Publications by authors named "Michael Hayden"

99Publications

Interrupting sequence variants and age of onset in Huntington's disease: clinical implications and emerging therapies.

Lancet Neurol 2020 Nov;19(11):930-939

Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada; BC Children's Hospital Research Institute, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(20)30343-4DOI Listing
November 2020

Frequency of the loss of CAA interruption in the HTT CAG tract and implications for Huntington disease in the reduced penetrance range.

Genet Med 2020 Aug 3. Epub 2020 Aug 3.

Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1038/s41436-020-0917-zDOI Listing
August 2020

Tracing the mutated HTT and haplotype of the African ancestor who spread Huntington disease into the Middle East.

Genet Med 2020 Jul 14. Epub 2020 Jul 14.

Centre for Molecular Medicine Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1038/s41436-020-0895-1DOI Listing
July 2020

Compromised IGF signaling causes caspase-6 activation in Huntington disease.

Exp Neurol 2020 Oct 2;332:113396. Epub 2020 Jul 2.

Centre for Molecular Medicine and Therapeutics (CMMT), Department of Medical Genetics, University of British Columbia, 950 West 28th Avenue, Vancouver, BC V5Z 4H4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2020.113396DOI Listing
October 2020

Impairment and Restoration of Homeostatic Plasticity in Cultured Cortical Neurons From a Mouse Model of Huntington Disease.

Front Cell Neurosci 2019 16;13:209. Epub 2019 May 16.

Department of Psychiatry, Djavad Mowafaghian Centre for Brain Health, The University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.3389/fncel.2019.00209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532531PMC
May 2019

Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor.

Neurobiol Dis 2019 09 17;129:118-129. Epub 2019 May 17.

Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States of America; Departments of Neurology, Neuroscience and Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States of America. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09699961183061
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http://dx.doi.org/10.1016/j.nbd.2019.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996243PMC
September 2019

Altered Regulation of Striatal Neuronal -Methyl-D-Aspartate Receptor Trafficking by Palmitoylation in Huntington Disease Mouse Model.

Front Synaptic Neurosci 2019 21;11. Epub 2019 Feb 21.

Department of Psychiatry, Brain Research Centre and Djavad Mowafaghian Centre for Brain Health, The University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.3389/fnsyn.2019.00003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393405PMC
February 2019

Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1 Model.

Cell Death Dis 2019 03 1;10(3):210. Epub 2019 Mar 1.

Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel.

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http://www.nature.com/articles/s41419-019-1451-2
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http://dx.doi.org/10.1038/s41419-019-1451-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397200PMC
March 2019

Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinson's Disease.

Neurotherapeutics 2019 04;16(2):465-479

Basal Ganglia Pathophysiology Unit, Department of Experimental Medical Science, Lund University, BMC F11, Lund, Sweden.

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http://dx.doi.org/10.1007/s13311-018-00699-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554374PMC
April 2019

Pridopidine stabilizes mushroom spines in mouse models of Alzheimer's disease by acting on the sigma-1 receptor.

Neurobiol Dis 2019 04 27;124:489-504. Epub 2018 Dec 27.

Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Laboratory of Molecular Neurodegeneration, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2018.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363865PMC
April 2019

Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance.

FASEB J 2019 03 13;33(3):3190-3197. Epub 2018 Nov 13.

Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, The University of British Columbia, Vancouver, British Columbia, Canada.

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https://www.fasebj.org/doi/10.1096/fj.201701510RRR
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http://dx.doi.org/10.1096/fj.201701510RRRDOI Listing
March 2019

Laquinimod Treatment Improves Myelination Deficits at the Transcriptional and Ultrastructural Levels in the YAC128 Mouse Model of Huntington Disease.

Mol Neurobiol 2019 Jun 17;56(6):4464-4478. Epub 2018 Oct 17.

Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore (A*STAR), 8A Biomedical Grove, Immunos, Level 5, Singapore, 138648, Singapore.

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http://link.springer.com/10.1007/s12035-018-1393-1
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http://dx.doi.org/10.1007/s12035-018-1393-1DOI Listing
June 2019

Therapeutic approaches to Huntington disease: from the bench to the clinic.

Nat Rev Drug Discov 2018 10 21;17(10):729-750. Epub 2018 Sep 21.

Centre for Molecular Medicine and Therapeutics (CMMT), University of British Columbia, Vancouver, British Columbia, Canada.

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http://www.nature.com/doifinder/10.1038/nrd.2018.133
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http://dx.doi.org/10.1038/nrd.2018.133DOI Listing
October 2018

Altering cortical input unmasks synaptic phenotypes in the YAC128 cortico-striatal co-culture model of Huntington disease.

BMC Biol 2018 06 27;16(1):58. Epub 2018 Jun 27.

Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, University of British Columbia, 950 West 28th Avenue, Vancouver, V5Z 4H4, Canada.

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http://dx.doi.org/10.1186/s12915-018-0526-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020351PMC
June 2018

Constitutive ablation of caspase-6 reduces the inflammatory response and behavioural changes caused by peripheral pro-inflammatory stimuli.

Cell Death Discov 2018 12;4:40. Epub 2018 Mar 12.

1Centre for Molecular Medicine and Therapeutics (CMMT), CFRI, Department of Medical Genetics, University of British Columbia, 950 West 28th Avenue, Vancouver, BC V5Z 4H4 Canada.

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http://www.nature.com/articles/s41420-018-0043-8
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http://dx.doi.org/10.1038/s41420-018-0043-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849887PMC
March 2018

Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease.

Acta Neuropathol Commun 2018 03 6;6(1):16. Epub 2018 Mar 6.

Centre for Molecular Medicine and Therapeutics (CMMT), CFRI, Department of Medical Genetics, University of British Columbia, 950 West 28th Avenue, Vancouver, BC, V5Z 4H4, Canada.

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http://dx.doi.org/10.1186/s40478-018-0518-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839066PMC
March 2018

HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo.

Hum Mol Genet 2018 01;27(2):239-253

Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics (CMMT), CFRI, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.

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http://dx.doi.org/10.1093/hmg/ddx394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886116PMC
January 2018

Genetic ablation of Cyp8b1 preserves host metabolic function by repressing steatohepatitis and altering gut microbiota composition.

Am J Physiol Endocrinol Metab 2018 05 24;314(5):E418-E432. Epub 2017 Oct 24.

Centre for Molecular Medicine and Therapeutics, University of British Columbia , Vancouver, British Columbia , Canada.

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http://dx.doi.org/10.1152/ajpendo.00172.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008057PMC
May 2018

Epidemiology of Huntington disease.

Handb Clin Neurol 2017 ;144:31-46

Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-801893-4.00003-1DOI Listing
March 2018

Characterization of subventricular zone-derived progenitor cells from mild and late symptomatic YAC128 mouse model of Huntington's disease.

Biochim Biophys Acta Mol Basis Dis 2018 Jan 20;1864(1):34-44. Epub 2017 Sep 20.

CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal; FMUC-Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2017.09.009DOI Listing
January 2018

Honey bees possess a polarity-sensitive magnetoreceptor.

J Comp Physiol A Neuroethol Sens Neural Behav Physiol 2017 Dec 15;203(12):1029-1036. Epub 2017 Sep 15.

Department of Biological Sciences, Simon Fraser University, Burnaby, BC, Canada.

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http://link.springer.com/10.1007/s00359-017-1214-4
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http://dx.doi.org/10.1007/s00359-017-1214-4DOI Listing
December 2017

ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels.

Arterioscler Thromb Vasc Biol 2017 11 7;37(11):2147-2155. Epub 2017 Sep 7.

From the Translational Laboratory in Genetic Medicine, A*STAR Institute, and Yong Loo Lin School of Medicine, National University of Singapore (L.T.-M., D.C., E.C.C., L.J.T., D.H.W., G.K.Y., M.R.H., R.R.S.); Departments of Vascular Medicine and Experimental Vascular Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands (J.C.v.C., A.W.M.S., G.M.D.-T., G.K.H.); Faculty of Health Sciences, Simon Fraser University, Canada (I.T.); Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (F.T., P.N., M.R.W.); Centre for Molecular Medicine and Therapeutics and Child and Family Research Institute, University of British Columbia, Canada (L.-H.Z., M.K., M.R.H.); Department of Pediatrics, University Medical Center Groningen, University of Groningen, The Netherlands (L.G.D., U.J.F.T.); Xenon Pharmaceuticals, Burnaby, Canada (I.T., C.R.); Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore (C.H.T., V.A.); Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Austria (F.D., J.B.); Beaulieu-Saucier Université de Montréal Pharmacogenomics Centre, Canada (A.B., M.-P.D.); Montréal Heart Institute Research Centre, Canada (A.B., M.-P.D.); and Université de Montréal, Canada (A.B., M.-P.D.).

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http://dx.doi.org/10.1161/ATVBAHA.117.309574DOI Listing
November 2017

Laquinimod treatment in the R6/2 mouse model.

Sci Rep 2017 07 10;7(1):4947. Epub 2017 Jul 10.

Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany.

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http://dx.doi.org/10.1038/s41598-017-04990-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504033PMC
July 2017

Neurodegeneration: Role of repeats in protein clearance.

Nature 2017 05 26;545(7652):33-34. Epub 2017 Apr 26.

Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia V5H 4H4, Canada.

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http://dx.doi.org/10.1038/nature22489DOI Listing
May 2017

Linking magnetite in the abdomen of honey bees to a magnetoreceptive function.

Proc Biol Sci 2017 Mar;284(1851)

Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada

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http://rspb.royalsocietypublishing.org/lookup/doi/10.1098/rs
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http://dx.doi.org/10.1098/rspb.2016.2873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378088PMC
March 2017

Pharmacogenomic screening for anthracycline-induced cardiotoxicity in childhood cancer.

Br J Clin Pharmacol 2017 05 19;83(5):1143-1145. Epub 2017 Mar 19.

BC Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1111/bcp.13218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401971PMC
May 2017

Cardiovascular Health Disparities in Underserved Populations.

Prim Care 2017 Mar;44(1):e37-e71

Department of Oral and Maxillofacial Surgery, School of Dentistry, Meharry Medical College, 1005 Dr. DB Todd, Jr. Boulevard, Nashville, TN 37208, USA.

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http://dx.doi.org/10.1016/j.pop.2016.09.019DOI Listing
March 2017

The targetable A1 Huntington disease haplotype has distinct Amerindian and European origins in Latin America.

Eur J Hum Genet 2017 02 21;25(3):332-340. Epub 2016 Dec 21.

Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, V5Z 4H4 Canada.

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http://dx.doi.org/10.1038/ejhg.2016.169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315506PMC
February 2017

Sudden death due to paralysis and synaptic and behavioral deficits when Hip14/Zdhhc17 is deleted in adult mice.

BMC Biol 2016 12 7;14(1):108. Epub 2016 Dec 7.

Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child & Family Research Institute, University of British Columbia (UBC), Vancouver, BC, V5Z 4H4, Canada.

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http://dx.doi.org/10.1186/s12915-016-0333-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142322PMC
December 2016

Palmitoylation of caspase-6 by HIP14 regulates its activation.

Cell Death Differ 2017 03 2;24(3):433-444. Epub 2016 Dec 2.

Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1038/cdd.2016.139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344205PMC
March 2017

The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease.

Neurobiol Dis 2017 01 3;97(Pt A):46-59. Epub 2016 Nov 3.

Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2016.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214572PMC
January 2017

eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response.

Acta Neuropathol 2017 01 17;133(1):101-119. Epub 2016 Oct 17.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1007/s00401-016-1634-1DOI Listing
January 2017

Comparative Mitochondrial-Based Protective Effects of Resveratrol and Nicotinamide in Huntington's Disease Models.

Mol Neurobiol 2017 09 2;54(7):5385-5399. Epub 2016 Sep 2.

CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504, Coimbra, Portugal.

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http://dx.doi.org/10.1007/s12035-016-0048-3DOI Listing
September 2017

Huntington disease reduced penetrance alleles occur at high frequency in the general population.

Neurology 2016 Jul 22;87(3):282-8. Epub 2016 Jun 22.

From the Centre for Molecular Medicine and Therapeutics (C.K., J.A.C., R.A.S., M.R.H.), University of British Columbia, Canada; Medical Genetics Group (Z.M., M.D.), School of Medicine and Dentistry, University of Aberdeen, UK; and Molecular Biology Group (S.J.M., E.S.G., N.G.), Coriell Institute for Medical Research, Camden, NJ.

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http://dx.doi.org/10.1212/WNL.0000000000002858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955276PMC
July 2016

Laquinimod decreases Bax expression and reduces caspase-6 activation in neurons.

Exp Neurol 2016 09 11;283(Pt A):121-8. Epub 2016 Jun 11.

Centre for Molecular Medicine and Therapeutics (CMMT), CFRI, Department of Medical Genetics, University of British Columbia, 950 West 28(th) Avenue, Vancouver, BC, V5Z 4H4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2016.06.008DOI Listing
September 2016

A true mentor and pioneer in medical genetics.

Authors:
Michael Hayden

S Afr Med J 2016 May 26;106(6 Suppl 1):S7-9. Epub 2016 May 26.

Honorary Professor affiliated with the Division of Human Genetics and Department of Pathology, Faculty of Health Sciences, University of Cape Town; President of Research and Development, and Chief Scientific Officer, Teva Pharmaceuticals; University Killam Professor, Department of Medical Genetics, University of British Colombia, Vancouver, Canada; Distinguished Professor, National University of Singapore, Singapore.

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http://dx.doi.org/10.7196/SAMJ.2016.v106i6.11022DOI Listing
May 2016

Dopamine D2 receptor gene variants and response to rasagiline in early Parkinson's disease: a pharmacogenetic study.

Brain 2016 07 13;139(Pt 7):2050-62. Epub 2016 May 13.

4 Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Canada 5 Institute of Medical Science, University of Toronto, Toronto, Canada 7 Department of Psychiatry, University of Toronto, Toronto, Canada 8 Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada 11 Biostatistics Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada 12 Lancaster Medical School and Data Science Institute, Lancaster University, Lancaster, UK.

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http://dx.doi.org/10.1093/brain/aww109DOI Listing
July 2016

Modeling Doxorubicin-Induced Cardiotoxicity in Human Pluripotent Stem Cell Derived-Cardiomyocytes.

Sci Rep 2016 05 4;6:25333. Epub 2016 May 4.

Translational Laboratory in Genetic Medicine, National University of Singapore and the Agency for Science Technology and Research (A*STAR), Singapore.

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http://dx.doi.org/10.1038/srep25333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855185PMC
May 2016

ABCA1 deficiency and cellular cholesterol accumulation increases islet amyloidogenesis in mice.

Diabetologia 2016 06 12;59(6):1242-6. Epub 2016 Mar 12.

Department of Pathology & Laboratory Medicine, Child & Family Research Institute, University of British Columbia, 950 West 28th Avenue, Vancouver, BC, V5Z 4H4, Canada.

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http://dx.doi.org/10.1007/s00125-016-3907-6DOI Listing
June 2016

Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.

Hum Mol Genet 2016 Apr 11;25(8):1600-18. Epub 2016 Feb 11.

Department of Pharmacology and Physiology and, Research Center on Aging, University of Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4,

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http://dx.doi.org/10.1093/hmg/ddw036DOI Listing
April 2016

Insulin and IGF-1 regularize energy metabolites in neural cells expressing full-length mutant huntingtin.

Neuropeptides 2016 Aug 3;58:73-81. Epub 2016 Feb 3.

CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3004-504, Portugal; Faculty of Medicine, University of Coimbra, Coimbra 3004-504, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.npep.2016.01.009DOI Listing
August 2016

Treatment with the MAO-A inhibitor clorgyline elevates monoamine neurotransmitter levels and improves affective phenotypes in a mouse model of Huntington disease.

Exp Neurol 2016 Apr 26;278:4-10. Epub 2016 Jan 26.

Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos, Level 5, Singapore 138648; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2016.01.019DOI Listing
April 2016

Laquinimod dampens hyperactive cytokine production in Huntington's disease patient myeloid cells.

J Neurochem 2016 06 5;137(5):782-94. Epub 2016 Apr 5.

Department of Neurodegenerative Diseases, University College London, Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK.

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http://dx.doi.org/10.1111/jnc.13553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982105PMC
June 2016

Genetic diversity of variants involved in drug response and metabolism in Sri Lankan populations: implications for clinical implementation of pharmacogenomics.

Pharmacogenet Genomics 2016 Jan;26(1):28-39

aTranslational Laboratory in Genetic Medicine, Agency for Science, Technology, and Research bSaw Swee Hock School of Public Health cNUS Graduate School for Integrative Sciences and Engineering dLife Sciences Institute Departments of eStatistics and Applied Probability fMedicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Departments of gParasitology hAnatomy, University of Colombo, Colombo, Sri Lanka iDepartment of Pediatrics, Division of Translational Therapeutics jCentre for Molecular Medicine and Therapeutics, Child and Family Research Institute kDepartment of Medicine, Centre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1097/FPC.0000000000000182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890825PMC
January 2016

Comment on Rickels et al. Loss-of-Function Mutations in ABCA1 and Enhanced β-Cell Secretory Capacity in Young Adults. Diabetes 2015;64:193-199.

Diabetes 2015 Sep;64(9):e25-6; discussion e27

Centre for Molecular Medicine and Therapeutics, Child & Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, Canada Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

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http://dx.doi.org/10.2337/db15-0518DOI Listing
September 2015

Curation of the Mammalian Palmitoylome Indicates a Pivotal Role for Palmitoylation in Diseases and Disorders of the Nervous System and Cancers.

PLoS Comput Biol 2015 Aug 14;11(8):e1004405. Epub 2015 Aug 14.

Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1371/journal.pcbi.1004405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537140PMC
August 2015

Targeted next-generation sequencing to diagnose disorders of HDL cholesterol.

J Lipid Res 2015 Oct 8;56(10):1993-2001. Epub 2015 Aug 8.

Translational Laboratory in Genetic Medicine, Agency for Science Technology and Research (ASTAR) and National University of Singapore, Singapore Healthy Heart Program Prevention Clinic, St. Paul's Hospital, Vancouver, Canada Centre for Heart Lung Innovation, University of British Columbia, Vancouver, Canada Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Departments of Medicine University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1194/jlr.P058891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583092PMC
October 2015

Genetic variants in SLC22A17 and SLC22A7 are associated with anthracycline-induced cardiotoxicity in children.

Pharmacogenomics 2015 31;16(10):1065-76. Epub 2015 Jul 31.

Centre for Molecular Medicine & Therapeutics, Child & Family Research Institute, Department of Medical Genetics, University of British Columbia, 950 West 28th Avenue, Vancouver, BC V5Z 4H4, Canada.

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http://dx.doi.org/10.2217/pgs.15.61DOI Listing
June 2016

Huntingtin Haplotypes Provide Prioritized Target Panels for Allele-specific Silencing in Huntington Disease Patients of European Ancestry.

Mol Ther 2015 Nov 23;23(11):1759-1771. Epub 2015 Jul 23.

Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1038/mt.2015.128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817952PMC
November 2015

Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression.

Sci Rep 2015 Jul 15;5:12166. Epub 2015 Jul 15.

Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, and Department of Medical Genetics, University of British Columbia, Vancouver, BC V5Z 4H4; Canada.

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http://dx.doi.org/10.1038/srep12166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502413PMC
July 2015

Direct intracerebral delivery of a miR-33 antisense oligonucleotide into mouse brain increases brain ABCA1 expression. [Corrected].

Neurosci Lett 2015 Jun 6;598:66-72. Epub 2015 May 6.

Centre for Molecular Medicine and Therapeutics, University of British Columbia, 950 West 28th Avenue, Vancouver, BC V5Z 4H4, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043940150035
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http://dx.doi.org/10.1016/j.neulet.2015.05.007DOI Listing
June 2015

Post-translational myristoylation at the cross roads of cell death, autophagy and neurodegeneration.

Biochem Soc Trans 2015 Apr;43(2):229-34

*Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1042/BST20140281DOI Listing
April 2015

Aberrant palmitoylation in Huntington disease.

Biochem Soc Trans 2015 Apr;43(2):205-10

*Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia, V5Z 4H4, Canada.

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http://www.biochemsoctrans.org/content/ppbiost/43/2/205.full
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http://biochemsoctrans.org/lookup/doi/10.1042/BST20140242
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http://dx.doi.org/10.1042/BST20140242DOI Listing
April 2015

A longitudinal study of magnetic resonance spectroscopy Huntington's disease biomarkers.

Mov Disord 2015 Mar 18;30(3):393-401. Epub 2015 Feb 18.

Centre for Molecular Medicine & Therapeutics, Vancouver, Canada; Centre for Huntington Disease, University of British Columbia (UBC) Hospital, Vancouver, Canada.

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http://dx.doi.org/10.1002/mds.26118DOI Listing
March 2015