Publications by authors named "Michael E Jung"

136Publications

Selective Aster inhibitors distinguish vesicular and nonvesicular sterol transport mechanisms.

Proc Natl Acad Sci U S A 2021 Jan;118(2)

Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095;

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January 2021

Development of a Potent Brain-Penetrant EGFR Tyrosine Kinase Inhibitor against Malignant Brain Tumors.

ACS Med Chem Lett 2020 Oct 1;11(10):1799-1809. Epub 2020 May 1.

Departments of Molecular and Medical Pharmacology, Chemistry and Biochemistry, Jane and Terry Semel Institute for Neuroscience and Human Behavior and Department of Psychiatry and Biobehavioral Sciences, Neurology, and Crump Institute for Molecular Imaging, University of California, Los Angeles, California 90095, United States.

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October 2020

Development and preclinical pharmacology of a novel dCK inhibitor, DI-87.

Biochem Pharmacol 2020 02 6;172:113742. Epub 2019 Dec 6.

Division of Hematology-Oncology, University of California San Diego, La Jolla, CA, United States. Electronic address:

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February 2020

Metabolic Modifier Screen Reveals Secondary Targets of Protein Kinase Inhibitors within Nucleotide Metabolism.

Cell Chem Biol 2020 02 13;27(2):197-205.e6. Epub 2019 Nov 13.

Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, USA; Ahmanson Translational Imaging Division, University of California Los Angeles, Los Angeles, CA, USA. Electronic address:

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February 2020

Antiestrogens in combination with immune checkpoint inhibitors in breast cancer immunotherapy.

J Steroid Biochem Mol Biol 2019 10 19;193:105415. Epub 2019 Jun 19.

UCLA David Geffen School of Medicine, Department of Medicine, Division of Hematology-Oncology, Los Angeles CA 90095, USA; UCLA Jonsson Comprehensive Cancer Center, Los Angeles CA 90095, USA. Electronic address:

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October 2019

Synthesis of β-Amino Diaryldienones Using the Mannich Reaction.

Org Lett 2019 06 13;21(11):4039-4043. Epub 2019 May 13.

Department of Chemistry and Biochemistry , University of California , Los Angeles , California 90095 , United States.

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June 2019

Molecules targeting the androgen receptor (AR) signaling axis beyond the AR-Ligand binding domain.

Med Res Rev 2019 05 22;39(3):910-960. Epub 2018 Nov 22.

Department of Chemistry and Biochemistry, UCLA, Los Angeles, California.

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May 2019

A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model.

Sci Rep 2018 12 4;8(1):17574. Epub 2018 Dec 4.

The Drug Discovery Lab, Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA.

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December 2018

Broad-spectrum antiviral JL122 blocks infection and inhibits transmission of aquatic rhabdoviruses.

Virology 2018 12 1;525:143-149. Epub 2018 Oct 1.

Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. Electronic address:

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December 2018

Synthesis and Structure-Activity Relationship (SAR) Studies of Novel Pyrazolopyridine Derivatives as Inhibitors of Enterovirus Replication.

J Med Chem 2018 02 31;61(4):1688-1703. Epub 2018 Jan 31.

Department of Chemistry and Biochemistry, ‡Department of Pediatrics, and §Department of Molecular and Medical Pharmacology, University of California , Los Angeles, California 90095, United States.

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February 2018

Structure-activity relationship study of small molecule inhibitors of the DEPTOR-mTOR interaction.

Bioorg Med Chem Lett 2017 10 6;27(20):4714-4724. Epub 2017 Sep 6.

Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA; Jonnson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Research and Development, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, CA 91343, USA. Electronic address:

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October 2017