Publications by authors named "Michael Clarkson"

65Publications

Cooperative dynamics across distinct structural elements regulate PTP1B activity.

J Biol Chem 2020 Oct 31;295(40):13829-13837. Epub 2020 Jul 31.

Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, USA

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October 2020

Retinoic Acid Binding Leads to CRABP2 Rigidification and Dimerization.

Biochemistry 2019 10 7;58(41):4183-4194. Epub 2019 Oct 7.

Department of Biochemistry, Institute of Chemistry , Federal University of Rio de Janeiro , Rio de Janeiro , RJ 21941909 , Brazil.

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October 2019

Preparation of fluorescent in situ hybridisation probes without the need for optimisation of fragmentation.

MethodsX 2019 27;6:22-34. Epub 2018 Nov 27.

Departments of Surgery and Urology, University of Melbourne, Royal Melbourne Hospital, Parkville, Australia.

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November 2018

Structural Dynamics of the Activation of Elongation Factor 2 Kinase by Ca-Calmodulin.

J Mol Biol 2018 08 22;430(17):2802-2821. Epub 2018 May 22.

Department of Chemistry and Biochemistry, The City College of New York, New York, NY 10031, USA; Graduate Program in Biochemistry, The Graduate Center of CUNY, New York, NY 10016, USA; Graduate Program in Chemistry, The Graduate Center of CUNY, New York, NY 10016, USA; Graduate Program in Physics, The Graduate Center of CUNY, New York, NY 10016, USA. Electronic address:

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August 2018

Dynamic activation and regulation of the mitogen-activated protein kinase p38.

Proc Natl Acad Sci U S A 2018 05 16;115(18):4655-4660. Epub 2018 Apr 16.

Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721;

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May 2018

Rescue of conformational dynamics in enzyme catalysis by directed evolution.

Nat Commun 2018 04 3;9(1):1314. Epub 2018 Apr 3.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94158, USA.

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April 2018

Neurological consults on the renal unit.

Pract Neurol 2017 Apr 24;17(2):104-112. Epub 2017 Jan 24.

Department of Neurology, Cork University Hospital, Cork, Ireland

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April 2017

Molecular Pathways: Targeting DNA Repair Pathway Defects Enriched in Metastasis.

Clin Cancer Res 2016 07 11;22(13):3132-7. Epub 2016 May 11.

Department of Surgery, Division of Urology, Royal Melbourne Hospital and University of Melbourne and The Epworth Prostate Centre, Epworth Hospital, Victoria, Australia.

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July 2016

A urinary microRNA signature can predict the presence of bladder urothelial carcinoma in patients undergoing surveillance.

Br J Cancer 2016 Feb 26;114(4):454-62. Epub 2016 Jan 26.

Department of Surgery, Division of Urology, Royal Melbourne Hospital, The University of Melbourne, Parkville, Melbourne, Victoria, Australia.

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February 2016

Alternatively spliced isoforms of WT1 control podocyte-specific gene expression.

Kidney Int 2015 Aug 20;88(2):321-31. Epub 2015 May 20.

1] Institute of Biology Valrose, Université de Nice-Sophia, Nice, France [2] Inserm, UMR1091, Nice, France [3] CNRS, UMR7277, Nice, France.

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August 2015

Posterior reversible encephalopathy syndrome in end-stage kidney disease: not strictly posterior or reversible.

Am J Nephrol 2015 8;41(3):177-82. Epub 2015 Apr 8.

Department of Renal Medicine, Cork University Hospital, Cork, Ireland.

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May 2016

WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors.

Nat Commun 2014 Jul 17;5:4444. Epub 2014 Jul 17.

1] Institute of Biology Valrose, Université de Nice-Sophia, F-06108 Nice, France [2] Inserm, UMR1091, F-06108 Nice, France [3] CNRS, UMR7277, F-06108 Nice, France.

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July 2014

Evidence against the "Y-T coupling" mechanism of activation in the response regulator NtrC.

J Mol Biol 2014 Apr 7;426(7):1554-67. Epub 2014 Jan 7.

Department of Biochemistry and Howard Hughes Medical Institute, Waltham, MA 02452, USA. Electronic address:

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April 2014

WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland.

Dev Cell 2013 Oct;27(1):5-18

Institute of Biology Valrose, iBV, University of Nice Sophia-Antipolis, 06108 Nice Cedex 2, France; INSERM UMR 1091, CNRS UMR 7277 Parc Valrose, 06108 Nice Cedex 2, France.

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October 2013

CD160Ig fusion protein targets a novel costimulatory pathway and prolongs allograft survival.

PLoS One 2013 4;8(4):e60391. Epub 2013 Apr 4.

Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

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November 2013

Ligand binding reduces conformational flexibility in the active site of tyrosine phosphatase related to biofilm formation A (TpbA) from Pseudomonasaeruginosa.

J Mol Biol 2013 Jun 21;425(12):2219-31. Epub 2013 Mar 21.

Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02903, USA.

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June 2013

Quiz page December 2012: bilateral kidney enlargement and acute kidney injury in a patient with HIV infection.

Am J Kidney Dis 2012 Dec;60(6):quiz A31-3

Department of Renal Medicine, Cardiac Renal Centre, Cork University Hospital, Cork, Ireland.

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December 2012

Carbon monoxide poisoning: Novel magnetic resonance imaging pattern in the acute setting.

Int J Emerg Med 2012 Jun 28;5(1):30. Epub 2012 Jun 28.

Department of Medicine, Neurology Service, Cork University Hospital, Cork, Ireland.

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June 2012

Development of reagents to study the turkey's immune response: cloning and characterisation of two turkey cytokines, interleukin (IL)-10 and IL-13.

Vet Immunol Immunopathol 2012 Jun 30;147(1-2):97-103. Epub 2012 Mar 30.

Institute for Animal Health, Compton, Berkshire RG20 7NN, UK.

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June 2012

Reliability of indicators of sheep welfare assessed by a group observation method.

Vet J 2012 Jul 21;193(1):257-63. Epub 2012 Jan 21.

University of Liverpool, Institute of Global Health and Infection, Department of Epidemiology and Population Health, Leahurst, Neston CH64 7TE, UK.

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July 2012

Antiparallel EmrE exports drugs by exchanging between asymmetric structures.

Nature 2011 Dec 18;481(7379):45-50. Epub 2011 Dec 18.

Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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December 2011

Haemodialysis-induced syncope due to Chiari II malformation.

NDT Plus 2011 Dec 2;4(6):390-1. Epub 2011 Aug 2.

Department of Renal Medicine, Cork University Hospital, Cork, Ireland.

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December 2011

Tim-4 inhibition of T-cell activation and T helper type 17 differentiation requires both the immunoglobulin V and mucin domains and occurs via the mitogen-activated protein kinase pathway.

Immunology 2011 Jun 5;133(2):179-89. Epub 2011 Apr 5.

Immunology, Moffitt Cancer Center Department of Biochemistry Department of Renal Medicine, Cork University Hospital, University College Cork, Ireland.

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June 2011

Dissecting the microscopic steps of the cyclophilin A enzymatic cycle on the biological HIV-1 capsid substrate by NMR.

J Mol Biol 2010 Nov 12;403(5):723-38. Epub 2010 Aug 12.

Department of Biochemistry and Howard Hughes Medical Institute, MS 009, Brandeis University, Waltham, MA 02454, USA.

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November 2010

Maintenance hemodialysis patients have high cumulative radiation exposure.

Kidney Int 2010 Oct 30;78(8):789-93. Epub 2010 Jun 30.

Department of Nephrology, Cork University Hospital, Wilton, Cork, Ireland.

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October 2010

Hidden alternative structures of proline isomerase essential for catalysis.

Nature 2009 Dec;462(7273):669-73

Department of Molecular and Cell Biology/QB3, University of California, Berkeley, California 94720-3220, USA.

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December 2009

A case report of spontaneous mutation (C33>U) in the iron-responsive element of L-ferritin causing hyperferritinemia-cataract syndrome.

Blood Cells Mol Dis 2010 Jan 2;44(1):22-7. Epub 2009 Oct 2.

Cell Biology Laboratory, Department of Biochemistry, University College Cork, Cork, Ireland.

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January 2010

Mesodynamics in the SARS nucleocapsid measured by NMR field cycling.

J Biomol NMR 2009 Sep 30;45(1-2):217-25. Epub 2009 Jul 30.

Department of Biochemistry and Howard Hughes Medical Institute, MS009 Brandeis University, Waltham, MA 02452, USA.

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September 2009

Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells.

Proc Natl Acad Sci U S A 2009 Jun 15;106(26):10734-9. Epub 2009 Jun 15.

Transplantation Research Center, Renal Division, Brigham and Women's Hospital and Children's Hospital Boston and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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June 2009

A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy.

J Exp Med 2008 Dec 1;205(13):3133-44. Epub 2008 Dec 1.

Transplantation Research Center, Renal Division, Brigham and Women's Hospital and Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

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December 2008

A case of desensitization, transplantation, and allograft dysfunction.

Clin J Am Soc Nephrol 2008 Sep 30;3(5):1573-81. Epub 2008 Jul 30.

Department of Nephrology, Beaumont Hospital, Dublin, Ireland.

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September 2008

Solution structure of polymerase mu's BRCT Domain reveals an element essential for its role in nonhomologous end joining.

Biochemistry 2007 Oct 4;46(43):12100-10. Epub 2007 Oct 4.

Laboratory of Structural Biology, National Institute of Environmental Health Sciences, 111 T. W. Alexander Drive, Research Triangle Park, North Carolina 27709, USA.

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October 2007

Regulation of IL-1 and TNF receptor expression and function by endogenous macrophage migration inhibitory factor.

J Immunol 2006 Oct;177(7):4818-25

Centre for Inflammatory Diseases, Monash Institute of Medical Research, Monash Medical Center, Clayton, Melbourne 3168, Australia.

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October 2006

A novel mechanism of action for anti-thymocyte globulin: induction of CD4+CD25+Foxp3+ regulatory T cells.

J Am Soc Nephrol 2006 Oct 16;17(10):2844-53. Epub 2006 Aug 16.

Brigham & Women's Hospital, Transplantation Research Center, EBRC, 221 Longwood Avenue, 3rd Floor, Boston, MA 02115, USA.

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October 2006

Dynamic coupling and allosteric behavior in a nonallosteric protein.

Biochemistry 2006 Jun;45(25):7693-9

Department of Biochemistry and Biophysics, School of Medicine, Division of Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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June 2006

Critical, but conditional, role of OX40 in memory T cell-mediated rejection.

J Immunol 2006 Feb;176(3):1394-401

Transplant Research Center, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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February 2006

T-cell costimulatory pathways in allograft rejection and tolerance.

Transplantation 2005 Sep;80(5):555-63

Transplantation Research Center, Brigham and Women's Hospital and Children's Hospital Boston, Harvard Medical School, Boston, MA, USA.

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September 2005

Role of structural plasticity in signal transduction by the cryptochrome blue-light photoreceptor.

Biochemistry 2005 Mar;44(10):3795-805

Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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March 2005

Long-range dynamic effects of point mutations propagate through side chains in the serine protease inhibitor eglin c.

Biochemistry 2004 Oct;43(39):12448-58

Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599-7360, USA.

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October 2004

Acute interstitial nephritis: clinical features and response to corticosteroid therapy.

Nephrol Dial Transplant 2004 Nov 31;19(11):2778-83. Epub 2004 Aug 31.

Renal Division, Brigham and Women's Hospital, 75 Frances Street, Boston, MA 02115, USA.

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November 2004

Increased rigidity of eglin c at acidic pH: evidence from NMR spin relaxation and MD simulations.

Biochemistry 2003 Dec;42(47):13856-68

Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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December 2003

Enteric-coated mycophenolate sodium.

Ann Pharmacother 2003 Nov;37(11):1685-93

Department of Pharmacy Services, Brigham and Women's Hospital, Boston, MA 02115-6110, USA.

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November 2003

Regulatory CD25+ T cells in human kidney transplant recipients.

J Am Soc Nephrol 2003 Jun;14(6):1643-51

Laboratory of Immunogenetics and Transplantation, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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June 2003

Reversal of pulmonary hypertension after ligation of a brachiocephalic arteriovenous fistula.

Am J Kidney Dis 2002 Sep;40(3):E8

Renal Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

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September 2002

Sex with two SOX on: SRY and SOX9 in testis development.

Trends Endocrinol Metab 2002 Apr;13(3):106-11

Prince Henry's Institute of Medical Research, PO 5152, Clayton, Victoria 3168, Australia.

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April 2002