Michael Downes

Michael Downes

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Low-dose ketamine provides poor analgesia for pain in redback spider envenoming.

Br J Clin Pharmacol 2019 Oct 6;85(10):2423-2427. Epub 2019 Aug 6.

Clinical Toxicology Research Group, University of Newcastle, Newcastle, New South Wales, Australia.

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http://dx.doi.org/10.1111/bcp.14052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783601PMC
October 2019

Use of a tablet-based application for clinical handover and data collection.

Clin Toxicol (Phila) 2019 Oct 11:1-6. Epub 2019 Oct 11.

Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Waratah, Australia.

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http://dx.doi.org/10.1080/15563650.2019.1674322DOI Listing
October 2019

The nuclear receptor REV-ERBα modulates Th17 cell-mediated autoimmune disease.

Proc Natl Acad Sci U S A 2019 09 27;116(37):18528-18536. Epub 2019 Aug 27.

NOMIS Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, La Jolla, CA 92037;

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http://dx.doi.org/10.1073/pnas.1907563116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744854PMC
September 2019

Retrospective evaluation of repeated supratherapeutic ingestion (RSTI) of paracetamol .

Clin Toxicol (Phila) 2019 Aug 21;57(8):703-711. Epub 2019 Feb 21.

c Department of Clinical Toxicology , Prince of Wales Hospital , Randwick , NSW , Australia.

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http://dx.doi.org/10.1080/15563650.2018.1547829DOI Listing
August 2019

Difficult to sedate case of acute behavioural disturbance secondary to baclofen withdrawal.

Emerg Med Australas 2019 06 8;31(3):493-494. Epub 2019 Apr 8.

Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, New South Wales, Australia.

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http://dx.doi.org/10.1111/1742-6723.13289DOI Listing
June 2019

β-Catenin is essential for differentiation of primary myoblasts via cooperation with MyoD and α-catenin.

Development 2019 03 19;146(6). Epub 2019 Mar 19.

Department of Clinical Pharmacology, Flinders University, Bedford Park, SA 5042, Australia

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http://dx.doi.org/10.1242/dev.167080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451316PMC
March 2019

FXR Regulates Intestinal Cancer Stem Cell Proliferation.

Cell 2019 02;176(5):1098-1112.e18

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.01.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701863PMC
February 2019

E47 modulates hepatic glucocorticoid action.

Nat Commun 2019 01 18;10(1):306. Epub 2019 Jan 18.

Molecular Endocrinology, Helmholtz Diabetes Center (HMGU) and German Center for Diabetes Research (DZD), IDO, Ingolstädter Landstr. 1, 85764, Neuherberg, Munich, Germany.

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http://www.nature.com/articles/s41467-018-08196-5
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http://dx.doi.org/10.1038/s41467-018-08196-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338785PMC
January 2019

Author Correction: Inflammation-induced IgA cells dismantle anti-liver cancer immunity.

Nature 2018 09;561(7721):E1

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, California, 92093, USA.

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http://dx.doi.org/10.1038/s41586-018-0304-yDOI Listing
September 2018

Vitamin D Switches BAF Complexes to Protect β Cells.

Cell 2018 05 10;173(5):1135-1149.e15. Epub 2018 May 10.

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987229PMC
May 2018

ERRγ Promotes Angiogenesis, Mitochondrial Biogenesis, and Oxidative Remodeling in PGC1α/β-Deficient Muscle.

Cell Rep 2018 03;22(10):2521-2529

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA; Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.02.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860878PMC
March 2018

ERRγ Preserves Brown Fat Innate Thermogenic Activity.

Cell Rep 2018 03;22(11):2849-2859

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.02.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884669PMC
March 2018

Targeting Transcriptional and Epigenetic Reprogramming in Stromal Cells in Fibrosis and Cancer.

Cold Spring Harb Symp Quant Biol 2015 22;80:249-55. Epub 2016 Jan 22.

Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037 Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, California 92037.

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http://dx.doi.org/10.1101/sqb.2015.80.027185DOI Listing
January 2018

Metabolic control of regulatory T cell (Treg) survival and function by Lkb1.

Proc Natl Acad Sci U S A 2017 11 6;114(47):12542-12547. Epub 2017 Nov 6.

Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037;

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http://dx.doi.org/10.1073/pnas.1715363114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703326PMC
November 2017

Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity.

Nature 2017 11 8;551(7680):340-345. Epub 2017 Nov 8.

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego (UCSD), 9500 Gilman Drive, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1038/nature24302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884449PMC
November 2017

FGF1 - a new weapon to control type 2 diabetes mellitus.

Nat Rev Endocrinol 2017 Oct 30;13(10):599-609. Epub 2017 Jun 30.

Gene Expression Laboratory, Salk Institute for Biological Studies.

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http://dx.doi.org/10.1038/nrendo.2017.78DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839646PMC
October 2017

NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection.

Nat Commun 2017 10 16;8(1):959. Epub 2017 Oct 16.

CAS Key Laboratory of Molecular Virology & Immunology, Unit of Immune Regulation, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai, 200031, China.

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http://dx.doi.org/10.1038/s41467-017-00931-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643384PMC
October 2017

Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes.

Cell Metab 2017 Jul;26(1):157-170.e7

Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Departments of Medicine and Pharmacology, University of California, San Diego School of Medicine, La Jolla, CA 92093, USA; Institute of Diabetes and Metabolic Health, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0757, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663294PMC
July 2017

Impact of an emergency short stay unit on emergency department performance of poisoned patients.

Am J Emerg Med 2017 May 26;35(5):764-768. Epub 2017 Jan 26.

Department of Clinical Toxicology, Calvary Mater Newcastle, Newcastle, NSW, Australia; Clinical Toxicology Research Group, University of Newcastle, Newcastle, NSW, Australia.

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http://dx.doi.org/10.1016/j.ajem.2017.01.027DOI Listing
May 2017

Farnesoid X Receptor an Emerging Target to Combat Obesity.

Dig Dis 2017 1;35(3):185-190. Epub 2017 Mar 1.

Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, Calif., USA.

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http://dx.doi.org/10.1159/000450909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417073PMC
May 2017

PPARδ Promotes Running Endurance by Preserving Glucose.

Cell Metab 2017 May;25(5):1186-1193.e4

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492977PMC
May 2017

Re-engineering the Pancreas Tumor Microenvironment: A "Regenerative Program" Hacked.

Clin Cancer Res 2017 Apr;23(7):1647-1655

Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-3275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381729PMC
April 2017

Intestinal PPARδ protects against diet-induced obesity, insulin resistance and dyslipidemia.

Sci Rep 2017 04 12;7(1):846. Epub 2017 Apr 12.

Section of Molecular Metabolism and Nutrition, Department of Pediatrics, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.

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http://dx.doi.org/10.1038/s41598-017-00889-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429805PMC
April 2017

Structural basis for specific ligation of the peroxisome proliferator-activated receptor δ.

Proc Natl Acad Sci U S A 2017 03 20;114(13):E2563-E2570. Epub 2017 Mar 20.

Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA 92037;

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http://dx.doi.org/10.1073/pnas.1621513114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380080PMC
March 2017

Barx2 and Pax7 Regulate Axin2 Expression in Myoblasts by Interaction with β-Catenin and Chromatin Remodelling.

Stem Cells 2016 08 6;34(8):2169-82. Epub 2016 Jun 6.

Department of Clinical Pharmacology, Flinders University, Bedford Park, South Australia, Australia.

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http://dx.doi.org/10.1002/stem.2396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019118PMC
August 2016

Bile Acid Analog Intercepts Liver Fibrosis.

Cell 2016 Aug;166(4):789

Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.08.001DOI Listing
August 2016

Nuclear receptors and AMPK: can exercise mimetics cure diabetes?

J Mol Endocrinol 2016 07 22;57(1):R49-58. Epub 2016 Apr 22.

Gene Expression LaboratorySalk Institute, La Jolla, California, USA Howard Hughes Medical InstituteSalk Institute, La Jolla, California, USA

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http://dx.doi.org/10.1530/JME-16-0073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929025PMC
July 2016

A prospective observational study of a novel 2-phase infusion protocol for the administration of acetylcysteine in paracetamol poisoning.

Clin Toxicol (Phila) 2016 22;54(2):120-6. Epub 2015 Dec 22.

a Clinical Toxicology Research Group, University of Newcastle , Newcastle , Australia ;

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http://dx.doi.org/10.3109/15563650.2015.1115057DOI Listing
June 2016

Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation.

Cell 2016 Jun 26;165(7):1644-1657. Epub 2016 May 26.

Gene Expression Laboratory, Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912445PMC
June 2016

Ketamine as Rescue Treatment for Difficult-to-Sedate Severe Acute Behavioral Disturbance in the Emergency Department.

Ann Emerg Med 2016 05 18;67(5):581-587.e1. Epub 2016 Feb 18.

Clinical Toxicology Research Group, University of Newcastle, Newcastle, New South Wales, Australia; Emergency Department, Calvary Mater Newcastle, Newcastle, New South Wales, Australia; Emergency Department, Princess Alexandra Hospital, and School of Medicine, University of Queensland, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1016/j.annemergmed.2015.11.028DOI Listing
May 2016

ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells.

Cell Metab 2016 Apr;23(4):622-34

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832237PMC
April 2016

Sodium azide ingestion and secondary contamination risk in healthcare workers.

Eur J Emerg Med 2016 Feb;23(1):68-70

Departments of aEmergency Medicine bClinical Toxicology and Pharmacology, Calvary Mater Newcastle, Waratah cDiscipline of Clinical Pharmacology, University of Newcastle, Callaghan, New South Wales, Australia.

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http://dx.doi.org/10.1097/MEJ.0000000000000244DOI Listing
February 2016

Fibroblast Growth Factor Signaling in Metabolic Regulation.

Front Endocrinol (Lausanne) 2015 19;6:193. Epub 2016 Jan 19.

Gene Expression Laboratory, Salk Institute for Biological Studies , La Jolla, CA , USA.

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http://dx.doi.org/10.3389/fendo.2015.00193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718082PMC
February 2016

Effective treatment of steatosis and steatohepatitis by fibroblast growth factor 1 in mouse models of nonalcoholic fatty liver disease.

Proc Natl Acad Sci U S A 2016 Feb 8;113(8):2288-93. Epub 2016 Feb 8.

Center for Liver, Digestive and Metabolic Diseases, Department of Pediatrics, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1525093113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776526PMC
February 2016

In reply.

Ann Emerg Med 2016 Jan;67(1):146-7

Clinical Toxicology Research Group, University of Newcastle, Newcastle, Australia; Emergency Department, Princess Alexandra Hospital, School of Medicine, Brisbane, Queensland, Australia; University of Queensland, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1016/j.annemergmed.2015.09.029DOI Listing
January 2016

Clinical features of serum sickness after Australian snake antivenom.

Toxicon 2015 Dec 23;108:181-3. Epub 2015 Oct 23.

Clinical Toxicology Research Group, The University of Newcastle, Newcastle, NSW, Australia; Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, NSW, Australia.

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http://dx.doi.org/10.1016/j.toxicon.2015.10.012DOI Listing
December 2015

Depletion of fat-resident Treg cells prevents age-associated insulin resistance.

Nature 2015 Dec 18;528(7580):137-41. Epub 2015 Nov 18.

Immunobiology and Microbial Pathogenesis Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/nature16151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670283PMC
December 2015

BRD4 is a novel therapeutic target for liver fibrosis.

Proc Natl Acad Sci U S A 2015 Dec 7;112(51):15713-8. Epub 2015 Dec 7.

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037; Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037

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http://dx.doi.org/10.1073/pnas.1522163112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697417PMC
December 2015

Calcipotriol Targets LRP6 to Inhibit Wnt Signaling in Pancreatic Cancer.

Mol Cancer Res 2015 Nov 29;13(11):1509-19. Epub 2015 Jul 29.

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California. Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644680PMC
November 2015

Acute behavioural disturbance associated with phenibut purchased via an internet supplier.

Clin Toxicol (Phila) 2015 26;53(7):636-8. Epub 2015 Jun 26.

Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle , Waratah, New South Wales , Australia.

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http://www.tandfonline.com/doi/full/10.3109/15563650.2015.10
Publisher Site
http://dx.doi.org/10.3109/15563650.2015.1059945DOI Listing
October 2015

Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling.

Science 2015 Oct;350(6260):558-63

Nomis Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1126/science.aac6468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732872PMC
October 2015

The Safety and Effectiveness of Droperidol for Sedation of Acute Behavioral Disturbance in the Emergency Department.

Ann Emerg Med 2015 Sep 15;66(3):230-238.e1. Epub 2015 Apr 15.

School of Medicine and Public Health, University of Newcastle, New South Wales, Australia; Emergency Department, Calvary Mater Newcastle, Newcastle, New South Wales, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.annemergmed.2015.03.016DOI Listing
September 2015

Vitamin D, muscle and bone: Integrating effects in development, aging and injury.

Mol Cell Endocrinol 2015 Jul 30;410:3-10. Epub 2015 Mar 30.

Salk Institute of Biological Studies, La Jolla, CA, USA.

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http://dx.doi.org/10.1016/j.mce.2015.03.020DOI Listing
July 2015

High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice.

Proc Natl Acad Sci U S A 2015 Jul 29;112(28):8714-9. Epub 2015 Jun 29.

Gene Expression Laboratory, Salk Institute, La Jolla, CA 92037; Howard Hughes Medical Institute, Salk Institute, La Jolla, CA 92037

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http://dx.doi.org/10.1073/pnas.1509930112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507233PMC
July 2015

2-Methyl-4-chlorophenoxyacetic acid and bromoxynil herbicide death.

Clin Toxicol (Phila) 2015 Jun 7;53(5):486-8. Epub 2015 Apr 7.

School of Medicine and Public Health, University of Newcastle , Newcastle, NSW , Australia.

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http://dx.doi.org/10.3109/15563650.2015.1030025DOI Listing
June 2015

ERRs Mediate a Metabolic Switch Required for Somatic Cell Reprogramming to Pluripotency.

Cell Stem Cell 2015 May 9;16(5):547-55. Epub 2015 Apr 9.

Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; Howard Hughes Medical Institute, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427539PMC
May 2015

Dependence of hippocampal function on ERRγ-regulated mitochondrial metabolism.

Cell Metab 2015 Apr;21(4):628-36

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393848PMC
April 2015

Inflammation-sensitive super enhancers form domains of coordinately regulated enhancer RNAs.

Proc Natl Acad Sci U S A 2015 Jan 6;112(3):E297-302. Epub 2015 Jan 6.

Gene Expression Laboratory, Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA 92037

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http://dx.doi.org/10.1073/pnas.1424028112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311831PMC
January 2015

Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer.

Nature 2014 Sep 16;513(7518):436-9. Epub 2014 Jul 16.

1] Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA [2] Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/nature13540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184286PMC
September 2014

Methylome, transcriptome, and PPAR(γ) cistrome analyses reveal two epigenetic transitions in fat cells.

Epigenetics 2014 Sep 10;9(9):1195-206. Epub 2014 Jul 10.

Research Center for Stem Cell Engineering; National Institute of Advanced Industrial Science and Technology (AIST); Tsukuba, Japan.

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http://dx.doi.org/10.4161/epi.29856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169011PMC
September 2014

Intralipid therapy does not improve level of consciousness in overdoses with sedating drugs: a case series.

Emerg Med Australas 2014 Jun 8;26(3):286-90. Epub 2014 May 8.

Department of Emergency Medicine, Calvary Mater Newcastle, Newcastle, New South Wales, Australia; Faculty of Public Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia; Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, New South Wales, Australia.

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http://dx.doi.org/10.1111/1742-6723.12237DOI Listing
June 2014

Nuclear receptors and metabolism: from feast to famine.

Diabetologia 2014 May 12;57(5):860-7. Epub 2014 Mar 12.

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.

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http://link.springer.com/10.1007/s00125-014-3209-9
Publisher Site
http://dx.doi.org/10.1007/s00125-014-3209-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980036PMC
May 2014

Nuclear receptors rock around the clock.

EMBO Rep 2014 May 15;15(5):518-28. Epub 2014 Apr 15.

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.

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http://dx.doi.org/10.1002/embr.201338271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210094PMC
May 2014

Road to exercise mimetics: targeting nuclear receptors in skeletal muscle.

J Mol Endocrinol 2013 Dec 26;51(3):T87-T100. Epub 2013 Nov 26.

Gene Expression Laboratory Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1530/JME-13-0258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936671PMC
December 2013

Hepatic actions of vitamin D receptor ligands: a sunshine option for chronic liver disease?

Expert Rev Clin Pharmacol 2013 Nov;6(6):597-9

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California, USA.

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http://dx.doi.org/10.1586/17512433.2013.841078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160153PMC
November 2013

PPARγ signaling and metabolism: the good, the bad and the future.

Nat Med 2013 May 7;19(5):557-66. Epub 2013 May 7.

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California, USA.

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http://dx.doi.org/10.1038/nm.3159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870016PMC
May 2013

Evidence for orphan nuclear receptor TR4 in the etiology of Cushing disease.

Proc Natl Acad Sci U S A 2013 May 7;110(21):8555-60. Epub 2013 May 7.

Department of Medicine and Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1073/pnas.1306182110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666748PMC
May 2013

The nuclear receptor TLX is required for gliomagenesis within the adult neurogenic niche.

Mol Cell Biol 2012 Dec 1;32(23):4811-20. Epub 2012 Oct 1.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1128/MCB.01122-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497606PMC
December 2012

Targeting the pregnane X receptor in liver injury.

Expert Opin Ther Targets 2012 Nov 23;16(11):1075-83. Epub 2012 Aug 23.

The Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1517/14728222.2012.715634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319648PMC
November 2012

FXR and PXR: potential therapeutic targets in cholestasis.

J Steroid Biochem Mol Biol 2012 Jul 20;130(3-5):147-58. Epub 2011 Jul 20.

Center for Liver, Digestive and Metabolic Diseases, Department of Pediatrics, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.jsbmb.2011.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750880PMC
July 2012

Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist.

Proc Natl Acad Sci U S A 2012 May 25;109(21):E1369-76. Epub 2012 Apr 25.

Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1073/pnas.1202464109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361396PMC
May 2012

Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/β-catenin signaling.

Cancer Prev Res (Phila) 2012 Apr 9;5(4):553-61. Epub 2012 Mar 9.

Storr Liver Unit, Westmead Millennium Institute and Sydney Medical School, University of Sydney, Westmead, New South Wales, Australia.

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http://dx.doi.org/10.1158/1940-6207.CAPR-12-0053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324648PMC
April 2012

Nuclear receptors as modulators of the tumor microenvironment.

Cancer Prev Res (Phila) 2012 Jan 1;5(1):3-10. Epub 2011 Dec 1.

Gene Expression Laboratory, Howard Hughes Medical Institute, 10010 N Torrey Pines Road, La Jolla, CA, USA

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http://dx.doi.org/10.1158/1940-6207.CAPR-11-0528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408218PMC
January 2012

Cryptochromes mediate rhythmic repression of the glucocorticoid receptor.

Nature 2011 Dec 14;480(7378):552-6. Epub 2011 Dec 14.

Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/nature10700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245818PMC
December 2011