Michael Grusch

Shifting the Immune-Suppressive to Predominant Immune-Stimulatory Radiation Effects by SBRT-PArtial Tumor Irradiation Targeting HYpoxic Segment (SBRT-PATHY).

Authors:

Slavisa Tubin Seema Gupta Michael Grusch Helmuth H Popper Luka Brcic Martin L Ashdown Samir N Khleif Barbara Peter-Vörösmarty Martin Hyden Simone Negrini Piero Fossati Eugen Hug

Cancers (Basel) 2020 Dec 26;13(1). Epub 2020 Dec 26.

MedAustron Ion Therapy Center, Marie Curie-Straße 5, 2700 Wiener Neustadt, Austria.

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December 2020

Effects of pharmacological calcimimetics on colorectal cancer cells over-expressing the human calcium-sensing receptor.

Authors:

Luca Iamartino Taha Elajnaf Katharina Gall Jacquelina David Teresa Manhardt Petra Heffeter Michael Grusch Sophia Derdak Sabina Baumgartner-Parzer Martin Schepelmann Enikö Kallay

Biochim Biophys Acta Mol Cell Res 2020 12 27;1867(12):118836. Epub 2020 Aug 27.

Medical University of Vienna, Center of Pathophysiology, Infectiology and Immunology, Institute for Pathophysiology and Allergy Research, Währinger Gürtel 18-20, 1090 Vienna, Austria. Electronic address:

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December 2020

YB-1 Knockdown Inhibits the Proliferation of Mesothelioma Cells through Multiple Mechanisms.

Authors:

Thomas G Johnson Karin Schelch Kaitao Lai Kamila A Marzec Marina Kennerson Michael Grusch Glen Reid Andrew Burgess

Cancers (Basel) 2020 Aug 14;12(8). Epub 2020 Aug 14.

The ANZAC Research Institute, Concord Repatriation General Hospital, Sydney 2139, Australia.

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August 2020

Activin A: an emerging target for improving cancer treatment?

Authors:

Alexander Ries Karin Schelch David Falch Laura Pany Mir Alireza Hoda Michael Grusch

Expert Opin Ther Targets 2020 10 6;24(10):985-996. Epub 2020 Aug 6.

Institute of Cancer Research, Department of Medicine I, Medical University of Vienna , Vienna, Austria.

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October 2020

P38 MAPK Promotes Migration and Metastatic Activity of BRAF Mutant Melanoma Cells by Inducing Degradation of PMCA4b.

Authors:

Randa Naffa Lisa Vogel Luca Hegedűs Katalin Pászty Sarolta Tóth Kornélia Kelemen Neha Singh Attila Reményi Enikő Kállay Mihály Cserepes József Tóvári Michael Grusch Ágnes Enyedi

Cells 2020 05 13;9(5). Epub 2020 May 13.

2nd Institute of Pathology, Semmelweis University, H-1091 Budapest, Hungary.

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May 2020

Interaction of FGF9 with FGFR3-IIIb/IIIc, a putative driver of growth and aggressive behaviour of hepatocellular carcinoma.

Authors:

Jakob Paur Maximilian Valler Rebecca Sienel Karin Taxauer Klaus Holzmann Brigitte Marian Andreas Unterberger Thomas Mohr Walter Berger Andja Gvozdenovich Johannes Schimming Michael Grusch Bettina Grasl-Kraupp

Liver Int 2020 09 17;40(9):2279-2290. Epub 2020 Jun 17.

Department of Medicine I, Division: Institute of Cancer Research, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria.

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September 2020

Telomerase Reverse Transcriptase Promoter Mutations Identify a Genomically Defined and Highly Aggressive Human Pleural Mesothelioma Subgroup.

Clin Cancer Res 2020 Jul 21;26(14):3819-3830. Epub 2020 Apr 21.

Institute of Cancer Research and Comprehensive Cancer Center, Department of Medicine I, Medical University of Vienna, Vienna, Austria.

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July 2020

Angioregulatory microRNAs in Colorectal Cancer.

Authors:

Mohammad Hasan Soheilifar Michael Grusch Hoda Keshmiri Neghab Razieh Amini Hamid Maadi Massoud Saidijam Zhixiang Wang

Cancers (Basel) 2019 Dec 26;12(1). Epub 2019 Dec 26.

Department of Medical Genetics, and Signal Transduction Research Group, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2H7, Canada.

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December 2019

Correction: Fibroblast growth factor receptor 4 induced resistance to radiation therapy in colorectal cancer.

Authors:

Mohamed A Ahmed Edgar Selzer Wolfgang Dörr Gerd Jomrich Felix Harpain Gerd R Silberhumer Leonhard Müllauer Klaus Holzmann Bettina Grasl-Kraupp Michael Grusch Walter Berger Brigitte Marian

Oncotarget 2019 Sep 3;10(51):5385-5386. Epub 2019 Sep 3.

Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Austria.

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September 2019

Expression of FGFR1-4 in Malignant Pleural Mesothelioma Tissue and Corresponding Cell Lines and its Relationship to Patient Survival and FGFR Inhibitor Sensitivity.

Cells 2019 09 16;8(9). Epub 2019 Sep 16.

Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, 1090 Vienna, Austria.

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September 2019

Long-Term Vemurafenib Exposure Induced Alterations of Cell Phenotypes in Melanoma: Increased Cell Migration and Its Association with EGFR Expression.

Authors:

Eszter Molnár Tamás Garay Marco Donia Marcell Baranyi Dominika Rittler Walter Berger József Tímár Michael Grusch Balázs Hegedűs

Int J Mol Sci 2019 Sep 11;20(18). Epub 2019 Sep 11.

2nd Department of Pathology, Semmelweis University, H-1091 Budapest, Hungary.

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September 2019

Modulation of cardiac optogenetics by vitamin A.

Authors:

Hoda Keshmiri Neghab Bahram Goliaei Ali A Saboury Gholamreza Esmaeeli Djavid Majid Pornour Jun Hong Michael Grusch

Biofactors 2019 Nov 11;45(6):983-990. Epub 2019 Sep 11.

Department of Medicine I, Comprehensive Cancer Center Vienna, Institute of Cancer Research, Medical University of Vienna, Vienna, Austria.

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November 2019

Lysosomal Sequestration Impairs the Activity of the Preclinical FGFR Inhibitor PD173074.

Authors:

Bernhard Englinger Sebastian Kallus Julia Senkiv Anna Laemmerer Patrick Moser Lisa Gabler Diana Groza Christian R Kowol Petra Heffeter Michael Grusch Walter Berger

Cells 2018 Dec 8;7(12). Epub 2018 Dec 8.

Institute of Cancer Research and Comprehensive Cancer Center, Department of Medicine I, Medical University of Vienna, A-1090 Vienna, Austria.

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December 2018

The FAK inhibitor BI 853520 inhibits spheroid formation and orthotopic tumor growth in malignant pleural mesothelioma.

Authors:

Viktoria Laszlo Zsuzsanna Valko Judit Ozsvar Ildiko Kovacs Tamas Garay Mir Alireza Hoda Thomas Klikovits Paul Stockhammer Clemens Aigner Marion Gröger Walter Klepetko Walter Berger Michael Grusch Jozsef Tovari Irene C Waizenegger Balazs Dome Balazs Hegedus

J Mol Med (Berl) 2019 02 11;97(2):231-242. Epub 2018 Dec 11.

Division of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.

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February 2019

The thiosemicarbazone MeNNMe induces paraptosis by disrupting the ER thiol redox homeostasis based on protein disulfide isomerase inhibition.

Authors:

Sonja Hager Katharina Korbula Björn Bielec Michael Grusch Christine Pirker Markus Schosserer Lisa Liendl Magdalena Lang Johannes Grillari Karin Nowikovsky Veronika F S Pape Thomas Mohr Gergely Szakács Bernhard K Keppler Walter Berger Christian R Kowol Petra Heffeter

Cell Death Dis 2018 10 15;9(11):1052. Epub 2018 Oct 15.

Institute of Cancer Research and Comprehensive Cancer Center, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090, Vienna, Austria.

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October 2018

FGF8 induces therapy resistance in neoadjuvantly radiated rectal cancer.

Authors:

Felix Harpain Mohamed A Ahmed Xenia Hudec Gerald Timelthaler Gerd Jomrich Leonhard Müllauer Edgar Selzer Wolfgang Dörr Michael Bergmann Klaus Holzmann Bettina Grasl-Kraupp Michael Grusch Walter Berger Brigitte Marian Gerd R Silberhumer

J Cancer Res Clin Oncol 2019 Jan 1;145(1):77-86. Epub 2018 Oct 1.

Department of Surgery, Medical University Vienna, Vienna, Austria.

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January 2019

Gallic acid, a common dietary phenolic protects against high fat diet induced DNA damage.

Authors:

Tahereh Setayesh Armen Nersesyan Miroslav Mišík Rahil Noorizadeh Elisabeth Haslinger Tahereh Javaheri Elisabeth Lang Michael Grusch Wolfgang Huber Alexander Haslberger Siegfried Knasmüller

Eur J Nutr 2019 Sep 23;58(6):2315-2326. Epub 2018 Jul 23.

Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria.

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September 2019

Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells.

Authors:

Eszter Molnár Dominika Rittler Marcell Baranyi Michael Grusch Walter Berger Balázs Döme József Tóvári Clemens Aigner József Tímár Tamás Garay Balázs Hegedűs

BMC Cancer 2018 May 8;18(1):542. Epub 2018 May 8.

2nd Department of Pathology, Semmelweis University, Budapest, 1091, Hungary.

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May 2018

Nintedanib Is Active in Malignant Pleural Mesothelioma Cell Models and Inhibits Angiogenesis and Tumor Growth .

Clin Cancer Res 2018 08 3;24(15):3729-3740. Epub 2018 May 3.

Division of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Centre Vienna, Medical University Vienna, Austria.

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August 2018

Bacterial ghosts as adjuvant to oxaliplatin chemotherapy in colorectal carcinomatosis.

Authors:

Diana Groza Sebastian Gehrig Pavol Kudela Martin Holcmann Christine Pirker Carina Dinhof Hemma H Schueffl Marek Sramko Julia Hoebart Fatih Alioglu Michael Grusch Manfred Ogris Werner Lubitz Bernhard K Keppler Irena Pashkunova-Martic Christian R Kowol Maria Sibilia Walter Berger Petra Heffeter

Oncoimmunology 2018;7(5):e1424676. Epub 2018 Feb 16.

Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

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February 2018

Epigenetic Biomarkers in Cancer.

Authors:

Yuen Yee Cheng Hong Chuan Jin Michael W Y Chan Wai Kit Chu Michael Grusch

Dis Markers 2018;2018:4987103. Epub 2018 Feb 20.

Institute of Cancer Research, Medical University of Vienna, Vienna, Austria.

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October 2018

FGF2 and EGF induce epithelial-mesenchymal transition in malignant pleural mesothelioma cells via a MAPKinase/MMP1 signal.

Carcinogenesis 2018 04;39(4):534-545

Translational Thoracic Oncology Laboratory, Division of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center Vienna.

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April 2018

Circulating complement component 4d (C4d) correlates with tumor volume, chemotherapeutic response and survival in patients with malignant pleural mesothelioma.

Authors:

Thomas Klikovits Paul Stockhammer Viktoria Laszlo Yawen Dong Mir Alireza Hoda Bahil Ghanim Isabelle Opitz Thomas Frauenfelder Thi Dan Linh Nguyen-Kim Walter Weder Walter Berger Michael Grusch Clemens Aigner Walter Klepetko Balazs Dome Ferenc Renyi-Vamos Rudolf Oehler Balazs Hegedus

Sci Rep 2017 11 28;7(1):16456. Epub 2017 Nov 28.

Translational Thoracic Oncology Laboratory, Division of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center Vienna, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

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November 2017

FGF5 is expressed in melanoma and enhances malignancy and .

Authors:

Sara Ghassemi Katharina Vejdovszky Emine Sahin Lukas Ratzinger Karin Schelch Thomas Mohr Barbara Peter-Vörösmarty Jelena Brankovic Andreas Lackner Alexandra Leopoldi Diana Meindl Christine Pirker Balazs Hegedus Brigitte Marian Klaus Holzmann Bettina Grasl-Kraupp Petra Heffeter Walter Berger Michael Grusch

Oncotarget 2017 Oct 23;8(50):87750-87762. Epub 2017 Sep 23.

Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria.

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October 2017

A link between the fibroblast growth factor axis and the miR-16 family reveals potential new treatment combinations in mesothelioma.

Authors:

Karin Schelch Michaela B Kirschner Marissa Williams Yuen Y Cheng Nico van Zandwijk Michael Grusch Glen Reid

Mol Oncol 2018 01 18;12(1):58-73. Epub 2017 Nov 18.

Asbestos Diseases Research Institute, Sydney, Australia.

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January 2018

DNA Methylation as a Noninvasive Epigenetic Biomarker for the Detection of Cancer.

Authors:

Catherine Leygo Marissa Williams Hong Chuan Jin Michael W Y Chan Wai Kit Chu Michael Grusch Yuen Yee Cheng

Dis Markers 2017 5;2017:3726595. Epub 2017 Sep 5.

Asbestos Disease Research Institute, Sydney Medical School, University of Sydney, Rhodes, NSW, Australia.

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June 2018

Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer.

Authors:

Bernhard Englinger Sebastian Kallus Julia Senkiv Daniela Heilos Lisa Gabler Sushilla van Schoonhoven Alessio Terenzi Patrick Moser Christine Pirker Gerald Timelthaler Walter Jäger Christian R Kowol Petra Heffeter Michael Grusch Walter Berger

J Exp Clin Cancer Res 2017 09 7;36(1):122. Epub 2017 Sep 7.

Institute of Cancer Research and Comprehensive Cancer Center, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, A-1090, Vienna, Austria.

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September 2017

Histone Deacetylase Inhibitor Treatment Increases the Expression of the Plasma Membrane Ca Pump PMCA4b and Inhibits the Migration of Melanoma Cells Independent of ERK.

Authors:

Luca Hegedüs Rita Padányi Judit Molnár Katalin Pászty Karolina Varga István Kenessey Eszter Sárközy Matthias Wolf Michael Grusch Zoltán Hegyi László Homolya Clemens Aigner Tamás Garay Balázs Hegedüs József Tímár Enikö Kállay Ágnes Enyedi

Front Oncol 2017 24;7:95. Epub 2017 May 24.

2nd Institute of Pathology, Semmelweis University, Budapest, Hungary.

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May 2017

Irinotecan Upregulates Fibroblast Growth Factor Receptor 3 Expression in Colorectal Cancer Cells, Which Mitigates Irinotecan-Induced Apoptosis.

Authors:

Zeynep N Erdem Stefanie Schwarz Daniel Drev Christine Heinzle Andrea Reti Petra Heffeter Xenia Hudec Klaus Holzmann Bettina Grasl-Kraupp Walter Berger Michael Grusch Brigitte Marian

Transl Oncol 2017 Jun 22;10(3):332-339. Epub 2017 Mar 22.

Medical University of Vienna, Department of Medicine 1, Institute of Cancer Research and Comprehensive Cancer Center Vienna, Borschkegasse 8a, 1090 Vienna, Austria. Electronic address:

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June 2017

The plasma membrane Ca pump PMCA4b inhibits the migratory and metastatic activity of BRAF mutant melanoma cells.

Authors:

Luca Hegedũs Tamás Garay Eszter Molnár Karolina Varga Ágnes Bilecz Szilvia Török Rita Padányi Katalin Pászty Matthias Wolf Michael Grusch Enikõ Kállay Balázs Döme Walter Berger Balázs Hegedũs Agnes Enyedi

Int J Cancer 2017 06 17;140(12):2758-2770. Epub 2016 Nov 17.

2nd Department of Pathology, Semmelweis University, Budapest, Hungary.

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June 2017

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