Publications by authors named "Michael D Gunn"

43Publications

Brain immunology and immunotherapy in brain tumours.

Nat Rev Cancer 2020 01 5;20(1):12-25. Epub 2019 Dec 5.

The Preston Robert Tisch Brain Tumor Center at Duke, Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.

View Article and Find Full Text PDF
January 2020

Improved efficacy against malignant brain tumors with EGFRwt/EGFRvIII targeting immunotoxin and checkpoint inhibitor combinations.

J Immunother Cancer 2019 05 29;7(1):142. Epub 2019 May 29.

Department of Neurosurgery and the Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Medical Sciences Research Building, Rm 181c, Box 3156, Durham, NC, 27710, USA.

View Article and Find Full Text PDF
May 2019

Interleukin 1 receptor (IL-1R1) activation exacerbates toxin-induced acute kidney injury.

Am J Physiol Renal Physiol 2018 09 23;315(3):F682-F691. Epub 2018 May 23.

Department of Medicine, Duke University Medical Center , Durham, North Carolina.

View Article and Find Full Text PDF
September 2018

Nanoparticle formulation improves doxorubicin efficacy by enhancing host antitumor immunity.

J Control Release 2018 01 13;269:364-373. Epub 2017 Nov 13.

Department of Biomedical Engineering, Duke University, Durham, NC, USA; Center for Biologically Inspired Materials and Materials Systems, Duke University, Durham, NC, USA. Electronic address:

View Article and Find Full Text PDF
January 2018

C-C Motif Chemokine 5 Attenuates Angiotensin II-Dependent Kidney Injury by Limiting Renal Macrophage Infiltration.

Am J Pathol 2016 11 15;186(11):2846-2856. Epub 2016 Sep 15.

Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina; Durham VA Medical Center, Durham, North Carolina. Electronic address:

View Article and Find Full Text PDF
November 2016

A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues.

PLoS One 2016 3;11(3):e0150606. Epub 2016 Mar 3.

Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, North Carolina, United States of America.

View Article and Find Full Text PDF
August 2016

Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients.

Nature 2015 Mar 11;519(7543):366-9. Epub 2015 Mar 11.

1] Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA [2] Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA [3] Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA [4] Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA [5] Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA.

View Article and Find Full Text PDF
March 2015

S1P-Dependent trafficking of intracellular yersinia pestis through lymph nodes establishes Buboes and systemic infection.

Immunity 2014 Sep;41(3):440-450

Program in Emerging Infectious Diseases, Duke-National University of Singapore, Singapore 169857, Singapore; Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA; Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.

View Article and Find Full Text PDF
September 2014

Natural genetic variation of integrin alpha L (Itgal) modulates ischemic brain injury in stroke.

PLoS Genet 2013 10;9(10):e1003807. Epub 2013 Oct 10.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America.

View Article and Find Full Text PDF
March 2014

CCR2 deficiency, dysregulation of Notch signaling, and spontaneous pulmonary arterial hypertension.

Am J Respir Cell Mol Biol 2013 May;48(5):647-54

Division of Pulmonary and Critical Care, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.

View Article and Find Full Text PDF
May 2013

NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis.

Proc Natl Acad Sci U S A 2012 Jun 13;109(26):10480-5. Epub 2012 Jun 13.

Department of Immunology, and School of Nursing, Duke University Medical Center, Durham, NC 27710, USA.

View Article and Find Full Text PDF
June 2012

Cowpox virus induces interleukin-10 both in vitro and in vivo.

Virology 2011 Aug 11;417(1):87-97. Epub 2011 Jun 11.

Department of Molecular Genetics and Microbiology, Box 3020, Duke University Medical Center, Durham, NC 27710, USA.

View Article and Find Full Text PDF
August 2011

Recruited exudative macrophages selectively produce CXCL10 after noninfectious lung injury.

Am J Respir Cell Mol Biol 2011 Oct 17;45(4):781-8. Epub 2011 Feb 17.

Department of Medicine, Duke University Medical Center, Durham, NC, USA.

View Article and Find Full Text PDF
October 2011

Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses.

Nat Immunol 2009 Apr 1;10(4):394-402. Epub 2009 Mar 1.

Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.

View Article and Find Full Text PDF
April 2009

Identification of recombinant antibodies against multiple distinct toll-like receptors by homolog mining a single immune scFv phage library.

J Immunol Methods 2009 Jan 17;340(2):144-53. Epub 2008 Nov 17.

Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, United States.

View Article and Find Full Text PDF
January 2009

Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs.

Nat Immunol 2008 Apr 9;9(4):415-23. Epub 2008 Mar 9.

Department of Anatomy, Program in Immunology, Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94143, USA.

View Article and Find Full Text PDF
April 2008

Enhanced allergen-induced airway inflammation in paucity of lymph node T cell (plt) mutant mice.

J Allergy Clin Immunol 2006 Dec 6;118(6):1234-41. Epub 2006 Oct 6.

Division of Pulmonary and Critical Care Medicine, University of Virginia School of Medicine, Charlottesville, VA 22901, USA.

View Article and Find Full Text PDF
December 2006

TLR4 signaling attenuates ongoing allergic inflammation.

J Immunol 2006 May;176(10):5856-62

Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA.

View Article and Find Full Text PDF
May 2006

Permanent survival of fully MHC-mismatched islet allografts by targeting a single chemokine receptor pathway.

J Immunol 2005 Nov;175(10):6311-8

Division of Transplantation Immunology, Department of Pathology and Laboratory Medicine, Joseph Stokes Jr. Research Institute and Biesecker Pediatric Liver Center, Philadelphia, PA 19104, USA.

View Article and Find Full Text PDF
November 2005

Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection.

Nat Immunol 2003 Dec 2;4(12):1199-205. Epub 2003 Nov 2.

Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA.

View Article and Find Full Text PDF
December 2003

FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes.

J Clin Invest 2003 Mar;111(5):627-37

Carl C. Icahn Center For Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA.

View Article and Find Full Text PDF
March 2003