International Journal of Nephrology and Kidney Failure
Connexin 26 mutation is associated with profound bilateral sensory neural deafness. Other isoforms of Connexins also form gap junctions in kidneys including endothelial cells and renal vasculature; however, Connexin 26 mutation has never been reported to be linked with acute kidney injury. We report a case of a young patient having Connexin 26 mutation with progressive acute kidney injury on background of therapeutic dose of Non Steroidal Anti inflammatory Drugs.
nt J Nephrol Kidney Fail 5(2): dx.doi.org/10.16966/2380-5498.177
Int J Nephrol Kidney Fail 5(2): dx.doi.org/10.16966/2380-5498.177
Chronic Kidney Disease (CKD) is a condition where a gradual kidney function loss leads to a build-up of toxic waste products in the blood, increasing morbidity and premature deaths from enhanced risks of cardiovascular disease, stroke and mineral bone diseases. The most common causes of CKD include type 2 diabetes and arterial hypertension, both accounting for two-thirds of all cases. CKD is asymptomatic in early stages and is only diagnosed via routine screening tests unless severe symptoms arise from the advanced CKD. Management of CKD via Multidisciplinary Team (MDT) consisting of professionals from various disciplines has been hailed as the best modality in treating such a multi-faceted chronic disease, and it has been shown to have positive impacts on patients’ experience and clinical outcomes.
CEN Case Rep 2017 Nov 15;6(2):152-155. Epub 2017 Jul 15.
Department of Renal Medicine, Kent and Canterbury Hospital, East Kent Hospitals University NHS Foundation Trust, Ethelbert Road, Canterbury, Kent, CT1 3NG, UK.
Until the law in the United Kingdom (UK) changed in May 2016 so called "legal highs" or "new psychoactive substances" were freely available in high street shops across the UK. Following prohibition these drugs are still easily purchased illegally via the internet. We report a case of a patient who self-administered 3-fluorophenmetrazine intravenously with catastrophic consequences. Adverse effects were almost immediate with symptoms of malaise and tachycardia. Two days post administration he was transferred to the intensive therapy unit with acute kidney injury and irreversible four limb ischaemia. He required a period of renal replacement therapy and bilateral lower limb amputation. This case highlights the fact that new psychoactive substances have many unintended adverse effect which have not been previously described. Multiple routes of administration are used by people taking these agents including intravenously. Medical practitioners should always consider ingestion of new psychoactive substances in the differential diagnosis of acutely ill patients.
Nabil Mohie Abdel-Hamid, Maiiada Hasan Nazmy, Ahmed Wahid Mahmoud, Michael Atef Fawzy, Marco Youssof, Biochemistry Department, Unit of Liver cancer research, Faulty of Pharmacy, Minia University, Minia 002086, Egypt.
Timely diagnosis and treatment of SBP are essential to survival. Therefore the purpose of the present study is to assess the levels and the diagnostic efficacy of CRP and TNF-α in the ascitic fluid and their blood ascitic gradient among cirrhotic patients with SBP versus those with sterile ascitis.