Publications by authors named "Michael G Kharas"

56Publications

High Fructose Drives the Serine Synthesis Pathway in Acute Myeloid Leukemic Cells.

Cell Metab 2021 Jan 22;33(1):145-159.e6. Epub 2020 Dec 22.

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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January 2021

RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction.

Nat Commun 2020 08 27;11(1):4305. Epub 2020 Aug 27.

Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, TX, 77555, USA.

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August 2020

Rubbing Out Leukemia Stem Cells by Erasing the Eraser.

Cell Stem Cell 2020 Jul;27(1):3-5

Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, New York, USA. Electronic address:

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July 2020

Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells.

Cell Rep 2020 06;31(9):107688

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

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June 2020

HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells.

Nat Commun 2020 04 24;11(1):2026. Epub 2020 Apr 24.

Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

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April 2020

High-speed automatic characterization of rare events in flow cytometric data.

PLoS One 2020 11;15(2):e0228651. Epub 2020 Feb 11.

Public Health Dynamics Laboratory, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States of America.

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April 2020

RNA Regulators in Leukemia and Lymphoma.

Cold Spring Harb Perspect Med 2020 05 1;10(5). Epub 2020 May 1.

Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

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May 2020

mA RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment.

Cell Rep 2019 08;28(7):1703-1716.e6

Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

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August 2019

The Biology of mA RNA Methylation in Normal and Malignant Hematopoiesis.

Cancer Discov 2019 01 21;9(1):25-33. Epub 2018 Dec 21.

Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Memorial Sloan Kettering Cancer Center, New York, New York.

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January 2019

Targeting the Residual Leukemia Cells after Chemotherapy.

Cancer Cell 2018 09;34(3):353-355

Molecular Pharmacology Program and Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

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September 2018

Dual Strategies for Argonaute2-Mediated Biogenesis of Erythroid miRNAs Underlie Conserved Requirements for Slicing in Mammals.

Mol Cell 2018 01;69(2):265-278.e6

Department of Developmental Biology, Sloan Kettering Institute, 1275 York Ave., Box 252, New York, NY 10065, USA; Weill Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA. Electronic address:

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January 2018

The N-methyladenosine (mA)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells.

Nat Med 2017 Nov 18;23(11):1369-1376. Epub 2017 Sep 18.

Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

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November 2017

Stem Cells, Cancer, and MUSASHI in Blood and Guts.

Trends Cancer 2017 05 8;3(5):347-356. Epub 2017 Apr 8.

Department of Biomedical Sciences, School of Veterinary Medicine, and Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19146, USA. Electronic address:

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May 2017

Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia.

Cell Stem Cell 2017 03 16;20(3):315-328.e7. Epub 2017 Feb 16.

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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March 2017

Emerging links between mA and misregulated mRNA methylation in cancer.

Genome Med 2017 01 12;9(1). Epub 2017 Jan 12.

Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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January 2017

Msi RNA-binding proteins control reserve intestinal stem cell quiescence.

J Cell Biol 2016 Nov 31;215(3):401-413. Epub 2016 Oct 31.

Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104

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November 2016

MUSASHI-2 duels in myelodysplastic syndromes.

Cell Cycle 2016 07 22;15(14):1799-800. Epub 2016 Apr 22.

a Molecular Pharmacology Program and Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Memorial Sloan Kettering Cancer Center , New York , NY , USA.

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July 2016

The Msi Family of RNA-Binding Proteins Function Redundantly as Intestinal Oncoproteins.

Cell Rep 2015 Dec 8;13(11):2440-2455. Epub 2015 Dec 8.

Center for Molecular Studies in Digestive and Liver Diseases, University of Pennsylvania, Philadelphia, PA 19104, USA; Cell and Molecular Biology Graduate Program, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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December 2015

Integrative genetic analysis of mouse and human AML identifies cooperating disease alleles.

J Exp Med 2016 Jan 14;213(1):25-34. Epub 2015 Dec 14.

Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136 Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136 Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136

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January 2016

Transformation of the intestinal epithelium by the MSI2 RNA-binding protein.

Nat Commun 2015 Mar 16;6:6517. Epub 2015 Mar 16.

1] Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA [2] Cell and Molecular Biology Graduate Program, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA [3] Center for Molecular Studies in Digestive and Liver Diseases, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA [4] Department of Cell and Developmental Biology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA [5] Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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March 2015

Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs.

J Exp Med 2014 Jan 6;211(1):71-87. Epub 2014 Jan 6.

Molecular Pharmacology and Chemistry Program, 2 Center for Cell Engineering, and 3 Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065.

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January 2014

The Lin28/let-7 axis regulates glucose metabolism.

Cell 2011 Sep;147(1):81-94

Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Children's Hospital Boston and Dana Farber Cancer Institute, Boston, MA, USA.

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September 2011

From Hen House to Bedside: Tracing Hanafusa's Legacy from Avian Leukemia Viruses to SRC to ABL and Beyond.

Genes Cancer 2010 Dec;1(12):1164-9

Division of Hematology, Brigham and Women's Hospital, Boston, MA, USA.

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December 2010

Akt: a double-edged sword for hematopoietic stem cells.

Cell Cycle 2010 Apr 1;9(7):1223-4. Epub 2010 Apr 1.

Brigham and Women's Hospital, Boston, MA.

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April 2010

Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice.

Blood 2010 Feb 14;115(7):1406-15. Epub 2009 Dec 14.

Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

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February 2010

Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells.

J Clin Invest 2008 Sep;118(9):3038-50

Department of Molecular Biology and Biochemistry, Center for Immunology, University of California, Irvine, Irvine, California, USA.

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September 2008

KLF4 is a FOXO target gene that suppresses B cell proliferation.

Int Immunol 2008 May 28;20(5):671-81. Epub 2008 Mar 28.

Department of Molecular Biology and Biochemistry, University of California-Irvine, Irvine, CA, USA.

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May 2008

Measuring phosphorylated Akt and other phosphoinositide 3-kinase-regulated phosphoproteins in primary lymphocytes.

Methods Enzymol 2007 ;434:131-54

Department of Molecular Biology and Biochemistry and Center for Immunology, University of California-Irvine, Irvine, California, USA.

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December 2007

Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase.

Proc Natl Acad Sci U S A 2006 Nov 27;103(45):16882-7. Epub 2006 Oct 27.

Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USA.

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November 2006

KLF4 suppresses transformation of pre-B cells by ABL oncogenes.

Blood 2007 Jan 5;109(2):747-55. Epub 2006 Sep 5.

Department of Molecular Biology and Biochemistry, University of California-Irvine, 3242 McGaugh Hall, Irvine, CA 92697-3900, USA.

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January 2007

S6 kinase 2 potentiates interleukin-3-driven cell proliferation.

J Leukoc Biol 2005 Dec 4;78(6):1378-85. Epub 2005 Oct 4.

Department of Biological Sciences, California State University at Long Beach, 1250 Bellflower Blvd., Long Beach, CA 90840, USA.

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December 2005

ABL oncogenes and phosphoinositide 3-kinase: mechanism of activation and downstream effectors.

Cancer Res 2005 Mar;65(6):2047-53

Center for Immunology and Department of Molecular Biology and Biochemistry, University of California at Irvine, Irvine, CA 92697-3900, USA.

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March 2005

Optimal B-cell proliferation requires phosphoinositide 3-kinase-dependent inactivation of FOXO transcription factors.

Blood 2004 Aug 6;104(3):784-7. Epub 2004 Apr 6.

Department of Molecular Biology and Biochemistry, University of California, Irvine, 92697-3900, USA.

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August 2004

Phosphoinositide 3-kinase signaling is essential for ABL oncogene-mediated transformation of B-lineage cells.

Blood 2004 Jun 19;103(11):4268-75. Epub 2004 Feb 19.

University of California, Irvine, Department of Molecular Biology and Biochemistry, 3242 McGaugh Hall, Irvine, CA 92697-3900, USA.

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June 2004