Michael D Taylor

Michael D Taylor

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Michael D Taylor

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Conservative gadolinium administration to patients with Duchenne muscular dystrophy: decreasing exposure, cost, and time, without change in medical management.

Int J Cardiovasc Imaging 2019 Dec 18;35(12):2213-2219. Epub 2019 Jul 18.

Heart Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 2003, Cincinnati, OH, 45229, USA.

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http://dx.doi.org/10.1007/s10554-019-01670-1DOI Listing
December 2019

Effects of Normal Variation in the Rotational Position of the Aortic Root on Hemodynamics and Tissue Biomechanics of the Thoracic Aorta.

Cardiovasc Eng Technol 2019 Nov 7. Epub 2019 Nov 7.

Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.

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http://dx.doi.org/10.1007/s13239-019-00441-2DOI Listing
November 2019

Postoperative isolated lower extremity supplementary motor area syndrome: case report and review of the literature.

Childs Nerv Syst 2019 Nov 9. Epub 2019 Nov 9.

Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s00381-019-04362-2DOI Listing
November 2019

Re-irradiation for children with recurrent medulloblastoma in Toronto, Canada: a 20-year experience.

J Neurooncol 2019 Oct 29;145(1):107-114. Epub 2019 Aug 29.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, 610 University Avenue, Toronto, ON, M5G 2M9, Canada.

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http://dx.doi.org/10.1007/s11060-019-03272-2DOI Listing
October 2019

Medulloblastoma in the age of molecular subgroups: a review.

J Neurosurg Pediatr 2019 Oct;24(4):353-363

1Division of Neurosurgery.

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http://dx.doi.org/10.3171/2019.5.PEDS18381DOI Listing
October 2019

The U1 spliceosomal RNA is recurrently mutated in multiple cancers.

Nature 2019 Oct 9;574(7780):712-716. Epub 2019 Oct 9.

Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41586-019-1651-zDOI Listing
October 2019

Commentary: An unusual case of crossing coronaries.

Authors:
Michael D Taylor

J Thorac Cardiovasc Surg 2019 Sep 24;158(3):e111-e112. Epub 2019 Apr 24.

Department of Pediatric Cardiology, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. Electronic address:

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http://dx.doi.org/10.1016/j.jtcvs.2019.04.030DOI Listing
September 2019

Cardiac MRI Evaluation of Neonatal Bronchopulmonary Dysplasia Associated Pulmonary Hypertension.

Am J Respir Crit Care Med 2019 Sep 20. Epub 2019 Sep 20.

Cincinnati Children's Hospital Medical Center, Pediatrics & Radiology, Cincinnati, Ohio, United States;

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http://dx.doi.org/10.1164/rccm.201904-0826OCDOI Listing
September 2019

Upregulation of the chromatin remodeler HELLS is mediated by YAP1 in Sonic Hedgehog Medulloblastoma.

Sci Rep 2019 Sep 20;9(1):13611. Epub 2019 Sep 20.

Department of Pediatric Oncology, Emory University, Atlanta, GA, 30322, USA.

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http://dx.doi.org/10.1038/s41598-019-50088-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754407PMC
September 2019

mDixon ECG-gated 3-dimensional cardiovascular magnetic resonance angiography in patients with congenital cardiovascular disease.

J Cardiovasc Magn Reson 2019 Aug 8;21(1):52. Epub 2019 Aug 8.

The Heart Institute, Department of Pediatrics, David's Medical Center, 919 East 32nd Street, Austin, TX, 78705, USA.

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http://dx.doi.org/10.1186/s12968-019-0554-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686451PMC
August 2019

A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor.

Cancer Cell 2019 Jul;36(1):51-67.e7

Arthur and Sonia Labatt Brain Tumor Research Centre, Division of Haematology/Oncology, Hospital for Sick Children, Toronto, ON M5G0A4, Canada; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S1A8, Canada; Division of Hematology-Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON M5G1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.06.002DOI Listing
July 2019

Subgroup-specific prognostic signaling and metabolic pathways in pediatric medulloblastoma.

BMC Cancer 2019 Jun 11;19(1):571. Epub 2019 Jun 11.

Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1186/s12885-019-5742-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560914PMC
June 2019

Incidence of metastatic disease and survival among patients with newly diagnosed primary CNS tumors in the United States from 2004-2013.

J Cancer 2019 2;10(13):3037-3045. Epub 2019 Jun 2.

Department of Pediatric Neurosurgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.

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http://dx.doi.org/10.7150/jca.30624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590036PMC
June 2019

Antitumor Activities and Cellular Changes Induced by TrkB Inhibition in Medulloblastoma.

Front Pharmacol 2019 26;10:698. Epub 2019 Jun 26.

Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, Brazil.

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http://dx.doi.org/10.3389/fphar.2019.00698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606946PMC
June 2019

Bioinformatic Strategies for the Genomic and Epigenomic Characterization of Brain Tumors.

Methods Mol Biol 2019 ;1869:37-56

Division of Neurosurgery, Hospital for Sick Children, Toronto, ON, Canada.

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http://link.springer.com/10.1007/978-1-4939-8805-1_4
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http://dx.doi.org/10.1007/978-1-4939-8805-1_4DOI Listing
May 2019

Picosecond Infrared Laser Desorption Mass Spectrometry Identifies Medulloblastoma Subgroups on Intrasurgical Timescales.

Cancer Res 2019 May 19;79(9):2426-2434. Epub 2019 Mar 19.

Techna Institute for the Advancement of Technology for Health, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-3411DOI Listing
May 2019

The influence of depth and a subsea pipeline on fish assemblages and commercially fished species.

PLoS One 2018 26;13(11):e0207703. Epub 2018 Nov 26.

The UWA Oceans Institute, The University of Western Australia, Crawley, Western Australia, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207703PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257935PMC
April 2019

Anatomical predictors of conduction damage after transcatheter implantation of the aortic valve.

Open Heart 2019 9;6(1):e000972. Epub 2019 Apr 9.

Department of Ohio Heart and Vascular, The Christ Hospital and Lindner Center for Research and Education, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1136/openhrt-2018-000972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519402PMC
April 2019

Medulloblastoma.

Nat Rev Dis Primers 2019 02 14;5(1):11. Epub 2019 Feb 14.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41572-019-0063-6DOI Listing
February 2019

Leptomeningeal dissemination: a sinister pattern of medulloblastoma growth.

J Neurosurg Pediatr 2019 Feb 15:1-9. Epub 2019 Feb 15.

3Cancer Research Program, Research Institute of the McGill University Health Center and Department of Surgery, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.3171/2018.11.PEDS18506DOI Listing
February 2019

p53 Function Is Compromised by Inhibitor 2 of Phosphatase 2A in Sonic Hedgehog Medulloblastoma.

Mol Cancer Res 2019 01 17;17(1):186-198. Epub 2018 Sep 17.

Department of Pediatrics, Emory University, Atlanta, Georgia.

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http://dx.doi.org/10.1158/1541-7786.MCR-18-0485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318027PMC
January 2019

Magnetic resonance imaging computation of intracardiac flow derangements in heart failure dyssynchrony.

Am J Physiol Heart Circ Physiol 2019 Jan 19;316(1):H10-H12. Epub 2018 Oct 19.

Taussig Heart Center, Johns Hopkins University School of Medicine , Baltimore, Maryland.

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http://dx.doi.org/10.1152/ajpheart.00676.2018DOI Listing
January 2019

Infusion of 5-Azacytidine (5-AZA) into the fourth ventricle or resection cavity in children with recurrent posterior Fossa Ependymoma: a pilot clinical trial.

J Neurooncol 2019 Jan 20;141(2):449-457. Epub 2018 Nov 20.

Developmental and Stem Cell Biology Program, The Arthur and Sonia Labatt Brain Tumour Center, Division of Neurosurgery, Hospital for Sick children, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s11060-018-03055-1DOI Listing
January 2019

Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma.

Dev Cell 2019 01 13;48(2):167-183.e5. Epub 2018 Dec 13.

Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Joint Institute of Genetics and Genomic Medicine, Zhejiang University and University of Toronto, Toronto, ON, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15345807183093
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http://dx.doi.org/10.1016/j.devcel.2018.11.015DOI Listing
January 2019

Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors.

Acta Neuropathol Commun 2018 12 4;6(1):134. Epub 2018 Dec 4.

Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

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https://actaneurocomms.biomedcentral.com/articles/10.1186/s4
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http://dx.doi.org/10.1186/s40478-018-0630-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278135PMC
December 2018

A functional genomics approach to identify pathways of drug resistance in medulloblastoma.

Acta Neuropathol Commun 2018 12 27;6(1):146. Epub 2018 Dec 27.

Department of Developmental and Stem Cell Biology and Regenerative Medicine, The Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.1186/s40478-018-0652-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307130PMC
December 2018

Physiologically-based pharmacokinetic modeling suggests similar bioavailability of Mn from diet and drinking water.

Toxicol Appl Pharmacol 2018 11 20;359:70-81. Epub 2018 Sep 20.

ScitoVation, LLC., Research Triangle Park, NC, USA; ToxStrategies, Inc., Cary, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2018.09.023DOI Listing
November 2018

Evaluation of pulmonary artery stenosis in congenital heart disease patients using functional diagnostic parameters: An in vitro study.

J Biomech 2018 11 15;81:58-67. Epub 2018 Sep 15.

The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jbiomech.2018.09.014DOI Listing
November 2018

The clinical importance of medulloblastoma extent of resection: a systematic review.

J Neurooncol 2018 Sep 23;139(3):523-539. Epub 2018 May 23.

Division of Haematology/Oncology, The Arthur and Sonia Labatt Brain Tumour Research Centre, Programme in Neuroscience and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s11060-018-2906-5DOI Listing
September 2018

Diastolic dysfunction is associated with exercise impairment in patients with sickle cell anemia.

Pediatr Blood Cancer 2018 08 21;65(8):e27113. Epub 2018 May 21.

Division of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://dx.doi.org/10.1002/pbc.27113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019177PMC
August 2018

CD271 Cells Are Diagnostic and Prognostic and Exhibit Elevated MAPK Activity in SHH Medulloblastoma.

Cancer Res 2018 08 21;78(16):4745-4759. Epub 2018 Jun 21.

Regenerative Medicine Program, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-0027DOI Listing
August 2018

Three-dimensional printing and virtual surgery for congenital heart procedural planning.

Birth Defects Res 2018 08 6;110(13):1082-1090. Epub 2018 Aug 6.

The Heart Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati Department of Pediatrics, Cincinnati, Ohio.

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http://doi.wiley.com/10.1002/bdr2.1370
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http://dx.doi.org/10.1002/bdr2.1370DOI Listing
August 2018

Editorial commentary: Preserving myocardium in muscular dystrophy patients using ACE inhibition.

Authors:
Michael D Taylor

Trends Cardiovasc Med 2018 07 20;28(5):338-339. Epub 2018 Feb 20.

The Heart Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue Cincinnati, OH 45229. Electronic address:

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http://dx.doi.org/10.1016/j.tcm.2018.02.006DOI Listing
July 2018

Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.

Lancet Oncol 2018 06 9;19(6):785-798. Epub 2018 May 9.

Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Hopp Children's Cancer Center at the NCT Heidelberg, Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14702045183024
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http://dx.doi.org/10.1016/S1470-2045(18)30242-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984248PMC
June 2018

Proteomic analysis of Medulloblastoma reveals functional biology with translational potential.

Acta Neuropathol Commun 2018 06 7;6(1):48. Epub 2018 Jun 7.

Center for Cancer and Immunology Research, Children's Research Institute, Children's National Health System, Washington, DC, USA.

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http://dx.doi.org/10.1186/s40478-018-0548-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992829PMC
June 2018

TGF-β Determines the Pro-migratory Potential of bFGF Signaling in Medulloblastoma.

Cell Rep 2018 06;23(13):3798-3812.e8

Paediatric Neuro-Oncology Research Group, Department of Oncology, Children's Research Center, University Children's Hospital Zürich, August-Forel Strasse 1, CH-8008 Zürich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.05.083DOI Listing
June 2018

CAR T cells for childhood diffuse midline gliomas.

Nat Med 2018 05;24(5):534-535

Division of Neurosurgery, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41591-018-0031-9DOI Listing
May 2018

Medulloblastoma in the Molecular Era.

J Korean Neurosurg Soc 2018 May 1;61(3):292-301. Epub 2018 May 1.

Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.3340/jkns.2018.0028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957312PMC
May 2018

DNA methylation-based classification of central nervous system tumours.

Authors:
David Capper David T W Jones Martin Sill Volker Hovestadt Daniel Schrimpf Dominik Sturm Christian Koelsche Felix Sahm Lukas Chavez David E Reuss Annekathrin Kratz Annika K Wefers Kristin Huang Kristian W Pajtler Leonille Schweizer Damian Stichel Adriana Olar Nils W Engel Kerstin Lindenberg Patrick N Harter Anne K Braczynski Karl H Plate Hildegard Dohmen Boyan K Garvalov Roland Coras Annett Hölsken Ekkehard Hewer Melanie Bewerunge-Hudler Matthias Schick Roger Fischer Rudi Beschorner Jens Schittenhelm Ori Staszewski Khalida Wani Pascale Varlet Melanie Pages Petra Temming Dietmar Lohmann Florian Selt Hendrik Witt Till Milde Olaf Witt Eleonora Aronica Felice Giangaspero Elisabeth Rushing Wolfram Scheurlen Christoph Geisenberger Fausto J Rodriguez Albert Becker Matthias Preusser Christine Haberler Rolf Bjerkvig Jane Cryan Michael Farrell Martina Deckert Jürgen Hench Stephan Frank Jonathan Serrano Kasthuri Kannan Aristotelis Tsirigos Wolfgang Brück Silvia Hofer Stefanie Brehmer Marcel Seiz-Rosenhagen Daniel Hänggi Volkmar Hans Stephanie Rozsnoki Jordan R Hansford Patricia Kohlhof Bjarne W Kristensen Matt Lechner Beatriz Lopes Christian Mawrin Ralf Ketter Andreas Kulozik Ziad Khatib Frank Heppner Arend Koch Anne Jouvet Catherine Keohane Helmut Mühleisen Wolf Mueller Ute Pohl Marco Prinz Axel Benner Marc Zapatka Nicholas G Gottardo Pablo Hernáiz Driever Christof M Kramm Hermann L Müller Stefan Rutkowski Katja von Hoff Michael C Frühwald Astrid Gnekow Gudrun Fleischhack Stephan Tippelt Gabriele Calaminus Camelia-Maria Monoranu Arie Perry Chris Jones Thomas S Jacques Bernhard Radlwimmer Marco Gessi Torsten Pietsch Johannes Schramm Gabriele Schackert Manfred Westphal Guido Reifenberger Pieter Wesseling Michael Weller Vincent Peter Collins Ingmar Blümcke Martin Bendszus Jürgen Debus Annie Huang Nada Jabado Paul A Northcott Werner Paulus Amar Gajjar Giles W Robinson Michael D Taylor Zane Jaunmuktane Marina Ryzhova Michael Platten Andreas Unterberg Wolfgang Wick Matthias A Karajannis Michel Mittelbronn Till Acker Christian Hartmann Kenneth Aldape Ulrich Schüller Rolf Buslei Peter Lichter Marcel Kool Christel Herold-Mende David W Ellison Martin Hasselblatt Matija Snuderl Sebastian Brandner Andrey Korshunov Andreas von Deimling Stefan M Pfister

Nature 2018 03 14;555(7697):469-474. Epub 2018 Mar 14.

Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature26000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093218PMC
March 2018

Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma.

Dev Cell 2018 03 15;44(6):709-724.e6. Epub 2018 Mar 15.

Center for Neuropathology, Ludwig-Maximilians-University, 81377 Munich, Germany; Research Institute Children's Cancer Center Hamburg, Martinistrasse 52, N63 (HPI), Hamburg 20251, Germany; Institute of Neuropathology, University Medical Center, Hamburg-Eppendorf, 20246 Hamburg, Germany; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, 20246 Hamburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2018.02.012DOI Listing
March 2018

Review of molecular classification and treatment implications of pediatric brain tumors.

Curr Opin Pediatr 2018 02;30(1):3-9

The Arthur and Sonia Labatt Brain Tumour Research Centre and the Developmental & Stem Cell Biology Program, The Hospital for Sick Children.

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http://dx.doi.org/10.1097/MOP.0000000000000562DOI Listing
February 2018

A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases.

Cell 2018 02;172(5):1050-1062.e14

Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.01.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346737PMC
February 2018

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling.

Nature 2018 01 20;553(7686):101-105. Epub 2017 Dec 20.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1038/nature25169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993422PMC
January 2018