Publications by authors named "Michael Hallek"

100Publications

Relevant Cytokines in the B Cell Lymphoma Micro-Environment.

Cancers (Basel) 2020 Sep 5;12(9). Epub 2020 Sep 5.

Department I of Internal Medicine, University of Cologne, Kerpener Str. 62, 50937 Köln, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers12092525DOI Listing
September 2020

[Current diagnosis and treatment of chronic lymphocytic leukaemia].

Dtsch Med Wochenschr 2020 Aug 13;145(16):1139-1144. Epub 2020 Aug 13.

Uniklink Köln, Klinik I für Innere Medizin, Deutsche CLL Studiengruppe; Kerpener Str. 62, 50937 Köln.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-1039-8472DOI Listing
August 2020

Meta-Analysis Reveals Significant Sex Differences in Chronic Lymphocytic Leukemia Progression in the Transgenic Mouse Model.

Cancers (Basel) 2020 Jul 20;12(7). Epub 2020 Jul 20.

University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Center for Molecular Medicine Cologne, CECAD Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases, 50931 Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers12071980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409315PMC
July 2020

CD74 is dispensable for development of chronic lymphocytic leukemia in -TCL1 transgenic mice.

Leuk Lymphoma 2020 Jul 15:1-12. Epub 2020 Jul 15.

University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10428194.2020.1791851DOI Listing
July 2020

[Non-cellular immunotherapy in oncology].

Authors:
Michael Hallek

Internist (Berl) 2020 Jul;61(7):651

Klinik I für Innere Medizin, Universitätsklinikum Köln, Kerpener Str. 62, 50937, Köln, Deutschland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00108-020-00817-wDOI Listing
July 2020

COVID-19 associated pulmonary aspergillosis.

Mycoses 2020 Jun 15;63(6):528-534. Epub 2020 May 15.

Department I of Internal Medicine, Medical Faculty and University Hospital Cologne, University of Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/myc.13096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267243PMC
June 2020

Invasive Aspergillosis in Patients Treated With Ibrutinib.

Hemasphere 2020 Apr 13;4(2):e309. Epub 2020 Feb 13.

Department I for Internal Medicine, Excellence Centre for Medical Mycology (ECMM), University Hospital Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/HS9.0000000000000309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162080PMC
April 2020

Role of ADAM10 as a CD30 Sheddase in Classical Hodgkin Lymphoma.

Front Immunol 2020 31;11:398. Epub 2020 Mar 31.

Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf, Center for Molecular Medicine Cologne, CECAD Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases, University Hospital of Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2020.00398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136452PMC
March 2020

The use of circulating cell-free tumor DNA in routine diagnostics of metastatic melanoma patients.

Sci Rep 2020 03 18;10(1):4940. Epub 2020 Mar 18.

Department of Dermatology and Venerology, University of Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-61818-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080785PMC
March 2020

[Chronic lymphocytic leukemia].

Internist (Berl) 2020 Mar;61(3):277-287

Klinik I für Innere Medizin, Centrum für Integrierte Onkologie Aachen Bonn Köln Düsseldorf, Deutsche CLL-Studiengruppe, Universität zu Köln, Kerpener Straße 62, 50937, Köln, Deutschland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00108-019-00733-8DOI Listing
March 2020

Cell line-based assessment of BTK inhibitors.

Br J Pharmacol 2020 May 28;177(9):2163-2165. Epub 2020 Jan 28.

Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Köln, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bph.14948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161538PMC
May 2020

Minimal Residual Disease Assessment in CLL: Ready for Use in Clinical Routine?

Hemasphere 2019 Oct 9;3(5):e287. Epub 2019 Aug 9.

Department I of Internal Medicine and Center of Integrated Oncology Aachen Bonn Cologne Düsseldorf, German CLL Study Group, University Hospital Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/HS9.0000000000000287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919470PMC
October 2019

Bridging antifungal prophylaxis with 50 mg or 100 mg micafungin in allogeneic stem cell transplantation: A retrospective analysis.

Eur J Haematol 2020 Apr 20;104(4):291-298. Epub 2020 Jan 20.

Department 1 of Internal Medicine, University of Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejh.13372DOI Listing
April 2020

Relapsed disease and aspects of undetectable MRD and treatment discontinuation.

Hematology Am Soc Hematol Educ Program 2019 12;2019(1):482-489

Department I for Internal Medicine, Center of Integrated Oncology Aachen Bonn Cologne Duesseldorf; and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/hematology.2019000070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913464PMC
December 2019

Acquisition of the recurrent Gly101Val mutation in confers resistance to venetoclax in patients with progressive chronic lymphocytic leukemia ().

Haematologica 2019 11;104(11):e540

University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3324/haematol.2019.232835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821598PMC
November 2019

Sequential and combination treatments with novel agents in chronic lymphocytic leukemia.

Haematologica 2019 11 4;104(11):2144-2154. Epub 2019 Oct 4.

University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, German CLL Study Group, University Hospital Cologne

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3324/haematol.2018.208603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821614PMC
November 2019

Chronic lymphocytic leukemia: 2020 update on diagnosis, risk stratification and treatment.

Authors:
Michael Hallek

Am J Hematol 2019 11 4;94(11):1266-1287. Epub 2019 Oct 4.

Department I of Internal Medicine, University of Cologne, Center for Integrated Oncology Aachen Bonn Köln Düsseldorf, Center of Excellence on "Cellular Stress Responses in Aging-Associated Diseases", Köln, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajh.25595DOI Listing
November 2019

Dynamic Risk Profiling Using Serial Tumor Biomarkers for Personalized Outcome Prediction.

Cell 2019 07 4;178(3):699-713.e19. Epub 2019 Jul 4.

Division of Oncology, Department of Medicine, Stanford University, Stanford, CA, USA; Division of Hematology, Department of Medicine, Stanford University, Stanford, CA, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA; Stanford Cancer Institute, Stanford University, Stanford, CA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2019.06.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380118PMC
July 2019

Characteristics and course of patients with advanced hematologic malignancies receiving specialized inpatient palliative care at a German university hospital.

Ann Hematol 2019 Nov 28;98(11):2605-2607. Epub 2019 Jun 28.

Department of Palliative Medicine, Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf, University of Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00277-019-03748-1DOI Listing
November 2019

Mode of progression after first line treatment correlates with outcome of chronic lymphocytic leukemia (CLL).

Am J Hematol 2019 09 8;94(9):1002-1006. Epub 2019 Jul 8.

University of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf; German CLL Study Group, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajh.25561DOI Listing
September 2019

How to approach CLL in clinical practice.

Hematol Oncol 2019 Jun;37 Suppl 1:38-42

Department I of Internal Medicine, University of Cologne.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hon.2583DOI Listing
June 2019

FimH-based display of functional eukaryotic proteins on bacteria surfaces.

Sci Rep 2019 06 10;9(1):8410. Epub 2019 Jun 10.

Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-44883-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557881PMC
June 2019

Venetoclax and Obinutuzumab in Patients with CLL and Coexisting Conditions.

N Engl J Med 2019 Jun 4;380(23):2225-2236. Epub 2019 Jun 4.

From Department I of Internal Medicine, Center for Integrated Oncology Aachen-Bonn-Cologne-Duesseldorf, University Hospital Cologne and University of Cologne (K.F., O.A.-S., J.B., A.-M.F., S. Robrecht, B.E., K.-A.K., M.H.), the Oncogeriatric Unit, Department of Geriatric Medicine, St. Marien Hospital (V.G.), CECAD (Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases) (M.H.), Center for Molecular Medicine Cologne (M.H.), Cologne, Department III of Internal Medicine, University Hospital Rostock, Rostock (S.B.), Department III of Internal Medicine, Ulm University, Ulm (E.T., S.S.), the Departments of Hematology, Oncology, Immunology, Palliative Care, Infectious Diseases, and Tropical Medicine, Klinikum Schwabing, Munich (C.-M.W.), Department II of Internal Medicine, Campus Kiel, University of Schleswig-Holstein, Kiel (M.R.), and the Department of Hematology, Oncology, and Rheumatology, Saarland University Medical School, Homburg (S.S.) - all in Germany; Roche Products, Welwyn Garden City, United Kingdom (M.T., M.D., S.W., K.H.); Regional Clinical Hospital N.A. Semashko, Nizhny Novgorod, Russia (O.S.); the Division of Onco-Hematology, Santa Maria Terni Hospital, University of Perugia, Perugia, Italy (A.M.L.); the Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL (J.P.-I.); the Haematology Department, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia (S.O.); First Internal Department, Multiprofile Hospital for Active Treatment Hristo Botev, Vratsa, Bulgaria (L.S.); the Hematology Department, Clinique Victor Hugo, Le Mans, France (K.L.D.); Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil (L.M.F.); the Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen (C.U.N.); Wellington Blood and Cancer Centre, Capital and Coast District Health Board, and Malaghan Institute of Medical Research, Wellington, New Zealand (R.W.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (S. Robinson); Moores Cancer Center, University of California San Diego, San Diego (T.J.K.), and Genentech, South San Francisco (M.M.) - both in California; AbbVie, North Chicago, IL (R.H.); and the Department of Immunology, Laboratory Medical Immunology, Erasmus MC, Rotterdam, the Netherlands (A.W.L.).

View Article

Download full-text PDF

Source
http://www.nejm.org/doi/10.1056/NEJMoa1815281
Publisher Site
http://dx.doi.org/10.1056/NEJMoa1815281DOI Listing
June 2019

Extracellular vesicle measurements with nanoparticle tracking analysis - An accuracy and repeatability comparison between NanoSight NS300 and ZetaView.

J Extracell Vesicles 2019 1;8(1):1596016. Epub 2019 Apr 1.

Experimental Tumor Research, Center for Tumor Biology and Immunology, Department of Hematology, Oncology and Immunology, Philipps University Marburg, Marburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/20013078.2019.1596016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450530PMC
April 2019

The Treatment of Chronic Lymphatic Leukemia.

Dtsch Arztebl Int 2019 01;116(4):41-46

Department of Internal Medicine I - Oncology, Hematology, Clinical Infectiology, Clinical Immunology, Hemostaseology, Internal Intensive Care; University Hospital Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3238/arztebl.2019.0041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415618PMC
January 2019

New roles for B cell receptor associated kinases: when the B cell is not the target.

Leukemia 2019 03 30;33(3):576-587. Epub 2019 Jan 30.

Department I of Internal Medicine, University Hospital of Cologne; Center for Integrated Oncology Cologne-Bonn; CECAD Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41375-018-0366-8
Publisher Site
http://dx.doi.org/10.1038/s41375-018-0366-8DOI Listing
March 2019

Early Palliative Care: Pro, but Please Be Precise!

Oncol Res Treat 2019 26;42(1-2):11-18. Epub 2019 Jan 26.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496184DOI Listing
August 2019

CLL2-BIG: sequential treatment with bendamustine, ibrutinib and obinutuzumab (GA101) in chronic lymphocytic leukemia.

Leukemia 2019 05 19;33(5):1161-1172. Epub 2018 Dec 19.

Department I of Internal Medicine and Center of Integrated Oncology Cologne-Bonn, CECAD Cluster of Excellence at the University of Cologne, Clinical Research Unit (KFO) 286, German CLL Study Group, University of Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41375-018-0313-8DOI Listing
May 2019

Management of unfit elderly patients with chronic lymphocytic leukemia.

Eur J Intern Med 2018 12;58:7-13

German CLL Study Group (GCLLSG), Dept. I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University Hospital Cologne, Cologne, Germany; Oncogeriatric Unit, Dept. of Geriatric Medicine, St. Marien Hospital, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejim.2018.02.001DOI Listing
December 2018

On the architecture of translational research designed to control chronic lymphocytic leukemia.

Authors:
Michael Hallek

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):1-8

Department I of Internal Medicine, University of Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/asheducation-2018.1.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245981PMC
November 2018

Does Exercise Have a Preventive Effect on Secondary Lymphedema in Breast Cancer Patients Following Local Treatment? - A Systematic Review.

Breast Care (Basel) 2018 Oct 3;13(5):380-385. Epub 2018 May 3.

Department I of Internal Medicine, Center of Integrated Oncology Cologne Bonn, University Hospital of Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000487428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257143PMC
October 2018

Outcome of patients aged 80 years or older treated for chronic lymphocytic leukaemia.

Br J Haematol 2018 12 21;183(5):727-735. Epub 2018 Nov 21.

Department I of Internal Medicine and Centre of Integrated Oncology Cologne-Bonn, German CLL Study Group, University Hospital, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjh.15604DOI Listing
December 2018

[Individualized Treatment of Chronic Lymphocytic Leukemia (CLL)].

Dtsch Med Wochenschr 2018 09 10;143(18):1318-1324. Epub 2018 Sep 10.

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/a-0550-2286
Publisher Site
http://dx.doi.org/10.1055/a-0550-2286DOI Listing
September 2018

Copanlisib for treatment of B-cell malignancies: the development of a PI3K inhibitor with considerable differences to idelalisib.

Drug Des Devel Ther 2018 21;12:2577-2590. Epub 2018 Aug 21.

Department I of Internal Medicine, University of Cologne, Center of Integrated Oncology Köln Bonn, Cologne Cluster of Excellence on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/DDDT.S142406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109662PMC
December 2018

Vorwort.

Oncol Res Treat 2018 26;41 Suppl 3. Epub 2018 Jul 26.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000491683DOI Listing
August 2019

Effects of Kyusho Jitsu on Physical Activity-levels and Quality of Life in Breast Cancer Patients.

In Vivo 2018 Jul-Aug;32(4):819-824

Department I of Internal Medicine, Center of Integrated Oncology Köln Bonn, University Hospital of Cologne, Cologne, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/invivo.11313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117768PMC
October 2018

Venetoclax for Patients With Chronic Lymphocytic Leukemia With 17p Deletion: Results From the Full Population of a Phase II Pivotal Trial.

J Clin Oncol 2018 07 1;36(19):1973-1980. Epub 2018 May 1.

Stephan Stilgenbauer and Johannes Bloehdorn, Ulm University, Ulm; Stephan Stilgenbauer, Klinik für Innere Medizin I, Universitätsklinikum des Saarlandes, Homburg; Barbara Eichhorst and Michael Hallek, Universitätsklinikum Köln, Köln; Johannes Schetelig, University Hospital, Technische Universität Dresden, Dresden; Clemens-Martin Wendtner, Klinikum Schwabing, Munich; Sebastian Böttcher, University Hospital of Schleswig-Holstein, Kiel, Germany; Peter Hillmen and Talha Munir, St James's University Hospital, Leeds; Anna Schuh, University of Oxford; Anna Schuh, Oxford Cancer and Haematology Centre, Churchill Hospital, Oxford, United Kingdom; John F. Seymour, Peter MacCallum Cancer Centre; John F. Seymour, University of Melbourne; Andrew W. Roberts, Royal Melbourne Hospital, Parkville, Victoria; Stephen P. Mulligan, Royal North Shore Hospital, St Leonards, New South Wales, Australia; Steven Coutre, Stanford University Medical Center, Stanford, CA; Wojciech Jurczak, Jagiellonian University, Kraków, Poland; Sarit Assouline, McGill University, Montreal, Quebec, Canada; Matthew S. Davids, Dana-Farber Cancer Institute, Boston, MA; Lang Zhou, Ahmed Hamed Salem, Monali Desai, Brenda Chyla, Jennifer Arzt, Su Young Kim, Maria Verdugo, and Gary Gordon, AbbVie, North Chicago, IL; Ahmed Hamed Salem, Ain Shams University, Cairo, Egypt; and William G. Wierda, The University of Texas MD Anderson Cancer Center, Houston, TX.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2017.76.6840DOI Listing
July 2018

Venetoclax after idelalisib: relevant progress for CLL.

Blood 2018 04;131(15):1632-1633

University Hospital of Cologne.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2018-02-826396DOI Listing
April 2018

Chronic lymphocytic leukaemia.

Lancet 2018 04 21;391(10129):1524-1537. Epub 2018 Feb 21.

Department of Internal Medicine, Center of Integrated Oncology Köln Bonn, University Hospital of Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0140-6736(18)30422-7DOI Listing
April 2018

[Which drugs in Hemato-Oncology are Unnecessary or Inappropriate for Use in the Elderly?]

Dtsch Med Wochenschr 2018 02 22;143(4):244-252. Epub 2018 Feb 22.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0043-106791DOI Listing
February 2018

CLL2-BXX Phase II trials: sequential, targeted treatment for eradication of minimal residual disease in chronic lymphocytic leukemia.

Future Oncol 2018 Mar 21;14(6):499-513. Epub 2018 Feb 21.

Department I of Internal Medicine & Center of Integrated Oncology Cologne-Bonn, German CLL Study Group, University Hospital Cologne, Cologne, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/fon-2017-0442DOI Listing
March 2018

Optimizing frontline therapy of CLL based on clinical and biological factors.

Hematology Am Soc Hematol Educ Program 2017 12;2017(1):338-345

Department I of Internal Medicine, Center of Integrated Oncology Cologne Bonn, University of Cologne, Cologne, Germany; and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/asheducation-2017.1.338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142543PMC
December 2017