Michael E Hughes

Michael E Hughes

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Michael E Hughes

Michael E Hughes

Publications by authors named "Michael E Hughes"

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Circadian Rhythms Influence the Severity of Sepsis in Mice via a TLR2-Dependent, Leukocyte-Intrinsic Mechanism.

J Immunol 2018 Jul 14;201(1):193-201. Epub 2018 May 14.

Center of Emphasis in Infectious Diseases, Department of Biomedical Sciences, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX 79905;

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http://dx.doi.org/10.4049/jimmunol.1701677DOI Listing
July 2018

Daily oscillations in expression and responsiveness of Toll-like receptors in splenic immune cells.

Heliyon 2018 Mar 20;4(3):e00579. Epub 2018 Mar 20.

Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1016/j.heliyon.2018.e00579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968137PMC
March 2018

ExpressionDB: An open source platform for distributing genome-scale datasets.

PLoS One 2017 2;12(11):e0187457. Epub 2017 Nov 2.

Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187457PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667849PMC
December 2017

Guidelines for Genome-Scale Analysis of Biological Rhythms.

J Biol Rhythms 2017 Oct 3;32(5):380-393. Epub 2017 Nov 3.

27 Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1177/0748730417728663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692188PMC
October 2017

Achilles is a circadian clock-controlled gene that regulates immune function in Drosophila.

Brain Behav Immun 2017 Mar 14;61:127-136. Epub 2016 Nov 14.

Department of Biology, University of Missouri - St. Louis, St. Louis, MO 63121, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbi.2016.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316375PMC
March 2017

MetaCycle: an integrated R package to evaluate periodicity in large scale data.

Bioinformatics 2016 11 4;32(21):3351-3353. Epub 2016 Jul 4.

Department of Systems Pharmacology and Translational Therapeutics, Institute for Translational Medicine and Therapeutics.

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http://dx.doi.org/10.1093/bioinformatics/btw405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079475PMC
November 2016

The daily rhythms of mitochondrial gene expression and oxidative stress regulation are altered by aging in the mouse liver.

Chronobiol Int 2015 29;32(9):1254-63. Epub 2015 Oct 29.

a State Key Laboratory of Virology, College of Life Sciences, Wuhan University , Wuhan, Hubei Province , P.R. China and.

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http://dx.doi.org/10.3109/07420528.2015.1085388DOI Listing
September 2016

Considerations for RNA-seq analysis of circadian rhythms.

Methods Enzymol 2015 26;551:349-67. Epub 2014 Dec 26.

Department of Biology, University of Missouri-St. Louis, St. Louis, Missouri, USA. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2014.10.020DOI Listing
October 2015

A circadian gene expression atlas in mammals: implications for biology and medicine.

Proc Natl Acad Sci U S A 2014 Nov 27;111(45):16219-24. Epub 2014 Oct 27.

Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; and

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http://dx.doi.org/10.1073/pnas.1408886111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234565PMC
November 2014

Calcitonin gene-related peptide neurons mediate sleep-specific circadian output in Drosophila.

Curr Biol 2014 Nov 30;24(22):2652-64. Epub 2014 Oct 30.

Department of Cellular and Molecular Physiology, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA; Department of Genetics, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA; Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2014.09.077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255360PMC
November 2014

The growth and impact of Alzheimer disease centers as measured by social network analysis.

JAMA Neurol 2014 Apr;71(4):412-20

Center for Neurodegenerative Disease Research, Philadelphia, Pennsylvania5Department of Pathology and Laboratory Medicine, Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia.

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http://dx.doi.org/10.1001/jamaneurol.2013.6225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096555PMC
April 2014

Machine learning helps identify CHRONO as a circadian clock component.

PLoS Biol 2014 Apr 15;12(4):e1001840. Epub 2014 Apr 15.

Center for Sleep and Circadian Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America; Department of Pharmacology and the Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.1001840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988006PMC
April 2014

O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination.

Cell Metab 2013 Feb;17(2):303-10

Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1016/j.cmet.2012.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647362PMC
February 2013

Brain-specific rescue of Clock reveals system-driven transcriptional rhythms in peripheral tissue.

PLoS Genet 2012 26;8(7):e1002835. Epub 2012 Jul 26.

Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1371/journal.pgen.1002835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405989PMC
January 2013

Deep sequencing the circadian and diurnal transcriptome of Drosophila brain.

Genome Res 2012 Jul 3;22(7):1266-81. Epub 2012 Apr 3.

Department of Cellular and Molecular Physiology, and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale School of Medicine, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1101/gr.128876.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396368PMC
July 2012

Circadian expression of clock genes in mouse macrophages, dendritic cells, and B cells.

Brain Behav Immun 2012 Mar 13;26(3):407-13. Epub 2011 Oct 13.

Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520-8022, USA.

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http://dx.doi.org/10.1016/j.bbi.2011.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336152PMC
March 2012

The circadian clock interacts with metabolic physiology to influence reproductive fitness.

Cell Metab 2011 Jun;13(6):639-54

Department of Neuroscience, Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.cmet.2011.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152999PMC
June 2011

The network as the target.

Wiley Interdiscip Rev Syst Biol Med 2010 Mar-Apr;2(2):127-133

Institution for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/wsbm.57DOI Listing
February 2011

JTK_CYCLE: an efficient nonparametric algorithm for detecting rhythmic components in genome-scale data sets.

J Biol Rhythms 2010 Oct;25(5):372-80

Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1177/0748730410379711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119870PMC
October 2010

Network dynamics to evaluate performance of an academic institution.

Sci Transl Med 2010 Oct;2(53):53ps49

Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1126/scitranslmed.3001580DOI Listing
October 2010

Harmonics of circadian gene transcription in mammals.

PLoS Genet 2009 Apr 3;5(4):e1000442. Epub 2009 Apr 3.

Department of Pharmacology, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1000442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654964PMC
April 2009

Immune reconstitution and predictors of virologic failure in adolescents infected through risk behaviors and initiating HAART: week 60 results from the PACTG 381 cohort.

AIDS Res Hum Retroviruses 2006 Mar;22(3):213-21

Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1089/aid.2006.22.213DOI Listing
March 2006