Dr. Michael Dean, PhD - National Cancer Institute - Sr. Scientist, LTG, DCEG

Dr. Michael Dean

PhD

National Cancer Institute

Sr. Scientist, LTG, DCEG

Gaithersburg, MD | United States

Additional Specialties: Human Genetics

Dr. Michael Dean, PhD - National Cancer Institute - Sr. Scientist, LTG, DCEG

Dr. Michael Dean

PhD

Introduction

Primary Affiliation: National Cancer Institute - Gaithersburg, MD , United States

Additional Specialties:

Research Interests:

Education

Jan 1983
Boston University
PhD
Biochemistry

Publications

56Publications

2488Reads

1Profile Views

1284PubMed Central Citations

LMTK3 confers chemo-resistance in breast cancer.

Oncogene 2018 06 15;37(23):3113-3130. Epub 2018 Mar 15.

School of Life Sciences, Department of Biochemistry and Biomedicine, University of Sussex, Brighton, BN1 9QG, UK.

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http://dx.doi.org/10.1038/s41388-018-0197-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992129PMC
June 2018
20 Reads
8.460 Impact Factor

The Intersection of HPV Epidemiology, Genomics and Mechanistic Studies of HPV-Mediated Carcinogenesis.

Viruses 2018 02 13;10(2). Epub 2018 Feb 13.

Departments of Pediatrics, Microbiology and Immunology, Epidemiology and Population Health, and Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.3390/v10020080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850387PMC
February 2018
13 Reads
1 Citation
3.280 Impact Factor

Prevalence and spectrum of germline rare variants in BRCA1/2 and PALB2 among breast cancer cases in Sarawak, Malaysia.

Breast Cancer Res Treat 2017 Oct 29;165(3):687-697. Epub 2017 Jun 29.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, NCI/NIH, Bethesda, Rockville, MD, USA.

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http://dx.doi.org/10.1007/s10549-017-4356-8DOI Listing
October 2017
51 Reads
3 Citations
3.940 Impact Factor

ABCC6 and Pseudoxanthoma Elasticum: The Face of a Rare Disease from Genetics to Advocacy.

Int J Mol Sci 2017 Jul 11;18(7). Epub 2017 Jul 11.

Laboratory of Translational Genomics, The Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute, National Institutes of Health, Gaithersburg, MD 20885, USA.

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http://dx.doi.org/10.3390/ijms18071488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535978PMC
July 2017
93 Reads
1 Citation
2.862 Impact Factor

Traceback: A Proposed Framework to Increase Identification and Genetic Counseling of BRCA1 and BRCA2 Mutation Carriers Through Family-Based Outreach.

J Clin Oncol 2017 Jul 11;35(20):2329-2337. Epub 2017 Apr 11.

Goli Samimi, Charlisse F. Caga-anan, Michael Dean, Leah E. Mechanic, Lori M. Minasian, and Mark E. Sherman, National Cancer Institute; Lawrence C. Brody, National Human Genome Research Institute, Bethesda, MD; Marcus Q. Bernardini, Stephanie Lheureux, Patricia A. Shaw, Princess Margaret Cancer Centre, Toronto, Ontario; Janice S. Kwon, University of British Columbia; British Columbia Cancer Agency, Vancouver, British Columbia, Canada; Ian G. Campbell, Paul A. James, Masataka Takenaka, and David D. Bowtell, Peter MacCallum Cancer Centre; David D. Bowtell, University of Melbourne, Melbourne, Victoria; Georgia Chenevix-Trench, QIMR Berghofer Medical Research Institute, Brisbane, Queensland; Michael Friedlander, The Prince of Wales Hospital; Susan J. Ramus, University of New South Wales; Susan J. Ramus and David D. Bowtell, Garvan Institute of Medical Research, Sydney, New South Wales, Australia; Fergus J. Couch, Mayo Clinic, Rochester, MN; Joanne A. de Hullu and Marline G. Harmsen, Radboud University Medical Center, Nijmegen, the Netherlands; Susan M. Domchek and Ronny Drapkin, University of Pennsylvania, Philadelphia; Phuong L. Mai, Magee-Women's Hospital of the University of Pittsburgh Medical Center, Pittsburgh, PA; Heather Spencer Feigelson, Kaiser Permanente Institute for Health Research, Denver, CO; Mia M. Gaudet, American Cancer Society, Atlanta, GA; Karen Hurley and Mark E. Robson, Memorial Sloan Kettering Cancer Center; Mark E. Robson, Weill Cornell Medical College, New York, NY; Felicitas Lacbawan, Quest Diagnostics Nichols Institute, San Juan Capistrano; Thomas P. Slavin, City of Hope, Duarte, CA; Evan R. Myers, Duke University Medical Center, Durham, NC; Lisa F. Rezende, FORCE: Facing Our Risk of Cancer Empowered, Tampa; Mark E. Sherman, Mayo Clinic, Jacksonville, FL; and Elizabeth M. Swisher, University of Washington Medical Center, Seattle, WA.

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http://dx.doi.org/10.1200/JCO.2016.70.3439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501360PMC
July 2017
54 Reads
6 Citations
18.430 Impact Factor

TET2 binds the androgen receptor and loss is associated with prostate cancer.

Oncogene 2017 04 7;36(15):2172-2183. Epub 2016 Nov 7.

Protein Characterization Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.

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http://dx.doi.org/10.1038/onc.2016.376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391277PMC
April 2017
6 Reads
6 Citations
8.460 Impact Factor

Next Generation Sequencing Reveals High Prevalence of BRCA1 and BRCA2 Variants of Unknown Significance in Early-Onset Breast Cancer in African American Women.

Ethn Dis 2017 20;27(2):169-178. Epub 2017 Apr 20.

National Human Genome Center, Howard University Department of Community and Family Medicine, Washington, DC.

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http://dx.doi.org/10.18865/ed.27.2.169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398176PMC
April 2017
17 Reads
2 Citations
0.921 Impact Factor

Mosaic chromosome 20q deletions are more frequent in the aging population.

Blood Adv 2017 Feb 13;1(6):380-385. Epub 2017 Feb 13.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD.

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http://dx.doi.org/10.1182/bloodadvances.2016003129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738991PMC
February 2017
13 Reads
2 Citations

Molecular analysis of urothelial cancer cell lines for modeling tumor biology and drug response.

Oncogene 2017 01 6;36(1):35-46. Epub 2016 Jun 6.

Department of Surgery (Urology), University of Colorado, Aurora, CO, USA.

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http://dx.doi.org/10.1038/onc.2016.172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140783PMC
January 2017
5 Reads
10 Citations
8.460 Impact Factor

Comparison of variations detection between whole-genome amplification methods used in single-cell resequencing.

Gigascience 2015 6;4:37. Epub 2015 Aug 6.

BGI-Shenzhen, Shenzhen, 518083 China ; Princess Al Jawhara Centre of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, 21589 Saudi Arabia ; Department of Biology and the Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, 1599 Denmark.

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http://dx.doi.org/10.1186/s13742-015-0068-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527218PMC
July 2016
102 Reads
28 Citations

Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome.

Authors:
Mitchell J Machiela Weiyin Zhou Eric Karlins Joshua N Sampson Neal D Freedman Qi Yang Belynda Hicks Casey Dagnall Christopher Hautman Kevin B Jacobs Christian C Abnet Melinda C Aldrich Christopher Amos Laufey T Amundadottir Alan A Arslan Laura E Beane-Freeman Sonja I Berndt Amanda Black William J Blot Cathryn H Bock Paige M Bracci Louise A Brinton H Bas Bueno-de-Mesquita Laurie Burdett Julie E Buring Mary A Butler Federico Canzian Tania Carreón Kari G Chaffee I-Shou Chang Nilanjan Chatterjee Chu Chen Constance Chen Kexin Chen Charles C Chung Linda S Cook Marta Crous Bou Michael Cullen Faith G Davis Immaculata De Vivo Ti Ding Jennifer Doherty Eric J Duell Caroline G Epstein Jin-Hu Fan Jonine D Figueroa Joseph F Fraumeni Christine M Friedenreich Charles S Fuchs Steven Gallinger Yu-Tang Gao Susan M Gapstur Montserrat Garcia-Closas Mia M Gaudet J Michael Gaziano Graham G Giles Elizabeth M Gillanders Edward L Giovannucci Lynn Goldin Alisa M Goldstein Christopher A Haiman Goran Hallmans Susan E Hankinson Curtis C Harris Roger Henriksson Elizabeth A Holly Yun-Chul Hong Robert N Hoover Chao A Hsiung Nan Hu Wei Hu David J Hunter Amy Hutchinson Mazda Jenab Christoffer Johansen Kay-Tee Khaw Hee Nam Kim Yeul Hong Kim Young Tae Kim Alison P Klein Robert Klein Woon-Puay Koh Laurence N Kolonel Charles Kooperberg Peter Kraft Vittorio Krogh Robert C Kurtz Andrea LaCroix Qing Lan Maria Teresa Landi Loic Le Marchand Donghui Li Xiaolin Liang Linda M Liao Dongxin Lin Jianjun Liu Jolanta Lissowska Lingeng Lu Anthony M Magliocco Nuria Malats Keitaro Matsuo Lorna H McNeill Robert R McWilliams Beatrice S Melin Lisa Mirabello Lee Moore Sara H Olson Irene Orlow Jae Yong Park Ana Patiño-Garcia Beata Peplonska Ulrike Peters Gloria M Petersen Loreall Pooler Jennifer Prescott Ludmila Prokunina-Olsson Mark P Purdue You-Lin Qiao Preetha Rajaraman Francisco X Real Elio Riboli Harvey A Risch Benjamin Rodriguez-Santiago Avima M Ruder Sharon A Savage Fredrick Schumacher Ann G Schwartz Kendra L Schwartz Adeline Seow Veronica Wendy Setiawan Gianluca Severi Hongbing Shen Xin Sheng Min-Ho Shin Xiao-Ou Shu Debra T Silverman Margaret R Spitz Victoria L Stevens Rachael Stolzenberg-Solomon Daniel Stram Ze-Zhong Tang Philip R Taylor Lauren R Teras Geoffrey S Tobias David Van Den Berg Kala Visvanathan Sholom Wacholder Jiu-Cun Wang Zhaoming Wang Nicolas Wentzensen William Wheeler Emily White John K Wiencke Brian M Wolpin Maria Pik Wong Chen Wu Tangchun Wu Xifeng Wu Yi-Long Wu Jay S Wunder Lucy Xia Hannah P Yang Pan-Chyr Yang Kai Yu Krista A Zanetti Anne Zeleniuch-Jacquotte Wei Zheng Baosen Zhou Regina G Ziegler Luis A Perez-Jurado Neil E Caporaso Nathaniel Rothman Margaret Tucker Michael C Dean Meredith Yeager Stephen J Chanock

Nat Commun 2016 06 13;7:11843. Epub 2016 Jun 13.

Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/ncomms11843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909985PMC
June 2016
93 Reads
10 Citations
10.742 Impact Factor

Mosaic 13q14 deletions in peripheral leukocytes of non-hematologic cancer cases and healthy controls.

J Hum Genet 2016 May 14;61(5):411-8. Epub 2016 Jan 14.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.

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http://dx.doi.org/10.1038/jhg.2015.166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880507PMC
May 2016
28 Reads
6 Citations
2.462 Impact Factor

The distribution of high-risk human papillomaviruses is different in young and old patients with cervical cancer.

PLoS One 2014 8;9(10):e109406. Epub 2014 Oct 8.

Unidad de Medicina Genómica, Facultad de Medicina, Universidad Nacional Autónoma de México/Hospital General de México, México, D.F. México; Departamento de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México. México, D.F. México.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109406PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190176PMC
October 2015
33 Reads
4 Citations
3.234 Impact Factor

The genome of Diuraphis noxia, a global aphid pest of small grains.

BMC Genomics 2015 Jun 5;16:429. Epub 2015 Jun 5.

USDA Agricultural Research Service, Stillwater, OK, 74075, USA.

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http://dx.doi.org/10.1186/s12864-015-1525-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561433PMC
June 2015
10 Reads
14 Citations
3.990 Impact Factor

Characterization of large structural genetic mosaicism in human autosomes.

Authors:
Mitchell J Machiela Weiyin Zhou Joshua N Sampson Michael C Dean Kevin B Jacobs Amanda Black Louise A Brinton I-Shou Chang Chu Chen Constance Chen Kexin Chen Linda S Cook Marta Crous Bou Immaculata De Vivo Jennifer Doherty Christine M Friedenreich Mia M Gaudet Christopher A Haiman Susan E Hankinson Patricia Hartge Brian E Henderson Yun-Chul Hong H Dean Hosgood Chao A Hsiung Wei Hu David J Hunter Lea Jessop Hee Nam Kim Yeul Hong Kim Young Tae Kim Robert Klein Peter Kraft Qing Lan Dongxin Lin Jianjun Liu Loic Le Marchand Xiaolin Liang Jolanta Lissowska Lingeng Lu Anthony M Magliocco Keitaro Matsuo Sara H Olson Irene Orlow Jae Yong Park Loreall Pooler Jennifer Prescott Radhai Rastogi Harvey A Risch Fredrick Schumacher Adeline Seow Veronica Wendy Setiawan Hongbing Shen Xin Sheng Min-Ho Shin Xiao-Ou Shu David VanDen Berg Jiu-Cun Wang Nicolas Wentzensen Maria Pik Wong Chen Wu Tangchun Wu Yi-Long Wu Lucy Xia Hannah P Yang Pan-Chyr Yang Wei Zheng Baosen Zhou Christian C Abnet Demetrius Albanes Melinda C Aldrich Christopher Amos Laufey T Amundadottir Sonja I Berndt William J Blot Cathryn H Bock Paige M Bracci Laurie Burdett Julie E Buring Mary A Butler Tania Carreón Nilanjan Chatterjee Charles C Chung Michael B Cook Michael Cullen Faith G Davis Ti Ding Eric J Duell Caroline G Epstein Jin-Hu Fan Jonine D Figueroa Joseph F Fraumeni Neal D Freedman Charles S Fuchs Yu-Tang Gao Susan M Gapstur Ana Patiño-Garcia Montserrat Garcia-Closas J Michael Gaziano Graham G Giles Elizabeth M Gillanders Edward L Giovannucci Lynn Goldin Alisa M Goldstein Mark H Greene Goran Hallmans Curtis C Harris Roger Henriksson Elizabeth A Holly Robert N Hoover Nan Hu Amy Hutchinson Mazda Jenab Christoffer Johansen Kay-Tee Khaw Woon-Puay Koh Laurence N Kolonel Charles Kooperberg Vittorio Krogh Robert C Kurtz Andrea LaCroix Annelie Landgren Maria Teresa Landi Donghui Li Linda M Liao Nuria Malats Katherine A McGlynn Lorna H McNeill Robert R McWilliams Beatrice S Melin Lisa Mirabello Beata Peplonska Ulrike Peters Gloria M Petersen Ludmila Prokunina-Olsson Mark Purdue You-Lin Qiao Kari G Rabe Preetha Rajaraman Francisco X Real Elio Riboli Benjamín Rodríguez-Santiago Nathaniel Rothman Avima M Ruder Sharon A Savage Ann G Schwartz Kendra L Schwartz Howard D Sesso Gianluca Severi Debra T Silverman Margaret R Spitz Victoria L Stevens Rachael Stolzenberg-Solomon Daniel Stram Ze-Zhong Tang Philip R Taylor Lauren R Teras Geoffrey S Tobias Kala Viswanathan Sholom Wacholder Zhaoming Wang Stephanie J Weinstein William Wheeler Emily White John K Wiencke Brian M Wolpin Xifeng Wu Jay S Wunder Kai Yu Krista A Zanetti Anne Zeleniuch-Jacquotte Regina G Ziegler Mariza de Andrade Kathleen C Barnes Terri H Beaty Laura J Bierut Karl C Desch Kimberly F Doheny Bjarke Feenstra David Ginsburg John A Heit Jae H Kang Cecilia A Laurie Jun Z Li William L Lowe Mary L Marazita Mads Melbye Daniel B Mirel Jeffrey C Murray Sarah C Nelson Louis R Pasquale Kenneth Rice Janey L Wiggs Anastasia Wise Margaret Tucker Luis A Pérez-Jurado Cathy C Laurie Neil E Caporaso Meredith Yeager Stephen J Chanock

Am J Hum Genet 2015 Mar;96(3):487-97

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375431PMC
March 2015
131 Reads
25 Citations
10.931 Impact Factor

CHRM2 but not CHRM1 or CHRM3 polymorphisms are associated with asthma susceptibility in Mexican patients.

Mol Biol Rep 2014 16;41(4):2109-17. Epub 2014 Jan 16.

Laboratory of Immunogenomics and Metabolic Diseases, Instituto Nacional de Medicina Genómica, SS, Periférico Sur 4809, Col. Arenal Tepepan, CP. 014610, Mexico City, Mexico.

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http://dx.doi.org/10.1007/s11033-014-3060-6DOI Listing
December 2014
13 Reads
2.024 Impact Factor

Concurrent alterations in TERT, KDM6A, and the BRCA pathway in bladder cancer.

Clin Cancer Res 2014 Sep;20(18):4935-48

Department of Surgery, University of Colorado, Aurora, Colorado. Department of Pharmacology, University of Colorado, Aurora, Colorado. University of Colorado Comprehensive Cancer Center, Aurora, Colorado.

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http://clincancerres.aacrjournals.org/content/20/18/4935.ful
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-14-0330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166537PMC
September 2014
90 Reads
17 Citations
8.722 Impact Factor

Increased incidence and disparity of diagnosis of retinoblastoma patients in Guatemala.

Cancer Lett 2014 Aug 6;351(1):59-63. Epub 2014 May 6.

Stanford University, Stanford, CA 94305, USA; Unidad Nacional de Oncología Pediátrica, Guatemala City, Guatemala; Pediatric Hematology/Oncology/SCT/Cancer Bio, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.canlet.2014.04.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490907PMC
August 2014
8 Reads
5 Citations
5.621 Impact Factor

The new sequencer on the block: comparison of Life Technology's Proton sequencer to an Illumina HiSeq for whole-exome sequencing.

Hum Genet 2013 Oct 12;132(10):1153-63. Epub 2013 Jun 12.

Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 8717 Grovemont Circle, Gaithersburg, MD, 20877, USA,

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http://dx.doi.org/10.1007/s00439-013-1321-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564298PMC
October 2013
18 Reads
24 Citations
4.824 Impact Factor

Somatic alterations contributing to metastasis of a castration-resistant prostate cancer.

Hum Mutat 2013 Sep 3;34(9):1231-41. Epub 2013 Jun 3.

Cancer and Inflammation Program, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA.

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http://dx.doi.org/10.1002/humu.22346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745530PMC
September 2013
6 Reads
13 Citations
5.144 Impact Factor

Polymorphisms in metalloproteinase-9 are associated with the risk for asthma in Mexican pediatric patients.

Hum Immunol 2013 Aug 29;74(8):998-1002. Epub 2013 Apr 29.

Laboratorio de Inmunogenómica y Enfermedades Metabólicas, Instituto Nacional de Medicina Genómica, SS, Mexico City, Mexico.

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http://dx.doi.org/10.1016/j.humimm.2013.04.036DOI Listing
August 2013
16 Reads
4 Citations
2.140 Impact Factor

Genetics and genomics of prostate cancer.

Asian J Androl 2013 May 8;15(3):309-13. Epub 2013 Apr 8.

Cancer and Inflammation Program, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1038/aja.2013.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739637PMC
May 2013
7 Reads
9 Citations
2.530 Impact Factor

Differential gene and microRNA expression between etoposide resistant and etoposide sensitive MCF7 breast cancer cell lines.

PLoS One 2012 18;7(9):e45268. Epub 2012 Sep 18.

Laboratory of Experimental Immunology, Cancer and Inflammation Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0045268PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445463PMC
February 2013
25 Reads
10 Citations
3.234 Impact Factor

The UBIAD1 prenyltransferase links menaquinone-4 [corrected] synthesis to cholesterol metabolic enzymes.

Hum Mutat 2013 Feb 27;34(2):317-29. Epub 2012 Nov 27.

Cancer and Inflammation Program, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1002/humu.22230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444929PMC
February 2013
48 Reads
20 Citations
5.144 Impact Factor

Promoter variants in the MSMB gene associated with prostate cancer regulate MSMB/NCOA4 fusion transcripts.

Hum Genet 2012 Sep 4;131(9):1453-1466. Epub 2012 Jun 4.

Cancer and Inflammation Program, Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1007/s00439-012-1182-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956317PMC
September 2012
11 Reads
8 Citations
4.824 Impact Factor

Multicenter cohort association study of SLC2A1 single nucleotide polymorphisms and age-related macular degeneration.

Mol Vis 2012 17;18:657-74. Epub 2012 Mar 17.

Department of Clinical and Molecular Ophthalmogenetics, The Netherlands Institute for Neuroscience (NIN), Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324365PMC
July 2012
27 Reads
2 Citations
1.990 Impact Factor

Detectable clonal mosaicism and its relationship to aging and cancer.

Authors:
Kevin B Jacobs Meredith Yeager Weiyin Zhou Sholom Wacholder Zhaoming Wang Benjamin Rodriguez-Santiago Amy Hutchinson Xiang Deng Chenwei Liu Marie-Josephe Horner Michael Cullen Caroline G Epstein Laurie Burdett Michael C Dean Nilanjan Chatterjee Joshua Sampson Charles C Chung Joseph Kovaks Susan M Gapstur Victoria L Stevens Lauren T Teras Mia M Gaudet Demetrius Albanes Stephanie J Weinstein Jarmo Virtamo Philip R Taylor Neal D Freedman Christian C Abnet Alisa M Goldstein Nan Hu Kai Yu Jian-Min Yuan Linda Liao Ti Ding You-Lin Qiao Yu-Tang Gao Woon-Puay Koh Yong-Bing Xiang Ze-Zhong Tang Jin-Hu Fan Melinda C Aldrich Christopher Amos William J Blot Cathryn H Bock Elizabeth M Gillanders Curtis C Harris Christopher A Haiman Brian E Henderson Laurence N Kolonel Loic Le Marchand Lorna H McNeill Benjamin A Rybicki Ann G Schwartz Lisa B Signorello Margaret R Spitz John K Wiencke Margaret Wrensch Xifeng Wu Krista A Zanetti Regina G Ziegler Jonine D Figueroa Montserrat Garcia-Closas Nuria Malats Gaelle Marenne Ludmila Prokunina-Olsson Dalsu Baris Molly Schwenn Alison Johnson Maria Teresa Landi Lynn Goldin Dario Consonni Pier Alberto Bertazzi Melissa Rotunno Preetha Rajaraman Ulrika Andersson Laura E Beane Freeman Christine D Berg Julie E Buring Mary A Butler Tania Carreon Maria Feychting Anders Ahlbom J Michael Gaziano Graham G Giles Goran Hallmans Susan E Hankinson Patricia Hartge Roger Henriksson Peter D Inskip Christoffer Johansen Annelie Landgren Roberta McKean-Cowdin Dominique S Michaud Beatrice S Melin Ulrike Peters Avima M Ruder Howard D Sesso Gianluca Severi Xiao-Ou Shu Kala Visvanathan Emily White Alicja Wolk Anne Zeleniuch-Jacquotte Wei Zheng Debra T Silverman Manolis Kogevinas Juan R Gonzalez Olaya Villa Donghui Li Eric J Duell Harvey A Risch Sara H Olson Charles Kooperberg Brian M Wolpin Li Jiao Manal Hassan William Wheeler Alan A Arslan H Bas Bueno-de-Mesquita Charles S Fuchs Steven Gallinger Myron D Gross Elizabeth A Holly Alison P Klein Andrea LaCroix Margaret T Mandelson Gloria Petersen Marie-Christine Boutron-Ruault Paige M Bracci Federico Canzian Kenneth Chang Michelle Cotterchio Edward L Giovannucci Michael Goggins Judith A Hoffman Bolton Mazda Jenab Kay-Tee Khaw Vittorio Krogh Robert C Kurtz Robert R McWilliams Julie B Mendelsohn Kari G Rabe Elio Riboli Anne Tjønneland Geoffrey S Tobias Dimitrios Trichopoulos Joanne W Elena Herbert Yu Laufey Amundadottir Rachael Z Stolzenberg-Solomon Peter Kraft Fredrick Schumacher Daniel Stram Sharon A Savage Lisa Mirabello Irene L Andrulis Jay S Wunder Ana Patiño García Luis Sierrasesúmaga Donald A Barkauskas Richard G Gorlick Mark Purdue Wong-Ho Chow Lee E Moore Kendra L Schwartz Faith G Davis Ann W Hsing Sonja I Berndt Amanda Black Nicolas Wentzensen Louise A Brinton Jolanta Lissowska Beata Peplonska Katherine A McGlynn Michael B Cook Barry I Graubard Christian P Kratz Mark H Greene Ralph L Erickson David J Hunter Gilles Thomas Robert N Hoover Francisco X Real Joseph F Fraumeni Neil E Caporaso Margaret Tucker Nathaniel Rothman Luis A Pérez-Jurado Stephen J Chanock

Nat Genet 2012 May 6;44(6):651-8. Epub 2012 May 6.

Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), Rockville, Maryland, USA.

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http://dx.doi.org/10.1038/ng.2270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372921PMC
May 2012
72 Reads
160 Citations
29.352 Impact Factor

Variation and evolution of the ABC transporter genes ABCB1, ABCC1, ABCG2, ABCG5 and ABCG8: implication for pharmacogenetics and disease.

Drug Metabol Drug Interact 2011 18;26(4):169-79. Epub 2011 Nov 18.

Laboratory of Experimental Immunology, Cancer and Inflammation Program, National Cancer Institute at Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1515/DMDI.2011.027DOI Listing
March 2012
3 Reads
12 Citations

Moving out: from sterol transport to drug resistance - the ABCG subfamily of efflux pumps.

Drug Metabol Drug Interact 2011 27;26(3):105-11. Epub 2011 Sep 27.

National Cancer Institute, Frederick, MD, USA.

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http://dx.doi.org/10.1515/DMDI.2011.015DOI Listing
February 2012
3 Reads
4 Citations

Association assessment of copy number polymorphism and risk of age-related macular degeneration.

Ophthalmology 2011 Dec;118(12):2442-6

SAIC-Frederick, Inc, Frederick, Maryland, USA.

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http://dx.doi.org/10.1016/j.ophtha.2011.05.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223559PMC
December 2011
2 Reads
11 Citations
6.135 Impact Factor

Haplotype structure in Ashkenazi Jewish BRCA1 and BRCA2 mutation carriers.

Authors:
Kate M Im Tomas Kirchhoff Xianshu Wang Todd Green Clement Y Chow Joseph Vijai Joshua Korn Mia M Gaudet Zachary Fredericksen V Shane Pankratz Candace Guiducci Andrew Crenshaw Lesley McGuffog Christiana Kartsonaki Jonathan Morrison Sue Healey Olga M Sinilnikova Phuong L Mai Mark H Greene Marion Piedmonte Wendy S Rubinstein Frans B Hogervorst Matti A Rookus J Margriet Collée Nicoline Hoogerbrugge Christi J van Asperen Hanne E J Meijers-Heijboer Cees E Van Roozendaal Trinidad Caldes Pedro Perez-Segura Anna Jakubowska Jan Lubinski Tomasz Huzarski Paweł Blecharz Heli Nevanlinna Kristiina Aittomäki Conxi Lazaro Ignacio Blanco Rosa B Barkardottir Marco Montagna Emma D'Andrea Peter Devilee Olufunmilayo I Olopade Susan L Neuhausen Bernard Peissel Bernardo Bonanni Paolo Peterlongo Christian F Singer Gad Rennert Flavio Lejbkowicz Irene L Andrulis Gord Glendon Hilmi Ozcelik Amanda Ewart Toland Maria Adelaide Caligo Mary S Beattie Salina Chan Susan M Domchek Katherine L Nathanson Timothy R Rebbeck Catherine Phelan Steven Narod Esther M John John L Hopper Saundra S Buys Mary B Daly Melissa C Southey Mary-Beth Terry Nadine Tung Thomas V O Hansen Ana Osorio Javier Benitez Mercedes Durán Jeffrey N Weitzel Judy Garber Ute Hamann Susan Peock Margaret Cook Clare T Oliver Debra Frost Radka Platte D Gareth Evans Ros Eeles Louise Izatt Joan Paterson Carole Brewer Shirley Hodgson Patrick J Morrison Mary Porteous Lisa Walker Mark T Rogers Lucy E Side Andrew K Godwin Rita K Schmutzler Barbara Wappenschmidt Yael Laitman Alfons Meindl Helmut Deissler Raymonda Varon-Mateeva Sabine Preisler-Adams Karin Kast Laurence Venat-Bouvet Dominique Stoppa-Lyonnet Georgia Chenevix-Trench Douglas F Easton Robert J Klein Mark J Daly Eitan Friedman Michael Dean Andrew G Clark David M Altshuler Antonis C Antoniou Fergus J Couch Kenneth Offit Bert Gold

Hum Genet 2011 Nov 20;130(5):685-99. Epub 2011 May 20.

Center for Cancer Research, Cancer Inflammation Program, Human Genetics Section, National Cancer Institute, Frederick, MD, USA.

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http://dx.doi.org/10.1007/s00439-011-1003-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196382PMC
November 2011
118 Reads
7 Citations
4.824 Impact Factor

Analysis of the ABCA4 gene by next-generation sequencing.

Invest Ophthalmol Vis Sci 2011 Oct 31;52(11):8479-87. Epub 2011 Oct 31.

Department of Ophthalmology, Columbia University, New York, New York 10032, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208189PMC
October 2011
24 Reads
46 Citations
3.404 Impact Factor

Conserved intramolecular disulfide bond is critical to trafficking and fate of ATP-binding cassette (ABC) transporters ABCB6 and sulfonylurea receptor 1 (SUR1)/ABCC8.

J Biol Chem 2011 Mar 3;286(10):8481-92. Epub 2011 Jan 3.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1074/jbc.M110.174516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048732PMC
March 2011
8 Reads
17 Citations
4.573 Impact Factor

Evolution of ABC transporters by gene duplication and their role in human disease.

Biol Chem 2011 Jan;392(1-2):29-37

Laboratory of Experimental Immunology, Human Genetics Section, Cancer and Inflammation Program, National Cancer Institute at Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1515/BC.2011.006DOI Listing
January 2011
5 Reads
15 Citations
3.270 Impact Factor

Molecular evolutionary analysis of ABCB5: the ancestral gene is a full transporter with potentially deleterious single nucleotide polymorphisms.

PLoS One 2011 Jan 27;6(1):e16318. Epub 2011 Jan 27.

Laboratory of Experimental Immunology, Human Genetics Section, Cancer and Inflammation Program, National Cancer Institute at Frederick, Frederick, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0016318PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029322PMC
January 2011
4 Reads
10 Citations
3.234 Impact Factor

The ERCC6 gene and age-related macular degeneration.

PLoS One 2010 Nov 1;5(11):e13786. Epub 2010 Nov 1.

Department of Clinical and Molecular Ophthalmogenetics, The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967476PMC
November 2010
18 Reads
6 Citations
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Common genetic variants and modification of penetrance of BRCA2-associated breast cancer.

Authors:
Mia M Gaudet Tomas Kirchhoff Todd Green Joseph Vijai Joshua M Korn Candace Guiducci Ayellet V Segrè Kate McGee Lesley McGuffog Christiana Kartsonaki Jonathan Morrison Sue Healey Olga M Sinilnikova Dominique Stoppa-Lyonnet Sylvie Mazoyer Marion Gauthier-Villars Hagay Sobol Michel Longy Marc Frenay GEMO Study Collaborators Frans B L Hogervorst Matti A Rookus J Margriet Collée Nicoline Hoogerbrugge Kees E P van Roozendaal Marion Piedmonte Wendy Rubinstein Stacy Nerenstone Linda Van Le Stephanie V Blank Trinidad Caldés Miguel de la Hoya Heli Nevanlinna Kristiina Aittomäki Conxi Lazaro Ignacio Blanco Adalgeir Arason Oskar T Johannsson Rosa B Barkardottir Peter Devilee Olofunmilayo I Olopade Susan L Neuhausen Xianshu Wang Zachary S Fredericksen Paolo Peterlongo Siranoush Manoukian Monica Barile Alessandra Viel Paolo Radice Catherine M Phelan Steven Narod Gad Rennert Flavio Lejbkowicz Anath Flugelman Irene L Andrulis Gord Glendon Hilmi Ozcelik Amanda E Toland Marco Montagna Emma D'Andrea Eitan Friedman Yael Laitman Ake Borg Mary Beattie Susan J Ramus Susan M Domchek Katherine L Nathanson Tim Rebbeck Amanda B Spurdle Xiaoqing Chen Helene Holland Esther M John John L Hopper Saundra S Buys Mary B Daly Melissa C Southey Mary Beth Terry Nadine Tung Thomas V Overeem Hansen Finn C Nielsen Mark H Greene Mark I Greene Phuong L Mai Ana Osorio Mercedes Durán Raquel Andres Javier Benítez Jeffrey N Weitzel Judy Garber Ute Hamann Susan Peock Margaret Cook Clare Oliver Debra Frost Radka Platte D Gareth Evans Fiona Lalloo Ros Eeles Louise Izatt Lisa Walker Jacqueline Eason Julian Barwell Andrew K Godwin Rita K Schmutzler Barbara Wappenschmidt Stefanie Engert Norbert Arnold Dorothea Gadzicki Michael Dean Bert Gold Robert J Klein Fergus J Couch Georgia Chenevix-Trench Douglas F Easton Mark J Daly Antonis C Antoniou David M Altshuler Kenneth Offit

PLoS Genet 2010 Oct 28;6(10):e1001183. Epub 2010 Oct 28.

Department of Epidemiology and Population Health and Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine, New York, New York, United States of America.

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October 2010
114 Reads
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