Dr. Michael Dourson, PhD, DABT, FATS, FSRA - Toxicology Excellence for Risk Assessment - Director of Science

Dr. Michael Dourson

PhD, DABT, FATS, FSRA

Toxicology Excellence for Risk Assessment

Director of Science

Cincinnati, Ohio | United States

Main Specialties: Public Health

Additional Specialties: toxicology

ORCID logohttps://orcid.org/0000-0002-0735-9089


Top Author

Dr. Michael Dourson, PhD, DABT, FATS, FSRA - Toxicology Excellence for Risk Assessment - Director of Science

Dr. Michael Dourson

PhD, DABT, FATS, FSRA

Introduction

Michael Dourson is a board-certified toxicologist serving as the Director of Science at the 501c3 environmental science NGO, Toxicology Excellence for Risk Assessment (TERA). Prior to this, he was Senior Advisor in the Office of the Administrator at the US EPA. Before this, he was a Professor in the Risk Science Center at the University of Cincinnati, College of Medicine and also worked at TERA and US EPA. He was awarded the Arnold J. Lehman award from the Society of Toxicology, the International Achievement Award by the International Society of Regulatory Toxicology and Pharmacology, and 4 bronze medals from the U.S. Environmental Protection Agency. He has been elected as a Fellow of the Academy of Toxicological Sciences and as a Fellow for the Society for Risk Analysis. He has co-published more than 150 papers on risk assessment methods or chemical-specific analyses, and co-authored well over 100 government risk assessment documents, many of them risk assessment guidance texts. He has made over 150 invited presentations to a variety of organizations, and has chaired over 150 sessions at scientific meetings and independent peer reviews. He has been elected to multiple officer positions in the American Board of Toxicology (including its President), the Society of Toxicology (including the presidency of 3 specialty sections), the Society for Risk Analysis (including its Secretary), and is currently the President of the Toxicology Education Foundation, a nonprofit organization with a vision to help our public understand the essentials of toxicology. In addition to numerous appointments on government panels, such as EPA’s Science Advisory Board, he is a current member on the editorial board of Regulatory Toxicology and Pharmacology and Human and Experimental Toxicology. His passion is building collaborations among diverse organizations to reduce excess environmental exposures and to resolve controversial issues, so that public health is protected.

Primary Affiliation: Toxicology Excellence for Risk Assessment - Cincinnati, Ohio , United States

Specialties:

Additional Specialties:

Research Interests:


View Dr. Michael Dourson’s Resume / CV

Experience

Sep 2019

see attached resume

Publications

46Publications

1377Reads

6Profile Views

159PubMed Central Citations

Data derived Extrapolation Factors for developmental toxicity: A preliminary research case study with perfluorooctanoate (PFOA).

Regul Toxicol Pharmacol 2019 Nov 16;108:104446. Epub 2019 Aug 16.

RG York and Associates, LLC, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1016/j.yrtph.2019.104446DOI Listing
November 2019
125 Reads
2.031 Impact Factor

Let the IRIS Bloom:Regrowing the integrated risk information system (IRIS) of the U.S. Environmental Protection Agency.

Regul Toxicol Pharmacol 2018 Aug 3;97:A4-A5. Epub 2018 May 3.

Toxicology Excellence for Risk Assessment (TERA), Cincinnati, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yrtph.2018.05.003DOI Listing
August 2018
161 Reads
2.031 Impact Factor

Derivation of a no-significant-risk-level for tetrabromobisphenol A based on a threshold non-mutagenic cancer mode of action.

J Appl Toxicol 2018 06 13;38(6):862-878. Epub 2018 Feb 13.

Risk Science Center, Department of Environmental Health, College of Medicine, University of Cincinnati, 160 Panzeca Way, Cincinnati, OH, 45213, USA.

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http://dx.doi.org/10.1002/jat.3594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099322PMC
June 2018
10 Reads
1 Citation
2.982 Impact Factor

Benchmark dose (BMD) modeling: current practice, issues, and challenges.

Crit Rev Toxicol 2018 05 8;48(5):387-415. Epub 2018 Mar 8.

d Imperial College London , London , UK.

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http://dx.doi.org/10.1080/10408444.2018.1430121DOI Listing
May 2018
60 Reads
1 Citation
5.100 Impact Factor

Update: Mode of action (MOA) for liver tumors induced by oral exposure to 1,4-dioxane.

Regul Toxicol Pharmacol 2017 Aug 30;88:45-55. Epub 2017 Mar 30.

University of Cincinnati, College of Medicine, Cincinnati, OH, United States.

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http://dx.doi.org/10.1016/j.yrtph.2017.02.025DOI Listing
August 2017
15 Reads
2.031 Impact Factor

Quantitative weight of evidence to assess confidence in potential modes of action.

Regul Toxicol Pharmacol 2017 Jun 20;86:205-220. Epub 2017 Feb 20.

Exponent, Washington, DC, United States.

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http://dx.doi.org/10.1016/j.yrtph.2017.02.017DOI Listing
June 2017
15 Reads
1 Citation
2.031 Impact Factor

A case study of potential human health impacts from petroleum coke transfer facilities.

J Air Waste Manag Assoc 2016 11;66(11):1061-1076

a Toxicology Excellence Risk Assessment Center, University of Cincinnati , Cincinnati , OH , USA.

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http://dx.doi.org/10.1080/10962247.2016.1180328DOI Listing
November 2016
129 Reads
1.342 Impact Factor

Approaches for describing and communicating overall uncertainty in toxicity characterizations: U.S. Environmental Protection Agency's Integrated Risk Information System (IRIS) as a case study.

Environ Int 2016 Apr-May;89-90:110-28. Epub 2016 Jan 28.

Toxicology Excellence for Risk Assessment (TERA) Center, Department of Environmental Health College of Medicine, University of Cincinnati, 160 Panzeca Way, Kettering Laboratory, Room G24, Cincinnati, OH 45267, United States. Electronic address:

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http://dx.doi.org/10.1016/j.envint.2015.12.031DOI Listing
November 2016
43 Reads
5.560 Impact Factor

Managing risks of noncancer health effects at hazardous waste sites: A case study using the Reference Concentration (RfC) of trichloroethylene (TCE).

Regul Toxicol Pharmacol 2016 Oct 22;80:125-33. Epub 2016 Jun 22.

CH2M, Spokane, WA, USA.

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http://dx.doi.org/10.1016/j.yrtph.2016.06.013DOI Listing
October 2016
18 Reads
2.031 Impact Factor

Bayesian methods for uncertainty factor application for derivation of reference values.

Regul Toxicol Pharmacol 2016 Oct 19;80:9-24. Epub 2016 May 19.

Regulatory Science Policy, Regulatory and Technical Affairs, American Chemistry Council, 700 2nd Street NE, Washington, DC 20002, United States.

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http://dx.doi.org/10.1016/j.yrtph.2016.05.018DOI Listing
October 2016
33 Reads
2 Citations
2.031 Impact Factor

Advances in assessing ingredient safety.

Regul Toxicol Pharmacol 2016 Aug 15;79 Suppl 2:S112-8. Epub 2016 Jul 15.

R G York & Associates LLC, Cincinnati, OH, USA.

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http://dx.doi.org/10.1016/j.yrtph.2016.07.008DOI Listing
August 2016
13 Reads
2.031 Impact Factor

Whither Risk Assessment: New Challenges and Opportunities a Third of a Century After the Red Book.

Risk Anal 2015 Nov 23;35(11):1959-68. Epub 2015 Nov 23.

NorthWorks, San Francisco, CA, USA.

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http://dx.doi.org/10.1111/risa.12535DOI Listing
November 2015
8 Reads
1 Citation
2.502 Impact Factor

A reproductive, developmental and neurobehavioral study following oral exposure of tetrabromobisphenol A on Sprague-Dawley rats.

Toxicology 2015 Mar 15;329:49-59. Epub 2014 Dec 15.

Toxicology Excellence in Risk Assessment, Cincinnati, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2014.12.013DOI Listing
March 2015
21 Reads
9 Citations
3.621 Impact Factor

Mode of action analysis for liver tumors from oral 1,4-dioxane exposures and evidence-based dose response assessment.

Regul Toxicol Pharmacol 2014 Apr 1;68(3):387-401. Epub 2014 Feb 1.

ToxPath, Inc., 3028 Ethan Lane, Laurdane Est., Raleigh, NC 27613, United States.

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http://dx.doi.org/10.1016/j.yrtph.2014.01.011DOI Listing
April 2014
7 Reads
2.031 Impact Factor

Peer consultation on relationship between PAC profile and toxicity of petroleum substances.

Regul Toxicol Pharmacol 2013 Nov 19;67(2 Suppl):S86-93. Epub 2012 Nov 19.

Toxicology Excellence for Risk Assessment (TERA), USA. Electronic address:

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http://dx.doi.org/10.1016/j.yrtph.2012.11.005DOI Listing
November 2013
15 Reads
2.031 Impact Factor

A framework for fit-for-purpose dose response assessment.

Regul Toxicol Pharmacol 2013 Jul 6;66(2):234-40. Epub 2013 Apr 6.

R. Samuel McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, One Stewart Street, Suite 309, Ottawa, ON K1N 6N5, Canada.

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http://dx.doi.org/10.1016/j.yrtph.2013.03.012DOI Listing
July 2013
37 Reads
1 Citation
2.031 Impact Factor

The importance of problem formulations in risk assessment: a case study involving dioxin-contaminated soil.

Regul Toxicol Pharmacol 2013 Jul 29;66(2):208-16. Epub 2013 Mar 29.

Toxicology Excellence for Risk Assessment, Cincinnati, OH, USA.

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http://dx.doi.org/10.1016/j.yrtph.2013.03.010DOI Listing
July 2013
31 Reads
2.031 Impact Factor

Safety assessment of boron by application of new uncertainty factors and their subdivision.

Regul Toxicol Pharmacol 2013 Feb 5;65(1):108-14. Epub 2012 Nov 5.

National Institute of Health Sciences, 1-18-1 Kamiyoga, Tokyo 158-8501, Japan.

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http://dx.doi.org/10.1016/j.yrtph.2012.10.013DOI Listing
February 2013
10 Reads
2.031 Impact Factor

Incorporating nonchemical stressors into cumulative risk assessments.

Toxicol Sci 2012 May 17;127(1):10-7. Epub 2012 Feb 17.

National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1093/toxsci/kfs088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469279PMC
May 2012
6 Reads
4 Citations

Critical review of dose-response options for F344 rat mammary tumors for acrylamide - additional insights based on mode of action.

Food Chem Toxicol 2012 May 17;50(5):1763-75. Epub 2012 Feb 17.

Toxicology Excellence for Risk Assessment, Cincinnati, OH 45211, United States.

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http://dx.doi.org/10.1016/j.fct.2012.02.002DOI Listing
May 2012
9 Reads
2.900 Impact Factor

Proposal of new uncertainty factor application to derive tolerable daily intake.

Regul Toxicol Pharmacol 2010 Nov 16;58(2):237-42. Epub 2010 Jun 16.

National Institute of Health Sciences, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.yrtph.2010.06.006DOI Listing
November 2010
38 Reads
3 Citations
2.031 Impact Factor

Human chemosensory perception of methyl isothiocyanate: chemesthesis and odor.

Regul Toxicol Pharmacol 2010 Nov 13;58(2):173-80. Epub 2010 Jul 13.

Department of Surgery (Otolaryngology), University of California, San Diego, La Jolla, CA 92093-0957, USA.

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http://dx.doi.org/10.1016/j.yrtph.2010.06.018DOI Listing
November 2010
14 Reads
2 Citations
2.031 Impact Factor

Dose response assessment for effects of acute exposure to methyl isothiocyanate (MITC).

Regul Toxicol Pharmacol 2010 Nov 18;58(2):181-8. Epub 2010 Apr 18.

Toxicology Excellence for Risk Assessment (TERA), Cincinnati, OH 45241, USA.

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http://dx.doi.org/10.1016/j.yrtph.2010.04.006DOI Listing
November 2010
10 Reads
1 Citation
2.031 Impact Factor

An exposure-response curve for copper excess and deficiency.

J Toxicol Environ Health B Crit Rev 2010 Oct;13(7-8):546-78

Institute of Population Health, McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Ontario, Canada.

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http://www.tera.org/Publications/Chambers%20et%20al.%20_Copp
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http://www.tandfonline.com/doi/abs/10.1080/10937404.2010.538
Publisher Site
http://dx.doi.org/10.1080/10937404.2010.538657DOI Listing
October 2010
25 Reads
6 Citations
4.970 Impact Factor

Derived Reference Doses (RfDs) for the environmental degradates of the herbicides alachlor and acetochlor: results of an independent expert panel deliberation.

Regul Toxicol Pharmacol 2010 Jul-Aug;57(2-3):220-34. Epub 2010 Mar 4.

Toxicology Excellence for Risk Assessment, Cincinnati, OH 45211, USA.

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http://dx.doi.org/10.1016/j.yrtph.2010.02.010DOI Listing
September 2010
14 Reads
1 Citation
2.031 Impact Factor

Evidence-based dose-response assessment for thyroid tumorigenesis from acrylamide.

Regul Toxicol Pharmacol 2008 Dec 20;52(3):264-89. Epub 2008 Aug 20.

Toxicology Excellence for Risk Assessment (TERA) N/A, 2300 Montana Ave Suite #409, Cincinnati, OH 45211, USA.

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http://dx.doi.org/10.1016/j.yrtph.2008.08.004DOI Listing
December 2008
27 Reads
7 Citations
2.031 Impact Factor

Resources for global risk assessment: the International Toxicity Estimates for Risk (ITER) and Risk Information Exchange (RiskIE) databases.

Toxicol Appl Pharmacol 2008 Nov 2;233(1):45-53. Epub 2008 Jul 2.

Toxicology Excellence for Risk Assessment, 2300 Montana Avenue, Suite 409, Cincinnati, OH 45211, USA.

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http://dx.doi.org/10.1016/j.taap.2007.12.035DOI Listing
November 2008
56 Reads
4 Citations
3.705 Impact Factor

The application of non-default uncertainty factors in the U.S. EPA's Integrated Risk Information System (IRIS). Part I: UF(L), UF(S), and "other uncertainty factors".

J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2007 Jul-Sep;25(3):245-79

Integrated Risk Information System, National Center for Environmental Assessment, Office of Research and Development, United States Environmental Protection Agency, Washington, DC, USA.

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http://dx.doi.org/10.1080/10590500701569430DOI Listing
March 2008
27 Reads
3 Citations
3.560 Impact Factor

Copper and human health: biochemistry, genetics, and strategies for modeling dose-response relationships.

J Toxicol Environ Health B Crit Rev 2007 Apr-May;10(3):157-222

Consulting in Health Sciences and Risk Assessment, BR Stern Associates, Annandale, Virginia 22003, USA.

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http://dx.doi.org/10.1080/10937400600755911DOI Listing
September 2007
33 Reads
13 Citations
4.970 Impact Factor

Data considerations for regulation of water contaminants.

Toxicology 2006 Apr 17;221(2-3):217-24. Epub 2006 Feb 17.

Office of Water, U.S. Environmental Protection Agency, ML4301, 1200 Pennsylvania Avenue NW, Washington, DC 20460, USA.

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http://www.tera.org/Publications/schoeny%20et%20al%202006.pd
Web Search
http://linkinghub.elsevier.com/retrieve/pii/S0300483X0600031
Publisher Site
http://dx.doi.org/10.1016/j.tox.2006.01.019DOI Listing
April 2006
13 Reads
2 Citations
3.621 Impact Factor

A review of the reference dose for chlorpyrifos.

Regul Toxicol Pharmacol 2006 Mar 15;44(2):111-24. Epub 2005 Dec 15.

Toxicology Excellence for Risk Assessment (TERA), 2300 Montana Avenue, Suite 409, Cincinnati, OH 45211, USA.

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http://dx.doi.org/10.1016/j.yrtph.2005.10.003DOI Listing
March 2006
26 Reads
5 Citations
2.031 Impact Factor

The NAS perchlorate review: is the RfD acceptable?

Environ Health Perspect 2005 Nov;113(11):A729-30; author reply A730-2

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1310938PMC
http://dx.doi.org/10.1289/ehp.113-a729DOI Listing
November 2005
17 Reads
1 Citation
7.980 Impact Factor

Application of the threshold of toxicological concern concept to pharmaceutical manufacturing operations.

Regul Toxicol Pharmacol 2005 Oct;43(1):1-9

Occupational and Environmental Health Sciences, Merck & Co., Inc., Whitehouse Station, NJ 08889-0200, USA.

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http://dx.doi.org/10.1016/j.yrtph.2005.06.010DOI Listing
October 2005
51 Reads
3 Citations
2.031 Impact Factor

Human milk biomonitoring data: interpretation and risk assessment issues.

J Toxicol Environ Health A 2005 Oct;68(20):1713-69

Department of Pediatrics, Milton S. Hershey Medical Center, Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1080/15287390500225724DOI Listing
October 2005
7 Reads
5 Citations

Lower birth weight as a critical effect of chlorpyrifos: a comparison of human and animal data.

Regul Toxicol Pharmacol 2005 Jun 26;42(1):55-63. Epub 2005 Mar 26.

Toxicology Excellence for Risk Assessment (TERA), 2300 Montana Ave., Suite 409, Cincinnati, OH 45211, USA.

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http://dx.doi.org/10.1016/j.yrtph.2005.01.009DOI Listing
June 2005
8 Reads
5 Citations
2.031 Impact Factor

Iodine-deficient vegetarians: a hypothetical perchlorate-susceptible population?

Regul Toxicol Pharmacol 2005 Jun;42(1):37-46

Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1016/j.yrtph.2005.01.001DOI Listing
June 2005
14 Reads
2 Citations
2.031 Impact Factor

Reference dose for perchlorate based on thyroid hormone change in pregnant women as the critical effect.

Regul Toxicol Pharmacol 2004 Feb;39(1):44-65

Toxicology Excellence for Risk Assessment, 1757 Chase Ave., Cincinnati, OH 45223, USA.

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http://dx.doi.org/10.1016/j.yrtph.2003.10.003DOI Listing
February 2004
11 Reads
2 Citations
2.031 Impact Factor

Differential sensitivity of children and adults to chemical toxicity. I. Biological basis.

Regul Toxicol Pharmacol 2002 Jun;35(3):429-47

Keller and Heckman, Stafford, Virginia 22554, USA.

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http://dx.doi.org/10.1006/rtph.2002.1558DOI Listing
June 2002
6 Reads
19 Citations
2.031 Impact Factor

Differential sensitivity of children and adults to chemical toxicity. II. Risk and regulation.

Regul Toxicol Pharmacol 2002 Jun;35(3):448-67

Toxicology Excellence for Risk Assessment, Cincinnati, Ohio 45223, USA.

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http://dx.doi.org/10.1006/rtph.2002.1559DOI Listing
June 2002
9 Reads
11 Citations
2.031 Impact Factor

Top co-authors

Andrew Maier
Andrew Maier

University Cincinnati College of Medicine

6
Ann Parker
Ann Parker

Johns Hopkins University School of Medicine

6
Rita Schoeny
Rita Schoeny

University of Ottawa

5
Lynne T Haber
Lynne T Haber

University of Chile

5
Judy S LaKind
Judy S LaKind

Pennsylvania State University College of Medicine

5
Richard A Becker
Richard A Becker

American Chemistry Council

4
Bette Meek
Bette Meek

University of Ottawa

4
Sam Kacew
Sam Kacew

Pennsylvania State University College of Medicine

4
Daniel Krewski
Daniel Krewski

University of Ottawa

4