Michael D Burkart

Michael D Burkart

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Michael D Burkart

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Splice Modulation Synergizes Cell Cycle Inhibition.

ACS Chem Biol 2020 Feb 17. Epub 2020 Feb 17.

Department of Chemistry and Biochemistry , University of California, San Diego , La Jolla , California 92093-0358 , United States.

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http://dx.doi.org/10.1021/acschembio.9b00833DOI Listing
February 2020

Dissecting modular synthases through inhibition: A complementary chemical and genetic approach.

Bioorg Med Chem Lett 2020 Jan 25;30(2):126820. Epub 2019 Nov 25.

Department of Chemistry and Biochemistry, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2019.126820DOI Listing
January 2020

Tailoring chemoenzymatic oxidation via in situ peracids.

Org Biomol Chem 2019 11;17(43):9418-9424

Department of Chemistry and Biochemistry, UC San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA.

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http://dx.doi.org/10.1039/c9ob01814jDOI Listing
November 2019

Type II non-ribosomal peptide synthetase proteins: structure, mechanism, and protein-protein interactions.

Nat Prod Rep 2019 Oct 8. Epub 2019 Oct 8.

Department of Chemistry and Biochemistry, University of California, 9500 Gilman Drive, La Jolla, San Diego, California 92093-0358, USA.

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http://dx.doi.org/10.1039/c9np00047jDOI Listing
October 2019

A Single Tool to Monitor Multiple Protein-Protein Interactions of the Acyl Carrier Protein.

ACS Infect Dis 2019 09 30;5(9):1518-1523. Epub 2019 Jul 30.

Department of Chemistry and Biochemistry , University of California, San Diego , 9500 Gilman Drive , La Jolla , California 92093-0358 , United States.

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http://dx.doi.org/10.1021/acsinfecdis.9b00150DOI Listing
September 2019

Modifying the Thioester Linkage Affects the Structure of the Acyl Carrier Protein.

Angew Chem Int Ed Engl 2019 Aug 2;58(32):10888-10892. Epub 2019 Jul 2.

Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093-0358, USA.

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http://dx.doi.org/10.1002/anie.201903815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663632PMC
August 2019

Shifting the Hydrolysis Equilibrium of Substrate Loaded Acyl Carrier Proteins.

Biochemistry 2019 Aug 14;58(34):3557-3560. Epub 2019 Aug 14.

Department of Chemistry and Biochemistry , University of California, San Diego , 9500 Gilman Drive , La Jolla , California 92093-0358 , United States.

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http://dx.doi.org/10.1021/acs.biochem.9b00612DOI Listing
August 2019

Molecular basis for interactions between an acyl carrier protein and a ketosynthase.

Nat Chem Biol 2019 07 17;15(7):669-671. Epub 2019 Jun 17.

Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, USA.

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http://dx.doi.org/10.1038/s41589-019-0301-yDOI Listing
July 2019

Active site labeling of fatty acid and polyketide acyl-carrier protein transacylases.

Org Biomol Chem 2019 05;17(19):4720-4724

Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA.

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http://dx.doi.org/10.1039/c8ob03229gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597490PMC
May 2019

Preparation, Assay, and Application of Chlorinase SalL for the Chemoenzymatic Synthesis of S-Adenosyl-l-Methionine and Analogs.

Methods Enzymol 2018 2;604:367-388. Epub 2018 Apr 2.

University of Illinois at Chicago, College of Pharmacy, and Center for Biomolecular Sciences, Chicago, IL, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2018.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625345PMC
April 2019

Structural and dynamical rationale for fatty acid unsaturation in .

Proc Natl Acad Sci U S A 2019 04 14;116(14):6775-6783. Epub 2019 Mar 14.

Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0340;

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http://dx.doi.org/10.1073/pnas.1818686116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452729PMC
April 2019

Mechanistic Probes for the Epimerization Domain of Nonribosomal Peptide Synthetases.

Chembiochem 2019 01 9;20(2):147-152. Epub 2018 Nov 9.

Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0358, USA.

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http://doi.wiley.com/10.1002/cbic.201800439
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http://dx.doi.org/10.1002/cbic.201800439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6632073PMC
January 2019

Trapping the Complex Molecular Machinery of Polyketide and Fatty Acid Synthases with Tunable Silylcyanohydrin Crosslinkers.

Angew Chem Int Ed Engl 2018 12 27;57(52):17009-17013. Epub 2018 Nov 27.

Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0358, USA.

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http://dx.doi.org/10.1002/anie.201806865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407627PMC
December 2018

Discovering de novo peptide substrates for enzymes using machine learning.

Nat Commun 2018 12 7;9(1):5253. Epub 2018 Dec 7.

Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0358, USA.

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http://www.nature.com/articles/s41467-018-07717-6
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http://dx.doi.org/10.1038/s41467-018-07717-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286390PMC
December 2018

Daedal Facets of Splice Modulator Optimization.

ACS Med Chem Lett 2018 Nov 29;9(11):1070-1072. Epub 2018 Oct 29.

Department of Chemistry and Biochemistry, UC San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, United States.

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http://pubs.acs.org/doi/10.1021/acsmedchemlett.8b00456
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http://dx.doi.org/10.1021/acsmedchemlett.8b00456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231189PMC
November 2018

Type II fatty acid and polyketide synthases: deciphering protein-protein and protein-substrate interactions.

Nat Prod Rep 2018 10;35(10):1029-1045

Department of Chemistry and Biochemistry, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA.

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http://dx.doi.org/10.1039/c8np00040aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233901PMC
October 2018

Development of a cyanobacterial heterologous polyketide production platform.

Metab Eng 2018 09 21;49:94-104. Epub 2018 Jul 21.

Microbiology Division, IBR (Instituto de Biología Molecular y Celular de Rosario), Consejo Nacional de Investigaciones Científicas y Técnicas, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Ocampo y Esmeralda, 2000 Rosario, Argentina.

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http://dx.doi.org/10.1016/j.ymben.2018.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279439PMC
September 2018

A coupled in vitro/in vivo approach for engineering a heterologous type III PKS to enhance polyketide biosynthesis in Saccharomyces cerevisiae.

Biotechnol Bioeng 2018 06 13;115(6):1394-1402. Epub 2018 Mar 13.

Howard Hughes Medical Institute, Jack H. Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies, La Jolla, California.

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http://dx.doi.org/10.1002/bit.26564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701952PMC
June 2018

Matching Protein Interfaces for Improved Medium-Chain Fatty Acid Production.

ACS Synth Biol 2018 05 3;7(5):1179-1187. Epub 2018 May 3.

School of Chemistry and Biochemistry , Georgia Institute of Technology , Atlanta , Georgia 30332 , United States.

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http://dx.doi.org/10.1021/acssynbio.7b00334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296256PMC
May 2018

Manipulating Protein-Protein Interactions in Nonribosomal Peptide Synthetase Type II Peptidyl Carrier Proteins.

Biochemistry 2017 10 2;56(40):5269-5273. Epub 2017 Oct 2.

Department of Chemistry and Biochemistry, University of California, San Diego , 9500 Gilman Drive, La Jolla, California 92093-0358, United States.

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http://dx.doi.org/10.1021/acs.biochem.7b00884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873958PMC
October 2017

A Challenging Pie to Splice: Drugging the Spliceosome.

Angew Chem Int Ed Engl 2017 09 15;56(40):12052-12063. Epub 2017 Aug 15.

Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0358, USA.

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http://dx.doi.org/10.1002/anie.201701065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311392PMC
September 2017

Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases.

Proc Natl Acad Sci U S A 2017 05 8;114(21):E4142-E4148. Epub 2017 May 8.

Departments of Molecular Biology and Biochemistry, Chemistry, and Pharmaceutical Sciences, University of California, Irvine, CA 92697;

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http://dx.doi.org/10.1073/pnas.1609001114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448209PMC
May 2017

Utilizing Mechanistic Cross-Linking Technology to Study Protein-Protein Interactions: An Experiment Designed for an Undergraduate Biochemistry Lab.

J Chem Educ 2017 Mar 3;94(3):375-379. Epub 2017 Feb 3.

Department of Chemistry, Haverford College, Haverford, Pennsylvania, 19041, United States.

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http://dx.doi.org/10.1021/acs.jchemed.6b00453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731787PMC
March 2017

A Platform to Enable the Pharmacological Profiling of Small Molecules in Gel-Based Electrophoretic Mobility Shift Assays.

J Biomol Screen 2016 Dec 10;21(10):1125-1131. Epub 2016 Jul 10.

1 Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.

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http://dx.doi.org/10.1177/1087057116652895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269537PMC
December 2016

Unveiling the functional diversity of the alpha/beta hydrolase superfamily in the plant kingdom.

Curr Opin Struct Biol 2016 12 21;41:233-246. Epub 2016 Sep 21.

Howard Hughes Medical Institute, The Salk Institute for Biological Studies, Jack H. Skirball Center for Chemical Biology and Proteomics, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2016.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687975PMC
December 2016

Corrigendum to "Unveiling the functional diversity of the alpha/beta hydrolase superfamily in the plant kingdom" [Curr Opin Struct Biol 2016, 41:233-246].

Curr Opin Struct Biol 2016 12 21;41:256-257. Epub 2016 Nov 21.

Howard Hughes Medical Institute, The Salk Institute for Biological Studies, Jack H. Skirball Center for Chemical Biology and Proteomics, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2016.11.008DOI Listing
December 2016

RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML.

Cell Stem Cell 2016 11 25;19(5):599-612. Epub 2016 Aug 25.

Division of Regenerative Medicine, Moores Cancer Center, and Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097015PMC
November 2016

Structural and Biochemical Analysis of Protein-Protein Interactions Between the Acyl-Carrier Protein and Product Template Domain.

Angew Chem Int Ed Engl 2016 10;55(42):13005-13009

Department of Molecular Biology and Biochemistry, Chemistry, and Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, 92697, USA.

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http://dx.doi.org/10.1002/anie.201605401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161458PMC
October 2016

Selectivity in Small Molecule Splicing Modulation.

ACS Chem Biol 2016 10 8;11(10):2716-2723. Epub 2016 Aug 8.

The Moores Cancer Center, University of California San Diego , La Jolla, California 92093, United States.

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http://dx.doi.org/10.1021/acschembio.6b00399DOI Listing
October 2016

Recent progress and future challenges in algal biofuel production.

F1000Res 2016 4;5. Epub 2016 Oct 4.

Department of Ecology and Evolutionary Biology, University of Kansas, Kansas, USA.

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http://dx.doi.org/10.12688/f1000research.9217.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054820PMC
October 2016

Fluorescent Mechanism-Based Probe for Aerobic Flavin-Dependent Enzyme Activity.

Chembiochem 2016 09 5;17(17):1598-601. Epub 2016 Aug 5.

Department of Chemistry and Biochemistry, University of California, 9500 Gilman Drive, San Diego, La Jolla, CA, 92093-0358, USA.

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http://dx.doi.org/10.1002/cbic.201600275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656434PMC
September 2016

Data from mass spectrometry, NMR spectra, GC-MS of fatty acid esters produced by Lasiodiplodia theobromae.

Data Brief 2016 Sep 9;8:31-9. Epub 2016 May 9.

Centro de Investigación Científica y de Educación Superior de Ensenada (CICESE), Carretera Ensenada-Tijuana 3918, Zona Playitas, 22860 Ensenada, B.C., Mexico.

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http://dx.doi.org/10.1016/j.dib.2016.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885019PMC
September 2016

Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants.

J Antibiot (Tokyo) 2016 07 22;69(7):524-33. Epub 2016 Jun 22.

Howard Hughes Medical Institute, The Salk Institute for Biological Studies, Jack H Skirball Center for Chemical Biology and Proteomics, La Jolla, CA, USA.

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http://dx.doi.org/10.1038/ja.2016.68DOI Listing
July 2016

An unusual intramolecular -amidation.

Tetrahedron 2016 Jun;72(25):3605-3608

Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, United States.

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http://dx.doi.org/10.1016/j.tet.2016.01.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917018PMC
June 2016

Harvesting the biosynthetic machineries that cultivate a variety of indispensable plant natural products.

Curr Opin Chem Biol 2016 04 4;31:66-73. Epub 2016 Feb 4.

Department of Chemistry and Biochemistry, The University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cbpa.2016.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217535PMC
April 2016

Probing fatty acid metabolism in bacteria, cyanobacteria, green microalgae and diatoms with natural and unnatural fatty acids.

Mol Biosyst 2016 Apr 17;12(4):1299-312. Epub 2016 Feb 17.

Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA.

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http://dx.doi.org/10.1039/c5mb00804bDOI Listing
April 2016

Fatty acid esters produced by Lasiodiplodia theobromae function as growth regulators in tobacco seedlings.

Biochem Biophys Res Commun 2016 Apr 27;472(2):339-45. Epub 2016 Feb 27.

Centro de Investigación Científica y de Educación Superior de Ensenada (CICESE), Carretera Ensenada-Tijuana 3918, Zona Playitas, 22860 Ensenada, B.C., Mexico. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X163029
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http://dx.doi.org/10.1016/j.bbrc.2016.02.104DOI Listing
April 2016

A Carbohydrate-Derived Splice Modulator.

J Am Chem Soc 2016 Apr 8;138(15):5063-8. Epub 2016 Apr 8.

Department of Chemistry and Biochemistry, University of California-San Diego , 9500 Gilman Drive, La Jolla, California 92093-0358, United States.

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http://dx.doi.org/10.1021/jacs.5b13427DOI Listing
April 2016

Trapping of the Enoyl-Acyl Carrier Protein Reductase-Acyl Carrier Protein Interaction.

J Am Chem Soc 2016 Mar 15;138(12):3962-5. Epub 2016 Mar 15.

Department of Chemistry and Biochemistry, University of California, San Diego , 9500 Gilman Drive, La Jolla, California 92093-0358, United States.

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http://dx.doi.org/10.1021/jacs.5b13456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988885PMC
March 2016

A Substrate Mimic Allows High-Throughput Assay of the FabA Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas aeruginosa FabA.

J Mol Biol 2016 Jan 10;428(1):108-120. Epub 2015 Nov 10.

Biomedical Sciences Research Complex and EaStCHEM, School of Chemistry, University of St. Andrews, North Haugh, St. Andrews, Fife KY16 9ST, United Kingdom; State Key Laboratory of Biotherapy, Sichuan University, Chengdu, Sichuan, China 610065. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2015.10.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840175PMC
January 2016

Sea Spray Aerosol Structure and Composition Using Cryogenic Transmission Electron Microscopy.

ACS Cent Sci 2016 Jan 15;2(1):40-47. Epub 2016 Jan 15.

Department of Chemistry & Biochemistry and Scripps Institution of Oceanography, University of California, San Diego , La Jolla, California 92093, United States.

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http://dx.doi.org/10.1021/acscentsci.5b00344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731829PMC
January 2016

Traffic Control in Modular Polyketide Synthases.

ACS Cent Sci 2016 Jan 15;2(1):9-11. Epub 2016 Jan 15.

Department of Chemistry and Biochemistry, University of California, San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.

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http://dx.doi.org/10.1021/acscentsci.6b00007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827489PMC
January 2016

Selenocystamine improves protein accumulation in chloroplasts of eukaryotic green algae.

AMB Express 2015 Dec 3;5(1):126. Epub 2015 Jul 3.

Division of Biological Sciences, UC San Diego, 9500 Gilman Drive, Bonner Hall, La Jolla, CA, 92093-0368, USA,

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http://dx.doi.org/10.1186/s13568-015-0126-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489976PMC
December 2015

Probing the Substrate Specificity and Protein-Protein Interactions of the E. coli Fatty Acid Dehydratase, FabA.

Chem Biol 2015 Nov 29;22(11):1453-1460. Epub 2015 Oct 29.

Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0358, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10745521150037
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http://dx.doi.org/10.1016/j.chembiol.2015.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656083PMC
November 2015

Structure and Substrate Sequestration in the Pyoluteorin Type II Peptidyl Carrier Protein PltL.

J Am Chem Soc 2015 Sep 4;137(36):11546-9. Epub 2015 Sep 4.

Department of Chemistry and Biochemistry, University of California, San Diego , 9500 Gilman Drive, La Jolla, California 92093-0358, United States.

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http://dx.doi.org/10.1021/jacs.5b04525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847951PMC
September 2015

Online analysis of single cyanobacteria and algae cells under nitrogen-limited conditions using aerosol time-of-flight mass spectrometry.

Anal Chem 2015 Aug 6;87(16):8039-46. Epub 2015 Aug 6.

‡Department of Chemistry and Biochemistry, University of California, La Jolla, California 92093, United States.

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http://dx.doi.org/10.1021/acs.analchem.5b02326DOI Listing
August 2015

Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B.

Haematologica 2015 Jul 10;100(7):945-54. Epub 2015 Apr 10.

Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA CLL Research Consortium, and Department of Medicine, University of California, San Diego, La Jolla, CA, USA

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http://dx.doi.org/10.3324/haematol.2014.122069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486229PMC
July 2015

Azithromycin Synergizes with Cationic Antimicrobial Peptides to Exert Bactericidal and Therapeutic Activity Against Highly Multidrug-Resistant Gram-Negative Bacterial Pathogens.

EBioMedicine 2015 Jul 10;2(7):690-8. Epub 2015 Jun 10.

Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA ; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA ; Rady Children's Hospital, San Diego, CA 92123, USA.

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http://dx.doi.org/10.1016/j.ebiom.2015.05.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534682PMC
July 2015

Using modern tools to probe the structure-function relationship of fatty acid synthases.

Chembiochem 2015 Mar 10;16(4):528-547. Epub 2015 Feb 10.

Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0358 (USA).

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http://dx.doi.org/10.1002/cbic.201402578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545599PMC
March 2015

Active site-directed proteomic probes for adenylation domains in nonribosomal peptide synthetases.

Chem Commun (Camb) 2015 Feb;51(12):2262-5

Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo, Kyoto 606-8501, Japan.

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http://dx.doi.org/10.1039/c4cc09412cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795001PMC
February 2015

In silico screening for Plasmodium falciparum enoyl-ACP reductase inhibitors.

J Comput Aided Mol Des 2015 Jan 25;29(1):79-87. Epub 2014 Oct 25.

Department of Pharmacology, University of California San Diego, La Jolla, CA, 92093, USA,

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http://dx.doi.org/10.1007/s10822-014-9806-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278936PMC
January 2015

Fatty acid biosynthesis revisited: structure elucidation and metabolic engineering.

Mol Biosyst 2015 Jan 31;11(1):38-59. Epub 2014 Oct 31.

Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA.

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http://dx.doi.org/10.1039/c4mb00443dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276719PMC
January 2015

Visualizing the chain-flipping mechanism in fatty-acid biosynthesis.

Angew Chem Int Ed Engl 2014 Dec 29;53(52):14456-61. Epub 2014 Oct 29.

Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358 (USA).

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http://doi.wiley.com/10.1002/anie.201408576
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http://dx.doi.org/10.1002/anie.201408576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425425PMC
December 2014

Modeling linear and cyclic PKS intermediates through atom replacement.

J Am Chem Soc 2014 Dec 19;136(48):16792-9. Epub 2014 Nov 19.

Departments of Molecular Biology and Biochemistry, Chemistry, and Pharmaceutical Sciences, University of California , Irvine, California 92697, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277753PMC
December 2014

Tapping a bacterial enzymatic pathway for the preparation and manipulation of synthetic nanomaterials.

J Am Chem Soc 2014 Dec 3;136(50):17378-81. Epub 2014 Dec 3.

Department of Chemistry and Biochemistry, University of California, San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States.

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http://dx.doi.org/10.1021/ja509827sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407424PMC
December 2014

Versatility of acyl-acyl carrier protein synthetases.

Chem Biol 2014 Oct 9;21(10):1293-1299. Epub 2014 Oct 9.

Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2014.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224610PMC
October 2014

Structure, biochemistry, and inhibition of essential 4'-phosphopantetheinyl transferases from two species of Mycobacteria.

ACS Chem Biol 2014 Sep 9;9(9):1939-44. Epub 2014 Jul 9.

Department of Chemistry and Biochemistry, University of California, San Diego , 9500 Gilman Drive, La Jolla, California 92093-0358, United States.

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http://dx.doi.org/10.1021/cb500263pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168790PMC
September 2014

System and method for research-scale outdoor production of microalgae and cyanobacteria.

Bioresour Technol 2014 Aug 21;166:273-81. Epub 2014 May 21.

Department of Chemistry & Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States; The California Center for Algae Biotechnology, University of California San Diego, 9500 Gilman Drive MC0368, La Jolla, CA 92093, United States. Electronic address:

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http://dx.doi.org/10.1016/j.biortech.2014.05.046DOI Listing
August 2014

Evolution of acyl-ACP-thioesterases and β-ketoacyl-ACP-synthases revealed by protein-protein interactions.

J Appl Phycol 2014 Aug;26(4):1619-1629

Department of Chemistry and Biochemistry, University of California-San Diego, La Jolla, CA 92093-0358, USA.

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http://dx.doi.org/10.1007/s10811-013-0203-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125210PMC
August 2014

Chemoenzymatic exchange of phosphopantetheine on protein and peptide.

Chem Sci 2014 Mar 2;5(3):1179-1186. Epub 2014 Jan 2.

Department of Chemistry and Biochemistry, University of California, San Diego (UCSD), La Jolla, California, USA.

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http://dx.doi.org/10.1039/C3SC53154FDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795179PMC
March 2014

Fluorescent techniques for discovery and characterization of phosphopantetheinyl transferase inhibitors.

J Antibiot (Tokyo) 2014 Jan 6;67(1):113-20. Epub 2013 Nov 6.

Department of Chemistry and Biochemistry, University of California, San Diego (UCSD), La Jolla, CA, USA.

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http://dx.doi.org/10.1038/ja.2013.106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807864PMC
January 2014

The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life.

Nat Prod Rep 2014 Jan;31(1):61-108

Department of Chemistry and Biochemistry, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA.

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http://dx.doi.org/10.1039/c3np70054bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918677PMC
January 2014

Resin supported acyl carrier protein labeling strategies.

RSC Adv 2014 ;4(18):9092-9097

University of California, San Diego, Department of Chemistry and Biochemistry, 9500 Gilman Drive, San Diego, USA.

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http://dx.doi.org/10.1039/C3RA47847EDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012645PMC
January 2014

Chemoenzymatic synthesis and in situ application of S-adenosyl-L-methionine analogs.

Org Biomol Chem 2013 Nov;11(43):7606-10

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 162, DK-2100, Copenhagen, Denmark.

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http://dx.doi.org/10.1039/c3ob41702fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871182PMC
November 2013

The determinants of activity and specificity in actinorhodin type II polyketide ketoreductase.

Chem Biol 2013 Oct 12;20(10):1225-34. Epub 2013 Sep 12.

Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1016/j.chembiol.2013.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855848PMC
October 2013

Stabilized cyclopropane analogs of the splicing inhibitor FD-895.

J Med Chem 2013 Sep 21;56(17):6576-82. Epub 2013 Aug 21.

Department of Chemistry and Biochemistry, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093-0358, United States.

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http://dx.doi.org/10.1021/jm400861tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809018PMC
September 2013

Probing the selectivity and protein·protein interactions of a nonreducing fungal polyketide synthase using mechanism-based crosslinkers.

Chem Biol 2013 Sep 29;20(9):1135-46. Epub 2013 Aug 29.

Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697, USA; Department of Chemistry, University of California, Irvine, Irvine, CA 92697, USA; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1016/j.chembiol.2013.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796367PMC
September 2013

Novel inositol catabolic pathway in Thermotoga maritima.

Environ Microbiol 2013 Aug 27;15(8):2254-66. Epub 2013 Feb 27.

Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.

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http://doi.wiley.com/10.1111/1462-2920.12096
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August 2013

Confluence of structural and chemical biology: plant polyketide synthases as biocatalysts for a bio-based future.

Curr Opin Plant Biol 2013 Jun 5;16(3):365-72. Epub 2013 Mar 5.

Howard Hughes Medical Institute, The Salk Institute for Biological Studies, Jack H. Skirball Center for Chemical Biology and Proteomics, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.pbi.2013.02.004DOI Listing
June 2013

Engineering fatty acid biosynthesis in microalgae for sustainable biodiesel.

Curr Opin Chem Biol 2013 Jun 14;17(3):496-505. Epub 2013 May 14.

Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA.

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http://dx.doi.org/10.1016/j.cbpa.2013.04.007DOI Listing
June 2013

Sulfonyl 3-alkynyl pantetheinamides as mechanism-based cross-linkers of acyl carrier protein dehydratase.

J Am Chem Soc 2013 Jun 4;135(24):8846-9. Epub 2013 Jun 4.

Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, USA.

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http://dx.doi.org/10.1021/ja4042059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713789PMC
June 2013

Biofuels for the 21st century.

Curr Opin Chem Biol 2013 Jun 27;17(3):436-8. Epub 2013 May 27.

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June 2013

A tandem chemoenzymatic methylation by S-adenosyl-L-methionine.

Chembiochem 2013 May 6;14(8):950-3. Epub 2013 May 6.

Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA.

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http://dx.doi.org/10.1002/cbic.201300221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749784PMC
May 2013

Spirohexenolide A targets human macrophage migration inhibitory factor (hMIF).

J Nat Prod 2013 May 9;76(5):817-23. Epub 2013 May 9.

Department of Chemistry and Biochemistry, University of California-San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, United States.

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http://dx.doi.org/10.1021/np3004497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706094PMC
May 2013

Metabolic perturbation of an essential pathway: evaluation of a glycine precursor of coenzyme A.

J Am Chem Soc 2013 Apr 10;135(16):5962-5. Epub 2013 Apr 10.

Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, USA.

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http://dx.doi.org/10.1021/ja400795mDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657554PMC
April 2013

Manipulating fatty acid biosynthesis in microalgae for biofuel through protein-protein interactions.

PLoS One 2012 13;7(9):e42949. Epub 2012 Sep 13.

Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042949PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441505PMC
March 2013

Structure of FD-895 revealed through total synthesis.

Org Lett 2012 Nov 16;14(21):5396-9. Epub 2012 Oct 16.

Department of Chemistry and Biochemistry, University of Calfornia, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, USA.

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http://dx.doi.org/10.1021/ol3023006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518397PMC
November 2012

Reversible labeling of native and fusion-protein motifs.

Nat Methods 2012 Oct 16;9(10):981-4. Epub 2012 Sep 16.

Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1038/nmeth.2175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128096PMC
October 2012

Resin-based investigation of acyl carrier protein interaction networks in Escherichia coli.

Bioorg Med Chem 2012 Jan 31;20(2):667-71. Epub 2011 Oct 31.

Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA.

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http://dx.doi.org/10.1016/j.bmc.2011.10.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809020PMC
January 2012

Dehydratase-specific probes for fatty acid and polyketide synthases.

J Am Chem Soc 2012 Jan 29;134(2):769-72. Epub 2011 Dec 29.

Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, USA.

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http://dx.doi.org/10.1021/ja2082334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269962PMC
January 2012

Modifications of the metabolic pathways of lipid and triacylglycerol production in microalgae.

Microb Cell Fact 2011 Nov 2;10:91. Epub 2011 Nov 2.

Department of Chemistry & Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1186/1475-2859-10-91DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234195PMC
November 2011

Ganodone, a bioactive benzofuran from the fruiting bodies of Ganoderma tsugae.

J Nat Prod 2011 Oct 22;74(10):2045-51. Epub 2011 Sep 22.

Xenobe Research Institute, P.O. Box 3052, San Diego, California 92163-1052, United States.

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October 2011

Proteomic analysis of polyketide and nonribosomal peptide biosynthesis.

Curr Opin Chem Biol 2011 Feb 17;15(1):48-56. Epub 2010 Nov 17.

Department of Chemistry and Biochemistry, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA.

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http://dx.doi.org/10.1016/j.cbpa.2010.10.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050567PMC
February 2011

Activity-guided engineering of natural product carrier proteins.

Mol Biosyst 2011 Feb 24;7(2):365-70. Epub 2010 Dec 24.

Department of Chemistry and Biochemistry, University of California-San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, USA.

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http://dx.doi.org/10.1039/c0mb00251hDOI Listing
February 2011

Practical 4'-phosphopantetheine active site discovery from proteomic samples.

J Proteome Res 2011 Jan 13;10(1):320-9. Epub 2010 Dec 13.

Department of Chemistry and Biochemistry, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla California 92093, USA.

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http://dx.doi.org/10.1021/pr100953bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042426PMC
January 2011

Synthetic studies on the mycolactone core.

Org Biomol Chem 2010 Nov 19;8(22):5159-65. Epub 2010 Aug 19.

Department of Chemistry and Biochemistry, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA.

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http://dx.doi.org/10.1039/c0ob00540aDOI Listing
November 2010

Metabolic probes for imaging endosymbiotic bacteria within toxic dinoflagellates.

Chem Commun (Camb) 2010 Nov 6;46(43):8151-3. Epub 2010 Oct 6.

Department of Chemistry and Biochemistry, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA.

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http://dx.doi.org/10.1039/c0cc02876bDOI Listing
November 2010

Convergent route to the spirohexenolide macrocycle.

Org Lett 2010 Oct;12(20):4516-9

Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, USA.

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http://dx.doi.org/10.1021/ol1018163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956428PMC
October 2010