Michael D Wilson

Michael D Wilson

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Michael D Wilson

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Pharmacoinformatics-based identification of potential bioactive compounds against Ebola virus protein VP24.

Comput Biol Med 2019 Oct 28;113:103414. Epub 2019 Aug 28.

Department of Virology, Noguchi Memorial Institute for Medical Research (NMIMR), College of Health Sciences (CHS), University of Ghana, P.O. Box LG 581, Legon, Accra, Ghana.

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https://linkinghub.elsevier.com/retrieve/pii/S00104825193029
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http://dx.doi.org/10.1016/j.compbiomed.2019.103414DOI Listing
October 2019

Levels of serum eosinophil cationic protein are associated with hookworm infection and intensity in endemic communities in Ghana.

PLoS One 2019 12;14(9):e0222382. Epub 2019 Sep 12.

Department of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0222382PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742367PMC
September 2019

Regulation of expression in human vascular endothelial cells by a neighboring divergently transcribed long noncoding RNA.

Proc Natl Acad Sci U S A 2019 Aug 26;116(33):16410-16419. Epub 2019 Jul 26.

Toronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 2C4, Canada;

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http://dx.doi.org/10.1073/pnas.1904108116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697820PMC
August 2019

Break Check: Transcription-Driven Topoisomerase II Collisions near Chromatin Loop Anchors Are Hotspots for DNA Damage and Translocations.

Mol Cell 2019 Jul;75(2):203-205

Genetics and Genome Biology Program, SickKids Research Institute, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.07.003DOI Listing
July 2019

The long road home from distraction: Investigating the time-course of distraction recovery in driving.

Accid Anal Prev 2019 Mar 2;124:23-32. Epub 2019 Jan 2.

University of Western Australia, Australia.

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http://dx.doi.org/10.1016/j.aap.2018.12.012DOI Listing
March 2019

Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma.

Dev Cell 2019 01 13;48(2):167-183.e5. Epub 2018 Dec 13.

Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Joint Institute of Genetics and Genomic Medicine, Zhejiang University and University of Toronto, Toronto, ON, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15345807183093
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http://dx.doi.org/10.1016/j.devcel.2018.11.015DOI Listing
January 2019

Hey2 regulates the size of the cardiac progenitor pool during vertebrate heart development.

Development 2018 11 21;145(22). Epub 2018 Nov 21.

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada

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http://dx.doi.org/10.1242/dev.167510DOI Listing
November 2018

Heart enhancers with deeply conserved regulatory activity are established early in zebrafish development.

Nat Commun 2018 11 26;9(1):4977. Epub 2018 Nov 26.

Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.

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http://dx.doi.org/10.1038/s41467-018-07451-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255839PMC
November 2018

The transcriptional regulator CCCTC-binding factor limits oxidative stress in endothelial cells.

J Biol Chem 2018 06 2;293(22):8449-8461. Epub 2018 Apr 2.

From the Translational Medicine Research Program, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada,

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http://dx.doi.org/10.1074/jbc.M117.814699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986204PMC
June 2018

Screening of Isocitrate Lyase for Novel Anti-Buruli Ulcer Natural Products Originating from Africa.

Molecules 2018 06 27;23(7). Epub 2018 Jun 27.

Department of Parasitology, Noguchi Memorial Institute for Medical Research (NMIMR), College of Health Sciences (CHS), University of Ghana, P. O. Box LG 77, Legon, Accra, Ghana.

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http://dx.doi.org/10.3390/molecules23071550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100440PMC
June 2018

Twelve-month longitudinal parasitological assessment of lymphatic filariasis-positive individuals: impact of a biannual treatment with ivermectin and albendazole.

Trop Med Int Health 2017 11 26;22(11):1451-1456. Epub 2017 Sep 26.

Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.

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http://dx.doi.org/10.1111/tmi.12974DOI Listing
November 2017

Seasonality and Locality Affect the Diversity of Anopheles gambiae and Anopheles coluzzii Midgut Microbiota from Ghana.

PLoS One 2016 20;11(6):e0157529. Epub 2016 Jun 20.

Department of Parasitology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, P.O. Box LG 581, Legon, Accra, Ghana.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157529PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913965PMC
July 2017

G9a controls placental vascular maturation by activating the Notch Pathway.

Development 2017 06 28;144(11):1976-1987. Epub 2017 Apr 28.

Translational Medicine, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada

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http://dx.doi.org/10.1242/dev.148916DOI Listing
June 2017

A de novo deletion in a boy with cerebral palsy suggests a refined critical region for the 4q21.22 microdeletion syndrome.

Am J Med Genet A 2017 May 3;173(5):1287-1293. Epub 2017 Apr 3.

The Centre for Applied Genomics and Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/ajmg.a.38176DOI Listing
May 2017

Epigenetics of Atherosclerosis: Emerging Mechanisms and Methods.

Trends Mol Med 2017 04 11;23(4):332-347. Epub 2017 Mar 11.

Toronto General Hospital Research Institute, University Health Network, Toronto, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada; Heart & Stroke Richard Lewar Centre of Excellence in Cardiovascular Research, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2017.02.004DOI Listing
April 2017

Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia.

Elife 2017 01 9;6. Epub 2017 Jan 9.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.7554/eLife.15085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222559PMC
January 2017

Carriage of sub-microscopic sexual and asexual stages in the dry season at Navrongo, Ghana.

Ghana Med J 2016 Dec;50(4):220-227

Parasitology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, P. O. Box LG 581, Legon, Ghana.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443672PMC
http://dx.doi.org/10.4314/gmj.v50i4.4DOI Listing
December 2016

Onchocerciasis transmission in Ghana: the human blood index of sibling species of the Simulium damnosum complex.

Parasit Vectors 2016 08 5;9(1):432. Epub 2016 Aug 5.

London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine (St Mary's campus), Imperial College London, Norfolk Place, London, W2 1PG, UK.

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http://dx.doi.org/10.1186/s13071-016-1703-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975878PMC
August 2016

A microRNA-328 binding site in PAX6 is associated with centrotemporal spikes of rolandic epilepsy.

Ann Clin Transl Neurol 2016 07 2;3(7):512-22. Epub 2016 Jun 2.

Program in Genetics and Genome Biology The Hospital for Sick Children Toronto Ontario M5G 0A4 Canada; Division of Biostatistics Dalla Lana School of Public Health University of Toronto Toronto Ontario M5T 3M7 Canada; The Centre for Applied Genomics The Hospital for Sick Children Toronto Ontario M5G 0A4 Canada.

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http://dx.doi.org/10.1002/acn3.320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931716PMC
July 2016

Decreased Transcription Factor Binding Levels Nearby Primate Pseudogenes Suggest Regulatory Degeneration.

Mol Biol Evol 2016 06 16;33(6):1478-85. Epub 2016 Feb 16.

Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada

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http://dx.doi.org/10.1093/molbev/msw030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868113PMC
June 2016

Does Increasing Treatment Frequency Address Suboptimal Responses to Ivermectin for the Control and Elimination of River Blindness?

Clin Infect Dis 2016 06 21;62(11):1338-1347. Epub 2016 Mar 21.

London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London.

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http://dx.doi.org/10.1093/cid/ciw144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872292PMC
June 2016

Spell Checking Nature: Versatility of CRISPR/Cas9 for Developing Treatments for Inherited Disorders.

Am J Hum Genet 2016 Jan 10;98(1):90-101. Epub 2015 Dec 10.

Program in Genetics and Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Paediatrics, University of Toronto, Toronto, ON M5G 1X8, Canada; Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Centre for Genetic Medicine, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. Electronic address:

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http://www.cell.com/cms/attachment/2040911867/2054828527/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S000292971500457
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http://dx.doi.org/10.1016/j.ajhg.2015.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716669PMC
January 2016

RNAseq analysis for the diagnosis of muscular dystrophy.

Ann Clin Transl Neurol 2016 01 8;3(1):55-60. Epub 2015 Dec 8.

Division of Neurology Hospital for Sick Children Toronto Ontario Canada M5G A04; Program of Genetics and Genome Biology Hospital for Sick Children Toronto Ontario Canada M5G A04; Department of Paediatrics University of Toronto Toronto Ontario Canada M5G AO4; Department of Molecular Genetics University of Toronto Toronto Ontario Canada M5G AO4.

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http://dx.doi.org/10.1002/acn3.267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704476PMC
January 2016

Epigenetics: a new player in the regulation of mammalian puberty.

Neuroendocrinology 2014 4;99(3-4):139-55. Epub 2014 Apr 4.

Division of Endocrinology, Hospital for Sick Children, Toronto, Ont., Canada.

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http://dx.doi.org/10.1159/000362559DOI Listing
June 2015

Onchocerciasis transmission in Ghana: persistence under different control strategies and the role of the simuliid vectors.

PLoS Negl Trop Dis 2015 Apr 21;9(4):e0003688. Epub 2015 Apr 21.

London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pntd.0003688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405193PMC
April 2015

MACE: model based analysis of ChIP-exo.

Nucleic Acids Res 2014 Nov 23;42(20):e156. Epub 2014 Sep 23.

Division of Biostatistics, Dan L. Duncan Cancer Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA

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http://dx.doi.org/10.1093/nar/gku846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227761PMC
November 2014

Onchocerciasis transmission in Ghana: biting and parous rates of host-seeking sibling species of the Simulium damnosum complex.

Parasit Vectors 2014 Nov 21;7:511. Epub 2014 Nov 21.

London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, St Mary's Campus, London, W2 1PG, UK.

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http://dx.doi.org/10.1186/s13071-014-0511-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247625PMC
November 2014

Basophil depletion downregulates Schistosoma mansoni egg-induced granuloma formation.

Parasitol Int 2013 Dec 12;62(6):508-13. Epub 2013 Jul 12.

Department of Environmental Parasitology, Tokyo Medical and Dental University, Tokyo 113-8519, Japan; Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.

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http://dx.doi.org/10.1016/j.parint.2013.07.003DOI Listing
December 2013

Rapid turnover of long noncoding RNAs and the evolution of gene expression.

PLoS Genet 2012 26;8(7):e1002841. Epub 2012 Jul 26.

Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1002841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406015PMC
January 2013

Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules.

Genome Res 2012 Nov 10;22(11):2163-75. Epub 2012 Jul 10.

European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.

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http://dx.doi.org/10.1101/gr.136507.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483546PMC
November 2012

Pol III binding in six mammals shows conservation among amino acid isotypes despite divergence among tRNA genes.

Nat Genet 2011 Aug 28;43(10):948-55. Epub 2011 Aug 28.

Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184141PMC
August 2011

Plasmodium falciparum isolates from southern Ghana exhibit polymorphisms in the SERCA-type PfATPase6 though sensitive to artesunate in vitro.

Malar J 2011 Jul 11;10:187. Epub 2011 Jul 11.

Section of Environmental Parasitology, Department of International Health Development, Tokyo Medical and Dental University, 5-45 Yushima 1-chome, Bunkyo-ku, Tokyo, Japan.

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http://dx.doi.org/10.1186/1475-2875-10-187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146903PMC
July 2011

High body mass index is not associated with atopy in schoolchildren living in rural and urban areas of Ghana.

BMC Public Health 2011 Jun 14;11:469. Epub 2011 Jun 14.

Division of Epidemiology & Biostatistics, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

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http://dx.doi.org/10.1186/1471-2458-11-469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141453PMC
June 2011

Adaptive divergence between incipient species of Anopheles gambiae increases resistance to Plasmodium.

Proc Natl Acad Sci U S A 2011 Jan 20;108(1):244-9. Epub 2010 Dec 20.

Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.

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http://dx.doi.org/10.1073/pnas.1013648108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017163PMC
January 2011

Selective sweeps and genetic lineages of Plasmodium falciparum drug -resistant alleles in Ghana.

J Infect Dis 2011 Jan;203(2):220-7

Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.

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http://dx.doi.org/10.1093/infdis/jiq038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071065PMC
January 2011

Studies of Anopheles gambiae s.l (Diptera: Culicidae) exhibiting different vectorial capacities in lymphatic filariasis transmission in the Gomoa district, Ghana.

Parasit Vectors 2010 Sep 14;3:85. Epub 2010 Sep 14.

Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, P,O, Box LG 581, Legon, Accra, Ghana.

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http://parasitesandvectors.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/1756-3305-3-85DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949826PMC
September 2010

Zonadhesin is essential for species specificity of sperm adhesion to the egg zona pellucida.

J Biol Chem 2010 Aug 7;285(32):24863-70. Epub 2010 Jun 7.

Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430-6540, USA.

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http://www.jbc.org/content/285/32/24863.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M110.123125
Publisher Site
http://dx.doi.org/10.1074/jbc.M110.123125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915722PMC
August 2010

Disruption of the single copy gonadotropin-releasing hormone receptor in mice by gene trap: severe reduction of reproductive organs and functions in developing and adult mice.

Endocrinology 2010 Mar 12;151(3):1142-52. Epub 2010 Jan 12.

Department of Biology, University of Victoria, 3800 Finnerty Road, Victoria, British Columbia, Canada.

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http://dx.doi.org/10.1210/en.2009-0598DOI Listing
March 2010

Evolution of transcriptional control in mammals.

Curr Opin Genet Dev 2009 Dec 11;19(6):579-85. Epub 2009 Nov 11.

Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

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http://dx.doi.org/10.1016/j.gde.2009.10.003DOI Listing
December 2009

ChIP-seq: using high-throughput sequencing to discover protein-DNA interactions.

Methods 2009 Jul 9;48(3):240-8. Epub 2009 Mar 9.

Department of Oncology, Hutchison/MRC Research Centre, Hills Road, Cambridge CB20XZ, UK.

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http://dx.doi.org/10.1016/j.ymeth.2009.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052679PMC
July 2009

Genome-scale validation of deep-sequencing libraries.

PLoS One 2008 12;3(11):e3713. Epub 2008 Nov 12.

Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0003713PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577887PMC
December 2008

Species-specific transcription in mice carrying human chromosome 21.

Science 2008 Oct 11;322(5900):434-8. Epub 2008 Sep 11.

Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

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http://dx.doi.org/10.1126/science.1160930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717767PMC
October 2008

Impact of urban agriculture on malaria vectors in Accra, Ghana.

Malar J 2008 Aug 4;7:151. Epub 2008 Aug 4.

International Water Management Institute (IWMI), West Africa Office, Ghana.

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http://dx.doi.org/10.1186/1475-2875-7-151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515328PMC
August 2008

ARS2 is a conserved eukaryotic gene essential for early mammalian development.

Mol Cell Biol 2008 Mar 17;28(5):1503-14. Epub 2007 Dec 17.

Centre for Biomedical Research, University of Victoria, P.O. Box 3020 Station CSC, Victoria, BC, Canada.

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http://dx.doi.org/10.1128/MCB.01565-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258792PMC
March 2008

Ecological zones rather than molecular forms predict genetic differentiation in the malaria vector Anopheles gambiae s.s. in Ghana.

Genetics 2007 Feb 16;175(2):751-61. Epub 2006 Nov 16.

Vector Group, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom.

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http://dx.doi.org/10.1534/genetics.106.065888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1800615PMC
February 2007

Mutations in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance genes, and treatment outcomes in Ghanaian children with uncomplicated malaria.

J Trop Pediatr 2007 Feb 10;53(1):27-31. Epub 2006 Dec 10.

Noguchi Memorial Institute for Medical Research, University of Ghana, P.O. Box LG581, Legon, Ghana.

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http://dx.doi.org/10.1093/tropej/fml076DOI Listing
February 2007

Comparative analysis of the paired immunoglobulin-like receptor (PILR) locus in six mammalian genomes: duplication, conversion, and the birth of new genes.

Physiol Genomics 2006 Nov 22;27(3):201-18. Epub 2006 Aug 22.

Centre for Biomedical Research, Department of Biology, University of Victoria, British Columbia, Canada.

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http://dx.doi.org/10.1152/physiolgenomics.00284.2005DOI Listing
November 2006

Short report: ITS-1 DNA sequence confirmation of Leishmania major as a cause of cutaneous leishmaniasis from an outbreak focus in the Ho district, southeastern Ghana.

Am J Trop Med Hyg 2006 Sep;75(3):502-4

Research Science Directorate, Enteric Disease Research Program, Vector Biology Research Program, Ghana Detachment, US Naval Medical Research Unit 3, Cairo, Egypt.

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September 2006

Expression and genomic organization of zonadhesin-like genes in three species of fish give insight into the evolutionary history of a mosaic protein.

BMC Genomics 2005 Nov 22;6:165. Epub 2005 Nov 22.

Centre for Biomedical Research, University of Victoria, Victoria, British Columbia V8W 3N5, Canada.

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http://dx.doi.org/10.1186/1471-2164-6-165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1325057PMC
November 2005

Malaria and irrigated crops, Accra, Ghana.

Emerg Infect Dis 2005 Aug;11(8):1290-3

Liverpool School of Tropical Medicine, Liverpool, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320508PMC
http://dx.doi.org/10.3201/eid1108.041095DOI Listing
August 2005