Publications by authors named "Michael Detmar"

100Publications

Arterial Delivery of VEGF-C Stabilizes Atherosclerotic Lesions.

Circ Res 2020 Nov 19. Epub 2020 Nov 19.

Institute for Cardiovascular Prevention, LMU Munich, GERMANY.

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http://dx.doi.org/10.1161/CIRCRESAHA.120.317186DOI Listing
November 2020

Epigenetic regulation of the lineage specificity of primary human dermal lymphatic and blood vascular endothelial cells.

Angiogenesis 2020 Sep 12. Epub 2020 Sep 12.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Vladimir-Prelog-Weg 3, HCI H303, 8093, Zurich, Switzerland.

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http://dx.doi.org/10.1007/s10456-020-09743-9DOI Listing
September 2020

Rational design of a fluorescent microneedle tattoo for minimally invasive monitoring of lymphatic function.

J Control Release 2020 Nov 18;327:350-359. Epub 2020 Aug 18.

Faculté de Pharmacie, Université de Montréal, 2940 Chemin de Polytechnique, Montréal, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2020.08.017DOI Listing
November 2020

Keratinocyte-Expressed Podoplanin is Dispensable for Multi-Step Skin Carcinogenesis.

Cells 2020 06 24;9(6). Epub 2020 Jun 24.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Vladimir-Prelog-Weg 3, HCI H303, 8093 Zürich, Switzerland.

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http://dx.doi.org/10.3390/cells9061542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348927PMC
June 2020

Characterization of Tumor Blood Vasculature Expression of Human Invasive Bladder Cancer by Laser Capture Microdissection and Transcriptional Profiling.

Am J Pathol 2020 09 23;190(9):1960-1970. Epub 2020 Jun 23.

Institute of Pharmaceutical Sciences, ETH Zurich, Zürich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2020.05.020DOI Listing
September 2020

Antibody-Mediated Delivery of VEGFC Ameliorates Experimental Chronic Colitis.

ACS Pharmacol Transl Sci 2019 Oct 1;2(5):342-352. Epub 2019 Aug 1.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, 8093 Zurich, Switzerland.

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http://dx.doi.org/10.1021/acsptsci.9b00037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088901PMC
October 2019

Single-cell mapping reveals new markers and functions of lymphatic endothelial cells in lymph nodes.

PLoS Biol 2020 04 6;18(4):e3000704. Epub 2020 Apr 6.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1371/journal.pbio.3000704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162550PMC
April 2020

Differential effects of anaesthesia on the contractility of lymphatic vessels in vivo: authors' reply.

J Physiol 2020 May 1;598(10):2037. Epub 2020 Apr 1.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, HCI H303, Vladimir-Prelog-Weg 1-5, Zurich, 8093, Switzerland.

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http://dx.doi.org/10.1113/JP279712DOI Listing
May 2020

Lymphatic outflow of cerebrospinal fluid is reduced in glioma.

Sci Rep 2019 10 15;9(1):14815. Epub 2019 Oct 15.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1038/s41598-019-51373-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794292PMC
October 2019

An important role of podoplanin in hair follicle growth.

PLoS One 2019 23;14(7):e0219938. Epub 2019 Jul 23.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0219938PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650137PMC
February 2020

Inflammation and Lymphatic Function.

Front Immunol 2019 26;10:308. Epub 2019 Feb 26.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.3389/fimmu.2019.00308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399417PMC
September 2020

Differential effects of anaesthesia on the contractility of lymphatic vessels in vivo.

J Physiol 2019 06 20;597(11):2841-2852. Epub 2019 Mar 20.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Switzerland.

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http://dx.doi.org/10.1113/JP277254DOI Listing
June 2019

AutoTube: a novel software for the automated morphometric analysis of vascular networks in tissues.

Angiogenesis 2019 05 28;22(2):223-236. Epub 2018 Oct 28.

Institute of Pharmaceutical Sciences, ETH Zürich, Vladimir-Prelog-Weg 1-5/10, 8093, Zurich, Switzerland.

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http://dx.doi.org/10.1007/s10456-018-9652-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475513PMC
May 2019

Rapid lymphatic efflux limits cerebrospinal fluid flow to the brain.

Acta Neuropathol 2019 01 10;137(1):151-165. Epub 2018 Oct 10.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, HCI H398, 8093, Zurich, Switzerland.

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http://link.springer.com/10.1007/s00401-018-1916-x
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http://dx.doi.org/10.1007/s00401-018-1916-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338719PMC
January 2019

Visualization and Measurement of Lymphatic Function In Vivo.

Methods Mol Biol 2018 ;1846:197-211

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1007/978-1-4939-8712-2_13DOI Listing
May 2019

Light-sheet microscopy reveals site-specific 3-dimensional patterns of the cutaneous vasculature and pronounced rarefication in aged skin.

J Dermatol Sci 2018 Oct 24;92(1):3-5. Epub 2018 Jul 24.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.jdermsci.2018.07.006DOI Listing
October 2018

Quantitative histological analyses and transcriptional profiling reveal structural and molecular changes of the dermal extracellular matrix in cellulite.

J Dermatol Sci 2018 Oct 30;92(1):6-9. Epub 2018 Jun 30.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, 8093 Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jdermsci.2018.06.010DOI Listing
October 2018

Multiple roles of lymphatic vessels in tumor progression.

Curr Opin Immunol 2018 08 30;53:7-12. Epub 2018 Mar 30.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, 8093 Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2018.03.018DOI Listing
August 2018

Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice.

Nat Commun 2017 11 10;8(1):1434. Epub 2017 Nov 10.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, 8093, Zurich, Switzerland.

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http://www.nature.com/articles/s41467-017-01484-6
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http://dx.doi.org/10.1038/s41467-017-01484-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681558PMC
November 2017

Distinct transcriptional responses of lymphatic endothelial cells to VEGFR-3 and VEGFR-2 stimulation.

Sci Data 2017 08 29;4:170106. Epub 2017 Aug 29.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zurich, 8093 Zurich, Switzerland.

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http://dx.doi.org/10.1038/sdata.2017.106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574372PMC
August 2017

FANTOM5 CAGE profiles of human and mouse samples.

Authors:
Shuhei Noguchi Takahiro Arakawa Shiro Fukuda Masaaki Furuno Akira Hasegawa Fumi Hori Sachi Ishikawa-Kato Kaoru Kaida Ai Kaiho Mutsumi Kanamori-Katayama Tsugumi Kawashima Miki Kojima Atsutaka Kubosaki Ri-Ichiroh Manabe Mitsuyoshi Murata Sayaka Nagao-Sato Kenichi Nakazato Noriko Ninomiya Hiromi Nishiyori-Sueki Shohei Noma Eri Saijyo Akiko Saka Mizuho Sakai Christophe Simon Naoko Suzuki Michihira Tagami Shoko Watanabe Shigehiro Yoshida Peter Arner Richard A Axton Magda Babina J Kenneth Baillie Timothy C Barnett Anthony G Beckhouse Antje Blumenthal Beatrice Bodega Alessandro Bonetti James Briggs Frank Brombacher Ailsa J Carlisle Hans C Clevers Carrie A Davis Michael Detmar Taeko Dohi Albert S B Edge Matthias Edinger Anna Ehrlund Karl Ekwall Mitsuhiro Endoh Hideki Enomoto Afsaneh Eslami Michela Fagiolini Lynsey Fairbairn Mary C Farach-Carson Geoffrey J Faulkner Carmelo Ferrai Malcolm E Fisher Lesley M Forrester Rie Fujita Jun-Ichi Furusawa Teunis B Geijtenbeek Thomas Gingeras Daniel Goldowitz Sven Guhl Reto Guler Stefano Gustincich Thomas J Ha Masahide Hamaguchi Mitsuko Hara Yuki Hasegawa Meenhard Herlyn Peter Heutink Kelly J Hitchens David A Hume Tomokatsu Ikawa Yuri Ishizu Chieko Kai Hiroshi Kawamoto Yuki I Kawamura Judith S Kempfle Tony J Kenna Juha Kere Levon M Khachigian Toshio Kitamura Sarah Klein S Peter Klinken Alan J Knox Soichi Kojima Haruhiko Koseki Shigeo Koyasu Weonju Lee Andreas Lennartsson Alan Mackay-Sim Niklas Mejhert Yosuke Mizuno Hiromasa Morikawa Mitsuru Morimoto Kazuyo Moro Kelly J Morris Hozumi Motohashi Christine L Mummery Yutaka Nakachi Fumio Nakahara Toshiyuki Nakamura Yukio Nakamura Tadasuke Nozaki Soichi Ogishima Naganari Ohkura Hiroshi Ohno Mitsuhiro Ohshima Mariko Okada-Hatakeyama Yasushi Okazaki Valerio Orlando Dmitry A Ovchinnikov Robert Passier Margaret Patrikakis Ana Pombo Swati Pradhan-Bhatt Xian-Yang Qin Michael Rehli Patrizia Rizzu Sugata Roy Antti Sajantila Shimon Sakaguchi Hiroki Sato Hironori Satoh Suzana Savvi Alka Saxena Christian Schmidl Claudio Schneider Gundula G Schulze-Tanzil Anita Schwegmann Guojun Sheng Jay W Shin Daisuke Sugiyama Takaaki Sugiyama Kim M Summers Naoko Takahashi Jun Takai Hiroshi Tanaka Hideki Tatsukawa Andru Tomoiu Hiroo Toyoda Marc van de Wetering Linda M van den Berg Roberto Verardo Dipti Vijayan Christine A Wells Louise N Winteringham Ernst Wolvetang Yoko Yamaguchi Masayuki Yamamoto Chiyo Yanagi-Mizuochi Misako Yoneda Yohei Yonekura Peter G Zhang Silvia Zucchelli Imad Abugessaisa Erik Arner Jayson Harshbarger Atsushi Kondo Timo Lassmann Marina Lizio Serkan Sahin Thierry Sengstag Jessica Severin Hisashi Shimoji Masanori Suzuki Harukazu Suzuki Jun Kawai Naoto Kondo Masayoshi Itoh Carsten O Daub Takeya Kasukawa Hideya Kawaji Piero Carninci Alistair R R Forrest Yoshihide Hayashizaki

Sci Data 2017 08 29;4:170112. Epub 2017 Aug 29.

RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan.

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http://dx.doi.org/10.1038/sdata.2017.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574368PMC
August 2017

An Important Role of VEGF-C in Promoting Lymphedema Development.

J Invest Dermatol 2017 09 17;137(9):1995-2004. Epub 2017 May 17.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2017.04.033DOI Listing
September 2017

High-Fat Diet in the Absence of Obesity Does Not Aggravate Surgically Induced Lymphoedema in Mice.

Eur Surg Res 2017 17;58(3-4):180-192. Epub 2017 Mar 17.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1159/000461579DOI Listing
November 2017

Tumor-Associated Lymphatic Vessels Upregulate PDL1 to Inhibit T-Cell Activation.

Front Immunol 2017 3;8:66. Epub 2017 Feb 3.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zurich , Zurich , Switzerland.

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http://dx.doi.org/10.3389/fimmu.2017.00066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289955PMC
February 2017

New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate.

Oncotarget 2017 Jan;8(1):1007-1022

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.18632/oncotarget.13537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352030PMC
January 2017

Postnatal Deletion of Podoplanin in Lymphatic Endothelium Results in Blood Filling of the Lymphatic System and Impairs Dendritic Cell Migration to Lymph Nodes.

Arterioscler Thromb Vasc Biol 2017 01 3;37(1):108-117. Epub 2016 Nov 3.

From the Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, ETH Zurich, Switzerland (R.B., E.R., S.B.B., S.T.P., M.S., N.S., C.H., M.D.); Centre for Cardiovascular Sciences, College of Medical and Dental Sciences (S.P.W.) and Rheumatology Research Group, Institute for Biomedical Research, College of Medical and Dental Sciences (C.D.B.), University of Birmingham, United Kingdom.

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http://dx.doi.org/10.1161/ATVBAHA.116.308020DOI Listing
January 2017

Multidisciplinary Consideration of Potential Pathophysiologic Mechanisms of Paradoxical Erythema with Topical Brimonidine Therapy.

Adv Ther 2016 11 25;33(11):1885-1895. Epub 2016 Aug 25.

Dermatology Section, Department of Medicine, University of California San Diego, San Diego, CA, USA.

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http://dx.doi.org/10.1007/s12325-016-0404-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083782PMC
November 2016

Transgenic overexpression of VEGF-C induces weight gain and insulin resistance in mice.

Sci Rep 2016 08 11;6:31566. Epub 2016 Aug 11.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, 8093 Zurich, Switzerland.

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http://dx.doi.org/10.1038/srep31566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980670PMC
August 2016

Regulation of lymphangiogenesis in the diaphragm by macrophages and VEGFR-3 signaling.

Angiogenesis 2016 10 27;19(4):513-24. Epub 2016 Jul 27.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Vladimir-Prelog-Weg 3, HCI H303, 8093, Zurich, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026726PMC
http://dx.doi.org/10.1007/s10456-016-9523-8DOI Listing
October 2016

Prominent Lymphatic Vessel Hyperplasia with Progressive Dysfunction and Distinct Immune Cell Infiltration in Lymphedema.

Am J Pathol 2016 08 15;186(8):2193-2203. Epub 2016 Jun 15.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029440163011
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http://dx.doi.org/10.1016/j.ajpath.2016.04.006DOI Listing
August 2016

Restoration of lymphatic function rescues obesity in Prox1-haploinsufficient mice.

JCI Insight 2016 Feb 25;1(2). Epub 2016 Feb 25.

Department of Genetics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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https://insight.jci.org/articles/view/85096
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http://dx.doi.org/10.1172/jci.insight.85096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786184PMC
February 2016

Ectodomain Shedding of Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE-1) Is Induced by Vascular Endothelial Growth Factor A (VEGF-A).

J Biol Chem 2016 May 10;291(20):10490-500. Epub 2016 Mar 10.

From the Departments of Dermatology, Strategic Young Researcher Overseas Visiting Program for Accelerating Brain Circulation, Japan Society for the Promotion of Science (JSPS), 5-3-1 Kojimachi, Chiyoda-ku, Tokyo 102-0083, Japan, Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan

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http://dx.doi.org/10.1074/jbc.M115.683201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865900PMC
May 2016

In vivo visualization and quantification of collecting lymphatic vessel contractility using near-infrared imaging.

Sci Rep 2016 Mar 10;6:22930. Epub 2016 Mar 10.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, 8093 Zurich, Switzerland.

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http://dx.doi.org/10.1038/srep22930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785392PMC
March 2016

Endothelial cell-derived semaphorin 3A inhibits filopodia formation by blood vascular tip cells.

Development 2016 Feb;143(4):589-94

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich 8093, Switzerland

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http://dx.doi.org/10.1242/dev.127670DOI Listing
February 2016

Findings questioning the involvement of Sigma-1 receptor in the uptake of anisamide-decorated particles.

J Control Release 2016 Feb 13;224:229-238. Epub 2016 Jan 13.

Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Zurich (ETHZ), Zurich 8093, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2016.01.021DOI Listing
February 2016

Microneedles for the Noninvasive Structural and Functional Assessment of Dermal Lymphatic Vessels.

Small 2016 Feb 4;12(8):1053-61. Epub 2016 Jan 4.

Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 3, 8093, Zurich, Switzerland.

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http://dx.doi.org/10.1002/smll.201503093DOI Listing
February 2016

Tumor lymphangiogenesis and new drug development.

Adv Drug Deliv Rev 2016 Apr 17;99(Pt B):148-160. Epub 2015 Dec 17.

Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 3, CH-8093 Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2015.12.011DOI Listing
April 2016

Decline of lymphatic vessel density and function in murine skin during aging.

Angiogenesis 2015 Oct 11;18(4):489-98. Epub 2015 Aug 11.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, 8093, Zurich, Switzerland.

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http://dx.doi.org/10.1007/s10456-015-9479-0DOI Listing
October 2015

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules.

J Exp Med 2015 Jun 15;212(7):991-9. Epub 2015 Jun 15.

Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland

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http://dx.doi.org/10.1084/jem.20142290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493418PMC
June 2015

Drug Pharmacokinetics Determined by Real-Time Analysis of Mouse Breath.

Angew Chem Int Ed Engl 2015 Jun 27;54(27):7815-8. Epub 2015 May 27.

Department of Chemistry and Applied Biosciences, ETH Zürich, 8093 Zürich (Switzerland).

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http://dx.doi.org/10.1002/anie.201503312DOI Listing
June 2015

Characterization of macrophage--cancer cell crosstalk in estrogen receptor positive and triple-negative breast cancer.

Sci Rep 2015 Mar 17;5:9188. Epub 2015 Mar 17.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zürich, 8093 Zurich, Switzerland.

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http://dx.doi.org/10.1038/srep09188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361875PMC
March 2015

Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells.

Authors:
Erik Arner Carsten O Daub Kristoffer Vitting-Seerup Robin Andersson Berit Lilje Finn Drabløs Andreas Lennartsson Michelle Rönnerblad Olga Hrydziuszko Morana Vitezic Tom C Freeman Ahmad M N Alhendi Peter Arner Richard Axton J Kenneth Baillie Anthony Beckhouse Beatrice Bodega James Briggs Frank Brombacher Margaret Davis Michael Detmar Anna Ehrlund Mitsuhiro Endoh Afsaneh Eslami Michela Fagiolini Lynsey Fairbairn Geoffrey J Faulkner Carmelo Ferrai Malcolm E Fisher Lesley Forrester Daniel Goldowitz Reto Guler Thomas Ha Mitsuko Hara Meenhard Herlyn Tomokatsu Ikawa Chieko Kai Hiroshi Kawamoto Levon M Khachigian S Peter Klinken Soichi Kojima Haruhiko Koseki Sarah Klein Niklas Mejhert Ken Miyaguchi Yosuke Mizuno Mitsuru Morimoto Kelly J Morris Christine Mummery Yutaka Nakachi Soichi Ogishima Mariko Okada-Hatakeyama Yasushi Okazaki Valerio Orlando Dmitry Ovchinnikov Robert Passier Margaret Patrikakis Ana Pombo Xian-Yang Qin Sugata Roy Hiroki Sato Suzana Savvi Alka Saxena Anita Schwegmann Daisuke Sugiyama Rolf Swoboda Hiroshi Tanaka Andru Tomoiu Louise N Winteringham Ernst Wolvetang Chiyo Yanagi-Mizuochi Misako Yoneda Susan Zabierowski Peter Zhang Imad Abugessaisa Nicolas Bertin Alexander D Diehl Shiro Fukuda Masaaki Furuno Jayson Harshbarger Akira Hasegawa Fumi Hori Sachi Ishikawa-Kato Yuri Ishizu Masayoshi Itoh Tsugumi Kawashima Miki Kojima Naoto Kondo Marina Lizio Terrence F Meehan Christopher J Mungall Mitsuyoshi Murata Hiromi Nishiyori-Sueki Serkan Sahin Sayaka Nagao-Sato Jessica Severin Michiel J L de Hoon Jun Kawai Takeya Kasukawa Timo Lassmann Harukazu Suzuki Hideya Kawaji Kim M Summers Christine Wells David A Hume Alistair R R Forrest Albin Sandelin Piero Carninci Yoshihide Hayashizaki

Science 2015 Feb 12;347(6225):1010-4. Epub 2015 Feb 12.

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http://dx.doi.org/10.1126/science.1259418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681433PMC
February 2015

A novel role for microphthalmia-associated transcription factor-regulated pigment epithelium-derived factor during melanoma progression.

Am J Pathol 2015 Jan 6;185(1):252-65. Epub 2014 Nov 6.

Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts; Department of Pediatric Hematology/Oncology, Melanoma Program in Medical Oncology, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.ajpath.2014.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278358PMC
January 2015

Antibody-mediated delivery of interleukin 4 to the neo-vasculature reduces chronic skin inflammation.

J Dermatol Sci 2014 Nov 15;76(2):96-103. Epub 2014 Aug 15.

Department of Chemistry and Applied Biosciences, ETH Zürich, Wolfgang-Pauli-Strasse 10, CH-8093 Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jdermsci.2014.07.012DOI Listing
November 2014

Fingerprinting breast cancer vs. normal mammary cells by mass spectrometric analysis of volatiles.

Sci Rep 2014 Jun 6;4:5196. Epub 2014 Jun 6.

ETH Zurich, Department of Chemistry and Applied Biosciences, CH-8093 Zurich, Switzerland.

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http://dx.doi.org/10.1038/srep05196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381500PMC
June 2014

Chronic high-fat diet impairs collecting lymphatic vessel function in mice.

PLoS One 2014 8;9(4):e94713. Epub 2014 Apr 8.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094713PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979858PMC
December 2014

An important role of the SDF-1/CXCR4 axis in chronic skin inflammation.

PLoS One 2014 2;9(4):e93665. Epub 2014 Apr 2.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0093665PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973543PMC
February 2015

A promoter-level mammalian expression atlas.

Authors:
Alistair R R Forrest Hideya Kawaji Michael Rehli J Kenneth Baillie Michiel J L de Hoon Vanja Haberle Timo Lassmann Ivan V Kulakovskiy Marina Lizio Masayoshi Itoh Robin Andersson Christopher J Mungall Terrence F Meehan Sebastian Schmeier Nicolas Bertin Mette Jørgensen Emmanuel Dimont Erik Arner Christian Schmidl Ulf Schaefer Yulia A Medvedeva Charles Plessy Morana Vitezic Jessica Severin Colin A Semple Yuri Ishizu Robert S Young Margherita Francescatto Intikhab Alam Davide Albanese Gabriel M Altschuler Takahiro Arakawa John A C Archer Peter Arner Magda Babina Sarah Rennie Piotr J Balwierz Anthony G Beckhouse Swati Pradhan-Bhatt Judith A Blake Antje Blumenthal Beatrice Bodega Alessandro Bonetti James Briggs Frank Brombacher A Maxwell Burroughs Andrea Califano Carlo V Cannistraci Daniel Carbajo Yun Chen Marco Chierici Yari Ciani Hans C Clevers Emiliano Dalla Carrie A Davis Michael Detmar Alexander D Diehl Taeko Dohi Finn Drabløs Albert S B Edge Matthias Edinger Karl Ekwall Mitsuhiro Endoh Hideki Enomoto Michela Fagiolini Lynsey Fairbairn Hai Fang Mary C Farach-Carson Geoffrey J Faulkner Alexander V Favorov Malcolm E Fisher Martin C Frith Rie Fujita Shiro Fukuda Cesare Furlanello Masaaki Furino Jun-ichi Furusawa Teunis B Geijtenbeek Andrew P Gibson Thomas Gingeras Daniel Goldowitz Julian Gough Sven Guhl Reto Guler Stefano Gustincich Thomas J Ha Masahide Hamaguchi Mitsuko Hara Matthias Harbers Jayson Harshbarger Akira Hasegawa Yuki Hasegawa Takehiro Hashimoto Meenhard Herlyn Kelly J Hitchens Shannan J Ho Sui Oliver M Hofmann Ilka Hoof Furni Hori Lukasz Huminiecki Kei Iida Tomokatsu Ikawa Boris R Jankovic Hui Jia Anagha Joshi Giuseppe Jurman Bogumil Kaczkowski Chieko Kai Kaoru Kaida Ai Kaiho Kazuhiro Kajiyama Mutsumi Kanamori-Katayama Artem S Kasianov Takeya Kasukawa Shintaro Katayama Sachi Kato Shuji Kawaguchi Hiroshi Kawamoto Yuki I Kawamura Tsugumi Kawashima Judith S Kempfle Tony J Kenna Juha Kere Levon M Khachigian Toshio Kitamura S Peter Klinken Alan J Knox Miki Kojima Soichi Kojima Naoto Kondo Haruhiko Koseki Shigeo Koyasu Sarah Krampitz Atsutaka Kubosaki Andrew T Kwon Jeroen F J Laros Weonju Lee Andreas Lennartsson Kang Li Berit Lilje Leonard Lipovich Alan Mackay-Sim Ri-ichiroh Manabe Jessica C Mar Benoit Marchand Anthony Mathelier Niklas Mejhert Alison Meynert Yosuke Mizuno David A de Lima Morais Hiromasa Morikawa Mitsuru Morimoto Kazuyo Moro Efthymios Motakis Hozumi Motohashi Christine L Mummery Mitsuyoshi Murata Sayaka Nagao-Sato Yutaka Nakachi Fumio Nakahara Toshiyuki Nakamura Yukio Nakamura Kenichi Nakazato Erik van Nimwegen Noriko Ninomiya Hiromi Nishiyori Shohei Noma Shohei Noma Tadasuke Noazaki Soichi Ogishima Naganari Ohkura Hiroko Ohimiya Hiroshi Ohno Mitsuhiro Ohshima Mariko Okada-Hatakeyama Yasushi Okazaki Valerio Orlando Dmitry A Ovchinnikov Arnab Pain Robert Passier Margaret Patrikakis Helena Persson Silvano Piazza James G D Prendergast Owen J L Rackham Jordan A Ramilowski Mamoon Rashid Timothy Ravasi Patrizia Rizzu Marco Roncador Sugata Roy Morten B Rye Eri Saijyo Antti Sajantila Akiko Saka Shimon Sakaguchi Mizuho Sakai Hiroki Sato Suzana Savvi Alka Saxena Claudio Schneider Erik A Schultes Gundula G Schulze-Tanzil Anita Schwegmann Thierry Sengstag Guojun Sheng Hisashi Shimoji Yishai Shimoni Jay W Shin Christophe Simon Daisuke Sugiyama Takaai Sugiyama Masanori Suzuki Naoko Suzuki Rolf K Swoboda Peter A C 't Hoen Michihira Tagami Naoko Takahashi Jun Takai Hiroshi Tanaka Hideki Tatsukawa Zuotian Tatum Mark Thompson Hiroo Toyodo Tetsuro Toyoda Elvind Valen Marc van de Wetering Linda M van den Berg Roberto Verado Dipti Vijayan Ilya E Vorontsov Wyeth W Wasserman Shoko Watanabe Christine A Wells Louise N Winteringham Ernst Wolvetang Emily J Wood Yoko Yamaguchi Masayuki Yamamoto Misako Yoneda Yohei Yonekura Shigehiro Yoshida Susan E Zabierowski Peter G Zhang Xiaobei Zhao Silvia Zucchelli Kim M Summers Harukazu Suzuki Carsten O Daub Jun Kawai Peter Heutink Winston Hide Tom C Freeman Boris Lenhard Vladimir B Bajic Martin S Taylor Vsevolod J Makeev Albin Sandelin David A Hume Piero Carninci Yoshihide Hayashizaki

Nature 2014 Mar;507(7493):462-70

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http://dx.doi.org/10.1038/nature13182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529748PMC
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Mechanisms of lymphatic metastasis.

J Clin Invest 2014 Mar 3;124(3):922-8. Epub 2014 Mar 3.

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Lymphatics in nanophysiology.

Adv Drug Deliv Rev 2014 Jul 10;74:12-8. Epub 2014 Feb 10.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland.

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July 2014

Thrombospondin-2 overexpression in the skin of transgenic mice reduces the susceptibility to chemically induced multistep skin carcinogenesis.

J Dermatol Sci 2014 May 18;74(2):106-15. Epub 2014 Jan 18.

Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA; Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jdermsci.2014.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975683PMC
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VEGF-A promotes IL-17A-producing γδ T cell accumulation in mouse skin and serves as a chemotactic factor for plasmacytoid dendritic cells.

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Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan. Electronic address:

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The role of neuropilin-1/semaphorin 3A signaling in lymphatic vessel development and maturation.

Adv Anat Embryol Cell Biol 2014 ;214:143-52

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Wolfgang Pauli-Str. 10, HCI H303, 8093, Zurich, Switzerland.

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http://dx.doi.org/10.1007/978-3-7091-1646-3_11DOI Listing
April 2014

Lymphatic vessels: new targets for the treatment of inflammatory diseases.

Angiogenesis 2014 Apr 9;17(2):359-71. Epub 2013 Nov 9.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zurich, Wolfgang-Pauli-Strasse 10, HCI H 303, 8093, Zurich, Switzerland.

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http://dx.doi.org/10.1007/s10456-013-9406-1DOI Listing
April 2014

The orphan adhesion G protein-coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42.

J Biol Chem 2013 Dec 31;288(50):35736-48. Epub 2013 Oct 31.

From the Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861625PMC
December 2013

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Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zürich, Wolfgang-Pauli-Str. 10, 8093 Zürich (Switzerland).

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September 2013

Blockade of VEGF receptor-3 aggravates inflammatory bowel disease and lymphatic vessel enlargement.

Inflamm Bowel Dis 2013 Aug;19(9):1983-9

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732464PMC
August 2013

Activation of the epidermal growth factor receptor promotes lymphangiogenesis in the skin.

J Dermatol Sci 2013 Sep 4;71(3):184-94. Epub 2013 May 4.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745787PMC
September 2013

VEGF-C and VEGF-D blockade inhibits inflammatory skin carcinogenesis.

Cancer Res 2013 Jul 21;73(14):4212-21. Epub 2013 May 21.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland.

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July 2013

Expansion of the lymphatic vasculature in cancer and inflammation: new opportunities for in vivo imaging and drug delivery.

J Control Release 2013 Dec 9;172(2):550-7. Epub 2013 May 9.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, 8093 Zurich, Switzerland.

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December 2013

Dynamics of lymphatic regeneration and flow patterns after lymph node dissection.

Breast Cancer Res Treat 2013 May 24;139(1):81-6. Epub 2013 Apr 24.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Wolfgang Pauli-Str. 10, HCI H303, 8093, Zurich, Switzerland.

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May 2013

Molecular mechanisms and imaging of lymphatic metastasis.

Exp Cell Res 2013 Jul 13;319(11):1611-7. Epub 2013 Mar 13.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Wolfgang-Pauli-Str. 10, CH-8093 Zurich, Switzerland. Electronic address:

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July 2013

An important role of blood and lymphatic vessels in inflammation and allergy.

J Allergy (Cairo) 2013 31;2013:672381. Epub 2013 Jan 31.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Wolfgang Pauli-Strasse 10, HCI H303, 8093 Zurich, Switzerland.

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http://dx.doi.org/10.1155/2013/672381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574757PMC
February 2013

In vivo imaging of lymph node lymphangiogenesis by immuno-positron emission tomography.

Methods Mol Biol 2013 ;961:129-40

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1007/978-1-62703-227-8_6DOI Listing
June 2013

Non-invasive dynamic near-infrared imaging and quantification of vascular leakage in vivo.

Angiogenesis 2013 Jul 17;16(3):525-40. Epub 2013 Jan 17.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Wolfgang-Pauli-Str. 10, HCI H303, 8093 Zurich, Switzerland.

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http://dx.doi.org/10.1007/s10456-013-9332-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713856PMC
July 2013

The miR-290-295 cluster suppresses autophagic cell death of melanoma cells.

Sci Rep 2012 13;2:808. Epub 2012 Nov 13.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496171PMC
April 2013

Induced lymphatic sinus hyperplasia in sentinel lymph nodes by VEGF-C as the earliest premetastatic indicator.

Int J Oncol 2012 Dec 16;41(6):2073-8. Epub 2012 Oct 16.

Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.3892/ijo.2012.1665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583645PMC
December 2012

Phenotype-based high-content chemical library screening identifies statins as inhibitors of in vivo lymphangiogenesis.

Proc Natl Acad Sci U S A 2012 Oct 4;109(40):E2665-74. Epub 2012 Sep 4.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Eidgenössische Technische Hochschule Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland.

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http://dx.doi.org/10.1073/pnas.1206036109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479568PMC
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Lymphangiogenesis and cancer.

Genes Cancer 2011 Dec;2(12):1146-58

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1177/1947601911423028DOI Listing
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