of immunity.

Immunol Rev 2019 01;287(1):62-72

Department of Microbiology and Immunology, Laboratory for Childhood Immunology, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1111/imr.12722DOI Listing
January 2019

Complexities of genetic diagnosis illustrated by an atypical case of congenital hypoplastic anemia.

Cold Spring Harb Mol Case Stud 2018 12 17;4(6). Epub 2018 Dec 17.

Department of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1101/mcs.a003384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318771PMC
December 2018

Consensus approach for the management of severe combined immune deficiency caused by adenosine deaminase deficiency.

J Allergy Clin Immunol 2019 03 5;143(3):852-863. Epub 2018 Sep 5.

Division of Immunology and Allergy, and the Department of Pediatrics, Developmental and Stem Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.08.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688493PMC
March 2019

Disrupted N-linked glycosylation as a disease mechanism in deficiency of ADA2.

J Allergy Clin Immunol 2018 10 21;142(4):1363-1365.e8. Epub 2018 Jun 21.

Division of Immunology, Boston Children's Hospital, Boston, Mass; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Mass.

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http://dx.doi.org/10.1016/j.jaci.2018.05.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175612PMC
October 2018

ADA2 deficiency: Clonal lymphoproliferation in a subset of patients.

J Allergy Clin Immunol 2018 04 31;141(4):1534-1537.e8. Epub 2018 Jan 31.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.01.012DOI Listing
April 2018

Hematopoietic Stem Cell Transplantation in ADA2 Deficiency: Early Restoration of ADA2 Enzyme Activity and Disease Relapse upon Drop of Donor Chimerism.

J Clin Immunol 2017 11 10;37(8):746-750. Epub 2017 Oct 10.

Childhood Immunology, Department of Microbiology and Immunology, KU Leuven, Herestraat 49, Leuven, Belgium.

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http://dx.doi.org/10.1007/s10875-017-0449-8DOI Listing
November 2017

Deficiency of Adenosine Deaminase 2 (DADA2), an Inherited Cause of Polyarteritis Nodosa and a Mimic of Other Systemic Rheumatologic Disorders.

Curr Rheumatol Rep 2017 Oct 5;19(11):70. Epub 2017 Oct 5.

Duke University School of Medicine, Durham, NC, 27710, USA.

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http://dx.doi.org/10.1007/s11926-017-0699-8DOI Listing
October 2017

Extending the Clinical Phenotype of Adenosine Deaminase 2 Deficiency.

J Pediatr 2016 10 8;177:316-320. Epub 2016 Aug 8.

Department of Pediatric Hematology Oncology and Bone Marrow Transplantation, Hadassah Hebrew University Medical Center, Jerusalem, Israel.

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http://dx.doi.org/10.1016/j.jpeds.2016.06.058DOI Listing
October 2016

Adenosine deaminase type 2 deficiency masquerading as GATA2 deficiency: Successful hematopoietic stem cell transplantation.

J Allergy Clin Immunol 2016 08 6;138(2):628-630.e2. Epub 2016 Apr 6.

Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975951PMC
August 2016

Combined immunodeficiencies: twenty years experience from a single center in Turkey.

Cent Eur J Immunol 2016 20;41(1):107-15. Epub 2016 Jan 20.

Department of Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

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http://dx.doi.org/10.5114/ceji.2015.56168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829808PMC
April 2016

Novel compound heterozygous variants in CECR1 gene associated with childhood onset polyarteritis nodosa and deficiency of ADA2.

Rheumatology (Oxford) 2016 06 11;55(6):1145-7. Epub 2016 Apr 11.

Division of Rheumatology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1093/rheumatology/kew050DOI Listing
June 2016

Deficiency of Adenosine Deaminase 2 Causes Antibody Deficiency.

J Clin Immunol 2016 Apr 27;36(3):179-86. Epub 2016 Feb 27.

CCI-Center for Chronic Immunodeficiency, Universitätsklinikum Freiburg, Engesserstraße 4, 79108, Freiburg, Germany.

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http://link.springer.com/10.1007/s10875-016-0245-x
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http://dx.doi.org/10.1007/s10875-016-0245-xDOI Listing
April 2016

Pre-existing anti-polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer.

J Allergy Clin Immunol 2016 05 11;137(5):1610-1613.e7. Epub 2015 Dec 11.

Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC; Department of Biochemistry, Duke University Medical Center, Durham, NC. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.10.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819876PMC
May 2016

A 24-Year Enzyme Replacement Therapy in an Adenosine-deaminase-Deficient Patient.

Pediatrics 2016 Jan 18;137(1). Epub 2015 Dec 18.

Allergy and Immunology Section, Louisiana State University Health Sciences Center, Shreveport, Louisiana; and

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http://pediatrics.aappublications.org/content/pediatrics/ear
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http://pediatrics.aappublications.org/cgi/doi/10.1542/peds.2
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http://dx.doi.org/10.1542/peds.2015-2169DOI Listing
January 2016

Impulse oscillometry identifies peripheral airway dysfunction in children with adenosine deaminase deficiency.

Orphanet J Rare Dis 2015 Dec 18;10:159. Epub 2015 Dec 18.

National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1186/s13023-015-0365-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683718PMC
December 2015

Diagnosis, Treatment and Long-Term Follow Up of Patients with ADA Deficiency: a Single-Center Experience.

J Clin Immunol 2015 Oct 16;35(7):624-37. Epub 2015 Sep 16.

Stem Cell Laboratory, Section of Hematology and Blood Coagulation, Children's Hospital, Spedali Civili of Brescia, Brescia, Italy.

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http://dx.doi.org/10.1007/s10875-015-0191-zDOI Listing
October 2015

Effects of enzyme replacement therapy on immune function in ADA deficiency patient.

Clin Immunol 2015 Dec 27;161(2):391-3. Epub 2015 Jun 27.

Department of Human Genetics, National Research Institute for Child Health and Development, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2015.06.011DOI Listing
December 2015

A successful unrelated peripheral blood stem cell transplantation with reduced intensity-conditioning regimen in a patient with late-onset purine nucleoside phosphorylase deficiency.

Pediatr Transplant 2015 Mar 17;19(2):E47-50. Epub 2014 Dec 17.

Department of Pediatric Allergy-Immunology, Antalya Education and Research Hospital, Antalya, Turkey.

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http://dx.doi.org/10.1111/petr.12413DOI Listing
March 2015

Hematopoietic stem cell transplantation rescues the immunologic phenotype and prevents vasculopathy in patients with adenosine deaminase 2 deficiency.

J Allergy Clin Immunol 2015 Jan 25;135(1):283-7.e5. Epub 2014 Nov 25.

Department of Immunology and Microbiology, Childhood Immunology, Department of Pediatrics, University Hospitals Leuven and University of Leuven, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282724PMC
January 2015

Elevated IgE and atopy in patients treated for early-onset ADA-SCID.

J Allergy Clin Immunol 2013 Dec 26;132(6):1444-6. Epub 2013 Jul 26.

Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.

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http://dx.doi.org/10.1016/j.jaci.2013.05.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844080PMC
December 2013

Successful bone marrow transplantation with reduced intensity conditioning in a patient with delayed-onset adenosine deaminase deficiency.

Pediatr Transplant 2013 Feb 17;17(1):E29-32. Epub 2012 Jul 17.

Department of Pediatrics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.

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http://doi.wiley.com/10.1111/j.1399-3046.2012.01762.x
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http://dx.doi.org/10.1111/j.1399-3046.2012.01762.xDOI Listing
February 2013

Delayed onset adenosine deaminase deficiency associated with acute disseminated encephalomyelitis.

Int J Hematol 2012 Jun 24;95(6):692-6. Epub 2012 Mar 24.

Department of Pediatrics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan.

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http://link.springer.com/10.1007/s12185-012-1055-4
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http://dx.doi.org/10.1007/s12185-012-1055-4DOI Listing
June 2012

Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation.

Proc Natl Acad Sci U S A 2011 Feb 18;108(5):2088-93. Epub 2011 Jan 18.

Departments of Medicine and Radiology Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1073/pnas.1012743108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033282PMC
February 2011

Treating gout with pegloticase, a PEGylated urate oxidase, provides insight into the importance of uric acid as an antioxidant in vivo.

Proc Natl Acad Sci U S A 2010 Aug 26;107(32):14351-6. Epub 2010 Jul 26.

Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1073/pnas.1001072107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922538PMC
August 2010

Late-onset adenosine deaminase deficiency presenting with Heck's disease.

Eur J Pediatr 2010 Aug 29;169(8):1033-6. Epub 2009 Dec 29.

Department of Pediatric Immunology and Allergy, Meram Medical Faculty, Selcuk University, Beysehir yolu, 42080 Konya, Turkey.

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http://dx.doi.org/10.1007/s00431-009-1131-9DOI Listing
August 2010

Purine nucleoside phosphorylase deficiency with fatal course in two sisters.

Eur J Pediatr 2010 Mar 6;169(3):311-4. Epub 2009 Aug 6.

Dr. Sami Ulus Children's Health and Diseases Training and Research Center, 06080 Ankara, Turkey.

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http://dx.doi.org/10.1007/s00431-009-1029-6DOI Listing
March 2010

How I treat ADA deficiency.

Blood 2009 Oct 28;114(17):3524-32. Epub 2009 Jul 28.

Centre for Immunodeficiency, Molecular Immunology Unit, University College London Institute of Child Health, London, United Kingdom.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2009-06-18
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http://dx.doi.org/10.1182/blood-2009-06-189209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766674PMC
October 2009

Purine nucleoside phosphorylase deficiency in two unrelated Saudi patients.

Ann Saudi Med 2009 Jul-Aug;29(4):309-12

Department of Pediatrics, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841460PMC
http://dx.doi.org/10.4103/0256-4947.55320DOI Listing
September 2009

Reassessing serum urate targets in the management of refractory gout: can you go too low?

Curr Opin Rheumatol 2009 Mar;21(2):138-42

Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1097/BOR.0b013e3283257b83DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920449PMC
March 2009

Immunologic reconstitution during PEG-ADA therapy in an unusual mosaic ADA deficient patient.

Clin Immunol 2009 Feb 25;130(2):162-74. Epub 2008 Oct 25.

Department of Pediatrics, University of Washington and Seattle Children's Hospital Research Institute, Seattle, WA, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S152166160800810
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http://dx.doi.org/10.1016/j.clim.2008.08.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727638PMC
February 2009

In memoriam: J. Edwin Seegmiller, M.D. (1920-2006).

Nucleosides Nucleotides Nucleic Acids 2008 Jun;27(6):554-6

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http://dx.doi.org/10.1080/15257770802135638DOI Listing
June 2008

An unconditioned bone marrow transplantation in a child with purine nucleoside phosphorylase deficiency and its unique complication.

Pediatr Transplant 2008 Jun 14;12(4):479-82. Epub 2008 Jan 14.

Department of Pediatric Immunology and Allergy, Ankara University School of Medicine, Ankara, Turkey.

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http://dx.doi.org/10.1111/j.1399-3046.2007.00890.xDOI Listing
June 2008

A 9-yr evaluation of carrier erythrocyte encapsulated adenosine deaminase (ADA) therapy in a patient with adult-type ADA deficiency.

Eur J Haematol 2007 Oct 3;79(4):338-48. Epub 2007 Aug 3.

Child Health, Division of Clinical Developmental Sciences, St George's, University of London, London, UK.

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http://dx.doi.org/10.1111/j.1600-0609.2007.00927.xDOI Listing
October 2007

Uricase and other novel agents for the management of patients with treatment-failure gout.

Curr Rheumatol Rep 2007 Jun;9(3):258-64

Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1007/s11926-007-0041-yDOI Listing
June 2007

Prolonged pancytopenia in a gene therapy patient with ADA-deficient SCID and trisomy 8 mosaicism: a case report.

Blood 2007 Jan 14;109(2):503-6. Epub 2006 Sep 14.

Division of Research Immunology/Bone Marrow Transplantation, General Clinical Research Center, Department of Pathology, Children's Hospital Los Angeles, CA 90027, and Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.1182/blood-2006-06-031476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1785101PMC
January 2007

Cerebral lymphoma in an adenosine deaminase-deficient patient with severe combined immunodeficiency receiving polyethylene glycol-conjugated adenosine deaminase.

Pediatrics 2005 Dec 1;116(6):e876-9. Epub 2005 Nov 1.

Department of Pediatrics, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3239, USA.

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http://dx.doi.org/10.1542/peds.2005-1068DOI Listing
December 2005

Long-term efficacy of enzyme replacement therapy for adenosine deaminase (ADA)-deficient severe combined immunodeficiency (SCID).

Clin Immunol 2005 Nov 22;117(2):133-43. Epub 2005 Aug 22.

Division of Research Immunology/B.M.T., Mailstop number 62, Childrens Hospital Los Angeles, University of Southern California Keck School of Medicine, 4650 Sunset Blvd, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1016/j.clim.2005.07.006DOI Listing
November 2005

CD28 costimulatory signal induces protein arginine methylation in T cells.

J Exp Med 2005 Aug;202(3):371-7

Molecular Immunology Unit, Institut Pasteur, Paris 75015, Cedex 15, France.

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http://dx.doi.org/10.1084/jem.20050176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213083PMC
August 2005

New insights into adenosine-receptor-mediated immunosuppression and the role of adenosine in causing the immunodeficiency associated with adenosine deaminase deficiency.

Eur J Immunol 2005 Jan;35(1):25-30

Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1002/eji.200425738DOI Listing
January 2005

Purine nucleoside phosphorylase deficiency (PNP-def) presenting with lymphopenia and developmental delay: successful correction with umbilical cord blood transplantation.

J Pediatr 2004 Nov;145(5):710-2

Division of Allergy and Immunology, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1016/j.jpeds.2004.06.075DOI Listing
November 2004

The danger within.

N Engl J Med 2004 Jun;350(26):2721-2; author reply 2721-2

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http://dx.doi.org/10.1056/NEJM200406243502622DOI Listing
June 2004

Cell surface adenosine deaminase binds and stimulates plasminogen activation on 1-LN human prostate cancer cells.

J Biol Chem 2004 May 11;279(20):20993-8. Epub 2004 Mar 11.

Department of Pathology, Box 3712, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1074/jbc.M401023200DOI Listing
May 2004

Genotype is an important determinant of phenotype in adenosine deaminase deficiency.

Curr Opin Immunol 2003 Oct;15(5):571-7

Box 3049, Rom 418 Sands Building, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/s0952-7915(03)00104-3DOI Listing
October 2003

E. coli expression system for identifying folding mutations of human adenosine deaminase.

Methods Mol Biol 2003 ;232:175-82

Department of Medicine, Duke University Medical Center, Durham, NC, USA.

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http://link.springer.com/10.1385/1-59259-394-1:175
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http://dx.doi.org/10.1385/1-59259-394-1:175DOI Listing
March 2004

Clustered charged amino acids of human adenosine deaminase comprise a functional epitope for binding the adenosine deaminase complexing protein CD26/dipeptidyl peptidase IV.

J Biol Chem 2002 May 18;277(22):19720-6. Epub 2002 Mar 18.

Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1074/jbc.M111901200DOI Listing
May 2002

Flow cytometry analysis of adenosine deaminase (ADA) expression: a simple and reliable tool for the assessment of ADA-deficient patients before and after gene therapy.

Hum Gene Ther 2002 Feb;13(3):425-32

Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1089/10430340252792558DOI Listing
February 2002