Publications by authors named "Michael Costanzo"

100Publications

Functional link between mitochondria and Rnr3, the minor catalytic subunit of yeast ribonucleotide reductase.

Microb Cell 2019 May 20;6(6):286-294. Epub 2019 May 20.

School of Medical Sciences, North West Cancer Research Institute, Bangor University, Deniol Road, Bangor, LL57 2UW, United Kingdom.

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http://dx.doi.org/10.15698/mic2019.06.680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545439PMC
May 2019

Global Genetic Networks and the Genotype-to-Phenotype Relationship.

Cell 2019 03;177(1):85-100

The Donnelly Centre, University of Toronto, 160 College Street, Toronto ON, Canada; Department of Molecular Genetics, University of Toronto, 1 Kings College Circle, Toronto ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.01.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817365PMC
March 2019

Yeast Two-Hybrid Analysis for Ubiquitin Variant Inhibitors of Human Deubiquitinases.

J Mol Biol 2019 03 11;431(6):1160-1171. Epub 2019 Feb 11.

Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 3E1, Canada; Donnelly Centre for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, M5S3E1, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2019.02.007DOI Listing
March 2019

Essential Function of Mec1, the Budding Yeast ATM/ATR Checkpoint-Response Kinase, in Protein Homeostasis.

Dev Cell 2018 08;46(4):495-503.e2

North West Cancer Research Institute, School of Medical Sciences, Bangor University, Deniol Road, Bangor LL57 2UW, UK. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2018.07.011DOI Listing
August 2018

Integrating genetic and protein-protein interaction networks maps a functional wiring diagram of a cell.

Curr Opin Microbiol 2018 10 28;45:170-179. Epub 2018 Jul 28.

The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada; RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan.

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http://dx.doi.org/10.1016/j.mib.2018.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295359PMC
October 2018

Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity.

Cell 2018 03 8;173(1):62-73.e9. Epub 2018 Mar 8.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Cambridge, MA 02139, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183017
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http://dx.doi.org/10.1016/j.cell.2018.02.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945206PMC
March 2018

Portable FAIMS: Applications and Future Perspectives.

Int J Mass Spectrom 2017 11 8;422:188-196. Epub 2016 Dec 8.

Department of Chemistry; University of Florida; Gainesville, FL 32611.

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http://dx.doi.org/10.1016/j.ijms.2016.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765550PMC
November 2017

Pathway-based discovery of genetic interactions in breast cancer.

PLoS Genet 2017 Sep 28;13(9):e1006973. Epub 2017 Sep 28.

Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619706PMC
September 2017

Features of the Chaperone Cellular Network Revealed through Systematic Interaction Mapping.

Cell Rep 2017 Sep;20(11):2735-2748

Department of Biochemistry, University of Toronto, Toronto, ON M5G 1M1, Canada; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.08.074DOI Listing
September 2017

Budding Yeast Rif1 Controls Genome Integrity by Inhibiting rDNA Replication.

PLoS Genet 2016 Nov 7;12(11):e1006414. Epub 2016 Nov 7.

Department of Molecular Biology, University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1371/journal.pgen.1006414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098799PMC
November 2016

Synthetic Genetic Arrays: Automation of Yeast Genetics.

Cold Spring Harb Protoc 2016 Apr 1;2016(4):pdb.top086652. Epub 2016 Apr 1.

Department of Molecular Genetics, University of Toronto, Ontario M5S 1A8, Canada; Donnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario M5S 3E1, Canada.

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http://dx.doi.org/10.1101/pdb.top086652DOI Listing
April 2016

Synthetic Genetic Array Analysis.

Cold Spring Harb Protoc 2016 Apr 1;2016(4):pdb.prot088807. Epub 2016 Apr 1.

Department of Molecular Genetics, University of Toronto, Ontario M5S 1A8, Canada; Donnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario M5S 3E1, Canada.

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http://dx.doi.org/10.1101/pdb.prot088807DOI Listing
April 2016

An extended set of yeast-based functional assays accurately identifies human disease mutations.

Genome Res 2016 05 14;26(5):670-80. Epub 2016 Mar 14.

Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada; Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3E1, Canada; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario M5G 1X5, Canada; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA; Canadian Institute for Advanced Research, Toronto, Ontario, M5G 1Z8, Canada.

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http://dx.doi.org/10.1101/gr.192526.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864455PMC
May 2016

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

Cell 2016 Feb;164(4):805-17

Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science (CEGS), Dana-Farber Cancer Institute, Boston, MA 02215, USA; Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.01.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882190PMC
February 2016

Chromosome-Specific and Global Effects of Aneuploidy in Saccharomyces cerevisiae.

Genetics 2016 Apr 2;202(4):1395-409. Epub 2016 Feb 2.

Koch Institute for Integrative Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142 Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142

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http://dx.doi.org/10.1534/genetics.115.185660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905547PMC
April 2016

TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae.

Mol Biol Cell 2016 Jan 18;27(2):397-409. Epub 2015 Nov 18.

Department of Molecular Biology and Institute of Genetics and Genomics of Geneva, University of Geneva, CH-1211 Geneva, Switzerland Swiss National Centre for Competence in Research Programme Chemical Biology, 1211 Geneva, Switzerland

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http://dx.doi.org/10.1091/mbc.E15-08-0594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713140PMC
January 2016

Genetic Interactions Implicating Postreplicative Repair in Okazaki Fragment Processing.

PLoS Genet 2015 Nov 6;11(11):e1005659. Epub 2015 Nov 6.

Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1005659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636136PMC
November 2015

Acinetobacter baumannii OxPhos inhibitors as selective anti-infective agents.

Bioorg Med Chem Lett 2015 Jan 22;25(2):378-83. Epub 2014 Nov 22.

Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Rd., Doylestown, PA 18902, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.11.020DOI Listing
January 2015

Standardized method for solubility and storage of capsaicin-based solutions for cough induction.

Cough 2014 25;10. Epub 2014 Sep 25.

Department of Physiological Sciences, University of Florida, Gainesville, FL 32610, USA.

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http://coughjournal.biomedcentral.com/articles/10.1186/1745-
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http://dx.doi.org/10.1186/1745-9974-10-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194457PMC
October 2014

Synthetic genetic array analysis for global mapping of genetic networks in yeast.

Methods Mol Biol 2014 ;1205:143-68

The Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/978-1-4939-1363-3_10DOI Listing
May 2015

Genome-wide analysis reveals novel and discrete functions for tubulin carboxy-terminal tails.

Curr Biol 2014 Jun 15;24(12):1295-1303. Epub 2014 May 15.

Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2014.03.078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070440PMC
June 2014

De novo design of self-assembling foldamers that inhibit heparin-protein interactions.

ACS Chem Biol 2014 Apr 11;9(4):967-75. Epub 2014 Feb 11.

Department of Biochemistry & Biophysics and ‡Department of Chemistry, University of Pennsylvania , Philadelphia, Pennsylvania 19104, United States.

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http://dx.doi.org/10.1021/cb500026xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324449PMC
April 2014

A comparative genomic approach for identifying synthetic lethal interactions in human cancer.

Cancer Res 2013 Oct 26;73(20):6128-36. Epub 2013 Aug 26.

Authors' Affiliations: Department of Computer Science and Engineering; Program in Biomedical Informatics and Computational Biology, University of Minnesota, Minneapolis; Department of Surgery, Mayo Clinic, Rochester, Minnesota; Department of Laboratory Medicine & Pathology, Molecular Genetics Lab, Mayo Clinic, Rochester, Minnesota; Department of Molecular Genetics, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Ontario, Canada; Chemical Genomics Research Group, RIKEN Advance Science Institute, Saitama, Japan; and Great Lakes Bioenergy Research Center, University of Wisconsin, Madison, Wisconsin.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-3956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809957PMC
October 2013

Global linkage map connects meiotic centromere function to chromosome size in budding yeast.

G3 (Bethesda) 2013 Oct 3;3(10):1741-51. Epub 2013 Oct 3.

Banting and Best Department of Medical Research, The Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.

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http://dx.doi.org/10.1534/g3.113.007377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789798PMC
October 2013

Genetic interaction networks: toward an understanding of heritability.

Annu Rev Genomics Hum Genet 2013 26;14:111-33. Epub 2013 Jun 26.

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544.

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http://dx.doi.org/10.1146/annurev-genom-082509-141730DOI Listing
December 2013

SGAtools: one-stop analysis and visualization of array-based genetic interaction screens.

Nucleic Acids Res 2013 Jul 15;41(Web Server issue):W591-6. Epub 2013 May 15.

Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, M5S 3E1, Canada.

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http://dx.doi.org/10.1093/nar/gkt400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692131PMC
July 2013

Actin filament elongation in Arp2/3-derived networks is controlled by three distinct mechanisms.

Dev Cell 2013 Jan 17;24(2):182-95. Epub 2013 Jan 17.

Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3202, USA.

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http://dx.doi.org/10.1016/j.devcel.2012.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562429PMC
January 2013

Network evolution: rewiring and signatures of conservation in signaling.

PLoS Comput Biol 2012 15;8(3):e1002411. Epub 2012 Mar 15.

Department of Computer Science, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1371/journal.pcbi.1002411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305342PMC
June 2012

Systematic exploration of synergistic drug pairs.

Mol Syst Biol 2011 Nov 8;7:544. Epub 2011 Nov 8.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/msb.2011.71DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261710PMC
November 2011

Ubiquitin ligase Ufd2 is required for efficient degradation of Mps1 kinase.

J Biol Chem 2011 Dec 1;286(51):43660-7. Epub 2011 Nov 1.

Institute of Biotechnology, Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, Texas 78245, USA.

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http://dx.doi.org/10.1074/jbc.M111.286229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243506PMC
December 2011

Histone modifications influence mediator interactions with chromatin.

Nucleic Acids Res 2011 Oct 8;39(19):8342-54. Epub 2011 Jul 8.

Department of Biochemistry and Cell Biology, University of Gothenburg, SE-405 30 Gothenburg, Sweden.

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http://dx.doi.org/10.1093/nar/gkr551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201872PMC
October 2011

Protein complexes are central in the yeast genetic landscape.

PLoS Comput Biol 2011 Feb 24;7(2):e1001092. Epub 2011 Feb 24.

The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.

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http://dx.plos.org/10.1371/journal.pcbi.1001092
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http://dx.doi.org/10.1371/journal.pcbi.1001092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044758PMC
February 2011

Bringing order to protein disorder through comparative genomics and genetic interactions.

Genome Biol 2011 16;12(2):R14. Epub 2011 Feb 16.

Department of Computer Science and Engineering, University of Minnesota, 200 Union Street SE, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1186/gb-2011-12-2-r14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188796PMC
February 2012

Nutrients and the Pkh1/2 and Pkc1 protein kinases control mRNA decay and P-body assembly in yeast.

J Biol Chem 2011 Mar 16;286(11):8759-70. Epub 2010 Dec 16.

Department of Molecular and Cellular Biochemistry and the Lucille Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA.

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http://dx.doi.org/10.1074/jbc.M110.196030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059008PMC
March 2011

Charting the genetic interaction map of a cell.

Curr Opin Biotechnol 2011 Feb 24;22(1):66-74. Epub 2010 Nov 24.

Banting and Best Department of Medical Research and Department of Molecular Genetics, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.copbio.2010.11.001DOI Listing
February 2011

Identification of Saccharomyces cerevisiae spindle pole body remodeling factors.

PLoS One 2010 Nov 12;5(11):e15426. Epub 2010 Nov 12.

Department of Biochemistry, University of Washington, Seattle, Washington, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015426PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980476PMC
November 2010

Combining functional genomics and chemical biology to identify targets of bioactive compounds.

Curr Opin Chem Biol 2011 Feb 17;15(1):66-78. Epub 2010 Nov 17.

Banting and Best Department of Medical Research and Department of Molecular Genetics, The Donnelly Centre, University of Toronto, 160 College St., Toronto, ON, Canada M5S 3E1.

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http://dx.doi.org/10.1016/j.cbpa.2010.10.023DOI Listing
February 2011

Reconstitution and protein composition analysis of endocytic actin patches.

Curr Biol 2010 Nov 28;20(21):1890-9. Epub 2010 Oct 28.

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3202, USA.

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http://dx.doi.org/10.1016/j.cub.2010.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998891PMC
November 2010

Synthetic genetic array (SGA) analysis in Saccharomyces cerevisiae and Schizosaccharomyces pombe.

Methods Enzymol 2010 1;470:145-79. Epub 2010 Mar 1.

Banting and Best Department of Medical Research, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/S0076-6879(10)70007-0DOI Listing
January 2011

Cooperative antithrombotic effect from the simultaneous inhibition of thrombin and factor Xa.

Blood Coagul Fibrinolysis 2010 Mar;21(2):128-34

Johnson & Johnson Pharmaceutical Research & Development, Welsh and McKean Roads, Spring House, PA 19477, USA.

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http://dx.doi.org/10.1097/MBC.0b013e3283358100DOI Listing
March 2010

DRYGIN: a database of quantitative genetic interaction networks in yeast.

Nucleic Acids Res 2010 Jan 30;38(Database issue):D502-7. Epub 2009 Oct 30.

Banting and Best Department of Medical Research, The Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, ON, Canada.

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http://dx.doi.org/10.1093/nar/gkp820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808960PMC
January 2010

Systematic mapping of genetic interaction networks.

Annu Rev Genet 2009 ;43:601-25

Banting and Best Department of Medical Research, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 1A7, Canada.

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http://www.annualreviews.org/doi/10.1146/annurev.genet.39.07
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http://dx.doi.org/10.1146/annurev.genet.39.073003.114751DOI Listing
December 2009

SGAM: an array-based approach for high-resolution genetic mapping in Saccharomyces cerevisiae.

Methods Mol Biol 2009 ;548:37-53

Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, M5S 3E1, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/978-1-59745-540-4_3DOI Listing
July 2009

Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA.

Nature 2009 Mar 14;458(7235):228-32. Epub 2009 Jan 14.

Institute of Biochemistry, ETH Zurich, Schafmattstrasse 18, CH-8093 Zurich, Switzerland.

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http://dx.doi.org/10.1038/nature07643DOI Listing
March 2009

Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers.

Nat Methods 2008 Aug 11;5(8):719-25. Epub 2008 Jul 11.

Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.

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http://www.nature.com/articles/nmeth.1231
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http://dx.doi.org/10.1038/nmeth.1231DOI Listing
August 2008

The interaction network of the chaperonin CCT.

EMBO J 2008 Jul 29;27(13):1827-39. Epub 2008 May 29.

Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/emboj.2008.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486426PMC
July 2008

The extensive and condition-dependent nature of epistasis among whole-genome duplicates in yeast.

Genome Res 2008 Jul 7;18(7):1092-9. Epub 2008 May 7.

Banting and Best Department of Medical Research, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.

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http://www.genome.org/cgi/doi/10.1101/gr.076174.108
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http://dx.doi.org/10.1101/gr.076174.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493398PMC
July 2008

Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.

Bioorg Med Chem 2008 Feb 6;16(4):1562-95. Epub 2007 Nov 6.

Vascular Research Team, Johnson & Johnson Pharmaceutical Research & Development, Spring House, PA 19477-0776, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S096808960700983
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http://dx.doi.org/10.1016/j.bmc.2007.11.015DOI Listing
February 2008

Identification of a novel lysophospholipid acyltransferase in Saccharomyces cerevisiae.

J Biol Chem 2007 Oct 28;282(42):30562-9. Epub 2007 Aug 28.

Department of Bioscience and Biotechnology, Drexel University, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M706326200DOI Listing
October 2007

The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast.

Nat Genet 2007 Apr 11;39(4):486-95. Epub 2007 Mar 11.

Medical Research Council (MRC) Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1038/ng1994DOI Listing
April 2007

Experimental approaches to identify genetic networks.

Curr Opin Biotechnol 2006 Oct 8;17(5):472-80. Epub 2006 Sep 8.

Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S095816690600121
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http://dx.doi.org/10.1016/j.copbio.2006.08.005DOI Listing
October 2006

Exploration of potential prodrugs of RWJ-445167, an oxyguanidine-based dual inhibitor of thrombin and factor Xa.

Chem Biol Drug Des 2006 Jul;68(1):29-36

Vascular Research Team, Johnson & Johnson Pharmaceutical Research & Development, Spring House, PA 19477-0776, USA.

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http://dx.doi.org/10.1111/j.1747-0285.2006.00408.xDOI Listing
July 2006