Michael F Miles

Michael F Miles

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Michael F Miles

Michael F Miles

Publications by authors named "Michael F Miles"

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Pharmacological mechanisms of alcohol analgesic-like properties in mouse models of acute and chronic pain.

Neuropharmacology 2019 Dec 25;160:107793. Epub 2019 Sep 25.

Department of Pharmacology and Toxicology, Virginia Commonwealth University, Virginia Commonwealth University, Richmond, VA, 23298-0613, USA; Translational Research Initiative for Pain and Neuropathy, Virginia Commonwealth University, Virginia Commonwealth University, Richmond, VA, 23298-0613, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2019.107793DOI Listing
December 2019

A Novel Neighbor Housing Environment Enhances Social Interaction and Rescues Cognitive Deficits from Social Isolation in Adolescence.

Brain Sci 2019 Nov 22;9(12). Epub 2019 Nov 22.

VCU-Alcohol Research Center, Virginia Commonwealth University, Richmond, VA 23298-0613, USA.

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http://dx.doi.org/10.3390/brainsci9120336DOI Listing
November 2019

Adolescent but not adult ethanol binge drinking modulates ethanol behavioral effects in mice later in life.

Pharmacol Biochem Behav 2019 Sep 18;184:172740. Epub 2019 Jul 18.

Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, United States of America; The Center for the Study for Tobacco Products, Virginia Commonwealth University, Richmond, VA, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.pbb.2019.172740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697373PMC
September 2019

Cross-Species Co-analysis of Prefrontal Cortex Chronic Ethanol Transcriptome Responses in Mice and Monkeys.

Front Mol Neurosci 2019 13;12:197. Epub 2019 Aug 13.

Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, United States.

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http://dx.doi.org/10.3389/fnmol.2019.00197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701453PMC
August 2019

Connecting the Dots: Adolescent Alcohol, Enhancer RNA, and Anxiety.

Biol Psychiatry 2019 06;85(11):884-885

Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia; Department of Neurology, Virginia Commonwealth University, Richmond, Virginia; Virginia Commonwealth University Alcohol Research Center, Virginia Commonwealth University, Richmond, Virginia. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2019.04.004DOI Listing
June 2019

Beyond genome-wide significance: integrative approaches to the interpretation and extension of GWAS findings for alcohol use disorder.

Addict Biol 2019 Mar 9;24(2):275-289. Epub 2018 Jan 9.

Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.

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http://dx.doi.org/10.1111/adb.12591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037617PMC
March 2019

Chronic clozapine treatment restrains via HDAC2 the performance of mGlu2 receptor agonism in a rodent model of antipsychotic activity.

Neuropsychopharmacology 2019 01 7;44(2):443-454. Epub 2018 Jul 7.

Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA.

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http://dx.doi.org/10.1038/s41386-018-0143-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300555PMC
January 2019

Knockout of alpha 5 nicotinic acetylcholine receptors subunit alters ethanol-mediated behavioral effects and reward in mice.

Neuropharmacology 2018 08 23;138:341-348. Epub 2018 Jun 23.

Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298-0613, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2018.06.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400055PMC
August 2018

Integrative Analysis of Genetic, Genomic, and Phenotypic Data for Ethanol Behaviors: A Network-Based Pipeline for Identifying Mechanisms and Potential Drug Targets.

Methods Mol Biol 2017 ;1488:531-549

Department of Pharmacology and Toxicology, VCU Alcohol Research Center, Virginia Commonwealth University, 980613, Richmond, VA, 23298, USA.

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http://dx.doi.org/10.1007/978-1-4939-6427-7_26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152688PMC
January 2018

Intermittent Ethanol during Adolescence Leads to Lasting Behavioral Changes in Adulthood and Alters Gene Expression and Histone Methylation in the PFC.

Front Mol Neurosci 2017 26;10:307. Epub 2017 Sep 26.

Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, United States.

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http://dx.doi.org/10.3389/fnmol.2017.00307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622951PMC
September 2017

Differential potassium channel gene regulation in BXD mice reveals novel targets for pharmacogenetic therapies to reduce heavy alcohol drinking.

Alcohol 2017 Feb 27;58:33-45. Epub 2016 Jun 27.

Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA; Department of Psychiatry & Behavioral Sciences, Charleston Alcohol Research Center, Addiction Sciences Division, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address:

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http://dx.doi.org/10.1016/j.alcohol.2016.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191998PMC
February 2017

Variable effects of chronic intermittent ethanol exposure on ethanol drinking in a genetically diverse mouse cohort.

Alcohol 2017 Feb 13;58:73-82. Epub 2016 Oct 13.

Charleston Alcohol Research Center, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA; Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA; RHJ Department of Veterans Affairs Medical Center, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1016/j.alcohol.2016.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253308PMC
February 2017

The allostatic impact of chronic ethanol on gene expression: A genetic analysis of chronic intermittent ethanol treatment in the BXD cohort.

Alcohol 2017 Feb 1;58:93-106. Epub 2016 Nov 1.

Department of Pharmacology & Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S07418329153015
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http://dx.doi.org/10.1016/j.alcohol.2016.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253248PMC
February 2017

Initial genetic dissection of serum neuroactive steroids following chronic intermittent ethanol across BXD mouse strains.

Alcohol 2017 Feb 10;58:107-125. Epub 2016 Nov 10.

Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC, USA; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA; Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.alcohol.2016.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253318PMC
February 2017

Integrating mRNA and miRNA Weighted Gene Co-Expression Networks with eQTLs in the Nucleus Accumbens of Subjects with Alcohol Dependence.

PLoS One 2015 18;10(9):e0137671. Epub 2015 Sep 18.

Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, United States of America; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, United States of America; Center for Biomarker Research and Personalized Medicine, Virginia Commonwealth University, Richmond, VA, United States of America; Lieber Institute for Brain Development, Johns Hopkins University, Baltimore, MD, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0137671PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575063PMC
May 2016

Identifying gene networks underlying the neurobiology of ethanol and alcoholism.

Alcohol Res 2012 ;34(3):306-17

Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860407PMC
April 2016

Applying the new genomics to alcohol dependence.

Alcohol 2015 Dec 28;49(8):825-36. Epub 2015 Mar 28.

Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, 2500 Speedway, Austin, TX 78712, USA. Electronic address:

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http://dx.doi.org/10.1016/j.alcohol.2015.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586299PMC
December 2015

Translating Alcohol Research: Opportunities and Challenges.

Alcohol Res 2015 ;37(1):7-14

Departments of Pharmacology/Toxicology and Neurology; VCU Alcohol Research Center; Virginia Commonwealth University, Richmond, Virginia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476605PMC
September 2015

Effects of chronic HIV-1 Tat exposure in the CNS: heightened vulnerability of males versus females to changes in cell numbers, synaptic integrity, and behavior.

Brain Struct Funct 2015 Mar 19;220(2):605-23. Epub 2013 Dec 19.

Department of Anatomy and Neurobiology, Virginia Commonwealth University, Medical College of Virginia (MCV) Campus, PO Box 980709, Richmond, VA, 23298-0709, USA.

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http://dx.doi.org/10.1007/s00429-013-0676-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341022PMC
March 2015

Analysis of global changes in gene expression induced by human polynucleotide phosphorylase (hPNPase(old-35)).

J Cell Physiol 2014 Dec;229(12):1952-62

Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia.

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http://dx.doi.org/10.1002/jcp.24645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149605PMC
December 2014

Fyn-dependent gene networks in acute ethanol sensitivity.

PLoS One 2013 29;8(11):e82435. Epub 2013 Nov 29.

Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0082435PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843713PMC
August 2014

Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory.

Nat Neurosci 2014 Jul 25;17(7):971-80. Epub 2014 May 25.

1] Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA. [2] Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.

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http://dx.doi.org/10.1038/nn.3728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256678PMC
July 2014

Ethanol regulation of serum glucocorticoid kinase 1 expression in DBA2/J mouse prefrontal cortex.

PLoS One 2013 22;8(8):e72979. Epub 2013 Aug 22.

Virginia Commonwealth University Alcohol Research Center, Virginia Commonwealth University, Richmond, Virginia, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072979PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750005PMC
June 2014

Genetic studies in Drosophila and humans support a model for the concerted function of CISD2, PPT1 and CLN3 in disease.

Biol Open 2014 Apr 4;3(5):342-52. Epub 2014 Apr 4.

Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA Molecular Biology and Genetics Program, Virginia Commonwealth University, Richmond, VA 23298, USA

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http://dx.doi.org/10.1242/bio.20147559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021356PMC
April 2014

Role of adrenal glucocorticoid signaling in prefrontal cortex gene expression and acute behavioral responses to ethanol.

Alcohol Clin Exp Res 2013 Jan 4;37(1):57-66. Epub 2012 Jun 4.

VCU Alcohol Research Center, Virginia Commonwealth University, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1111/j.1530-0277.2012.01841.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507324PMC
January 2013

Systems genetic analysis of the effects of iron deficiency in mouse brain.

Neurogenetics 2012 May 29;13(2):147-57. Epub 2012 Mar 29.

Intercollege Graduate Degree Program in Neuroscience, The Pennsylvania State University, University Park, PA 16802, USA.

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http://dx.doi.org/10.1007/s10048-012-0321-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427775PMC
May 2012

Ethanol modulation of gene networks: implications for alcoholism.

Neurobiol Dis 2012 Jan 22;45(1):115-21. Epub 2011 Apr 22.

Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1016/j.nbd.2011.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158275PMC
January 2012

Genomic analysis of individual differences in ethanol drinking: evidence for non-genetic factors in C57BL/6 mice.

PLoS One 2011 16;6(6):e21100. Epub 2011 Jun 16.

Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0021100PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116881PMC
November 2011

The neuropeptide galanin and variants in the GalR1 gene are associated with nicotine dependence.

Neuropsychopharmacology 2011 Oct 27;36(11):2339-48. Epub 2011 Jul 27.

Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298-0613, USA

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http://dx.doi.org/10.1038/npp.2011.123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176570PMC
October 2011

Using expression genetics to study the neurobiology of ethanol and alcoholism.

Int Rev Neurobiol 2010 ;91:95-128

Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1016/S0074-7742(10)91004-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427772PMC
December 2010

Identifying gene regulatory networks in schizophrenia.

Neuroimage 2010 Nov 22;53(3):839-47. Epub 2010 Jun 22.

Department of Psychiatry & Human Behavior, 5251 California Avenue, Suite 240, University of California, Irvine, CA 92617, USA.

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http://dx.doi.org/10.1016/j.neuroimage.2010.06.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055795PMC
November 2010

A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice.

PLoS One 2010 Aug 17;5(8):e12181. Epub 2010 Aug 17.

Department of Anatomy and Neurobiology, Center for Integrative and Translational Genomics, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012181PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923157PMC
August 2010

Characterization of pharmacological and behavioral differences to nicotine in C57Bl/6 and DBA/2 mice.

Neuropharmacology 2009 Sep 18;57(4):347-55. Epub 2009 Jul 18.

Department of Pharmacology and Toxicology, Medical Campus, Virginia Commonwealth University, Richmond, VA 23298-0613, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2009.07.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753410PMC
September 2009

ERGR: An ethanol-related gene resource.

Nucleic Acids Res 2009 Jan 31;37(Database issue):D840-5. Epub 2008 Oct 31.

Department of Psychiatry and Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1093/nar/gkn816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686553PMC
January 2009

Microarray analysis of ethanol-induced changes in gene expression.

Methods Mol Biol 2008 ;447:395-410

Department of Pharmacology/Toxicology, Virginia Commonwealth University, Richmond, VA, USA.

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http://dx.doi.org/10.1007/978-1-59745-242-7_26DOI Listing
May 2008

Meta-analysis for microarray studies of the genetics of complex traits.

Trends Biotechnol 2007 Feb 18;25(2):45-7. Epub 2006 Dec 18.

Departments of Pharmacology/Toxicology and Neurology and the Center for Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1016/j.tibtech.2006.12.006DOI Listing
February 2007

Characterization of the ethanol-deprivation effect in substrains of C57BL/6 mice.

Alcohol 2006 Oct;40(2):119-26

Department of Pharmacology/Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1016/j.alcohol.2006.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082283PMC
October 2006

SScore: an R package for detecting differential gene expression without gene expression summaries.

Bioinformatics 2006 May 30;22(10):1272-4. Epub 2006 Mar 30.

Department of Biostatistics, Virginia Commonwealth University Box 980032, Richmond, VA 23298-0032, USA.

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http://dx.doi.org/10.1093/bioinformatics/btl108DOI Listing
May 2006

Empirical validation of the S-Score algorithm in the analysis of gene expression data.

BMC Bioinformatics 2006 Mar 17;7:154. Epub 2006 Mar 17.

Department of Biostatistics, Virginia Commonwealth University, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1186/1471-2105-7-154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1550434PMC
March 2006

The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice.

Psychopharmacology (Berl) 2006 Jan 15;183(4):429-38. Epub 2005 Nov 15.

Department of Psychiatry, Bowles Center for Alcohol Studies School of Medicine, CB#7178, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7178, USA.

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http://dx.doi.org/10.1007/s00213-005-0217-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854492PMC
January 2006

Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice.

J Neurosci 2005 Mar;25(9):2255-66

Department of Pharmacology/Toxicology and the Center for Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia 23298, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.4372-04.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726093PMC
March 2005

Alcohol effects on central nervous system gene expression in genetic animal models.

Alcohol Clin Exp Res 2005 Feb;29(2):167-75

Indiana University School of Medicine, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1097/01.alc.0000153539.40955.42DOI Listing
February 2005

Epistatic and environmental control of genome-wide gene expression.

Twin Res Hum Genet 2005 Feb;8(1):5-15

Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298-0003, USA.

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http://dx.doi.org/10.1375/1832427053435418DOI Listing
February 2005

Modulation of gene expression by tumor-derived p53 mutants.

Cancer Res 2004 Oct;64(20):7447-54

Department of Biochemistry, Massey Cancer Center, and Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-1568DOI Listing
October 2004

Candidate genes for nicotine dependence via linkage, epistasis, and bioinformatics.

Am J Med Genet B Neuropsychiatr Genet 2004 Apr;126B(1):23-36

Virginia Institute for Psychiatric & Behavioral Genetics, Virginia Commonwealth University, VA, USA.

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http://dx.doi.org/10.1002/ajmg.b.20138DOI Listing
April 2004

Application of the S-score algorithm for analysis of oligonucleotide microarrays.

Methods 2003 Dec;31(4):274-81

Departments of Pharmacology/Toxicology and Neurology, Virginia Commonwealth University, P.O. Box 980599, 1217 E. Marshall St., Rm. 630, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1016/s1046-2023(03)00156-7DOI Listing
December 2003

Pharmacogenomic analysis of mechanisms mediating ethanol regulation of dopamine beta-hydroxylase.

J Biol Chem 2003 Oct 3;278(40):38860-9. Epub 2003 Jul 3.

Departments of Pharmacology Toxicology and Neurology and the Center for Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia 23298, USA.

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http://dx.doi.org/10.1074/jbc.M305040200DOI Listing
October 2003

A model of molecular interactions on short oligonucleotide microarrays.

Nat Biotechnol 2003 Jul 8;21(7):818-21. Epub 2003 Jun 8.

Department of Biostatistics, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd. 447, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/nbt836DOI Listing
July 2003

Overlapping microarray profiles of dentate gyrus gene expression during development- and epilepsy-associated neurogenesis and axon outgrowth.

J Neurosci 2003 Mar;23(6):2218-27

Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742005PMC
March 2003

A new algorithm for analysis of oligonucleotide arrays: application to expression profiling in mouse brain regions.

J Mol Biol 2002 Mar;317(2):225-35

The Ernest Gallo Clinic and Research Center and Department of Neurology, University of California at San Francisco, 5858 Horton Street Suite 200 Emeryville, CA 94608, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S002228360195350
Publisher Site
http://dx.doi.org/10.1006/jmbi.2001.5350DOI Listing
March 2002

Alcohol's Effects on Gene Expression.

Authors:
Michael F Miles

Alcohol Health Res World 1995 ;19(3):237-245

Michael F. Miles, M.D., Ph.D., is an associate professor of neurology at the Ernest Gallo Clinic and Research Center, University of California, San Francisco, School of Medicine, San Francisco, California.

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January 1995