Publications by authors named "Michael H Cho"

100Publications

Inherited causes of clonal haematopoiesis in 97,691 whole genomes.

Authors:
Alexander G Bick Joshua S Weinstock Satish K Nandakumar Charles P Fulco Erik L Bao Seyedeh M Zekavat Mindy D Szeto Xiaotian Liao Matthew J Leventhal Joseph Nasser Kyle Chang Cecelia Laurie Bala Bharathi Burugula Christopher J Gibson Amy E Lin Margaret A Taub Francois Aguet Kristin Ardlie Braxton D Mitchell Kathleen C Barnes Arden Moscati Myriam Fornage Susan Redline Bruce M Psaty Edwin K Silverman Scott T Weiss Nicholette D Palmer Ramachandran S Vasan Esteban G Burchard Sharon L R Kardia Jiang He Robert C Kaplan Nicholas L Smith Donna K Arnett David A Schwartz Adolfo Correa Mariza de Andrade Xiuqing Guo Barbara A Konkle Brian Custer Juan M Peralta Hongsheng Gui Deborah A Meyers Stephen T McGarvey Ida Yii-Der Chen M Benjamin Shoemaker Patricia A Peyser Jai G Broome Stephanie M Gogarten Fei Fei Wang Quenna Wong May E Montasser Michelle Daya Eimear E Kenny Kari E North Lenore J Launer Brian E Cade Joshua C Bis Michael H Cho Jessica Lasky-Su Donald W Bowden L Adrienne Cupples Angel C Y Mak Lewis C Becker Jennifer A Smith Tanika N Kelly Stella Aslibekyan Susan R Heckbert Hemant K Tiwari Ivana V Yang John A Heit Steven A Lubitz Jill M Johnsen Joanne E Curran Sally E Wenzel Daniel E Weeks Dabeeru C Rao Dawood Darbar Jee-Young Moon Russell P Tracy Erin J Buth Nicholas Rafaels Ruth J F Loos Peter Durda Yongmei Liu Lifang Hou Jiwon Lee Priyadarshini Kachroo Barry I Freedman Daniel Levy Lawrence F Bielak James E Hixson James S Floyd Eric A Whitsel Patrick T Ellinor Marguerite R Irvin Tasha E Fingerlin Laura M Raffield Sebastian M Armasu Marsha M Wheeler Ester C Sabino John Blangero L Keoki Williams Bruce D Levy Wayne Huey-Herng Sheu Dan M Roden Eric Boerwinkle JoAnn E Manson Rasika A Mathias Pinkal Desai Kent D Taylor Andrew D Johnson Paul L Auer Charles Kooperberg Cathy C Laurie Thomas W Blackwell Albert V Smith Hongyu Zhao Ethan Lange Leslie Lange Stephen S Rich Jerome I Rotter James G Wilson Paul Scheet Jacob O Kitzman Eric S Lander Jesse M Engreitz Benjamin L Ebert Alexander P Reiner Siddhartha Jaiswal Gonçalo Abecasis Vijay G Sankaran Sekar Kathiresan Pradeep Natarajan

Nature 2020 Oct 14. Epub 2020 Oct 14.

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41586-020-2819-2DOI Listing
October 2020

A linear prognostic score based on the ratio of interleukin-6 to interleukin-10 predicts outcomes in COVID-19.

EBioMedicine 2020 Oct 8;61:103026. Epub 2020 Oct 8.

Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland; Beaumont Hospital, Dublin, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2020.103026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7543971PMC
October 2020

locStra: Fast analysis of regional/global stratification in whole-genome sequencing studies.

Genet Epidemiol 2020 Sep 14. Epub 2020 Sep 14.

Department of Biostatistics, T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/gepi.22356DOI Listing
September 2020

Protective effect of club cell secretory protein (CC-16) on COPD risk and progression: a Mendelian randomisation study.

Thorax 2020 Nov 24;75(11):934-943. Epub 2020 Aug 24.

Centre for Heart Lung Innovation, St Paul's Hospital, The University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1136/thoraxjnl-2019-214487DOI Listing
November 2020

CASTER: Cross-Sectional Asthma STEroid Response Measurement.

J Pers Med 2020 Aug 20;10(3). Epub 2020 Aug 20.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.3390/jpm10030095DOI Listing
August 2020

VTE in ICU Patients With COVID-19.

Chest 2020 Jul 22. Epub 2020 Jul 22.

Department of Medicine, Hematology Division, Brigham and Women's Hospital, Boston, MA; Hematology Department, Dana-Farber Cancer Institute, Boston, MA. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2020.07.031DOI Listing
July 2020

Statistical considerations for the analysis of massively parallel reporter assays data.

Genet Epidemiol 2020 Jul 18. Epub 2020 Jul 18.

Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1002/gepi.22337DOI Listing
July 2020

Why is Disease Penetration So Variable? Role of Genetic Modifiers of Lung Function in Alpha-1 Antitrypsin Deficiency.

Chronic Obstr Pulm Dis 2020 Jul;7(3):214-223

Channing Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.15326/jcopdf.7.3.2019.0159DOI Listing
July 2020

Trait Insights Gained by Comparing Genome-Wide Association Study Results using Different Chronic Obstructive Pulmonary Disease Definitions.

AMIA Jt Summits Transl Sci Proc 2020 30;2020:278-287. Epub 2020 May 30.

Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233028PMC
May 2020

A Between Ethnicities Comparison of Chronic Obstructive Pulmonary Disease Genetic Risk.

Front Genet 2020 21;11:329. Epub 2020 Apr 21.

Department of Public Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, South Korea.

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http://dx.doi.org/10.3389/fgene.2020.00329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187688PMC
April 2020

Machine Learning and Prediction of All-Cause Mortality in COPD.

Chest 2020 Sep 27;158(3):952-964. Epub 2020 Apr 27.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2020.02.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478228PMC
September 2020

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations.

PLoS Genet 2019 12 23;15(12):e1008500. Epub 2019 Dec 23.

Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1008500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953885PMC
December 2019

Mixed-model admixture mapping identifies smoking-dependent loci of lung function in African Americans.

Eur J Hum Genet 2020 May 13;28(5):656-668. Epub 2019 Dec 13.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41431-019-0545-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171162PMC
May 2020

Obstructive lung diseases and risk of rheumatoid arthritis.

Expert Rev Clin Immunol 2020 01 6;16(1):37-50. Epub 2020 Jan 6.

Brigham and Women's Hospital, Division of Rheumatology, Immunology and Allergy, Boston, MA, USA.

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http://dx.doi.org/10.1080/1744666X.2019.1698293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980732PMC
January 2020

A flexible and nearly optimal sequential testing approach to randomized testing: QUICK-STOP.

Genet Epidemiol 2020 03 11;44(2):139-147. Epub 2019 Nov 11.

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1002/gepi.22268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028451PMC
March 2020

COPDGene 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease.

Authors:
Katherine E Lowe Elizabeth A Regan Antonio Anzueto Erin Austin John H M Austin Terri H Beaty Panayiotis V Benos Christopher J Benway Surya P Bhatt Eugene R Bleecker Sandeep Bodduluri Jessica Bon Aladin M Boriek Adel Re Boueiz Russell P Bowler Matthew Budoff Richard Casaburi Peter J Castaldi Jean-Paul Charbonnier Michael H Cho Alejandro Comellas Douglas Conrad Corinne Costa Davis Gerard J Criner Douglas Curran-Everett Jeffrey L Curtis Dawn L DeMeo Alejandro A Diaz Mark T Dransfield Jennifer G Dy Ashraf Fawzy Margaret Fleming Eric L Flenaugh Marilyn G Foreman Spyridon Fortis Hirut Gebrekristos Sarah Grant Philippe A Grenier Tian Gu Abhya Gupta MeiLan K Han Nicola A Hanania Nadia N Hansel Lystra P Hayden Craig P Hersh Brian D Hobbs Eric A Hoffman James C Hogg John E Hokanson Karin F Hoth Albert Hsiao Stephen Humphries Kathleen Jacobs Francine L Jacobson Ella A Kazerooni Victor Kim Woo Jin Kim Gregory L Kinney Harald Koegler Sharon M Lutz David A Lynch Neil R MacIntye Barry J Make Nathaniel Marchetti Fernando J Martinez Diego J Maselli Anne M Mathews Meredith C McCormack Merry-Lynn N McDonald Charlene E McEvoy Matthew Moll Sarah S Molye Susan Murray Hrudaya Nath John D Newell Mariaelena Occhipinti Matteo Paoletti Trisha Parekh Massimo Pistolesi Katherine A Pratte Nirupama Putcha Margaret Ragland Joseph M Reinhardt Stephen I Rennard Richard A Rosiello James C Ross Harry B Rossiter Ingo Ruczinski Raul San Jose Estepar Frank C Sciurba Jessica C Sieren Harjinder Singh Xavier Soler Robert M Steiner Matthew J Strand William W Stringer Ruth Tal-Singer Byron Thomashow Gonzalo Vegas Sánchez-Ferrero John W Walsh Emily S Wan George R Washko J Michael Wells Chris H Wendt Gloria Westney Ava Wilson Robert A Wise Andrew Yen Kendra Young Jeong Yun Edwin K Silverman James D Crapo

Chronic Obstr Pulm Dis 2019 Nov;6(5):384-399

National Jewish Health, Denver, Colorado.

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http://dx.doi.org/10.15326/jcopdf.6.5.2019.0149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020846PMC
November 2019

DSP variants may be associated with longitudinal change in quantitative emphysema.

Respir Res 2019 Jul 19;20(1):160. Epub 2019 Jul 19.

Department of Epidemiology, Johns Hopkins School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, USA.

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http://dx.doi.org/10.1186/s12931-019-1097-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642569PMC
July 2019

Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Authors:
Nick Shrine Anna L Guyatt A Mesut Erzurumluoglu Victoria E Jackson Brian D Hobbs Carl A Melbourne Chiara Batini Katherine A Fawcett Kijoung Song Phuwanat Sakornsakolpat Xingnan Li Ruth Boxall Nicola F Reeve Ma'en Obeidat Jing Hua Zhao Matthias Wielscher Stefan Weiss Katherine A Kentistou James P Cook Benjamin B Sun Jian Zhou Jennie Hui Stefan Karrasch Medea Imboden Sarah E Harris Jonathan Marten Stefan Enroth Shona M Kerr Ida Surakka Veronique Vitart Terho Lehtimäki Richard J Allen Per S Bakke Terri H Beaty Eugene R Bleecker Yohan Bossé Corry-Anke Brandsma Zhengming Chen James D Crapo John Danesh Dawn L DeMeo Frank Dudbridge Ralf Ewert Christian Gieger Amund Gulsvik Anna L Hansell Ke Hao Joshua D Hoffman John E Hokanson Georg Homuth Peter K Joshi Philippe Joubert Claudia Langenberg Xuan Li Liming Li Kuang Lin Lars Lind Nicholas Locantore Jian'an Luan Anubha Mahajan Joseph C Maranville Alison Murray David C Nickle Richard Packer Margaret M Parker Megan L Paynton David J Porteous Dmitry Prokopenko Dandi Qiao Rajesh Rawal Heiko Runz Ian Sayers Don D Sin Blair H Smith María Soler Artigas David Sparrow Ruth Tal-Singer Paul R H J Timmers Maarten Van den Berge John C Whittaker Prescott G Woodruff Laura M Yerges-Armstrong Olga G Troyanskaya Olli T Raitakari Mika Kähönen Ozren Polašek Ulf Gyllensten Igor Rudan Ian J Deary Nicole M Probst-Hensch Holger Schulz Alan L James James F Wilson Beate Stubbe Eleftheria Zeggini Marjo-Riitta Jarvelin Nick Wareham Edwin K Silverman Caroline Hayward Andrew P Morris Adam S Butterworth Robert A Scott Robin G Walters Deborah A Meyers Michael H Cho David P Strachan Ian P Hall Martin D Tobin Louise V Wain

Nat Genet 2019 Jun;51(6):1067

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/s41588-019-0438-3DOI Listing
June 2019

Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis.

Authors:
Camille Moore Rachel Z Blumhagen Ivana V Yang Avram Walts Julie Powers Tarik Walker Makenna Bishop Pamela Russell Brian Vestal Jonathan Cardwell Cheryl R Markin Susan K Mathai Marvin I Schwarz Mark P Steele Joyce Lee Kevin K Brown James E Loyd James D Crapo Edwin K Silverman Michael H Cho Judith A James Joel M Guthridge Joy D Cogan Jonathan A Kropski Jeffrey J Swigris Carol Bair Dong Soon Kim Wonjun Ji Hocheol Kim Jin Woo Song Lisa A Maier Karin A Pacheco Nikhil Hirani Azin S Poon Feng Li R Gisli Jenkins Rebecca Braybrooke Gauri Saini Toby M Maher Philip L Molyneaux Peter Saunders Yingze Zhang Kevin F Gibson Daniel J Kass Mauricio Rojas John Sembrat Paul J Wolters Harold R Collard John S Sundy Thomas O'Riordan Mary E Strek Imre Noth Shwu-Fan Ma Mary K Porteous Maryl E Kreider Namrata B Patel Yoshikazu Inoue Masaki Hirose Toru Arai Shinobu Akagawa Oliver Eickelberg Isis Enlil Fernandez Jürgen Behr Nesrin Mogulkoc Tamera J Corte Ian Glaspole Sara Tomassetti Claudia Ravaglia Venerino Poletti Bruno Crestani Raphael Borie Caroline Kannengiesser Helen Parfrey Christine Fiddler Doris Rassl Maria Molina-Molina Carlos Machahua Ana Montes Worboys Gunnar Gudmundsson Helgi J Isaksson David J Lederer Anna J Podolanczuk Sydney B Montesi Elisabeth Bendstrup Vivi Danchel Moises Selman Annie Pardo Michael T Henry Michael P Keane Peter Doran Martina Vašáková Martina Sterclova Christopher J Ryerson Pearce G Wilcox Tsukasa Okamoto Haruhiko Furusawa Yasunari Miyazaki Geoffrey Laurent Svetlana Baltic Cecilia Prele Yuben Moodley Barry S Shea Ken Ohta Maho Suzukawa Osamu Narumoto Steven D Nathan Drew C Venuto Merte L Woldehanna Nurdan Kokturk Joao A de Andrade Tracy Luckhardt Tejaswini Kulkarni Francesco Bonella Seamus C Donnelly Aoife McElroy Michelle E Armstong Alvaro Aranda Roberto G Carbone Francesco Puppo Kenneth B Beckman Deborah A Nickerson Tasha E Fingerlin David A Schwartz

Am J Respir Crit Care Med 2019 07;200(2):199-208

1 National Jewish Health, Denver, Colorado.

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http://dx.doi.org/10.1164/rccm.201810-1891OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635791PMC
July 2019

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Authors:
Nick Shrine Anna L Guyatt A Mesut Erzurumluoglu Victoria E Jackson Brian D Hobbs Carl A Melbourne Chiara Batini Katherine A Fawcett Kijoung Song Phuwanat Sakornsakolpat Xingnan Li Ruth Boxall Nicola F Reeve Ma'en Obeidat Jing Hua Zhao Matthias Wielscher Stefan Weiss Katherine A Kentistou James P Cook Benjamin B Sun Jian Zhou Jennie Hui Stefan Karrasch Medea Imboden Sarah E Harris Jonathan Marten Stefan Enroth Shona M Kerr Ida Surakka Veronique Vitart Terho Lehtimäki Richard J Allen Per S Bakke Terri H Beaty Eugene R Bleecker Yohan Bossé Corry-Anke Brandsma Zhengming Chen James D Crapo John Danesh Dawn L DeMeo Frank Dudbridge Ralf Ewert Christian Gieger Amund Gulsvik Anna L Hansell Ke Hao Joshua D Hoffman John E Hokanson Georg Homuth Peter K Joshi Philippe Joubert Claudia Langenberg Xuan Li Liming Li Kuang Lin Lars Lind Nicholas Locantore Jian'an Luan Anubha Mahajan Joseph C Maranville Alison Murray David C Nickle Richard Packer Margaret M Parker Megan L Paynton David J Porteous Dmitry Prokopenko Dandi Qiao Rajesh Rawal Heiko Runz Ian Sayers Don D Sin Blair H Smith María Soler Artigas David Sparrow Ruth Tal-Singer Paul R H J Timmers Maarten Van den Berge John C Whittaker Prescott G Woodruff Laura M Yerges-Armstrong Olga G Troyanskaya Olli T Raitakari Mika Kähönen Ozren Polašek Ulf Gyllensten Igor Rudan Ian J Deary Nicole M Probst-Hensch Holger Schulz Alan L James James F Wilson Beate Stubbe Eleftheria Zeggini Marjo-Riitta Jarvelin Nick Wareham Edwin K Silverman Caroline Hayward Andrew P Morris Adam S Butterworth Robert A Scott Robin G Walters Deborah A Meyers Michael H Cho David P Strachan Ian P Hall Martin D Tobin Louise V Wain

Nat Genet 2019 03 25;51(3):481-493. Epub 2019 Feb 25.

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/s41588-018-0321-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397078PMC
March 2019

Childhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study.

Respir Res 2018 Oct 29;19(1):209. Epub 2018 Oct 29.

Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA.

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-018-0890-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206739PMC
October 2018

Dissecting respiratory disease heterogeneity through the genetics of diffusing capacity.

Eur Respir J 2018 09 15;52(3). Epub 2018 Sep 15.

Channing Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA.

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http://erj.ersjournals.com/lookup/doi/10.1183/13993003.01468
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http://dx.doi.org/10.1183/13993003.01468-2018DOI Listing
September 2018

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function.

Authors:
Annah B Wyss Tamar Sofer Mi Kyeong Lee Natalie Terzikhan Jennifer N Nguyen Lies Lahousse Jeanne C Latourelle Albert Vernon Smith Traci M Bartz Mary F Feitosa Wei Gao Tarunveer S Ahluwalia Wenbo Tang Christopher Oldmeadow Qing Duan Kim de Jong Mary K Wojczynski Xin-Qun Wang Raymond Noordam Fernando Pires Hartwig Victoria E Jackson Tianyuan Wang Ma'en Obeidat Brian D Hobbs Tianxiao Huan Hongsheng Gui Margaret M Parker Donglei Hu Lauren S Mogil Gleb Kichaev Jianping Jin Mariaelisa Graff Tamara B Harris Ravi Kalhan Susan R Heckbert Lavinia Paternoster Kristin M Burkart Yongmei Liu Elizabeth G Holliday James G Wilson Judith M Vonk Jason L Sanders R Graham Barr Renée de Mutsert Ana Maria Baptista Menezes Hieab H H Adams Maarten van den Berge Roby Joehanes Albert M Levin Jennifer Liberto Lenore J Launer Alanna C Morrison Colleen M Sitlani Juan C Celedón Stephen B Kritchevsky Rodney J Scott Kaare Christensen Jerome I Rotter Tobias N Bonten Fernando César Wehrmeister Yohan Bossé Shujie Xiao Sam Oh Nora Franceschini Jennifer A Brody Robert C Kaplan Kurt Lohman Mark McEvoy Michael A Province Frits R Rosendaal Kent D Taylor David C Nickle L Keoki Williams Esteban G Burchard Heather E Wheeler Don D Sin Vilmundur Gudnason Kari E North Myriam Fornage Bruce M Psaty Richard H Myers George O'Connor Torben Hansen Cathy C Laurie Patricia A Cassano Joohon Sung Woo Jin Kim John R Attia Leslie Lange H Marike Boezen Bharat Thyagarajan Stephen S Rich Dennis O Mook-Kanamori Bernardo Lessa Horta André G Uitterlinden Hae Kyung Im Michael H Cho Guy G Brusselle Sina A Gharib Josée Dupuis Ani Manichaikul Stephanie J London

Nat Commun 2018 07 30;9(1):2976. Epub 2018 Jul 30.

Epidemiology Branch National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC, 27709, USA.

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http://dx.doi.org/10.1038/s41467-018-05369-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065313PMC
July 2018

Genome-wide assessment of gene-by-smoking interactions in COPD.

Sci Rep 2018 06 18;8(1):9319. Epub 2018 Jun 18.

Department of public health sciences, Seoul national university, Seoul, Korea.

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http://dx.doi.org/10.1038/s41598-018-27463-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006158PMC
June 2018

Genotype imputation performance of three reference panels using African ancestry individuals.

Hum Genet 2018 Apr 10;137(4):281-292. Epub 2018 Apr 10.

Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/s00439-018-1881-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209094PMC
April 2018

Integrative genomics identifies new genes associated with severe COPD and emphysema.

Respir Res 2018 03 22;19(1):46. Epub 2018 Mar 22.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Room 451, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1186/s12931-018-0744-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863845PMC
March 2018

Adrenal insufficiency and ICS: genetics takes a breath.

Lancet Respir Med 2018 06 15;6(6):407-408. Epub 2018 Mar 15.

Brigham and Women's Hospital, Department of Medicine, Channing Division of Network Medicine, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/S2213-2600(18)30101-2DOI Listing
June 2018

What do polymorphisms tell us about the mechanisms of COPD?

Clin Sci (Lond) 2017 Dec 4;131(24):2847-2863. Epub 2017 Dec 4.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, U.S.A.

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http://clinsci.org/lookup/doi/10.1042/CS20160718
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http://dx.doi.org/10.1042/CS20160718DOI Listing
December 2017

Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression.

Chest 2018 01 21;153(1):65-76. Epub 2017 Sep 21.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Division of General Medicine and Primary Care, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2017.09.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026264PMC
January 2018

On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows.

Genet Epidemiol 2017 05 20;41(4):332-340. Epub 2017 Mar 20.

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1002/gepi.22040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525021PMC
May 2017

Screening for interaction effects in gene expression data.

PLoS One 2017 16;12(3):e0173847. Epub 2017 Mar 16.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0173847PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354413PMC
September 2017

Progress in disease progression genetics: dissecting the genetic origins of lung function decline in COPD.

Thorax 2017 05 14;72(5):389-390. Epub 2017 Mar 14.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1136/thoraxjnl-2016-209666DOI Listing
May 2017

Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.

Authors:
Philip C Haycock Stephen Burgess Aayah Nounu Jie Zheng George N Okoli Jack Bowden Kaitlin Hazel Wade Nicholas J Timpson David M Evans Peter Willeit Abraham Aviv Tom R Gaunt Gibran Hemani Massimo Mangino Hayley Patricia Ellis Kathreena M Kurian Karen A Pooley Rosalind A Eeles Jeffrey E Lee Shenying Fang Wei V Chen Matthew H Law Lisa M Bowdler Mark M Iles Qiong Yang Bradford B Worrall Hugh Stephen Markus Rayjean J Hung Chris I Amos Amanda B Spurdle Deborah J Thompson Tracy A O'Mara Brian Wolpin Laufey Amundadottir Rachael Stolzenberg-Solomon Antonia Trichopoulou N Charlotte Onland-Moret Eiliv Lund Eric J Duell Federico Canzian Gianluca Severi Kim Overvad Marc J Gunter Rosario Tumino Ulrika Svenson Andre van Rij Annette F Baas Matthew J Bown Nilesh J Samani Femke N G van t'Hof Gerard Tromp Gregory T Jones Helena Kuivaniemi James R Elmore Mattias Johansson James Mckay Ghislaine Scelo Robert Carreras-Torres Valerie Gaborieau Paul Brennan Paige M Bracci Rachel E Neale Sara H Olson Steven Gallinger Donghui Li Gloria M Petersen Harvey A Risch Alison P Klein Jiali Han Christian C Abnet Neal D Freedman Philip R Taylor John M Maris Katja K Aben Lambertus A Kiemeney Sita H Vermeulen John K Wiencke Kyle M Walsh Margaret Wrensch Terri Rice Clare Turnbull Kevin Litchfield Lavinia Paternoster Marie Standl Gonçalo R Abecasis John Paul SanGiovanni Yong Li Vladan Mijatovic Yadav Sapkota Siew-Kee Low Krina T Zondervan Grant W Montgomery Dale R Nyholt David A van Heel Karen Hunt Dan E Arking Foram N Ashar Nona Sotoodehnia Daniel Woo Jonathan Rosand Mary E Comeau W Mark Brown Edwin K Silverman John E Hokanson Michael H Cho Jennie Hui Manuel A Ferreira Philip J Thompson Alanna C Morrison Janine F Felix Nicholas L Smith Angela M Christiano Lynn Petukhova Regina C Betz Xing Fan Xuejun Zhang Caihong Zhu Carl D Langefeld Susan D Thompson Feijie Wang Xu Lin David A Schwartz Tasha Fingerlin Jerome I Rotter Mary Frances Cotch Richard A Jensen Matthias Munz Henrik Dommisch Arne S Schaefer Fang Han Hanna M Ollila Ryan P Hillary Omar Albagha Stuart H Ralston Chenjie Zeng Wei Zheng Xiao-Ou Shu Andre Reis Steffen Uebe Ulrike Hüffmeier Yoshiya Kawamura Takeshi Otowa Tsukasa Sasaki Martin Lloyd Hibberd Sonia Davila Gang Xie Katherine Siminovitch Jin-Xin Bei Yi-Xin Zeng Asta Försti Bowang Chen Stefano Landi Andre Franke Annegret Fischer David Ellinghaus Carlos Flores Imre Noth Shwu-Fan Ma Jia Nee Foo Jianjun Liu Jong-Won Kim David G Cox Olivier Delattre Olivier Mirabeau Christine F Skibola Clara S Tang Merce Garcia-Barcelo Kai-Ping Chang Wen-Hui Su Yu-Sun Chang Nicholas G Martin Scott Gordon Tracey D Wade Chaeyoung Lee Michiaki Kubo Pei-Chieng Cha Yusuke Nakamura Daniel Levy Masayuki Kimura Shih-Jen Hwang Steven Hunt Tim Spector Nicole Soranzo Ani W Manichaikul R Graham Barr Bratati Kahali Elizabeth Speliotes Laura M Yerges-Armstrong Ching-Yu Cheng Jost B Jonas Tien Yin Wong Isabella Fogh Kuang Lin John F Powell Kenneth Rice Caroline L Relton Richard M Martin George Davey Smith

JAMA Oncol 2017 May;3(5):636-651

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.

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http://dx.doi.org/10.1001/jamaoncol.2016.5945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638008PMC
May 2017

Selecting cases and controls for DNA sequencing studies using family histories of disease.

Stat Med 2017 06 21;36(13):2081-2099. Epub 2017 Feb 21.

Interdisciplinary Program of Bioinformatics, Seoul National University, Seoul, Korea.

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http://dx.doi.org/10.1002/sim.7248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810411PMC
June 2017

Gene-based segregation method for identifying rare variants in family-based sequencing studies.

Genet Epidemiol 2017 05 13;41(4):309-319. Epub 2017 Feb 13.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1002/gepi.22037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397337PMC
May 2017

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.

Nat Genet 2017 Mar 6;49(3):426-432. Epub 2017 Feb 6.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381275PMC
March 2017

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.

Authors:
Louise V Wain Nick Shrine María Soler Artigas A Mesut Erzurumluoglu Boris Noyvert Lara Bossini-Castillo Ma'en Obeidat Amanda P Henry Michael A Portelli Robert J Hall Charlotte K Billington Tracy L Rimington Anthony G Fenech Catherine John Tineka Blake Victoria E Jackson Richard J Allen Bram P Prins Archie Campbell David J Porteous Marjo-Riitta Jarvelin Matthias Wielscher Alan L James Jennie Hui Nicholas J Wareham Jing Hua Zhao James F Wilson Peter K Joshi Beate Stubbe Rajesh Rawal Holger Schulz Medea Imboden Nicole M Probst-Hensch Stefan Karrasch Christian Gieger Ian J Deary Sarah E Harris Jonathan Marten Igor Rudan Stefan Enroth Ulf Gyllensten Shona M Kerr Ozren Polasek Mika Kähönen Ida Surakka Veronique Vitart Caroline Hayward Terho Lehtimäki Olli T Raitakari David M Evans A John Henderson Craig E Pennell Carol A Wang Peter D Sly Emily S Wan Robert Busch Brian D Hobbs Augusto A Litonjua David W Sparrow Amund Gulsvik Per S Bakke James D Crapo Terri H Beaty Nadia N Hansel Rasika A Mathias Ingo Ruczinski Kathleen C Barnes Yohan Bossé Philippe Joubert Maarten van den Berge Corry-Anke Brandsma Peter D Paré Don D Sin David C Nickle Ke Hao Omri Gottesman Frederick E Dewey Shannon E Bruse David J Carey H Lester Kirchner Stefan Jonsson Gudmar Thorleifsson Ingileif Jonsdottir Thorarinn Gislason Kari Stefansson Claudia Schurmann Girish Nadkarni Erwin P Bottinger Ruth J F Loos Robin G Walters Zhengming Chen Iona Y Millwood Julien Vaucher Om P Kurmi Liming Li Anna L Hansell Chris Brightling Eleftheria Zeggini Michael H Cho Edwin K Silverman Ian Sayers Gosia Trynka Andrew P Morris David P Strachan Ian P Hall Martin D Tobin

Nat Genet 2017 Mar 6;49(3):416-425. Epub 2017 Feb 6.

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/ng.3787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5326681PMC
March 2017

Whole genome prediction and heritability of childhood asthma phenotypes.

Immun Inflamm Dis 2016 12 28;4(4):487-496. Epub 2016 Nov 28.

Channing Division of Network Medicine Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts.

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http://dx.doi.org/10.1002/iid3.133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134727PMC
December 2016

Genetic regulation of expression of leukotriene A4 hydrolase.

ERJ Open Res 2016 Jan 9;2(1). Epub 2016 Feb 9.

Dept of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, AL, USA; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, USA; Lung Health Center, University of Alabama at Birmingham, Birmingham, AL, USA; Medicine Service, United States Department of Veterans Affairs Medical Center, University of Alabama at Birmingham, Birmingham, AL, USA.

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http://dx.doi.org/10.1183/23120541.00058-2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005155PMC
January 2016