Michael Grusch

Michael Grusch

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Michael Grusch

Michael Grusch

Publications by authors named "Michael Grusch"

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Angioregulatory microRNAs in Colorectal Cancer.

Cancers (Basel) 2019 Dec 26;12(1). Epub 2019 Dec 26.

Department of Medical Genetics, and Signal Transduction Research Group, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2H7, Canada.

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http://dx.doi.org/10.3390/cancers12010071DOI Listing
December 2019

Modulation of cardiac optogenetics by vitamin A.

Biofactors 2019 Nov 11;45(6):983-990. Epub 2019 Sep 11.

Department of Medicine I, Comprehensive Cancer Center Vienna, Institute of Cancer Research, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1002/biof.1564DOI Listing
November 2019

Lysosomal Sequestration Impairs the Activity of the Preclinical FGFR Inhibitor PD173074.

Cells 2018 Dec 8;7(12). Epub 2018 Dec 8.

Institute of Cancer Research and Comprehensive Cancer Center, Department of Medicine I, Medical University of Vienna, A-1090 Vienna, Austria.

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http://www.mdpi.com/2073-4409/7/12/259
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http://dx.doi.org/10.3390/cells7120259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315953PMC
December 2018

Epigenetic Biomarkers in Cancer.

Dis Markers 2018;2018:4987103. Epub 2018 Feb 20.

Institute of Cancer Research, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1155/2018/4987103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838454PMC
October 2018

DNA Methylation as a Noninvasive Epigenetic Biomarker for the Detection of Cancer.

Dis Markers 2017 5;2017:3726595. Epub 2017 Sep 5.

Asbestos Disease Research Institute, Sydney Medical School, University of Sydney, Rhodes, NSW, Australia.

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http://dx.doi.org/10.1155/2017/3726595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605861PMC
June 2018

Irinotecan Upregulates Fibroblast Growth Factor Receptor 3 Expression in Colorectal Cancer Cells, Which Mitigates Irinotecan-Induced Apoptosis.

Transl Oncol 2017 Jun 22;10(3):332-339. Epub 2017 Mar 22.

Medical University of Vienna, Department of Medicine 1, Institute of Cancer Research and Comprehensive Cancer Center Vienna, Borschkegasse 8a, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.tranon.2017.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367848PMC
June 2017

Trabectedin Is Active against Malignant Pleural Mesothelioma Cell and Xenograft Models and Synergizes with Chemotherapy and Bcl-2 Inhibition In Vitro.

Mol Cancer Ther 2016 10 10;15(10):2357-2369. Epub 2016 Aug 10.

Applied and Experimental Oncology, Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0846DOI Listing
October 2016

Circulating activin A is a novel prognostic biomarker in malignant pleural mesothelioma - A multi-institutional study.

Eur J Cancer 2016 08 8;63:64-73. Epub 2016 Jun 8.

Division of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria; Department of Biomedical Imaging and Image-guided Therapy, Division of Molecular and Gender Imaging, Medical University of Vienna, Vienna, Austria; MTA-SE Molecular Oncology Research Group, Hungarian Academy of Sciences, Budapest, Hungary. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.04.018DOI Listing
August 2016

The optogenetic promise for oncology: Episode I.

Mol Cell Oncol 2014 Oct-Dec;1(4):e964045. Epub 2014 Oct 29.

Institute of Cancer Research; Department of Medicine I; Comprehensive Cancer Center Vienna; Medical University of Vienna ; Vienna, Austria.

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http://dx.doi.org/10.4161/23723548.2014.964045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905200PMC
June 2016

High circulating activin A level is associated with tumor progression and predicts poor prognosis in lung adenocarcinoma.

Oncotarget 2016 Mar;7(12):13388-99

Translational Thoracic Oncology Laboratory, Division of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.18632/oncotarget.7796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924649PMC
March 2016

Fibroblast growth factor receptor 3 isoforms: Novel therapeutic targets for hepatocellular carcinoma?

Hepatology 2015 Dec 16;62(6):1767-78. Epub 2015 Oct 16.

Department of Medicine I, Division: Institute of Cancer Research, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1002/hep.28023DOI Listing
December 2015

Light-assisted small-molecule screening against protein kinases.

Nat Chem Biol 2015 Dec 12;11(12):952-4. Epub 2015 Oct 12.

Institute of Science and Technology Austria (IST Austria), Klosterneuburg, Austria.

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http://dx.doi.org/10.1038/nchembio.1933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652335PMC
December 2015

Is fibroblast growth factor receptor 4 a suitable target of cancer therapy?

Curr Pharm Des 2014 ;20(17):2881-98

Institute of Cancer Research, Department of Medicine 1, Medical University Vienna, Borschkegasse 8a, 1090 Vienna, Austria.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453246PMC
http://dx.doi.org/10.2174/13816128113199990594DOI Listing
September 2015

Canine and human sarcomas exhibit predominant FGFR1 expression and impaired viability after inhibition of signaling.

Mol Carcinog 2015 Sep 9;54(9):841-52. Epub 2014 Apr 9.

Department for Companion Animals and Horses, University of Veterinary Medicine Vienna, Vienna, Austria.

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http://doi.wiley.com/10.1002/mc.22155
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http://dx.doi.org/10.1002/mc.22155DOI Listing
September 2015

Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells.

Int J Cancer 2015 May 3;136(9):2078-90. Epub 2014 Nov 3.

Signaling Networks Program, Division of Oncology, Department of Medicine I, Medical University Vienna, Vienna, Austria; Comprehensive Cancer Center, Medical University Vienna, Vienna, Austria.

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http://dx.doi.org/10.1002/ijc.29261DOI Listing
May 2015

Distinct Epidemiology and Clinical Consequence of Classic Versus Rare EGFR Mutations in Lung Adenocarcinoma.

J Thorac Oncol 2015 May;10(5):738-46

*Department of Tumor Biology, National Koranyi Institute of Pulmonology, Budapest, Hungary; †Translational Thoracic Oncology Laboratory, Division of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center, Medical University of Vienna, Austria; ‡Department of Thoracic Surgery, National Institute of Oncology-Semmelweis University; §Department of Pulmonology, ‖Second Department of Pathology, Semmelweis University; ¶Molecular Oncology Research Group, Hungarian Academy of Sciences-Semmelweis University, Budapest, Hungary; #First Department of Pathology, Experimental Cancer Research, Semmelweis University, Budapest, Hungary; and ** Department of Internal Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Austria.

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http://dx.doi.org/10.1097/JTO.0000000000000492DOI Listing
May 2015

Activin A is anti-lymphangiogenic in a melanoma mouse model.

J Invest Dermatol 2015 Jan 1;135(1):212-221. Epub 2014 Aug 1.

Skin & Endothelium Research Division SERD, Department of Dermatology, Medical University of Vienna, Vienna, Austria; Division of General Dermatology, Department of Dermatology, Medical University of Vienna, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1038/jid.2014.328DOI Listing
January 2015

The effect of organic anion-transporting polypeptides 1B1, 1B3 and 2B1 on the antitumor activity of flavopiridol in breast cancer cells.

Int J Oncol 2015 Jan 24;46(1):324-32. Epub 2014 Oct 24.

Department of Clinical Pharmacy and Diagnostics, University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.3892/ijo.2014.2731DOI Listing
January 2015

Fibroblast growth factor receptor 4: a putative key driver for the aggressive phenotype of hepatocellular carcinoma.

Carcinogenesis 2014 Oct 16;35(10):2331-8. Epub 2014 Jul 16.

Department of Medicine I, Division: Institute of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna, Austria and Institute of Clinical Pathology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria

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http://carcin.oxfordjournals.org/content/35/10/2331.full.pdf
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http://www.carcin.oxfordjournals.org/cgi/doi/10.1093/carcin/
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http://dx.doi.org/10.1093/carcin/bgu151DOI Listing
October 2014

Spatio-temporally precise activation of engineered receptor tyrosine kinases by light.

EMBO J 2014 Aug 1;33(15):1713-26. Epub 2014 Jul 1.

Institute of Science and Technology Austria (IST Austria), Klosterneuburg, Austria

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http://dx.doi.org/10.15252/embj.201387695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194103PMC
August 2014

Subtype-specific KRAS mutations in advanced lung adenocarcinoma: a retrospective study of patients treated with platinum-based chemotherapy.

Eur J Cancer 2014 Jul 22;50(10):1819-1828. Epub 2014 Apr 22.

Department of Tumor Biology, National Koranyi Institute of Pulmonology, Budapest, Hungary; Division of Thoracic Surgery, Medical University of Vienna, Austria; Department of Thoracic Surgery, National Institute of Oncology-Semmelweis University, Budapest, Hungary. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2014.04.001DOI Listing
July 2014

Apelin promotes lymphangiogenesis and lymph node metastasis.

Oncotarget 2014 Jun;5(12):4426-37

Division of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center, Medical University of Vienna, Austria; Department of Tumor Biology, National Koranyi Institute of Pulmonology, Budapest, Hungary; Thoracic Surgery, National Institute of Oncology and Semmelweis University, Budapest, Hungary.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147335PMC
http://dx.doi.org/10.18632/oncotarget.2032DOI Listing
June 2014

The major vault protein mediates resistance to epidermal growth factor receptor inhibition in human hepatoma cells.

Cancer Lett 2012 Jun 17;319(2):164-172. Epub 2012 Jan 17.

Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna, Austria. Electronic address:

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http://linkinghub.elsevier.com/retrieve/pii/S030438351200027
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http://dx.doi.org/10.1016/j.canlet.2012.01.002DOI Listing
June 2012

Stable protein expression in mammalian cells using baculoviruses.

Methods Mol Biol 2012 ;801:75-92

Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1007/978-1-61779-352-3_6DOI Listing
February 2012

The PI3 kinase/mTOR blocker NVP-BEZ235 overrides resistance against irreversible ErbB inhibitors in breast cancer cells.

Breast Cancer Res Treat 2011 Sep 3;129(2):387-400. Epub 2010 Nov 3.

Signaling Networks Program, Division of Oncology, Department of Medicine I, Medical University Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

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http://dx.doi.org/10.1007/s10549-010-1232-1DOI Listing
September 2011

Targeting fibroblast-growth-factor-receptor-dependent signaling for cancer therapy.

Expert Opin Ther Targets 2011 Jul 7;15(7):829-46. Epub 2011 Mar 7.

Medical University Vienna, Institute of Cancer Research, Department of Medicine 1, Vienna,Austria.

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http://dx.doi.org/10.1517/14728222.2011.566217DOI Listing
July 2011

A novel N-hydroxy-N'-aminoguanidine derivative inhibits ribonucleotide reductase activity: Effects in human HL-60 promyelocytic leukemia cells and synergism with arabinofuranosylcytosine (Ara-C).

Biochem Pharmacol 2011 Jan 16;81(1):50-9. Epub 2010 Sep 16.

Department of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, General Hospital of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1016/j.bcp.2010.09.006DOI Listing
January 2011

The crosstalk of RAS with the TGF-β family during carcinoma progression and its implications for targeted cancer therapy.

Curr Cancer Drug Targets 2010 Dec;10(8):849-57

Department of Medicine I, Division, Institute of Cancer Research, Medical University of Vienna, Borschke-Gasse 8a, A-1090 Vienna, Austria.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044462PMC
http://dx.doi.org/10.2174/156800910793357943DOI Listing
December 2010

Response of experimental malignant melanoma models to the pan-Aurora kinase inhibitor VE-465.

Exp Dermatol 2010 Dec;19(12):1040-7

Institute of Cancer Research, Clinics for Medicine I, Medical University Vienna, Vienna, Austria.

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http://dx.doi.org/10.1111/j.1600-0625.2010.01182.xDOI Listing
December 2010

Hydrogen peroxide mediates EGCG-induced antioxidant protection in human keratinocytes.

Free Radic Biol Med 2010 Nov 12;49(9):1444-52. Epub 2010 Aug 12.

Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, 1090 Vienna, Austria.

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http://dx.doi.org/10.1016/j.freeradbiomed.2010.08.008DOI Listing
November 2010

Bimodal expression of Sprouty2 during the cell cycle is mediated by phase-specific Ras/MAPK and c-Cbl activities.

Cell Mol Life Sci 2010 Oct 12;67(19):3299-311. Epub 2010 May 12.

Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, 1090 Vienna, Austria.

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http://dx.doi.org/10.1007/s00018-010-0379-6DOI Listing
October 2010

Indications for cell stress in response to adenoviral and baculoviral gene transfer observed by proteome profiling of human cancer cells.

Electrophoresis 2010 Jun;31(11):1822-32

Department of Medicine I, Division: Institute of Cancer Research, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1002/elps.200900753DOI Listing
June 2010

Antitumor effects of KITC, a new resveratrol derivative, in AsPC-1 and BxPC-3 human pancreatic carcinoma cells.

Invest New Drugs 2009 Oct 8;27(5):393-401. Epub 2008 Oct 8.

Clinical Institute of Medical and Chemical Laboratory Diagnostics, General Hospital of Vienna, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.

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http://link.springer.com/10.1007/s10637-008-9183-7
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http://dx.doi.org/10.1007/s10637-008-9183-7DOI Listing
October 2009

Activins and follistatins: Emerging roles in liver physiology and cancer.

World J Hepatol 2009 Oct;1(1):17-27

Emanuel Kreidl, Deniz Öztürk, Thomas Metzner, Walter Berger, Michael Grusch, Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, Vienna A-1090, Austria.

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http://dx.doi.org/10.4254/wjh.v1.i1.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999257PMC
October 2009

Interaction between fatty acid synthase- and ErbB-systems in ovarian cancer cells.

Biochem Biophys Res Commun 2009 Jul 23;385(3):454-9. Epub 2009 May 23.

Signaling Networks Program, Department of Medicine I, Medical University Vienna, Vienna, Austria.

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http://dx.doi.org/10.1016/j.bbrc.2009.05.085DOI Listing
July 2009

Microscopic analysis of adenoviral decontamination using GFP adenovirus with comparable sensitivity to flow cytometry.

Methods Mol Biol 2009 ;515:125-35

Department of Medicine I, Radical University of Vienna, Borschkepasse 8a, 1090, Vienna, Austria.

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http://dx.doi.org/10.1007/978-1-59745-559-6_8DOI Listing
May 2009

Digalloylresveratrol, a new phenolic acid derivative induces apoptosis and cell cycle arrest in human HT-29 colon cancer cells.

Cancer Lett 2009 Feb 25;274(2):299-304. Epub 2008 Oct 25.

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, General Hospital of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1016/j.canlet.2008.09.020DOI Listing
February 2009

NORE1B is a putative tumor suppressor in hepatocarcinogenesis and may act via RASSF1A.

Cancer Res 2009 Jan;69(1):235-42

Department of Medicine I, Division: Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, Vienna, Austria.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-2144DOI Listing
January 2009

HB-EGF is a paracrine growth stimulator for early tumor prestages in inflammation-associated hepatocarcinogenesis.

J Hepatol 2008 Dec 7;49(6):955-64. Epub 2008 Oct 7.

Department of Medicine I, Division: Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1016/j.jhep.2008.06.031DOI Listing
December 2008

Biochemical effects of piceatannol in human HL-60 promyelocytic leukemia cells--synergism with Ara-C.

Int J Oncol 2008 Oct;33(4):887-92

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, General Hospital of Vienna, A-1090 Vienna, Austria.

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October 2008

A bicistronic baculovirus vector for transient and stable protein expression in mammalian cells.

Anal Biochem 2008 Sep 22;380(1):146-8. Epub 2008 May 22.

Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1016/j.ab.2008.05.020DOI Listing
September 2008

Effects of coffee and its chemopreventive components kahweol and cafestol on cytochrome P450 and sulfotransferase in rat liver.

Food Chem Toxicol 2008 Apr 25;46(4):1230-8. Epub 2007 Sep 25.

Research Unit of Toxicology and Prevention, Division Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8A, A-1090 Vienna, Austria.

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http://ac.els-cdn.com/S0278691507004437/1-s2.0-S027869150700
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http://linkinghub.elsevier.com/retrieve/pii/S027869150700443
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http://dx.doi.org/10.1016/j.fct.2007.09.094DOI Listing
April 2008

Activins and activin antagonists in hepatocellular carcinoma.

World J Gastroenterol 2008 Mar;14(11):1699-709

Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschkegasse 8a, Vienna A-1090, Austria.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695910PMC
http://dx.doi.org/10.3748/wjg.14.1699DOI Listing
March 2008

Synergistic effects of deuterium oxide and gemcitabine in human pancreatic cancer cell lines.

Cancer Lett 2008 Feb 26;259(2):231-9. Epub 2007 Nov 26.

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, General Hospital of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1016/j.canlet.2007.10.010DOI Listing
February 2008

Novel resveratrol derivatives induce apoptosis and cause cell cycle arrest in prostate cancer cell lines.

Anticancer Res 2007 Sep-Oct;27(5A):3459-64

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Waehringer Guertel 18-20, A-1090, Vienna, Austria.

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November 2007