Michael Famulok

Michael Famulok

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Michael Famulok

Publications by authors named "Michael Famulok"

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Design, assembly, characterization, and operation of double-stranded interlocked DNA nanostructures.

Nat Protoc 2019 Oct 11;14(10):2818-2855. Epub 2019 Sep 11.

Chemical Biology and Medicinal Chemistry Unit, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1038/s41596-019-0198-7DOI Listing
October 2019

Orthogonally Photocontrolled Non-Autonomous DNA Walker.

Angew Chem Int Ed Engl 2019 May 12;58(21):6948-6951. Epub 2019 Apr 12.

LIMES Chemical Biology Unit, Universität Bonn, Gerhard-Domagk-Straße 1, 53121, Bonn, Germany.

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http://dx.doi.org/10.1002/anie.201901272DOI Listing
May 2019

Translocation of a Cell Surface Spliceosomal Complex Induces Alternative Splicing Events and Lymphoma Cell Necrosis.

Cell Chem Biol 2019 May 28;26(5):756-764.e6. Epub 2019 Mar 28.

Caris Life Sciences, 4610 South 44th Place, Phoenix, AZ 85040, USA; LIMES Program Unit Chemical Biology & Medicinal Chemistry, c/o Kekulé Institute for Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Straße 1, 53121 Bonn, Germany; Center of Aptamer Research and Development, University of Bonn, University of Bonn, Gerhard-Domagk-Straße 1, 53121 Bonn, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24519456193007
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http://dx.doi.org/10.1016/j.chembiol.2019.02.016DOI Listing
May 2019

Temporal and Reversible Control of a DNAzyme by Orthogonal Photoswitching.

J Am Chem Soc 2018 12 26;140(49):16868-16872. Epub 2018 Nov 26.

LIMES Chemical Biology Unit, Universität Bonn , Gerhard-Domagk-Straße 1 , 53121 Bonn , Germany.

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http://pubs.acs.org/doi/10.1021/jacs.8b08738
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http://dx.doi.org/10.1021/jacs.8b08738DOI Listing
December 2018

A bio-hybrid DNA rotor-stator nanoengine that moves along predefined tracks.

Nat Nanotechnol 2018 06 9;13(6):496-503. Epub 2018 Apr 9.

LIMES Program Unit Chemical Biology & Medicinal Chemistry, c/o Kekulé Institut für Organische Chemie und Biochemie, University of Bonn, Bonn, Germany.

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http://www.nature.com/articles/s41565-018-0109-z
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http://dx.doi.org/10.1038/s41565-018-0109-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994166PMC
June 2018

High-Yield Spin Labeling of Long RNAs for Electron Paramagnetic Resonance Spectroscopy.

Biochemistry 2018 05 10;57(20):2923-2931. Epub 2018 May 10.

Institute of Physical and Theoretical Chemistry , University of Bonn , Wegelerstrasse 12 , 53115 Bonn , Germany.

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http://dx.doi.org/10.1021/acs.biochem.8b00040DOI Listing
May 2018

Supramolecular aptamer nano-constructs for receptor-mediated targeting and light-triggered release of chemotherapeutics into cancer cells.

Nat Commun 2018 02 7;9(1):535. Epub 2018 Feb 7.

Life and Medical Sciences (LIMES) Institute, Chemical Biology & Medicinal Chemistry Unit, c/o Kekulé Institute of Organic Chemistry and Biochemistry, Gerhard-Domagk-Strasse 1, 53121, Bonn, Germany.

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http://dx.doi.org/10.1038/s41467-018-02929-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803212PMC
February 2018

Expanding the Toolbox of Photoswitches for DNA Nanotechnology Using Arylazopyrazoles.

Chemistry 2018 Jan 2;24(5):1062-1066. Epub 2018 Jan 2.

LIMES Chemical Biology Unit, Universität Bonn, Gerhard-Domagk-Straße 1, 53121, Bonn, Germany.

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http://doi.wiley.com/10.1002/chem.201705500
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http://dx.doi.org/10.1002/chem.201705500DOI Listing
January 2018

Interlocked DNA topologies for nanotechnology.

Curr Opin Biotechnol 2017 12 12;48:159-167. Epub 2017 May 12.

Life and Medical Sciences (LIMES) Institute, Chemical Biology and Medicinal Chemistry Unit, c/o Kekulé Institut für Organische Chemie und Biochemie, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany; Center of Advanced European Studies and Research (CASEAR), Ludwig-Erhard-Allee 2, 53175 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.copbio.2017.04.002DOI Listing
December 2017

Allosteric Control of Oxidative Catalysis by a DNA Rotaxane Nanostructure.

J Am Chem Soc 2017 11 1;139(45):16044-16047. Epub 2017 Nov 1.

LIMES Chemical Biology Unit, Universität Bonn , Gerhard-Domagk-Straße 1, 53121 Bonn, Germany.

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http://dx.doi.org/10.1021/jacs.7b08839DOI Listing
November 2017

Studying the Conformation of a Receptor Tyrosine Kinase in Solution by Inhibitor-Based Spin Labeling.

Angew Chem Int Ed Engl 2017 07 19;56(29):8417-8421. Epub 2017 Jun 19.

Max Planck Fellow Chemical Biology, Center of Advanced European Studies and Research (caesar), Ludwig-Erhard-Allee 2, 53175, Bonn, Germany.

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http://dx.doi.org/10.1002/anie.201703154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575716PMC
July 2017

Post-synthetic Spin-Labeling of RNA through Click Chemistry for PELDOR Measurements.

Chemistry 2016 Aug 14;22(34):12113-21. Epub 2016 Jul 14.

Life & Medical Sciences Institute, Chemical Biology & Medicinal Chemistry Unit c/o Kekulé-Institut für Organische Chemie und Biochemie, University of Bonn, Gerhard-Domagk-Str. 1, 53121, Bonn, Germany.

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http://dx.doi.org/10.1002/chem.201601897DOI Listing
August 2016

Single-Stranded Tile Stoppers for Interlocked DNA Architectures.

Chembiochem 2016 06 5;17(12):1146-9. Epub 2016 Apr 5.

Life and Medical Science (LIMES) Institute, Chemical Biology & Medicinal Chemistry Unit, University of Bonn, Gerhard-Domagk Strasse 1, 53121, Bonn, Germany.

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http://dx.doi.org/10.1002/cbic.201500685DOI Listing
June 2016

Daisy Chain Rotaxanes Made from Interlocked DNA Nanostructures.

Angew Chem Int Ed Engl 2016 04 24;55(18):5512-6. Epub 2016 Mar 24.

LIMES Chemical Biology Unit, Universität Bonn, Gerhard-Domagk-Strasse 1, 53121, Bonn, Germany.

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http://dx.doi.org/10.1002/anie.201601042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850751PMC
April 2016

Switchable Reconfiguration of a Seven-Ring Interlocked DNA Catenane Nanostructure.

Nano Lett 2015 Oct 21;15(10):7133-7. Epub 2015 Sep 21.

Institute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem , Jerusalem 91904, Israel.

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http://dx.doi.org/10.1021/acs.nanolett.5b03280DOI Listing
October 2015

Inhibition of Cytohesins Protects against Genetic Models of Motor Neuron Disease.

J Neurosci 2015 Jun;35(24):9088-105

Division of Pediatric Neurology and Department of Neurology and Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104,

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http://www.jneurosci.org/content/35/24/9088.full.pdf
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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.5032-13.2
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http://dx.doi.org/10.1523/JNEUROSCI.5032-13.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469736PMC
June 2015

Logic gating by macrocycle displacement using a double-stranded DNA [3]rotaxane shuttle.

Angew Chem Int Ed Engl 2014 Sep 30;53(39):10372-6. Epub 2014 Jul 30.

Life and Medical Science (LIMES) Institute, Chemical Biology & Medicinal Chemistry Unit, University of Bonn, Gerhard-Domagk Strasse 1, 53121 Bonn (Germany) http://www.famuloklab.de.

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http://dx.doi.org/10.1002/anie.201405447DOI Listing
September 2014

Interlocked DNA nanostructures controlled by a reversible logic circuit.

Nat Commun 2014 Sep 17;5:4940. Epub 2014 Sep 17.

1] Chemical Biology and Medicinal Chemistry Unit, Life and Medical Science (LIMES) Institute, University of Bonn, 53121 Bonn, Germany [2] Center of Advanced European Studies and Research (CAESAR), Ludwig-Erhard-Allee 2, 53175 Bonn, Germany.

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http://dx.doi.org/10.1038/ncomms5940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199106PMC
September 2014

Aptamers and SELEX in Chemistry & Biology.

Chem Biol 2014 Sep;21(9):1055-8

Life and Medical Sciences Institute, University of Bonn, Chemical Biology Unit, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2014.08.003DOI Listing
September 2014

Switchable reconfiguration of an interlocked DNA olympiadane nanostructure.

Angew Chem Int Ed Engl 2014 Jul 30;53(29):7499-503. Epub 2014 May 30.

Institute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904 (Israel).

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http://doi.wiley.com/10.1002/anie.201403202
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http://dx.doi.org/10.1002/anie.201403202DOI Listing
July 2014

Mechanically interlocked DNA nanostructures for functional devices.

Acc Chem Res 2014 Jun 14;47(6):1700-9. Epub 2014 Mar 14.

Kekulé-Institut für Organische Chemie und Biochemie and ‡LIMES Program Unit Chemical Biology & Medicinal Chemistry, c/o Kekulé Institut für Organische Chemie und Biochemie Universität Bonn , Gerhard-Domagk-Straße. 1, 53121 Bonn, Germany.

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http://dx.doi.org/10.1021/ar400321hDOI Listing
June 2014

A novel family of structurally stable double stranded DNA catenanes.

Chem Commun (Camb) 2014 Jun;50(46):6091-3

Universität Bonn, LIMES-Life and Medical Science Institut, Program Unit Chemical Biology & Medicinal Chemistry, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.

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http://dx.doi.org/10.1039/c4cc02030hDOI Listing
June 2014

wALADin benzimidazoles differentially modulate the function of porphobilinogen synthase orthologs.

J Med Chem 2014 Mar 25;57(6):2498-510. Epub 2014 Feb 25.

Institute of Medical Microbiology, Immunology and Parasitology, University Hospital of Bonn , Sigmund-Freud Strasse 25, 53127 Bonn, Germany.

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http://dx.doi.org/10.1021/jm401785nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983392PMC
March 2014

RNA-aptamers that modulate the RhoGEF activity of Tiam1.

Bioorg Med Chem 2013 Oct 23;21(20):6239-46. Epub 2013 May 23.

Life and Medical Sciences (LIMES) Institute, University of Bonn, Gerhard-Domagk-Str 1, 53121 Bonn, Germany.

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http://dx.doi.org/10.1016/j.bmc.2013.05.021DOI Listing
October 2013

New chemotypes for wALADin1-like inhibitors of delta-aminolevulinic acid dehydratase from Wolbachia endobacteria.

Bioorg Med Chem Lett 2013 Oct 20;23(20):5558-62. Epub 2013 Aug 20.

Institute of Medical Microbiology, Immunology and Parasitology, University Hospital of Bonn, Sigmund-Freud Str. 25, 53127 Bonn, Germany; LIMES Institute, Chemical Biology & Medicinal Chemistry Unit, Universität Bonn, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany.

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http://dx.doi.org/10.1016/j.bmcl.2013.08.052DOI Listing
October 2013

Cyplecksins are covalent inhibitors of the pleckstrin homology domain of cytohesin.

Angew Chem Int Ed Engl 2013 Sep 10;52(36):9529-33. Epub 2013 Jul 10.

Life and Medical Sciences Institute, Universität Bonn, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.

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http://www.limes-institut-bonn.de/fileadmin/user_upload/Grou
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http://doi.wiley.com/10.1002/anie.201302207
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http://dx.doi.org/10.1002/anie.201302207DOI Listing
September 2013

Pseudo-complementary PNA actuators as reversible switches in dynamic DNA nanotechnology.

Nucleic Acids Res 2013 Apr 26;41(8):4729-39. Epub 2013 Feb 26.

Chemical Biology and Medicinal Chemistry Unit, LIMES Institute, c/o Kekulé Institute of Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.

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http://dx.doi.org/10.1093/nar/gkt121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632119PMC
April 2013

A selective inhibitor of heme biosynthesis in endosymbiotic bacteria elicits antifilarial activity in vitro.

Chem Biol 2013 Feb;20(2):177-87

Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Sigmund-Freud Strasse 25, 53127 Bonn, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S10745521120045
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http://dx.doi.org/10.1016/j.chembiol.2012.11.009DOI Listing
February 2013

Anti-proliferative effect of cytohesin inhibition in gefitinib-resistant lung cancer cells.

PLoS One 2012 18;7(7):e41179. Epub 2012 Jul 18.

Chemical Biology and Medicinal Chemistry Unit, Life and Medical Sciences (LIMES) Institute, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041179PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399819PMC
January 2013

I-motif-programmed functionalization of DNA nanocircles.

J Am Chem Soc 2013 Jan 22;135(4):1593-9. Epub 2013 Jan 22.

Life and Medical Science (LIMES) Institute, Program Unit Chemical Biology and Medicinal Chemistry, University of Bonn, 53121 Bonn, Germany.

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http://dx.doi.org/10.1021/ja3118224DOI Listing
January 2013

Aptamer-based affinity labeling of proteins.

Angew Chem Int Ed Engl 2012 Sep 2;51(36):9176-80. Epub 2012 Aug 2.

University of Bonn, LIMES Institute, Bonn, Germany.

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http://dx.doi.org/10.1002/anie.201204174DOI Listing
September 2012

Design strategy for DNA rotaxanes with a mechanically reinforced PX100 axle.

Angew Chem Int Ed Engl 2012 Jul 31;51(27):6771-5. Epub 2012 May 31.

Universität Bonn, LIMES Institut, Chemical Biology & Med. Chem. Unit c/o Kekulé-Institut für Organische Chemie und Biochemie, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.

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http://dx.doi.org/10.1002/anie.201202816DOI Listing
July 2012

Pan-selective aptamers for the family of small GTPases.

Chembiochem 2012 Jul 11;13(10):1433-7. Epub 2012 Jun 11.

Life and Medical Sciences (LIMES) Institute, Chemical Biology & Medicinal Chemistry Unit, University of Bonn, Gerhard-Domagk-Strasse 1,53121 Bonn, Germany.

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http://dx.doi.org/10.1002/cbic.201200164DOI Listing
July 2012

Reversible light switch for macrocycle mobility in a DNA rotaxane.

J Am Chem Soc 2012 Jul 16;134(29):11884-7. Epub 2012 Jul 16.

LIMES Institute, Chemical Biology & Medicinal Chemistry Unit, c/o Kekulé Institute of Organic Chemistry and Biochemistry, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.

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http://dx.doi.org/10.1021/ja3042096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404550PMC
July 2012

Grp1 plays a key role in linking insulin signaling to glut4 recycling.

Dev Cell 2012 Jun 17;22(6):1286-98. Epub 2012 May 17.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.devcel.2012.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376201PMC
June 2012

Label-free impedimetric aptasensor for lysozyme detection based on carbon nanotube-modified screen-printed electrodes.

Anal Biochem 2012 Feb 2;421(2):454-9. Epub 2011 Dec 2.

LIMES Institute, Program Unit Chemical Biology and Medicinal Chemistry, University of Bonn, 53121 Bonn, Germany.

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http://dx.doi.org/10.1016/j.ab.2011.11.034DOI Listing
February 2012

Input-dependent induction of oligonucleotide structural motifs for performing molecular logic.

J Am Chem Soc 2012 Feb 8;134(7):3508-16. Epub 2012 Feb 8.

Life and Medical Science Institute, Program Unit Chemical Biology and Medicinal Chemistry, University of Bonn, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany.

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http://dx.doi.org/10.1021/ja2108883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284195PMC
February 2012

A trifluoromethylphenyl diazirine-based SecinH3 photoaffinity probe.

Chem Commun (Camb) 2012 Jan 16;48(9):1272-4. Epub 2011 Dec 16.

LIMES Institute, Chemical Biology & Medicinal Chemistry Unit, University of Bonn, 53121 Bonn, Germany.

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http://dx.doi.org/10.1039/c2cc16477aDOI Listing
January 2012

Aptamer modules as sensors and detectors.

Acc Chem Res 2011 Dec 5;44(12):1349-58. Epub 2011 Aug 5.

LIMES Institute, Chemical Biology and Medicinal Chemistry Unit, University of Bonn, 53121 Bonn, Germany.

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http://dx.doi.org/10.1021/ar2000293DOI Listing
December 2011

A luminescent oxygen channeling biosensor that measures small GTPase activation.

Chem Commun (Camb) 2011 Jul 31;47(26):7521-3. Epub 2011 May 31.

LIMES Institute, Chemical Biology & Medicinal Chemistry Unit, University of Bonn, 53121 Bonn, Germany.

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http://dx.doi.org/10.1039/c1cc11944cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961041PMC
July 2011

Aptamers for allosteric regulation.

Nat Chem Biol 2011 Jul 18;7(8):519-27. Epub 2011 Jul 18.

Life & Medical Sciences Institute, Chemical Biology & Medicinal Chemistry Unit, Laboratory of Chemical Biology, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.

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http://dx.doi.org/10.1038/nchembio.609DOI Listing
July 2011

A homogeneous fluorescence resonance energy transfer system for monitoring the activation of a protein switch in real time.

J Am Chem Soc 2011 Jun 4;133(21):8372-9. Epub 2011 May 4.

LIMES Institute, Chemical Biology and Medicinal Chemistry Unit, c/o Kekulé Institute of Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.

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http://pubs.acs.org/doi/abs/10.1021/ja202513s
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http://dx.doi.org/10.1021/ja202513sDOI Listing
June 2011

Gernot Boche (1938-2011).

Angew Chem Int Ed Engl 2011 May 3;50(23):5251-2. Epub 2011 May 3.

Fachbereich Chemie der Philipps Universität Marburg.

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http://doi.wiley.com/10.1002/anie.201102565
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http://dx.doi.org/10.1002/anie.201102565DOI Listing
May 2011

Fluorescence-activated cell sorting for aptamer SELEX with cell mixtures.

Nat Protoc 2010 Dec 2;5(12):1993-2004. Epub 2010 Dec 2.

Department of Life and Medical Sciences, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1038/nprot.2010.163DOI Listing
December 2010

Cytohesins are cytoplasmic ErbB receptor activators.

Cell 2010 Oct;143(2):201-11

LIMES Institute, Program Unit Chemical Biology & Medicinal Chemistry, Laboratory of Chemical Biology, Rheinische Friedrich-Wilhelms-Universität Bonn, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S009286741001059
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http://dx.doi.org/10.1016/j.cell.2010.09.011DOI Listing
October 2010

ADLOC: an aptamer-displacement assay based on luminescent oxygen channeling.

Chemistry 2010 Sep;16(36):11100-7

Life and Medical Sciences (LIMES) Institute, Chemical Biology and Medicinal Chemistry Unit, University of Bonn, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.

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http://dx.doi.org/10.1002/chem.201001192DOI Listing
September 2010

RNA nanotechnology: inspired by DNA.

Nat Nanotechnol 2010 Sep;5(9):634-5

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http://dx.doi.org/10.1038/nnano.2010.183DOI Listing
September 2010

A double-stranded DNA rotaxane.

Nat Nanotechnol 2010 Jun 18;5(6):436-42. Epub 2010 Apr 18.

LIMES Institute, Program Unit Chemical Biology & Medicinal Chemistry, c/o Kekulé Institut für Organische Chemie und Biochemie, University of Bonn, Bonn, Germany.

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http://www.nature.com/articles/nnano.2010.65
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http://dx.doi.org/10.1038/nnano.2010.65DOI Listing
June 2010

Assembly of dsDNA nanocircles into dimeric and oligomeric aggregates.

Chem Commun (Camb) 2010 Jun 17;46(23):4154-6. Epub 2010 May 17.

LIMES Institute, Chemical Biology & Medicinal Chemistry Unit, University of Bonn, 53121 Bonn, Germany.

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http://dx.doi.org/10.1039/c0cc00390eDOI Listing
June 2010

An aptamer targeting the apical-loop domain modulates pri-miRNA processing.

Angew Chem Int Ed Engl 2010 Jun;49(27):4674-7

Life and Medical Sciences (LIMES), University of Bonn, Gerhard-Domagk-Strasse 1, Bonn, Germany.

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http://dx.doi.org/10.1002/anie.200906919DOI Listing
June 2010

Exploring chemical space with aptamers.

Authors:
Michael Famulok

J Med Chem 2009 Nov;52(22):6951-7

LIMES Program Unit Chemical Biology and Medicinal Chemistry, University of Bonn, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.

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http://pubs.acs.org/doi/abs/10.1021/jm9014789
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http://dx.doi.org/10.1021/jm9014789DOI Listing
November 2009

Screening of novel inhibitors of HIV-1 reverse transcriptase with a reporter ribozyme assay.

Methods Mol Biol 2009 ;535:187-99

Life and Medical Sciences, University of Bonn, Bonn, Germany.

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http://link.springer.com/10.1007/978-1-59745-557-2_11
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http://dx.doi.org/10.1007/978-1-59745-557-2_11DOI Listing
May 2009

In vitro selection of conformational probes for riboswitches.

Methods Mol Biol 2009 ;540:291-300

Rheinische Friedrich-Wilhelms-Universität Bonn Life and Medical Sciences Institute, Gerhard-Domagk-Str.1, 53121, Bonn, Germany.

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http://dx.doi.org/10.1007/978-1-59745-558-9_21DOI Listing
May 2009

Affinity-based labeling of cytohesins with a bifunctional SecinH3 photoaffinity probe.

Angew Chem Int Ed Engl 2008 ;47(49):9565-8

LIMES Institute Program Unit Chemical Biology & Medicinal Chemistry, Universität Bonn, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.

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http://dx.doi.org/10.1002/anie.200803962DOI Listing
December 2008

Displacement of protein-bound aptamers with small molecules screened by fluorescence polarization.

Nat Protoc 2008 ;3(4):579-87

Program Unit Chemical Biology & Medicinal Chemistry, LIMES Institute, c/o Kekulé Institut für Organische Chemie und Biochemie, University of Bonn, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.

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http://dx.doi.org/10.1038/nprot.2008.15DOI Listing
October 2008

Modular reporter hairpin ribozymes for analyzing molecular interactions.

Methods Mol Biol 2008 ;429:237-50

Kekulé-Institute, University of Bonn, Bonn, Germany.

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http://link.springer.com/10.1007/978-1-60327-040-3_17
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http://dx.doi.org/10.1007/978-1-60327-040-3_17DOI Listing
September 2008

Screening of molecular interactions using reporter hammerhead ribozymes.

Methods Mol Biol 2008 ;429:251-63

Department of Chemistry, University of Konstanz, Konstanz, Germany.

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http://link.springer.com/10.1007/978-1-60327-040-3_18
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http://dx.doi.org/10.1007/978-1-60327-040-3_18DOI Listing
September 2008

Building objects from nucleic acids for a nanometer world.

Biochimie 2008 Jul 14;90(7):1096-107. Epub 2008 Feb 14.

University of Frankfurt, Cluster of Excellence Macromolecular Complexes, c/o Institute of Organic Chemistry and Chemical Biology, Max-von-Laue-Str. 7, 60438 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.biochi.2008.02.004DOI Listing
July 2008

Enrichment of cell-targeting and population-specific aptamers by fluorescence-activated cell sorting.

Angew Chem Int Ed Engl 2008 ;47(28):5190-3

Life and Medical Science, Universität Bonn, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.

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http://doi.wiley.com/10.1002/anie.200800216
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http://dx.doi.org/10.1002/anie.200800216DOI Listing
July 2008

Photocleavable initiator nucleotide substrates for an aldolase ribozyme.

J Org Chem 2008 Jul 3;73(13):5069-77. Epub 2008 Jun 3.

LIMES Institute, Program Unit Chemical Biology and Medicinal Chemistry, c/o Kekulé Institut für Organische Chemie & Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany.

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http://pubs.acs.org/doi/abs/10.1021/jo800639p
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http://dx.doi.org/10.1021/jo800639pDOI Listing
July 2008

DNA minicircles with gaps for versatile functionalization.

Angew Chem Int Ed Engl 2008 ;47(5):967-70

Universität Bonn, LIMES-Life and Medical Science, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.

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http://dx.doi.org/10.1002/anie.200704004DOI Listing
March 2008

Construction of DNA architectures with RNA hairpins.

Angew Chem Int Ed Engl 2008 ;47(5):971-3

Universität Bonn, LIMES-Life and Medical Science Institut, Programmeinheit Chemische Biologie und Medizinische Chemie, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.

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http://doi.wiley.com/10.1002/anie.200704709
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http://dx.doi.org/10.1002/anie.200704709DOI Listing
March 2008

Secondary structures and functional requirements for thiM riboswitches from Desulfovibrio vulgaris, Erwinia carotovora and Rhodobacter spheroides.

Biol Chem 2008 Feb;389(2):127-34

LIMES-Institute, Program Unit Chemical Biology and Medicinal Chemistry, c/o Kekulé-Institute for Organic Chemistry and Biochemistry of the University of Bonn, Gerhard-Domagk-Strasse 1, D-53121 Bonn, Germany.

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http://dx.doi.org/10.1515/BC.2008.012DOI Listing
February 2008

[Nucleic acids in the drug discovery process: aptamers as therapeutic and as active ingredients for drugs].

Pharm Unserer Zeit 2007 ;36(6):432-6

Rheinische Friedrich-Wilhelms Universität Bonn, LIMES Institut, Programmeinheit Chemische Biologie und Medizinische Chemie, c/o Kekulé Institut für Org. Chemie und Biochemie, Gerhard-Domagk-Str. 1, 53121 Bonn.

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http://dx.doi.org/10.1002/pauz.200700238DOI Listing
January 2008

DNA aptamer-mediated regulation of the hairpin ribozyme by human alpha-thrombin.

Blood Cells Mol Dis 2007 Jan-Feb;38(1):19-24. Epub 2006 Dec 5.

LIMES Program Unit Chemical Biology and Medicinal Chemistry, c/o Kekulé Institut für Organische Chemie und Biochemie, University of Bonn, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S107997960600232
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http://dx.doi.org/10.1016/j.bcmd.2006.10.007DOI Listing
October 2007

Polyamide struts for DNA architectures.

Angew Chem Int Ed Engl 2007 ;46(23):4382-4

University of Bonn, LIMES-Life and Medical Sciences, c/o Kekulé-Institute, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.

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http://dx.doi.org/10.1002/anie.200700469DOI Listing
September 2007

Functional aptamers and aptazymes in biotechnology, diagnostics, and therapy.

Chem Rev 2007 Sep 23;107(9):3715-43. Epub 2007 Aug 23.

LIMES Institute, Program Unit Chemical Biology and Medicinal Chemistry, c/o Kekulé-Institut für Organische Chemie und Biochemie, Gerhard Domagk-Strasse 1, 53121 Bonn, Germany.

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http://pubs.acs.org/doi/abs/10.1021/cr0306743
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September 2007

Functional nucleic acids in high throughput screening and drug discovery.

Comb Chem High Throughput Screen 2007 Sep;10(8):698-705

LIMES Institute, Program Unit Chemical Biology and Medicinal Chemistry, c/o Kekulé-Institut für Organische Chemie und Biochemie, Gerhard Domagk-Str. 1, D-53121 Bonn, Germany.

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http://dx.doi.org/10.2174/138620707782507359DOI Listing
September 2007

Conformational changes in the expression domain of the Escherichia coli thiM riboswitch.

Nucleic Acids Res 2007 21;35(11):3713-22. Epub 2007 May 21.

LIMES Program Unit Chemical Biology & Medicinal Chemistry, Kekulé Institute for Organic Chemistry & Biochemistry, University of Bonn, Gerhard-Domagk-Strasse 1, D-53121 Bonn, Germany.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkm300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1920254PMC
July 2007

Aptamer displacement identifies alternative small-molecule target sites that escape viral resistance.

Chem Biol 2007 Jul;14(7):804-12

LIMES Program Unit Chemical Biology & Medicinal Chemistry, c/o Kekulé Institute for Organic Chemistry & Biochemistry, University of Bonn, Gerhard-Domagk-Strasse 1, D-53121 Bonn, Germany.

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http://dx.doi.org/10.1016/j.chembiol.2007.06.003DOI Listing
July 2007

Anti-innexin 2 aptamers specifically inhibit the heterologous interaction of the innexin 2 and innexin 3 carboxyl-termini in vitro.

Biol Chem 2007 Jun;388(6):561-8

LIMES Institute, Program Unit Chemical Biology and Medicinal Chemistry, c/o Kekulé Institute for Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Strasse 1, D-53121 Bonn, Germany.

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https://www.degruyter.com/view/j/bchm.2007.388.issue-6/bc.20
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http://dx.doi.org/10.1515/BC.2007.074DOI Listing
June 2007

Chemical biology: ignore the nonsense.

Nature 2007 May;447(7140):42-3

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http://dx.doi.org/10.1038/nature05715DOI Listing
May 2007

RNA ligands that distinguish metabolite-induced conformations in the TPP riboswitch.

Angew Chem Int Ed Engl 2007 ;46(4):557-60

Life and Medical Sciences (LIMES), Program Unit Chemical Biology and Medicinal Chemistry c/o Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.

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http://dx.doi.org/10.1002/anie.200603166DOI Listing
April 2007

Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance.

Nature 2006 Dec;444(7121):941-4

LIMES Program Unit Chemical Biology & Medicinal Chemistry, c/o Kekulé Institut für Organische Chemie und Biochemie, University of Bonn, Germany.

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http://dx.doi.org/10.1038/nature05415DOI Listing
December 2006

RNA aptamers selectively modulate protein recruitment to the cytoplasmic domain of beta-secretase BACE1 in vitro.

RNA 2006 Sep 3;12(9):1650-60. Epub 2006 Aug 3.

LIMES Program Unit Chemical Biology & Medicinal Chemistry, Universität Bonn, 53121 Bonn, Germany.

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http://www.rnajournal.org/cgi/doi/10.1261/rna.126306
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http://dx.doi.org/10.1261/rna.126306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1557694PMC
September 2006

Discrimination of single mutations in cancer-related gene fragments with a surface acoustic wave sensor.

Anal Chem 2006 Jul;78(14):4865-71

LIMES Program Unit Chemical Biology & Medicinal Chemistry, c/o Kekulé Institute for Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.

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http://dx.doi.org/10.1021/ac060296cDOI Listing
July 2006

Heteromerization of innexin gap junction proteins regulates epithelial tissue organization in Drosophila.

Mol Biol Cell 2006 Apr 25;17(4):1676-85. Epub 2006 Jan 25.

Institut für Molekulare Physiologie und Entwicklungsbiologie der Universität Bonn, 53115 Bonn, Germany.

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http://dx.doi.org/10.1091/mbc.e05-11-1059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1415333PMC
April 2006

High-throughput-compatible assay for glmS riboswitch metabolite dependence.

Chembiochem 2006 Apr;7(4):602-4

Universität Bonn, Kekulé-Institut für Organische Chemie und Biochemie, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.

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http://dx.doi.org/10.1002/cbic.200500490DOI Listing
April 2006

Chemical biology: aptamers in nanoland.

Nature 2006 Feb;439(7077):666-9

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http://www.nature.com/articles/439666a
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February 2006

Structure of an RNA polymerase II-RNA inhibitor complex elucidates transcription regulation by noncoding RNAs.

Nat Struct Mol Biol 2006 Jan 11;13(1):44-8. Epub 2005 Dec 11.

Gene Center, University of Munich, Department of Chemistry and Biochemistry, Feodor-Lynen-Str. 25, 81377 Munich, Germany.

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http://dx.doi.org/10.1038/nsmb1032DOI Listing
January 2006

A versatile toolbox for variable DNA functionalization at high density.

J Am Chem Soc 2005 Nov;127(43):15071-82

Kekuké-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Strasse 1, D-53121 Bonn, Germany.

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http://dx.doi.org/10.1021/ja051725bDOI Listing
November 2005

Competitive regulation of modular allosteric aptazymes by a small molecule and oligonucleotide effector.

RNA 2005 Oct;11(10):1514-20

Kekulé Institut für Organische Chemie und Biochemie, University of Bonn, 53121 Bonn, Germany.

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http://www.rnajournal.org/cgi/doi/10.1261/rna.2840805
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http://dx.doi.org/10.1261/rna.2840805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370835PMC
October 2005

A ribozyme for the aldol reaction.

Chem Biol 2005 Aug;12(8):941-50

Universität Bonn, Kekulé-Institut für Organische Chemie und Biochemie, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.

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http://dx.doi.org/10.1016/j.chembiol.2005.06.008DOI Listing
August 2005

GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network.

Mol Cell Neurosci 2005 Jul;29(3):453-61

Department of Neurology, Laboratory of Molecular Cell Biology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S104474310500073
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http://dx.doi.org/10.1016/j.mcn.2005.03.014DOI Listing
July 2005

Allosteric aptamers and aptazymes as probes for screening approaches.

Authors:
Michael Famulok

Curr Opin Mol Ther 2005 Apr;7(2):137-43

Rheinische Friedrich-Wilhelms-Universität Bonn, Kekulé Institut für Organische Chemie und Biochemie, Gerhard-Domagk-Strasse 1, Bonn 53121, Germany.

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April 2005

Intramers and aptamers: applications in protein-function analyses and potential for drug screening.

Chembiochem 2005 Jan;6(1):19-26

Rheinische Friedrich-Wilhelms Universität Bonn, Kekulé-Institut für Organische Chemie und Biochemie, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.

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http://doi.wiley.com/10.1002/cbic.200400299
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http://dx.doi.org/10.1002/cbic.200400299DOI Listing
January 2005

Turning aptamers into anticoagulants.

Authors:
Michael Famulok

Nat Biotechnol 2004 Nov;22(11):1373-4

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http://www.nature.com/articles/nbt1104-1373
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http://dx.doi.org/10.1038/nbt1104-1373DOI Listing
November 2004

[In vitro selection of specific aptamers against microcystin-LR].

Zhonghua Yu Fang Yi Xue Za Zhi 2004 Nov;38(6):369-73

Institute of Environmental Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

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November 2004