Michael Hallek

Michael Hallek

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Michael Hallek

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Characteristics and course of patients with advanced hematologic malignancies receiving specialized inpatient palliative care at a German university hospital.

Ann Hematol 2019 Nov 28;98(11):2605-2607. Epub 2019 Jun 28.

Department of Palliative Medicine, Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1007/s00277-019-03748-1DOI Listing
November 2019

Chronic lymphocytic leukemia: 2020 update on diagnosis, risk stratification and treatment.

Authors:
Michael Hallek

Am J Hematol 2019 Nov 4;94(11):1266-1287. Epub 2019 Oct 4.

Department I of Internal Medicine, University of Cologne, Center for Integrated Oncology Aachen Bonn Köln Düsseldorf, Center of Excellence on "Cellular Stress Responses in Aging-Associated Diseases", Köln, Germany.

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http://dx.doi.org/10.1002/ajh.25595DOI Listing
November 2019

Sequential and combination treatments with novel agents in chronic lymphocytic leukemia.

Haematologica 2019 Nov 4;104(11):2144-2154. Epub 2019 Oct 4.

University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, German CLL Study Group, University Hospital Cologne

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http://dx.doi.org/10.3324/haematol.2018.208603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821614PMC
November 2019

Acquisition of the recurrent Gly101Val mutation in confers resistance to venetoclax in patients with progressive chronic lymphocytic leukemia ().

Haematologica 2019 Nov;104(11):e540

University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf.

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http://dx.doi.org/10.3324/haematol.2019.232835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821598PMC
November 2019

Vorwort.

Oncol Res Treat 2018 26;41 Suppl 3. Epub 2018 Jul 26.

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http://dx.doi.org/10.1159/000491683DOI Listing
August 2019

Early Palliative Care: Pro, but Please Be Precise!

Oncol Res Treat 2019 26;42(1-2):11-18. Epub 2019 Jan 26.

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http://dx.doi.org/10.1159/000496184DOI Listing
August 2019

Dynamic Risk Profiling Using Serial Tumor Biomarkers for Personalized Outcome Prediction.

Cell 2019 Jul 4;178(3):699-713.e19. Epub 2019 Jul 4.

Division of Oncology, Department of Medicine, Stanford University, Stanford, CA, USA; Division of Hematology, Department of Medicine, Stanford University, Stanford, CA, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA; Stanford Cancer Institute, Stanford University, Stanford, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.06.011DOI Listing
July 2019

Venetoclax and Obinutuzumab in Patients with CLL and Coexisting Conditions.

N Engl J Med 2019 06 4;380(23):2225-2236. Epub 2019 Jun 4.

From Department I of Internal Medicine, Center for Integrated Oncology Aachen-Bonn-Cologne-Duesseldorf, University Hospital Cologne and University of Cologne (K.F., O.A.-S., J.B., A.-M.F., S. Robrecht, B.E., K.-A.K., M.H.), the Oncogeriatric Unit, Department of Geriatric Medicine, St. Marien Hospital (V.G.), CECAD (Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases) (M.H.), Center for Molecular Medicine Cologne (M.H.), Cologne, Department III of Internal Medicine, University Hospital Rostock, Rostock (S.B.), Department III of Internal Medicine, Ulm University, Ulm (E.T., S.S.), the Departments of Hematology, Oncology, Immunology, Palliative Care, Infectious Diseases, and Tropical Medicine, Klinikum Schwabing, Munich (C.-M.W.), Department II of Internal Medicine, Campus Kiel, University of Schleswig-Holstein, Kiel (M.R.), and the Department of Hematology, Oncology, and Rheumatology, Saarland University Medical School, Homburg (S.S.) - all in Germany; Roche Products, Welwyn Garden City, United Kingdom (M.T., M.D., S.W., K.H.); Regional Clinical Hospital N.A. Semashko, Nizhny Novgorod, Russia (O.S.); the Division of Onco-Hematology, Santa Maria Terni Hospital, University of Perugia, Perugia, Italy (A.M.L.); the Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL (J.P.-I.); the Haematology Department, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia (S.O.); First Internal Department, Multiprofile Hospital for Active Treatment Hristo Botev, Vratsa, Bulgaria (L.S.); the Hematology Department, Clinique Victor Hugo, Le Mans, France (K.L.D.); Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil (L.M.F.); the Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen (C.U.N.); Wellington Blood and Cancer Centre, Capital and Coast District Health Board, and Malaghan Institute of Medical Research, Wellington, New Zealand (R.W.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (S. Robinson); Moores Cancer Center, University of California San Diego, San Diego (T.J.K.), and Genentech, South San Francisco (M.M.) - both in California; AbbVie, North Chicago, IL (R.H.); and the Department of Immunology, Laboratory Medical Immunology, Erasmus MC, Rotterdam, the Netherlands (A.W.L.).

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http://www.nejm.org/doi/10.1056/NEJMoa1815281
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http://dx.doi.org/10.1056/NEJMoa1815281DOI Listing
June 2019

FimH-based display of functional eukaryotic proteins on bacteria surfaces.

Sci Rep 2019 Jun 10;9(1):8410. Epub 2019 Jun 10.

Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1038/s41598-019-44883-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557881PMC
June 2019

How to approach CLL in clinical practice.

Hematol Oncol 2019 Jun;37 Suppl 1:38-42

Department I of Internal Medicine, University of Cologne.

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http://dx.doi.org/10.1002/hon.2583DOI Listing
June 2019

CLL2-BIG: sequential treatment with bendamustine, ibrutinib and obinutuzumab (GA101) in chronic lymphocytic leukemia.

Leukemia 2019 05 19;33(5):1161-1172. Epub 2018 Dec 19.

Department I of Internal Medicine and Center of Integrated Oncology Cologne-Bonn, CECAD Cluster of Excellence at the University of Cologne, Clinical Research Unit (KFO) 286, German CLL Study Group, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1038/s41375-018-0313-8DOI Listing
May 2019

Extracellular vesicle measurements with nanoparticle tracking analysis - An accuracy and repeatability comparison between NanoSight NS300 and ZetaView.

J Extracell Vesicles 2019 1;8(1):1596016. Epub 2019 Apr 1.

Experimental Tumor Research, Center for Tumor Biology and Immunology, Department of Hematology, Oncology and Immunology, Philipps University Marburg, Marburg, Germany.

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http://dx.doi.org/10.1080/20013078.2019.1596016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450530PMC
April 2019

New roles for B cell receptor associated kinases: when the B cell is not the target.

Leukemia 2019 03 30;33(3):576-587. Epub 2019 Jan 30.

Department I of Internal Medicine, University Hospital of Cologne; Center for Integrated Oncology Cologne-Bonn; CECAD Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany.

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http://www.nature.com/articles/s41375-018-0366-8
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http://dx.doi.org/10.1038/s41375-018-0366-8DOI Listing
March 2019

The Treatment of Chronic Lymphatic Leukemia.

Dtsch Arztebl Int 2019 01;116(4):41-46

Department of Internal Medicine I - Oncology, Hematology, Clinical Infectiology, Clinical Immunology, Hemostaseology, Internal Intensive Care; University Hospital Cologne, Cologne, Germany.

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http://dx.doi.org/10.3238/arztebl.2019.0041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415618PMC
January 2019

Copanlisib for treatment of B-cell malignancies: the development of a PI3K inhibitor with considerable differences to idelalisib.

Drug Des Devel Ther 2018 21;12:2577-2590. Epub 2018 Aug 21.

Department I of Internal Medicine, University of Cologne, Center of Integrated Oncology Köln Bonn, Cologne Cluster of Excellence on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany,

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http://dx.doi.org/10.2147/DDDT.S142406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109662PMC
December 2018

Outcome of patients aged 80 years or older treated for chronic lymphocytic leukaemia.

Br J Haematol 2018 12 21;183(5):727-735. Epub 2018 Nov 21.

Department I of Internal Medicine and Centre of Integrated Oncology Cologne-Bonn, German CLL Study Group, University Hospital, Cologne, Germany.

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http://dx.doi.org/10.1111/bjh.15604DOI Listing
December 2018

Management of unfit elderly patients with chronic lymphocytic leukemia.

Eur J Intern Med 2018 12;58:7-13

German CLL Study Group (GCLLSG), Dept. I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University Hospital Cologne, Cologne, Germany; Oncogeriatric Unit, Dept. of Geriatric Medicine, St. Marien Hospital, Cologne, Germany.

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http://dx.doi.org/10.1016/j.ejim.2018.02.001DOI Listing
December 2018

On the architecture of translational research designed to control chronic lymphocytic leukemia.

Authors:
Michael Hallek

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):1-8

Department I of Internal Medicine, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1182/asheducation-2018.1.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245981PMC
November 2018

Effects of Kyusho Jitsu on Physical Activity-levels and Quality of Life in Breast Cancer Patients.

In Vivo 2018 Jul-Aug;32(4):819-824

Department I of Internal Medicine, Center of Integrated Oncology Köln Bonn, University Hospital of Cologne, Cologne, Germany

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http://dx.doi.org/10.21873/invivo.11313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117768PMC
October 2018

Does Exercise Have a Preventive Effect on Secondary Lymphedema in Breast Cancer Patients Following Local Treatment? - A Systematic Review.

Breast Care (Basel) 2018 Oct 3;13(5):380-385. Epub 2018 May 3.

Department I of Internal Medicine, Center of Integrated Oncology Cologne Bonn, University Hospital of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1159/000487428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257143PMC
October 2018

[Individualized Treatment of Chronic Lymphocytic Leukemia (CLL)].

Dtsch Med Wochenschr 2018 09 10;143(18):1318-1324. Epub 2018 Sep 10.

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0550-2286
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http://dx.doi.org/10.1055/a-0550-2286DOI Listing
September 2018

Venetoclax for Patients With Chronic Lymphocytic Leukemia With 17p Deletion: Results From the Full Population of a Phase II Pivotal Trial.

J Clin Oncol 2018 07 1;36(19):1973-1980. Epub 2018 May 1.

Stephan Stilgenbauer and Johannes Bloehdorn, Ulm University, Ulm; Stephan Stilgenbauer, Klinik für Innere Medizin I, Universitätsklinikum des Saarlandes, Homburg; Barbara Eichhorst and Michael Hallek, Universitätsklinikum Köln, Köln; Johannes Schetelig, University Hospital, Technische Universität Dresden, Dresden; Clemens-Martin Wendtner, Klinikum Schwabing, Munich; Sebastian Böttcher, University Hospital of Schleswig-Holstein, Kiel, Germany; Peter Hillmen and Talha Munir, St James's University Hospital, Leeds; Anna Schuh, University of Oxford; Anna Schuh, Oxford Cancer and Haematology Centre, Churchill Hospital, Oxford, United Kingdom; John F. Seymour, Peter MacCallum Cancer Centre; John F. Seymour, University of Melbourne; Andrew W. Roberts, Royal Melbourne Hospital, Parkville, Victoria; Stephen P. Mulligan, Royal North Shore Hospital, St Leonards, New South Wales, Australia; Steven Coutre, Stanford University Medical Center, Stanford, CA; Wojciech Jurczak, Jagiellonian University, Kraków, Poland; Sarit Assouline, McGill University, Montreal, Quebec, Canada; Matthew S. Davids, Dana-Farber Cancer Institute, Boston, MA; Lang Zhou, Ahmed Hamed Salem, Monali Desai, Brenda Chyla, Jennifer Arzt, Su Young Kim, Maria Verdugo, and Gary Gordon, AbbVie, North Chicago, IL; Ahmed Hamed Salem, Ain Shams University, Cairo, Egypt; and William G. Wierda, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1200/JCO.2017.76.6840DOI Listing
July 2018

Chronic lymphocytic leukaemia.

Lancet 2018 04 21;391(10129):1524-1537. Epub 2018 Feb 21.

Department of Internal Medicine, Center of Integrated Oncology Köln Bonn, University Hospital of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1016/S0140-6736(18)30422-7DOI Listing
April 2018

Venetoclax after idelalisib: relevant progress for CLL.

Blood 2018 04;131(15):1632-1633

University Hospital of Cologne.

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http://dx.doi.org/10.1182/blood-2018-02-826396DOI Listing
April 2018

CLL2-BXX Phase II trials: sequential, targeted treatment for eradication of minimal residual disease in chronic lymphocytic leukemia.

Future Oncol 2018 Mar 21;14(6):499-513. Epub 2018 Feb 21.

Department I of Internal Medicine & Center of Integrated Oncology Cologne-Bonn, German CLL Study Group, University Hospital Cologne, Cologne, Germany.

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http://dx.doi.org/10.2217/fon-2017-0442DOI Listing
March 2018

[Which drugs in Hemato-Oncology are Unnecessary or Inappropriate for Use in the Elderly?]

Dtsch Med Wochenschr 2018 02 22;143(4):244-252. Epub 2018 Feb 22.

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http://dx.doi.org/10.1055/s-0043-106791DOI Listing
February 2018

Optimizing frontline therapy of CLL based on clinical and biological factors.

Hematology Am Soc Hematol Educ Program 2017 12;2017(1):338-345

Department I of Internal Medicine, Center of Integrated Oncology Cologne Bonn, University of Cologne, Cologne, Germany; and.

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http://dx.doi.org/10.1182/asheducation-2017.1.338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142543PMC
December 2017

Establishing a chemical genetic link between Bruton tyrosine kinase activity in malignant B cells and cell functions involved in the micro-environmental dialogue.

Br J Haematol 2017 09 1;178(6):949-953. Epub 2017 Jun 1.

Department I of Internal Medicine, University Hospital of Cologne, Centre of Integrated Oncology Cologne-Bonn, CECAD Centre of Excellence on "Cellular Stress Responses in Aging-associated Diseases", University of Cologne, Cologne, Germany.

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http://doi.wiley.com/10.1111/bjh.14781
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http://dx.doi.org/10.1111/bjh.14781DOI Listing
September 2017

Chronic lymphocytic leukemia: 2017 update on diagnosis, risk stratification, and treatment.

Authors:
Michael Hallek

Am J Hematol 2017 Sep;92(9):946-965

Department I of Internal Medicine, Center for Integrated Oncology Köln Bonn, Center of Excellence on "Cellular Stress Responses in Aging-Associated Diseases," University of Cologne, Kerpener Strasse 62, Köln, 50937, Germany.

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http://dx.doi.org/10.1002/ajh.24826DOI Listing
September 2017

[Priorities of German Oncologists. Results of the "choosing wisely" survey of the German Society of Hematology and Medical Oncology (DGHO)].

Dtsch Med Wochenschr 2017 Sep 8;142(18):e124-e130. Epub 2017 Sep 8.

Klinik für Hämatologie, Onkologie, Immunologie in Marburg, Universitätsklinikum Gießen und Marburg.

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http://dx.doi.org/10.1055/s-0043-109525DOI Listing
September 2017

Bendamustine and its role in the treatment of unfit patients with chronic lymphocytic leukaemia: a perspective review.

Ther Adv Hematol 2017 Jun 30;8(6):197-205. Epub 2017 Mar 30.

Klinik I für Innere Medizin, Kerpener Straße 62, 50937 Köln, Germany.

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http://dx.doi.org/10.1177/2040620717699365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424860PMC
June 2017

Role and timing of new drugs in CLL.

Authors:
Michael Hallek

Hematol Oncol 2017 Jun;35 Suppl 1:30-32

University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1002/hon.2397DOI Listing
June 2017

Obinutuzumab in chronic lymphocytic leukemia: design, development and place in therapy.

Drug Des Devel Ther 2017 25;11:295-304. Epub 2017 Jan 25.

German CLL Study Group, Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.

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https://www.dovepress.com/obinutuzumab-in-chronic-lymphocyti
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http://dx.doi.org/10.2147/DDDT.S104869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5279834PMC
May 2017

Alemtuzumab consolidation in chronic lymphocytic leukaemia: a phase I/II multicentre trial.

Eur J Haematol 2017 Mar 1;98(3):254-262. Epub 2016 Dec 1.

Department I of Internal Medicine and Center of Integrated Oncology Cologne-Bonn, German CLL Study group, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1111/ejh.12825DOI Listing
March 2017

Targeted Therapy of CLL.

Oncol Res Treat 2016 15;39(12):768-778. Epub 2016 Nov 15.

Department I of Internal Medicine, German CLL Study Group, Center for Integrated Oncology Cologne-Bonn, University Hospital of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1159/000452786DOI Listing
March 2017

Regulatory B10 cells display an altered homoeostasis in acute graft-versus-host disease.

Eur J Haematol 2017 Feb 6;98(2):128-133. Epub 2016 Nov 6.

Department I of Internal Medicine, Interventional Immunology Group, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1111/ejh.12810DOI Listing
February 2017

Economic evaluation of chronic lymphocytic leukemia from a hospital management perspective.

Eur J Haematol 2017 Feb 1;98(2):169-176. Epub 2016 Nov 1.

Department I of Internal Medicine, Center for Integrated Oncology Cologne, University Hospital of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1111/ejh.12817DOI Listing
February 2017

Prognostication of chronic lymphocytic leukemia in the era of new agents.

Hematology Am Soc Hematol Educ Program 2016 Dec;2016(1):149-155

Department I for Internal Medicine and Centre of Integrated Oncology, and.

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http://dx.doi.org/10.1182/asheducation-2016.1.149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142472PMC
December 2016

Minimal Residual Disease Assessment Improves Prediction of Outcome in Patients With Chronic Lymphocytic Leukemia (CLL) Who Achieve Partial Response: Comprehensive Analysis of Two Phase III Studies of the German CLL Study Group.

J Clin Oncol 2016 11;34(31):3758-3765

Gabor Kovacs, Sandra Robrecht, Anna Maria Fink, Jasmin Bahlo, Paula Cramer, Julia von Tresckow, Christian Maurer, Petra Langerbeins, Kirsten Fischer, Michael Hallek, and Barbara Eichhorst, University of Cologne and Center of Integrated Oncology Cologne/Bonn, Cologne; Matthias Ritgen, Michael Kneba, and Sebastian Böttcher, University of Schleswig-Holstein, Lubeck; Hartmut Döhner and Stephan Stilgenbauer, University of Ulm, Ulm; Wolfram Klapper, University of Kiel, Kiel; Clemens-Martin Wendtner, Klinikum Schwabing, Munich, Germany; and Günter Fingerle-Rowson, F. Hoffmann La-Roche, Basel, Switzerland.

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http://dx.doi.org/10.1200/JCO.2016.67.1305DOI Listing
November 2016

LYN Kinase in the Tumor Microenvironment Is Essential for the Progression of Chronic Lymphocytic Leukemia.

Cancer Cell 2016 10;30(4):610-622

Department I of Internal Medicine, University Hospital of Cologne, Center for Integrated Oncology Cologne-Bonn, CECAD Center of Excellence on "Cellular Stress Responses in Aging-Associated Diseases", University of Cologne, 50931 Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.09.007DOI Listing
October 2016

[Vorwort].

Oncol Res Treat 2016;39 Suppl 2. Epub 2016 Aug 31.

II. Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.

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http://dx.doi.org/10.1159/000448062DOI Listing
August 2016

Mono- and dual-targeting triplebodies activate natural killer cells and have anti-tumor activity and against chronic lymphocytic leukemia.

Oncoimmunology 2016 15;5(9):e1211220. Epub 2016 Jul 15.

Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany; Experimental Tumor Research, Center for Tumor Biology and Immunology, Philipps University Marburg, Marburg, Germany.

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https://www.tandfonline.com/doi/full/10.1080/2162402X.2016.1
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http://dx.doi.org/10.1080/2162402X.2016.1211220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049355PMC
July 2016

Current strategies to create tailored and risk-adapted therapies for CLL patients.

Best Pract Res Clin Haematol 2016 03 12;29(1):111-121. Epub 2016 Aug 12.

Department I of Internal Medicine and Center of Integrated Oncology Cologne-Bonn, University Hospital, Cologne, Germany; German CLL Study Group, University Hospital Cologne, Cologne, Germany; CECAD, University Hospital Cologne, Cologne Germany. Electronic address:

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http://dx.doi.org/10.1016/j.beha.2016.08.010DOI Listing
March 2016