Publications by authors named "Michael H Baumann"

100Publications

U-47700 and Its Analogs: Non-Fentanyl Synthetic Opioids Impacting the Recreational Drug Market.

Brain Sci 2020 Nov 23;10(11). Epub 2020 Nov 23.

Center for Forensic Science Research and Education, Fredric Rieders Family Foundation, 2300 Stratford Ave, Willow Grove, 19090 PA, USA.

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http://dx.doi.org/10.3390/brainsci10110895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700279PMC
November 2020

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J Pharmacol Exp Ther 2020 Oct 20. Epub 2020 Oct 20.

Designer Drug Research Unit (DDRU), IRP, NIDA, NIH, United States of America.

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http://dx.doi.org/10.1124/jpet.120.000129DOI Listing
October 2020

The psychoactive aminoalkylbenzofuran derivatives, 5-APB and 6-APB, mimic the effects of 3,4-methylenedioxyamphetamine (MDA) on monoamine transmission in male rats.

Psychopharmacology (Berl) 2020 Dec 1;237(12):3703-3714. Epub 2020 Sep 1.

Designer Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 333 Cassell Drive, Suite 4400, Baltimore, MD, 21224, USA.

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http://dx.doi.org/10.1007/s00213-020-05648-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686291PMC
December 2020

Pharmacodynamics and pharmacokinetics of the novel synthetic opioid, U-47700, in male rats.

Neuropharmacology 2020 10 10;177:108195. Epub 2020 Jun 10.

Designer Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2020.108195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554234PMC
October 2020

Syntheses and analytical characterizations of novel (2-aminopropyl)benzo[b]thiophene (APBT) based stimulants.

Drug Test Anal 2020 Aug 10;12(8):1109-1125. Epub 2020 Jun 10.

Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1002/dta.2813DOI Listing
August 2020

Transcranial photoacoustic imaging of NMDA-evoked focal circuit dynamics in the rat hippocampus.

J Neural Eng 2020 04 8;17(2):025001. Epub 2020 Apr 8.

Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States of America. Laboratory of Computational Sensing and Robotics, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, United States of America.

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http://dx.doi.org/10.1088/1741-2552/ab78caDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145727PMC
April 2020

Confronting the opioid crisis with basic research in neuropharmacology.

Neuropharmacology 2020 04 17;166:107972. Epub 2020 Jan 17.

Department of Pharmacology & Toxicology, Virginia Commonwealth University, 410 N. 12th Street, Richmond, VA 23298, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2020.107972DOI Listing
April 2020

Analysis for Alpha-Pyrrolidinovalerophenone and its 2-oxo-PVP Metabolite in Plasma by LiquidChromatography-Tandem Mass Spectrometry.

J Anal Toxicol 2019 Nov 27. Epub 2019 Nov 27.

Designer Drug Research Unit, IRP, NIDA, NIH, DHHS, 333 Cassell Drive, Suite 4400, Baltimore, MD 21224.

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http://dx.doi.org/10.1093/jat/bkz096DOI Listing
November 2019

Stereoselective neurochemical, behavioral, and cardiovascular effects of α-pyrrolidinovalerophenone enantiomers in male rats.

Addict Biol 2020 Nov 13;25(6):e12842. Epub 2019 Nov 13.

Designer Drug Research Unit, Intramural Research Program of the National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1111/adb.12842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217742PMC
November 2020

Newly Developed Dopamine D Receptor Antagonists, -VK4-40 and -VK4-116, Do Not Potentiate Cardiovascular Effects of Cocaine or Oxycodone in Rats.

J Pharmacol Exp Ther 2019 12 27;371(3):602-614. Epub 2019 Sep 27.

Molecular Targets and Medications Discovery Branch (C.J.J., B.A.H., A.B.S., Z.-X.X., A.H.N.), Designer Drug Research Unit (M.H.B., C.W.S.), and Preclinical Pharmacology Section (E.B.T., C.W.S.), Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland

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http://dx.doi.org/10.1124/jpet.119.259390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863462PMC
December 2019

Metabolites of the ring-substituted stimulants MDMA, methylone and MDPV differentially affect human monoaminergic systems.

J Psychopharmacol 2019 07 30;33(7):831-841. Epub 2019 Apr 30.

1 Division of Clinical Pharmacology and Toxicology, Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1177/0269881119844185DOI Listing
July 2019

Evidence for nonlinear accumulation of the ultrapotent fentanyl analog, carfentanil, after systemic administration to male rats.

Neuropharmacology 2019 11 6;158:107596. Epub 2019 Apr 6.

Designer Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2019.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263480PMC
November 2019

2-Aminoindan and its ring-substituted derivatives interact with plasma membrane monoamine transporters and α-adrenergic receptors.

Psychopharmacology (Berl) 2019 Mar 23;236(3):989-999. Epub 2019 Mar 23.

Designer Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, 21224, USA.

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http://dx.doi.org/10.1007/s00213-019-05207-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848746PMC
March 2019

The Supplement Adulterant -Methylphenethylamine Increases Blood Pressure by Acting at Peripheral Norepinephrine Transporters.

J Pharmacol Exp Ther 2019 06 21;369(3):328-336. Epub 2019 Mar 21.

Designer Drug Research Unit (C.W.S., J.S.P., M.H.B.) and Preclinical Pharmacology Section (E.B.T.), National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland; and Drug Design and Synthesis Section, National Institute on Drug Abuse and National Institute of Alcohol Abuse and Alcoholism Intramural Research Programs, Rockville, Maryland (K.C.R.).

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http://dx.doi.org/10.1124/jpet.118.255976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533570PMC
June 2019

Pharmacological Research as a Key Component in Mitigating the Opioid Overdose Crisis.

Trends Pharmacol Sci 2018 12;39(12):995-998

Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01656147183017
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http://dx.doi.org/10.1016/j.tips.2018.09.006DOI Listing
December 2018

Neuropharmacology of Synthetic Cathinones.

Handb Exp Pharmacol 2018;252:113-142

Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.

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http://link.springer.com/10.1007/164_2018_178
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http://dx.doi.org/10.1007/164_2018_178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257813PMC
June 2019

Systematic Structure-Activity Studies on Selected 2-, 3-, and 4-Monosubstituted Synthetic Methcathinone Analogs as Monoamine Transporter Releasing Agents.

ACS Chem Neurosci 2019 01 7;10(1):740-745. Epub 2018 Nov 7.

Department of Medicinal Chemistry, School of Pharmacy , Virginia Commonwealth University , Richmond , Virginia 23298 , United States.

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http://dx.doi.org/10.1021/acschemneuro.8b00524DOI Listing
January 2019

The synthetic cathinones, butylone and pentylone, are stimulants that act as dopamine transporter blockers but 5-HT transporter substrates.

Psychopharmacology (Berl) 2019 Mar 22;236(3):953-962. Epub 2018 Oct 22.

Designer Drug Research Unit (DDRU), Intramural Research Program (IRP), NIDA, NIH, DHHS, 333 Cassell Drive, Suite 4400, Baltimore, MD, 21224, USA.

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http://link.springer.com/10.1007/s00213-018-5075-5
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http://dx.doi.org/10.1007/s00213-018-5075-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476708PMC
March 2019

The dopamine, serotonin and norepinephrine releasing activities of a series of methcathinone analogs in male rat brain synaptosomes.

Psychopharmacology (Berl) 2019 Mar 20;236(3):915-924. Epub 2018 Oct 20.

Designer Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, 21224, USA.

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http://dx.doi.org/10.1007/s00213-018-5063-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475490PMC
March 2019

Pharmacodynamic Effects, Pharmacokinetics, and Metabolism of the Synthetic Cannabinoid AM-2201 in Male Rats.

J Pharmacol Exp Ther 2018 12 28;367(3):543-550. Epub 2018 Sep 28.

Chemistry and Drug Metabolism (J.C., A.W., K.B.S., M.A.H.) and Designer Drug Research Unit (B.D.S., M.H.B.), Intramural Research Program, National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Baltimore, Maryland

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http://dx.doi.org/10.1124/jpet.118.250530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246978PMC
December 2018

Analytical quantification, intoxication case series, and pharmacological mechanism of action for N-ethylnorpentylone (N-ethylpentylone or ephylone).

Drug Test Anal 2019 Mar 21;11(3):461-471. Epub 2018 Oct 21.

Designer Drug Research Unit of the Intramural Research Program, National Institute on Drug Abuse (NIDA), National Institutes of Health, Baltimore, MD, USA.

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http://dx.doi.org/10.1002/dta.2502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316160PMC
March 2019

Effects of N-Alkyl-4-Methylamphetamine Optical Isomers on Plasma Membrane Monoamine Transporters and Abuse-Related Behavior.

ACS Chem Neurosci 2018 07 14;9(7):1829-1839. Epub 2018 May 14.

Department of Physiology and Biophysics, School of Medicine , Virginia Commonwealth University , Richmond , Virginia 23298 United States.

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http://pubs.acs.org/doi/10.1021/acschemneuro.8b00138
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http://dx.doi.org/10.1021/acschemneuro.8b00138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051915PMC
July 2018

Repeated Exposure to the "Spice" Cannabinoid JWH-018 Induces Tolerance and Enhances Responsiveness to 5-HT Receptor Stimulation in Male Rats.

Front Psychiatry 2018 27;9:55. Epub 2018 Feb 27.

Designer Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, United States.

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http://dx.doi.org/10.3389/fpsyt.2018.00055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835089PMC
February 2018

Comparative neuropharmacology of N-(2-methoxybenzyl)-2,5-dimethoxyphenethylamine (NBOMe) hallucinogens and their 2C counterparts in male rats.

Neuropharmacology 2018 11 1;142:240-250. Epub 2018 Mar 1.

Designer Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, 21224, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00283908183009
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http://dx.doi.org/10.1016/j.neuropharm.2018.02.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119551PMC
November 2018

Fentanyl-related designer drugs W-18 and W-15 lack appreciable opioid activity in vitro and in vivo.

JCI Insight 2017 11 16;2(22). Epub 2017 Nov 16.

Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1172/jci.insight.97222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752382PMC
November 2017

Novel Synthetic Opioids and Overdose Deaths: Tip of the Iceberg?

Neuropsychopharmacology 2018 01;43(1):216-217

Department of Neurology and Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://www.nature.com/doifinder/10.1038/npp.2017.211
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http://dx.doi.org/10.1038/npp.2017.211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719114PMC
January 2018

Fluorinated phenmetrazine "legal highs" act as substrates for high-affinity monoamine transporters of the SLC6 family.

Neuropharmacology 2018 05 6;134(Pt A):149-157. Epub 2017 Oct 6.

Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Waehringerstrasse 13A, 1090, Vienna, Austria; Center for Addiction Research and Science - AddRess, Medical University Vienna, Waehringerstrasse 13A, 1090 Vienna, Austria. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00283908173047
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http://dx.doi.org/10.1016/j.neuropharm.2017.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294773PMC
May 2018

Trace amine-associated receptor 1 regulation of methamphetamine-induced neurotoxicity.

Neurotoxicology 2017 Dec 15;63:57-69. Epub 2017 Sep 15.

Research Service, VA Portland Health Care System, Portland, OR, USA; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA; The Methamphetamine Abuse Research Center, Oregon Health & Science University, Portland, OR, USA; Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuro.2017.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683899PMC
December 2017

Synthetic cannabinoids found in "spice" products alter body temperature and cardiovascular parameters in conscious male rats.

Drug Alcohol Depend 2017 10 18;179:387-394. Epub 2017 Aug 18.

Designer Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, United States.

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http://dx.doi.org/10.1016/j.drugalcdep.2017.07.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599362PMC
October 2017

Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates.

J Biol Chem 2017 10 23;292(40):16773-16786. Epub 2017 Aug 23.

From the Institute of Pharmacology and the Gaston H. Glock Research Laboratories for Exploratory Drug Development, Center of Physiology and Pharmacology, Medical University of Vienna, A-1090 Vienna, Austria,

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http://dx.doi.org/10.1074/jbc.M117.794081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633137PMC
October 2017

Impact of Novel Psychoactive Substances on Clinical and Forensic Toxicology and Global Public Health.

Clin Chem 2017 10 30;63(10):1564-1569. Epub 2017 Jun 30.

Staff Scientist and Facility Head, Designer Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD.

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http://dx.doi.org/10.1373/clinchem.2017.274662DOI Listing
October 2017

Misuse of Novel Synthetic Opioids: A Deadly New Trend.

J Addict Med 2017 Jul/Aug;11(4):256-265

Department of Internal Medicine, University of Nevada School of Medicine, Las Vegas (MPP); Touro University College of Osteopathic Medicine, Henderson, NV (PAM); and Designer Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD (MHM).

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http://dx.doi.org/10.1097/ADM.0000000000000324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537029PMC
June 2017

N-Alkylated Analogs of 4-Methylamphetamine (4-MA) Differentially Affect Monoamine Transporters and Abuse Liability.

Neuropsychopharmacology 2017 Sep 22;42(10):1950-1961. Epub 2017 May 22.

Designer Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/npp.2017.98DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561352PMC
September 2017

Deconstructed Analogues of Bupropion Reveal Structural Requirements for Transporter Inhibition versus Substrate-Induced Neurotransmitter Release.

ACS Chem Neurosci 2017 06 27;8(6):1397-1403. Epub 2017 Feb 27.

Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University , Richmond, Virginia 23298 United States.

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http://dx.doi.org/10.1021/acschemneuro.7b00055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261150PMC
June 2017

Atypical dopamine efflux caused by 3,4-methylenedioxypyrovalerone (MDPV) via the human dopamine transporter.

J Chem Neuroanat 2017 Oct 3;83-84:69-74. Epub 2017 Feb 3.

Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37232-8548, United States; Neuroscience Program in Substance Abuse (N-PISA), Vanderbilt University, Nashville, TN 37232-8548, United States; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232-8548, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jchemneu.2017.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540822PMC
October 2017

Neuropharmacology of 3,4-Methylenedioxypyrovalerone (MDPV), Its Metabolites, and Related Analogs.

Curr Top Behav Neurosci 2017 ;32:93-117

Chemistry and Drug Metabolism Section of the Intramural Research Program, National Institute on Drug Abuse (NIDA), National Institutes of Health, Baltimore, MD, USA.

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http://link.springer.com/10.1007/7854_2016_53
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http://dx.doi.org/10.1007/7854_2016_53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392131PMC
July 2017

Pharmacokinetic Profiles and Pharmacodynamic Effects for Methylone and Its Metabolites in Rats.

Neuropsychopharmacology 2017 02 23;42(3):649-660. Epub 2016 Sep 23.

Designer Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/npp.2016.213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240186PMC
February 2017

Enduring Loss of Serotonergic Control of Orbitofrontal Cortex Function Following Contingent and Noncontingent Cocaine Exposure.

Cereb Cortex 2017 12;27(12):5463-5476

Electrophysiology Research Section, Cellular Neurobiology Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1093/cercor/bhw312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075564PMC
December 2017

Pharmacological mechanisms underlying the cardiovascular effects of the "bath salt" constituent 3,4-methylenedioxypyrovalerone (MDPV).

Br J Pharmacol 2016 12 16;173(24):3492-3501. Epub 2016 Nov 16.

Designer Drug Research Unit, National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD.

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http://dx.doi.org/10.1111/bph.13640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120154PMC
December 2016

The Changing Face of Recreational Drug Use.

Cerebrum 2016 Jan-Feb;2016. Epub 2016 Jan 1.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938259PMC
July 2016

Quantification of [1-(5-fluoropentyl)-1H-indol-3-yl](naphthalene-1-yl)methanone (AM-2201) and 13 metabolites in human and rat plasma by liquid chromatography-tandem mass spectrometry.

J Chromatogr A 2016 Jun 6;1451:97-106. Epub 2016 May 6.

Clinical Pharmacology & Therapeutics Research Branch, Chemistry and Drug Metabolism Section, Intramural Research Program, National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), 251 Bayview Boulevard Suite 200, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/j.chroma.2016.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886661PMC
June 2016

Abuse-related neurochemical and behavioral effects of cathinone and 4-methylcathinone stereoisomers in rats.

Eur Neuropsychopharmacol 2016 Feb 11;26(2):288-297. Epub 2015 Dec 11.

Department of Pharmacology and Toxicology, Virginia Commonwealth University, 410 N. 12th St., PO Box 980613, Richmond, VA 23298, USA; Institute for Drug and Alcohol Studies, Virginia Commonwealth University, USA. Electronic address:

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http://dx.doi.org/10.1016/j.euroneuro.2015.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331761PMC
February 2016

Disruption of hippocampal synaptic transmission and long-term potentiation by psychoactive synthetic cannabinoid 'Spice' compounds: comparison with Δ -tetrahydrocannabinol.

Addict Biol 2017 Mar 5;22(2):390-399. Epub 2016 Jan 5.

Electrophysiology Research Section, Cellular Neurobiology Branch, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, USA.

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http://dx.doi.org/10.1111/adb.12334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935655PMC
March 2017

Binding Mode Selection Determines the Action of Ecstasy Homologs at Monoamine Transporters.

Mol Pharmacol 2016 Jan 30;89(1):165-75. Epub 2015 Oct 30.

Institute of Pharmacology, Center for Physiology and Pharmacology (W.S., T.Sto., P.S.H., M.H., T.Ste., H.H.S.) and Center for Addiction Research and Science (H.H.S.), Medical University of Vienna, Vienna, Austria; Designer Drug Research Unit (J.S.P., M.H.B.) and Medicinal Chemistry Section (J.J.C., A.H.N.), Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, Maryland; Department of Pharmaceutical Chemistry, University of Vienna, Vienna, Austria (A.S., G.F.E.); and Department of Pharmacology, Yale University, New Haven, Connecticut (Y.-W.Z., G.R.)

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http://molpharm.aspetjournals.org/content/early/2015/10/30/m
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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.115.10
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http://dx.doi.org/10.1124/mol.115.101394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702095PMC
January 2016

The new psychoactive substances 5-(2-aminopropyl)indole (5-IT) and 6-(2-aminopropyl)indole (6-IT) interact with monoamine transporters in brain tissue.

Neuropharmacology 2016 Feb 8;101:68-75. Epub 2015 Sep 8.

Designer Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2015.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681602PMC
February 2016

Reinforcing and neurochemical effects of the "bath salts" constituents 3,4-methylenedioxypyrovalerone (MDPV) and 3,4-methylenedioxy-N-methylcathinone (methylone) in male rats.

Psychopharmacology (Berl) 2016 05 29;233(10):1981-90. Epub 2015 Aug 29.

Designer Drug Research Unit, Intramural Research Program of the National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, 21224, USA.

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http://dx.doi.org/10.1007/s00213-015-4057-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772144PMC
May 2016

Abuse of New Psychoactive Substances: Threats and Solutions.

Neuropsychopharmacology 2016 Feb 25;41(3):663-5. Epub 2015 Aug 25.

Office of the Director, National Institute on Drug Abuse, National Institutes of Health, Rockville, MD, USA.

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http://www.nature.com/articles/npp2015260
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http://dx.doi.org/10.1038/npp.2015.260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707839PMC
February 2016

Ethylenedioxy homologs of N-methyl-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA) and its corresponding cathinone analog methylenedioxymethcathinone: Interactions with transporters for serotonin, dopamine, and norepinephrine.

Bioorg Med Chem 2015 Sep 23;23(17):5574-9. Epub 2015 Jul 23.

Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Box 980540, Richmond, VA 23298, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.07.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562428PMC
September 2015

Clinically Relevant Pharmacological Strategies That Reverse MDMA-Induced Brain Hyperthermia Potentiated by Social Interaction.

Neuropsychopharmacology 2016 Jan 24;41(2):549-59. Epub 2015 Jun 24.

National Institute on Drug Abuse-Intramural Research Program, NIH, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/npp.2015.182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130130PMC
January 2016

Studies of the biogenic amine transporters 15. Identification of novel allosteric dopamine transporter ligands with nanomolar potency.

J Pharmacol Exp Ther 2015 Jun 18;353(3):529-38. Epub 2015 Mar 18.

Medicinal Chemistry Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland (R.B.R., J.S.P., M.H.B.); and Department of Chemistry, Drug Discovery Division, Southern Research Institute, Birmingham, Alabama (S.A., S.K.S., O.M.-C., V.P.).

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.114.22229
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http://dx.doi.org/10.1124/jpet.114.222299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429677PMC
June 2015

Modafinil and its metabolites enhance the anticonvulsant action of classical antiepileptic drugs in the mouse maximal electroshock-induced seizure model.

Psychopharmacology (Berl) 2015 Jul 21;232(14):2463-79. Epub 2015 Feb 21.

Department of Neurology, School of Medicine, University of California, Davis, Sacramento, California, USA.

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http://dx.doi.org/10.1007/s00213-015-3884-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480820PMC
July 2015

Behavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporter.

Drug Alcohol Depend 2015 Feb 18;147:1-19. Epub 2014 Dec 18.

Psychobiology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/j.drugalcdep.2014.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297708PMC
February 2015

'Second-generation' mephedrone analogs, 4-MEC and 4-MePPP, differentially affect monoamine transporter function.

Neuropsychopharmacology 2015 May 15;40(6):1321-31. Epub 2014 Dec 15.

Designer Drug Research Unit (DDRU), Intramural Research Program (IRP), NIDA, NIH, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/npp.2014.325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397398PMC
May 2015

Linear pharmacokinetics of 3,4-methylenedioxypyrovalerone (MDPV) and its metabolites in the rat: relationship to pharmacodynamic effects.

Addict Biol 2016 Mar 5;21(2):339-47. Epub 2014 Dec 5.

Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA.

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http://doi.wiley.com/10.1111/adb.12201
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http://dx.doi.org/10.1111/adb.12201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362107PMC
March 2016

Stereochemistry of mephedrone neuropharmacology: enantiomer-specific behavioural and neurochemical effects in rats.

Br J Pharmacol 2015 Feb 15;172(3):883-94. Epub 2014 Dec 15.

Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA, USA; Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/bph.12951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301696PMC
February 2015

The authors reply.

Crit Care Med 2014 Oct;42(10):e678-9

Department of Anesthesiology and Critical Care Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD Critical Care Medicine, Houston Methodist Hospital, Houston, TX Center for Adult Critical Care, Division of Pulmonary and Critical Care Medicine, Virginia Commonwealth University Health System, Medical College of Virginia Hospitals and Physicians, Richmond, VA Division of Pulmonary, Critical Care, and Sleep Medicine, University of Mississippi Medical Center, Jackson, MS Department of Critical Care Medicine, Mayo Clinic Arizona, Phoenix, AZ Division of Pulmonary, Allergy and Critical Care, Emory University School of Medicine, Atlanta, GA; on behalf of the Critical Care Societies Collaborative Task Force on Critical Care Educational Pathways in Internal Medicine.

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http://dx.doi.org/10.1097/CCM.0000000000000531DOI Listing
October 2014

Alpha-ethyltryptamines as dual dopamine-serotonin releasers.

Bioorg Med Chem Lett 2014 Oct 29;24(19):4754-4758. Epub 2014 Jul 29.

Medicinal Chemistry Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/j.bmcl.2014.07.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211607PMC
October 2014

Awash in a sea of 'bath salts': implications for biomedical research and public health.

Addiction 2014 Oct 1;109(10):1577-9. Epub 2014 Jul 1.

Designer Drug Research Unit (DDRU), Intramural Research Program (IRP), National Institutes on Drug Abuse (NIDA), 333 Cassell Drive, Suite 4400, Baltimore, MD, 21224, USA.

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http://dx.doi.org/10.1111/add.12601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896154PMC
October 2014

Hybrid dopamine uptake blocker-serotonin releaser ligands: a new twist on transporter-focused therapeutics.

ACS Med Chem Lett 2014 Jun 15;5(6):623-7. Epub 2014 Apr 15.

Medicinal Chemistry Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health , Baltimore, Maryland 21224, United States.

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http://dx.doi.org/10.1021/ml500113sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060932PMC
June 2014

3,4-Methylenedioxypyrovalerone (MDPV) and metabolites quantification in human and rat plasma by liquid chromatography-high resolution mass spectrometry.

Anal Chim Acta 2014 May 12;827:54-63. Epub 2014 Apr 12.

Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.aca.2014.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150738PMC
May 2014

Interaction of psychoactive tryptamines with biogenic amine transporters and serotonin receptor subtypes.

Psychopharmacology (Berl) 2014 Oct 7;231(21):4135-44. Epub 2014 May 7.

Center for Drug Discovery, RTI International, 3040 Cornwallis Road, Research Triangle Park, Durham, NC, 27709, USA,

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http://dx.doi.org/10.1007/s00213-014-3557-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194234PMC
October 2014

Abuse-related effects of dual dopamine/serotonin releasers with varying potency to release norepinephrine in male rats and rhesus monkeys.

Exp Clin Psychopharmacol 2014 Jun 5;22(3):274-284. Epub 2014 May 5.

Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA USA.

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http://dx.doi.org/10.1037/a0036595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067459PMC
June 2014

Pharmacology of novel synthetic stimulants structurally related to the "bath salts" constituent 3,4-methylenedioxypyrovalerone (MDPV).

Neuropharmacology 2014 Dec 2;87:206-13. Epub 2014 Mar 2.

Designer Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2014.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152390PMC
December 2014

An official multi-society statement: ventilator-associated events--the new definition.

Ann Am Thorac Soc 2014 Jan;11(1):99-100

1 Department of Pulmonary and Critical Care Medicine New York Methodist Hospital Brooklyn, New York.

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http://dx.doi.org/10.1513/AnnalsATS.201311-401OTDOI Listing
January 2014

An official multi-society statement: ventilator-associated events: the new definition.

Chest 2014 Jan;145(1):10-12

The Critical Care Societies Collaborative consists of American College of Chest Physicians, American Association of Critical-Care Nurses, Society of Critical Care Medicine, and American Thoracic Society.

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http://dx.doi.org/10.1378/chest.13-2731DOI Listing
January 2014

Ventilator-associated events: the new definition.

Am J Crit Care 2014 Jan;23(1):7-9

Suhail Raoof is in the Department of Pulmonary and Critical Care Medicine at New York Methodist Hospital, Brooklyn, New York. Michael H. Baumann is professor of medicine within the Division of Pulmonary, Critical Care and Sleep Medicine at University of Mississippi Medical Center, Jackson, Mississippi.

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http://dx.doi.org/10.4037/ajcc2014469DOI Listing
January 2014

An official multi-society statement: ventilator-associated events: the new definition.

Crit Care Med 2014 Jan;42(1):228-9

Division of Pulmonary and Critical Care Medicine, New York Methodist Hospital, Brooklyn, NY Division of Pulmonary, Critical Care, and Sleep Medicine, University of Mississippi Medical Center, Jackson, MS consisting of the leadership of the American Association of Critical-Care Nurses, the American College of Chest Physicians, the American Thoracic Society, and the Society of Critical Care Medicine.

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http://dx.doi.org/10.1097/CCM.0000000000000191DOI Listing
January 2014

Effects of 3,4-methylenedioxymethamphetamine (MDMA) and its main metabolites on cardiovascular function in conscious rats.

Br J Pharmacol 2014 Jan;171(1):83-91

Preclinical Pharmacology, National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD, USA.

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http://dx.doi.org/10.1111/bph.12423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874698PMC
January 2014

Nonlinear pharmacokinetics of (+/-)3,4-methylenedioxymethamphetamine (MDMA) and its pharmacodynamic consequences in the rat.

Drug Metab Dispos 2014 Jan 18;42(1):119-25. Epub 2013 Oct 18.

Chemistry and Drug Metabolism Section (M.C., K.B.S., M.A.H.), and Designer Drug Research Unit (M.H.B., R.B.R.), Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland; and Department of Neuroscience, Weill Cornell Medical College, New York, New York (G.F.M.).

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.113.053678
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http://dx.doi.org/10.1124/dmd.113.053678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876787PMC
January 2014

Age differences in (±) 3,4-methylenedioxymethamphetamine (MDMA)-induced conditioned taste aversions and monoaminergic levels.

Dev Psychobiol 2014 May 15;56(4):635-46. Epub 2013 Jun 15.

Psychopharmacology Laboratory, Department of Psychology, American University, 4400 Massachusetts Ave NW, Washington, DC, 20016.

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http://dx.doi.org/10.1002/dev.21132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128552PMC
May 2014

Quality improvement and pay for performance: barriers to and strategies for success.

Chest 2013 Jun;143(6):1542-1547

Division of Pulmonary, Critical Care, and Sleep Medicine, University of Mississippi Medical Center, Jackson, MS.

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http://dx.doi.org/10.1378/chest.12-2491DOI Listing
June 2013

Psychoactive "bath salts": not so soothing.

Eur J Pharmacol 2013 Jan 23;698(1-3):1-5. Epub 2012 Nov 23.

Medicinal Chemistry Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 333 Cassell Drive, Suite 4500, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/j.ejphar.2012.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537229PMC
January 2013

Pharmacological examination of trifluoromethyl ring-substituted methcathinone analogs.

Eur J Pharmacol 2013 Jan 21;699(1-3):180-7. Epub 2012 Nov 21.

Neuropharmacology Laboratory, 2695 Medical Sciences Center, Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, 1300 University Avenue, Madison, WI 53706, USA.

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http://dx.doi.org/10.1016/j.ejphar.2012.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656655PMC
January 2013

Psychoactive 'bath salts': compounds, mechanisms, and toxicities.

Neuropsychopharmacology 2013 Jan;38(1):243-4

Medicinal Chemistry Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/npp.2012.162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521974PMC
January 2013

Powerful cocaine-like actions of 3,4-methylenedioxypyrovalerone (MDPV), a principal constituent of psychoactive 'bath salts' products.

Neuropsychopharmacology 2013 Mar 17;38(4):552-62. Epub 2012 Oct 17.

Medicinal Chemistry Section of the Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1038/npp.2012.204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572453PMC
March 2013

First, do no harm: less training ≠ quality care.

Am J Crit Care 2012 Jul 20;21(4):227-30. Epub 2012 Jun 20.

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http://dx.doi.org/10.4037/ajcc2012825DOI Listing
July 2012

First, do no harm: less training ≠ quality care.

Chest 2012 Jul;142(1):5-8

Medical College of Wisconsin, Milwaukee, WI.

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http://dx.doi.org/10.1378/chest.12-1354DOI Listing
July 2012

Studies of the biogenic amine transporters. 14. Identification of low-efficacy "partial" substrates for the biogenic amine transporters.

J Pharmacol Exp Ther 2012 Apr 23;341(1):251-62. Epub 2012 Jan 23.

Translational Pharmacology Section, Intramural Research Program, National Institute on Drug Abuse, 333 Cassell Drive, Suite 4500, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1124/jpet.111.188946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364510PMC
April 2012

The designer methcathinone analogs, mephedrone and methylone, are substrates for monoamine transporters in brain tissue.

Neuropsychopharmacology 2012 Apr 14;37(5):1192-203. Epub 2011 Dec 14.

Translational Pharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA.

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http://www.nature.com/articles/npp2011304
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http://dx.doi.org/10.1038/npp.2011.304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306880PMC
April 2012

Effects of MDMA and related analogs on plasma 5-HT: relevance to 5-HT transporters in blood and brain.

Eur J Pharmacol 2012 Jan 3;674(2-3):337-44. Epub 2011 Nov 3.

Human Pharmacology and Clinical Neurosciences Research Group, Neurosciences Research Program, IMIM-Hospital del Mar Research Institute, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.ejphar.2011.10.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253888PMC
January 2012

Chest ultrasonography: where's the beef?

Chest 2011 Oct;140(4):837-839

Division of Pulmonary, Critical Care and Sleep Medicine, University of Mississippi Medical Center, Jackson, MS. Electronic address:

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http://dx.doi.org/10.1378/chest.11-1093DOI Listing
October 2011