Publications by authors named "Michael G Fehlings"

100Publications

Prediction of independence in bowel function after spinal cord injury: validation of a logistic regression model.

Spinal Cord 2020 Sep 22. Epub 2020 Sep 22.

Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/s41393-020-00551-yDOI Listing
September 2020

Harnessing the Secretome of Mesenchymal Stromal Cells for Traumatic Spinal Cord Injury: Multi-cell Comparison and Assessment of In Vivo Efficacy.

Stem Cells Dev 2020 Sep 23. Epub 2020 Sep 23.

University of Toronto, Institute of Medical Science, Toronto Western Research Institute, MP 12-407, 399 Bathurst Street, Toronto, Ontario, Canada, M5T2S8.

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http://dx.doi.org/10.1089/scd.2020.0079DOI Listing
September 2020

Surgical Outcomes Following Laminectomy with Fusion versus Laminectomy Alone in Patients with Degenerative Cervical Myelopathy.

Spine (Phila Pa 1976) 2020 Sep 1. Epub 2020 Sep 1.

Division of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/BRS.0000000000003677DOI Listing
September 2020

A Personalized Medicine Approach for the Management of Spinal Metastases with Cord Compression: Development of a Novel Clinical Prediction Model for Postoperative Survival and Quality of Life.

World Neurosurg 2020 Aug;140:654-663.e13

Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Division of Neurosurgery, Krembil Neuroscience Centre, University Health Network, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.wneu.2020.03.098DOI Listing
August 2020

Use of Machine Learning and Artificial Intelligence to Drive Personalized Medicine Approaches for Spine Care.

World Neurosurg 2020 Aug;140:512-518

Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Division of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.wneu.2020.04.022DOI Listing
August 2020

Navigating the Postgraduate Research Fellowship: A Roadmap for Surgical Residents.

J Surg Res 2020 Jul 23;256:282-289. Epub 2020 Jul 23.

Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Division of Genetics and Development, Krembil Research Institute, Toronto Western Hospital, Toronto, Ontario, Canada; Spinal Program, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jss.2020.06.054DOI Listing
July 2020

The leading edge: Emerging neuroprotective and neuroregenerative cell-based therapies for spinal cord injury.

Stem Cells Transl Med 2020 Jul 21. Epub 2020 Jul 21.

Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/sctm.19-0135DOI Listing
July 2020

Multidisciplinary approach to degenerative cervical myelopathy.

Expert Rev Neurother 2020 Aug 4:1-10. Epub 2020 Aug 4.

Division of Neurosurgery and Spinal Program, Department of Surgery, University of Toronto , Toronto, Ontario, Canada.

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http://dx.doi.org/10.1080/14737175.2020.1798231DOI Listing
August 2020

Age as a determinant of inflammatory response and survival of glia and axons after human traumatic spinal cord injury.

Exp Neurol 2020 Oct 13;332:113401. Epub 2020 Jul 13.

Krembil Research Institute, University Health Network, Toronto, Ontario, Canada; Department of Surgery, Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.expneurol.2020.113401DOI Listing
October 2020

The Functional Role of Spinal Interneurons Following Traumatic Spinal Cord Injury.

Front Cell Neurosci 2020 18;14:127. Epub 2020 May 18.

Division of Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.3389/fncel.2020.00127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247430PMC
May 2020

"Time is spine": the importance of early intervention for traumatic spinal cord injury.

Spinal Cord 2020 Sep 11;58(9):1037-1039. Epub 2020 May 11.

Department of Surgery, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/s41393-020-0477-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471096PMC
September 2020

Efficacy of Ultra-Early (< 12 h), Early (12-24 h), and Late (>24-138.5 h) Surgery with Magnetic Resonance Imaging-Confirmed Decompression in American Spinal Injury Association Impairment Scale Grades A, B, and C Cervical Spinal Cord Injury.

J Neurotrauma 2020 Aug 3;37(15):1759-1760. Epub 2020 Jun 3.

Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1089/neu.2020.7034DOI Listing
August 2020

Epidemiology and Impact of Spinal Cord Injury in the Elderly: Results of a Fifteen-Year Population-Based Cohort Study.

J Neurotrauma 2020 Aug 11;37(15):1740-1751. Epub 2020 May 11.

Department of Physical Therapy, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1089/neu.2020.6985DOI Listing
August 2020

Benefits of physical exercise on cognition and glial white matter pathology in a mouse model of vascular cognitive impairment and dementia.

Glia 2020 Sep 10;68(9):1925-1940. Epub 2020 Mar 10.

Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada.

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http://dx.doi.org/10.1002/glia.23815DOI Listing
September 2020

Degenerative Cervical Myelopathy: Changing Frontiers.

World Neurosurg 2020 Mar;135:377-378

Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Division of Neurosurgery, Spinal Program, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.wneu.2019.12.138DOI Listing
March 2020

Methylprednisolone Reduces Persistent Post-ischemic Inflammation in a Rat Hypoxia-Ischemia Model of Perinatal Stroke.

Transl Stroke Res 2020 10 5;11(5):1117-1136. Epub 2020 Mar 5.

Division of Genetics and Development, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1007/s12975-020-00792-2DOI Listing
October 2020

Machine learning algorithms for prediction of health-related quality-of-life after surgery for mild degenerative cervical myelopathy.

Spine J 2020 Feb 8. Epub 2020 Feb 8.

Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.spinee.2020.02.003DOI Listing
February 2020

The Use of Magnetic Resonance Imaging by Spine Surgeons in Management of Spinal Trauma Across AO Regions-Results of AO Spine Survey.

World Neurosurg 2020 05 4;137:e389-e394. Epub 2020 Feb 4.

Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. Electronic address:

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http://dx.doi.org/10.1016/j.wneu.2020.01.200DOI Listing
May 2020

Degenerative cervical myelopathy - update and future directions.

Nat Rev Neurol 2020 02 23;16(2):108-124. Epub 2020 Jan 23.

Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41582-019-0303-0DOI Listing
February 2020

Early Surgery for Traumatic Spinal Cord Injury: Where Are We Now?

Global Spine J 2020 Jan 6;10(1 Suppl):84S-91S. Epub 2020 Jan 6.

Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1177/2192568219877860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947677PMC
January 2020

Ambulatory Surgical Centers: Improving Quality of Operative Spine Care?

Global Spine J 2020 Jan 6;10(1 Suppl):29S-35S. Epub 2020 Jan 6.

Rush University Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.1177/2192568219849391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947680PMC
January 2020

Quality and Safety Improvement in Spine Surgery.

Global Spine J 2020 Jan 6;10(1 Suppl):17S-28S. Epub 2020 Jan 6.

Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1177/2192568219839699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947676PMC
January 2020

The Use of Intraoperative Neurophysiological Monitoring in Spine Surgery.

Global Spine J 2020 Jan 6;10(1 Suppl):104S-114S. Epub 2020 Jan 6.

Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1177/2192568219859314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947672PMC
January 2020

GDNF rescues the fate of neural progenitor grafts by attenuating Notch signals in the injured spinal cord in rodents.

Sci Transl Med 2020 01;12(525)

Division of Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON M5T 0S8, Canada.

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http://dx.doi.org/10.1126/scitranslmed.aau3538DOI Listing
January 2020

Acidic Fibroblast Growth Factor in Spinal Cord Injury: A Potential Therapy Which Merits Further Investigation.

Neurospine 2019 Dec 31;16(4):739-741. Epub 2019 Dec 31.

Division of Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.14245/ns.19edi.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945001PMC
December 2019

Commentary: Reliability of the New AOSpine Classification System for Upper Cervical Traumatic Injuries.

Neurosurgery 2020 03;86(3):E271-E272

Division of Neurosurgery, Spinal Program, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/neuros/nyz537DOI Listing
March 2020

Best practices for enhancing surgical research: a perspective from the Canadian Association of Chairs of Surgical Research

Can J Surg 2019 12;62(6):488-498

From the Department of Surgery, Schulich School of Medicine & Dentistry, Western University, London, Ont. (Sener); the Department of Surgery, University of Alberta, Edmonton, Alta. (Anderson); the Department of Surgery, Université Laval, Québec, Que. (Auger,Lacombe); the Department of Surgery, McGill University, Montreal, Que. (Barralet); the Department of Surgery, University of Calgary, Calgary, Alta. (Brindle); the Department of Surgery, University of Saskatchewan, Saskatoon, Sask. (Cayabyab); the Department of Surgery, University of Toronto, Toronto, Ont. (Fehlings); the Department of Surgery, Montreal Heart Institute, Université de Montréal, Montreal, Que. (Perrault); the Department of Surgery, Université de Sherbrooke, Sherbrooke, Que. (Sabbagh); the Department of Surgery, University of Ottawa, Ottawa, Ont. (Seely); the Department of Surgery, Queen’s University, Kingston, Ont. (Wallace); the Department of Surgery, Dalhousie University, Halifax, NS (Ellsmere); and the Department of Surgery, University of Manitoba, Winnipeg, Man. (Keijzer).

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http://dx.doi.org/10.1503/cjs.012619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877375PMC
December 2019

Sensory cortical control of movement.

Nat Neurosci 2020 01 18;23(1):75-84. Epub 2019 Nov 18.

Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41593-019-0536-7DOI Listing
January 2020

An Age-old Debate: Anterior Versus Posterior Surgery for Ossification of the Posterior Longitudinal Ligament.

Neurospine 2019 Sep 30;16(3):544-547. Epub 2019 Sep 30.

Division of Neurosurgery and Spine Program, Department of Surgery, Toronto Western Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.14245/ns.19edi.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790737PMC
September 2019

Sex-related discrepancies in the epidemiology, injury characteristics and outcomes after acute spine trauma: A retrospective cohort study.

J Spinal Cord Med 2019 10;42(sup1):10-20

Department of Surgery, Division of Neurosurgery, University of Toronto , Toronto , Ontario , Canada.

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http://dx.doi.org/10.1080/10790268.2019.1607055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781464PMC
October 2019

The case for revisiting central cord syndrome.

Spinal Cord 2020 Jan 13;58(1):125-127. Epub 2019 Sep 13.

Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41393-019-0354-5DOI Listing
January 2020

Patient satisfaction with treatment outcomes after surgery and/or radiotherapy for spinal metastases.

Cancer 2019 12 6;125(23):4269-4277. Epub 2019 Sep 6.

Division of Spine Surgery, Department of Orthopaedics, University of British Columbia and Vancouver General Hospital, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/cncr.32465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900159PMC
December 2019

Degenerative Cervical Myelopathy; A Review of the Latest Advances and Future Directions in Management.

Neurospine 2019 Sep 26;16(3):494-505. Epub 2019 Aug 26.

Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.14245/ns.1938314.157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790745PMC
September 2019

The changes in systemic monocytes in humans undergoing surgical decompression for degenerative cervical myelopathy may influence clinical neurological recovery.

J Neuroimmunol 2019 11 16;336:577024. Epub 2019 Aug 16.

Division of Genetics & Development, Krembil Neuroscience Center and Spine Program, University Health Network, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Ontario, Canada; Department of Surgery, Division of Neurosurgery and Spine Program, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jneuroim.2019.577024DOI Listing
November 2019

National Spinal Cord Injury Registry of Iran (NSCIR-IR) - a critical appraisal of its strengths and weaknesses.

Chin J Traumatol 2019 Oct 13;22(5):300-303. Epub 2019 Jul 13.

Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran; Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

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http://dx.doi.org/10.1016/j.cjtee.2019.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823677PMC
October 2019

Advancing spinal fellowship training: an international multi-centre educational perspective.

Eur Spine J 2019 Nov 12;28(11):2437-2443. Epub 2019 Aug 12.

Department of Surgery, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1007/s00586-019-06098-8DOI Listing
November 2019

MRI in traumatic spinal cord injury: from clinical assessment to neuroimaging biomarkers.

Lancet Neurol 2019 12 9;18(12):1123-1135. Epub 2019 Aug 9.

Spinal Cord Injury Centre Balgrist, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1016/S1474-4422(19)30138-3DOI Listing
December 2019

Incomplete Spinal Cord Injury Reverses the Level-Dependence of Spinal Cord Injury Immune Deficiency Syndrome.

Int J Mol Sci 2019 Aug 1;20(15). Epub 2019 Aug 1.

Krembil Research Institute, Toronto Western Hospital, Toronto, ON M5T 0S8, Canada.

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http://dx.doi.org/10.3390/ijms20153762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695842PMC
August 2019

Demographics, presentation and symptoms of patients with Klippel-Feil syndrome: analysis of a global patient-reported registry.

Eur Spine J 2019 Oct 30;28(10):2257-2265. Epub 2019 Jul 30.

Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, USA.

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http://dx.doi.org/10.1007/s00586-019-06084-0DOI Listing
October 2019

The effects of human immunoglobulin G on enhancing tissue protection and neurobehavioral recovery after traumatic cervical spinal cord injury are mediated through the neurovascular unit.

J Neuroinflammation 2019 Jul 9;16(1):141. Epub 2019 Jul 9.

Department of Genetics and Development, Krembil Research Institute, University Health Network, Krembil Discovery Tower, 60 Leonard Avenue, 7KD-430, Toronto, Ontario, M5T 2S8, Canada.

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http://dx.doi.org/10.1186/s12974-019-1518-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615094PMC
July 2019

The discrepancy between functional outcome and self-reported health status after surgery for degenerative cervical myelopathy.

Spine J 2019 11 3;19(11):1809-1815. Epub 2019 Jul 3.

Division of Neurosurgery, Department of Surgery, St. Michael's Hospital, 30 Bond Street, Toronto, Canada M5W 1W8; Li Ka Shing Knowledge Institute, St. Michael's Hospital, 209 Victoria Street, Toronto, Canada M5B 1T8. Electronic address:

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http://dx.doi.org/10.1016/j.spinee.2019.06.026DOI Listing
November 2019

A Balanced Perspective on Surgery of the Craniovertebral Junction.

Neurospine 2019 Jun 30;16(2):216-218. Epub 2019 Jun 30.

Division of Neurosurgery and Spinal Program, Department of Surgery, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.14245/ns.19edi.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603823PMC
June 2019

Regeneration of Spinal Cord Connectivity Through Stem Cell Transplantation and Biomaterial Scaffolds.

Front Cell Neurosci 2019 6;13:248. Epub 2019 Jun 6.

Division of Genetics and Development, Krembil Research Institute, Toronto, ON, Canada.

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http://dx.doi.org/10.3389/fncel.2019.00248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563678PMC
June 2019

AOSpine Knowledge Forums: Research in Motion.

Global Spine J 2019 May 8;9(1 Suppl):5S-7S. Epub 2019 May 8.

Pontificia Universidade Catolica do Paraná, Curitiba, Brazil.

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http://dx.doi.org/10.1177/2192568219845647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512198PMC
May 2019

Endogenous Interleukin-10 Deficiency Exacerbates Vascular Pathology in Traumatic Cervical Spinal Cord Injury.

J Neurotrauma 2019 08 24;36(15):2298-2307. Epub 2019 Apr 24.

1Division of Genetics and Development, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1089/neu.2018.6081DOI Listing
August 2019

A Systematic Review of Classification Systems for Cervical Ossification of the Posterior Longitudinal Ligament.

Global Spine J 2019 Feb 15;9(1):85-103. Epub 2018 Aug 15.

Department of Surgery, Division of Neurosurgery and Spinal Program, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1177/2192568217720421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362555PMC
February 2019

Optical Topographic Imaging for Spinal Intraoperative Three-Dimensional Navigation in Mini-Open Approaches: A Prospective Cohort Study of Initial Preclinical and Clinical Feasibility.

World Neurosurg 2019 05 8;125:e863-e872. Epub 2019 Feb 8.

Division of Neurosurgery, Department of Surgery, University of Toronto. Toronto, Toronto, Ontario, Canada; Institute of Medical Science, School of Graduate Studies, University of Toronto. Toronto, Toronto, Ontario, Canada; Biophotonics and Bioengineering Laboratory, Sunnybrook Health Sciences Centre. Toronto, Toronto, Ontario, Canada; Department of Electrical and Computer Engineering, Ryerson University, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.wneu.2019.01.201DOI Listing
May 2019

Utilization of Spinal Intra-operative Three-dimensional Navigation by Canadian Surgeons and Trainees: A Population-based Time Trend Study.

Can J Neurol Sci 2019 01;46(1):87-95

1Division of Neurosurgery,Department of Surgery,University of Toronto,Toronto,Ontario,Canada.

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http://dx.doi.org/10.1017/cjn.2018.376DOI Listing
January 2019

Generation of Definitive Neural Progenitor Cells from Human Pluripotent Stem Cells for Transplantation into Spinal Cord Injury.

Methods Mol Biol 2019 ;1919:25-41

Division of Genetics and Development, Krembil Research Institute, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/978-1-4939-9007-8_3DOI Listing
June 2019

Time is spine: a review of translational advances in spinal cord injury.

J Neurosurg Spine 2018 12;30(1):1-18

1Division of Neurosurgery, Department of Surgery, and.

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http://dx.doi.org/10.3171/2018.9.SPINE18682DOI Listing
December 2018

Global burden of traumatic brain and spinal cord injury.

Lancet Neurol 2019 01 26;18(1):24-25. Epub 2018 Nov 26.

Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada; Division of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(18)30444-7DOI Listing
January 2019