Michael C Phillips

Michael C Phillips

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Reference Parameters for Protein Hydrogen Exchange Rates.

J Am Soc Mass Spectrom 2018 09 18;29(9):1936-1939. Epub 2018 Jul 18.

Johnson Research Foundation, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/s13361-018-2021-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087487PMC
September 2018

Is ABCA1 a lipid transfer protein?

J Lipid Res 2018 05 5;59(5):749-763. Epub 2018 Jan 5.

Division of Translational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-5158

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http://dx.doi.org/10.1194/jlr.R082313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928442PMC
May 2018

CRISPR/Cas9-Mediated Gene Editing in Human iPSC-Derived Macrophage Reveals Lysosomal Acid Lipase Function in Human Macrophages-Brief Report.

Arterioscler Thromb Vasc Biol 2017 11 7;37(11):2156-2160. Epub 2017 Sep 7.

From the Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York (H.Z., J.S., M.A.H., C.X., R.C.B., M.P.R.); Irving Institute for Clinical and Translational Research, Columbia University, New York (H.J., M.P.R.); Cardiovascular Institute, Perelman School of Medicine (W.L.), Division of Translational Medicine and Human Genetics, Departments of Genetics and Medicine, Perelman School of Medicine (J.T., J.B., M.C.P., D.J.R.), and Metabolic Tracer Resource, Institute for Diabetes, Obesity and Metabolism, Department of Medicine (J.M.), University of Pennsylvania, Philadelphia; and Department of Pathology and Immunology, Washington University in St. Louis, MO (B.R.).

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http://dx.doi.org/10.1161/ATVBAHA.117.310023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659288PMC
November 2017

ATP-Binding Cassette Transporter A1 Deficiency in Human Induced Pluripotent Stem Cell-Derived Hepatocytes Abrogates HDL Biogenesis and Enhances Triglyceride Secretion.

EBioMedicine 2017 Apr 14;18:139-145. Epub 2017 Mar 14.

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine of the University of Pennsylvania and Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405159PMC
April 2017

Helical structure, stability, and dynamics in human apolipoprotein E3 and E4 by hydrogen exchange and mass spectrometry.

Proc Natl Acad Sci U S A 2017 01 17;114(5):968-973. Epub 2017 Jan 17.

Division of Translational Medicine and Human Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104-5158;

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http://dx.doi.org/10.1073/pnas.1617523114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293021PMC
January 2017

Cell lipid metabolism modulators 2-bromopalmitate, D609, monensin, U18666A and probucol shift discoidal HDL formation to the smaller-sized particles: implications for the mechanism of HDL assembly.

Biochim Biophys Acta 2016 12 24;1861(12 Pt A):1968-1979. Epub 2016 Sep 24.

Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2016.09.017DOI Listing
December 2016

Robust passive and active efflux of cellular cholesterol to a designer functional mimic of high density lipoprotein.

J Lipid Res 2015 May 4;56(5):972-85. Epub 2015 Feb 4.

Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 International Institute for Nanotechnology, Northwestern University, Evanston, IL 60208 Simpson Querrey Institute for BioNanotechnology and Medicine, Northwestern University, Chicago, IL 60611.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M054635
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http://dx.doi.org/10.1194/jlr.M054635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409287PMC
May 2015

Kinetic and thermodynamic analyses of spontaneous exchange between high-density lipoprotein-bound and lipid-free apolipoprotein A-I.

Biochemistry 2015 Feb 16;54(4):1123-31. Epub 2015 Jan 16.

Institute of Health Biosciences, Graduate School of Pharmaceutical Sciences, Tokushima University , 1-78-1 Shomachi, Tokushima 770-8505, Japan.

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http://dx.doi.org/10.1021/bi501345jDOI Listing
February 2015

Apolipoprotein E isoforms and lipoprotein metabolism.

IUBMB Life 2014 Sep;66(9):616-23

Division of Translational Medicine and Human Genetics, Perelman School of Medicine at the University of Pennsylvania, 11-130 Translational Research Center, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/iub.1314DOI Listing
September 2014

Molecular mechanisms of cellular cholesterol efflux.

J Biol Chem 2014 Aug 29;289(35):24020-9. Epub 2014 Jul 29.

From the Division of Translational Medicine and Human Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104-5158

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http://dx.doi.org/10.1074/jbc.R114.583658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148835PMC
August 2014

The roles of C-terminal helices of human apolipoprotein A-I in formation of high-density lipoprotein particles.

Biochim Biophys Acta 2014 Jan 9;1841(1):80-7. Epub 2013 Oct 9.

Institute of Health Biosciences, The University of Tokushima, 1-78-1 Shomachi, Tokushima 770-8505, Japan; Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1-78-1 Shomachi, Tokushima 770-8505, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2013.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863607PMC
January 2014

Interaction of thioflavin T with amyloid fibrils of apolipoprotein A-I N-terminal fragment: resonance energy transfer study.

J Struct Biol 2014 Jan 15;185(1):116-24. Epub 2013 Nov 15.

Institute of Health Biosciences, Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1-78-1 Shomachi, Tokushima 770-8505, Japan.

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http://dx.doi.org/10.1016/j.jsb.2013.10.017DOI Listing
January 2014

Influence of apolipoprotein A-I and apolipoprotein A-II availability on nascent HDL heterogeneity.

J Lipid Res 2013 Dec 1;54(12):3464-70. Epub 2013 Oct 1.

GI/Nutrition/Hepatology Division, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104.

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http://dx.doi.org/10.1194/jlr.M043109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826692PMC
December 2013

New insights into the determination of HDL structure by apolipoproteins: Thematic review series: high density lipoprotein structure, function, and metabolism.

J Lipid Res 2013 Aug 10;54(8):2034-48. Epub 2012 Dec 10.

Lipid Research Group, Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1194/jlr.R034025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708355PMC
August 2013

Mechanisms responsible for the compositional heterogeneity of nascent high density lipoprotein.

J Biol Chem 2013 Aug 8;288(32):23150-60. Epub 2013 Jul 8.

Lipid Research Group, The Children's Hospital of Philadelphia, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104-4318, USA.

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http://www.jbc.org/content/early/2013/07/08/jbc.M113.495523.
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http://www.jbc.org/cgi/doi/10.1074/jbc.M113.495523
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http://dx.doi.org/10.1074/jbc.M113.495523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743487PMC
August 2013

Factors controlling nascent high-density lipoprotein particle heterogeneity: ATP-binding cassette transporter A1 activity and cell lipid and apolipoprotein AI availability.

FASEB J 2013 Jul 29;27(7):2880-92. Epub 2013 Mar 29.

Lipid Research Group, Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://www.fasebj.org/doi/10.1096/fj.12-216564
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http://dx.doi.org/10.1096/fj.12-216564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688743PMC
July 2013

Comparison of apoA-I helical structure and stability in discoidal and spherical HDL particles by HX and mass spectrometry.

J Lipid Res 2013 Jun 10;54(6):1589-97. Epub 2013 Apr 10.

Lipid Research Group, Gastroenterology, Hepatology, and Nutrition Division, Children's Hospital of Philadelphia, Philadelphia, PA 19104-4318, USA.

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http://dx.doi.org/10.1194/jlr.M034785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646460PMC
June 2013

Molecular mechanisms responsible for the differential effects of apoE3 and apoE4 on plasma lipoprotein-cholesterol levels.

Arterioscler Thromb Vasc Biol 2013 Apr 14;33(4):687-93. Epub 2013 Feb 14.

Institute for Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1161/ATVBAHA.112.301193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660844PMC
April 2013

Serum albumin acts as a shuttle to enhance cholesterol efflux from cells.

J Lipid Res 2013 Mar 3;54(3):671-6. Epub 2013 Jan 3.

Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://dx.doi.org/10.1194/jlr.M031336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617942PMC
March 2013

Apolipoprotein E-mediated cell cycle arrest linked to p27 and the Cox2-dependent repression of miR221/222.

Atherosclerosis 2013 Mar 19;227(1):65-71. Epub 2012 Dec 19.

Department of Pharmacology, University of Pennsylvania Perelman School of Medicine, 3620 Hamilton Walk, Philadelphia, PA 19104-6084, USA.

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http://dx.doi.org/10.1016/j.atherosclerosis.2012.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638207PMC
March 2013

Interactions of apolipoprotein A-I with high-density lipoprotein particles.

Biochemistry 2013 Mar 4;52(11):1963-72. Epub 2013 Mar 4.

Lipid Research Group, Gastroenterology, Hepatology and Nutrition Division, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104-4318, United States.

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http://dx.doi.org/10.1021/bi400032yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603221PMC
March 2013

Dual role of an N-terminal amyloidogenic mutation in apolipoprotein A-I: destabilization of helix bundle and enhancement of fibril formation.

J Biol Chem 2013 Jan 11;288(4):2848-56. Epub 2012 Dec 11.

Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1-78-1 Shomachi, Tokushima 770-8505, Japan.

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http://dx.doi.org/10.1074/jbc.M112.428052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554949PMC
January 2013

Effects of the Iowa and Milano mutations on apolipoprotein A-I structure and dynamics determined by hydrogen exchange and mass spectrometry.

Biochemistry 2012 Nov 24;51(44):8993-9001. Epub 2012 Oct 24.

Lipid Research Group, Gastroenterology, Hepatology and Nutrition Division, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104-4318, United States.

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http://dx.doi.org/10.1021/bi300926jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493162PMC
November 2012

Cardiovascular protection by ApoE and ApoE-HDL linked to suppression of ECM gene expression and arterial stiffening.

Cell Rep 2012 Nov 25;2(5):1259-71. Epub 2012 Oct 25.

Institute for Translational Medicine and Therapeutics, Departments of Pharmacology, Medicine, and Physiology, and the Molecular Profiling Facility, University of Pennsylvania, Philadelphia, PA 19104, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S22111247120032
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http://dx.doi.org/10.1016/j.celrep.2012.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535179PMC
November 2012

Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism.

J Clin Invest 2012 Aug 2;122(8):2807-16. Epub 2012 Jul 2.

Institute for Translational Medicine and Therapeutics, Cardiovascular Institute, and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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http://www.jci.org/articles/view/63563
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http://dx.doi.org/10.1172/JCI63563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408750PMC
August 2012

Fluorescence analysis of the lipid binding-induced conformational change of apolipoprotein E4.

Biochemistry 2012 Jul 3;51(28):5580-8. Epub 2012 Jul 3.

Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1-78-1 Shomachi, Tokushima 770-8505, Japan.

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http://dx.doi.org/10.1021/bi300672sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447985PMC
July 2012

Apolipoprotein A-I helical structure and stability in discoidal high-density lipoprotein (HDL) particles by hydrogen exchange and mass spectrometry.

Proc Natl Acad Sci U S A 2012 Jul 27;109(29):11687-92. Epub 2012 Jun 27.

Lipid Research Group, Gastroenterology, Hepatology and Nutrition Division, Children's Hospital of Philadelphia, Philadelphia, PA 19104-4318, USA.

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http://dx.doi.org/10.1073/pnas.1209305109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406875PMC
July 2012

Influence of C-terminal α-helix hydrophobicity and aromatic amino acid content on apolipoprotein A-I functionality.

Biochim Biophys Acta 2012 Mar 5;1821(3):456-63. Epub 2011 Aug 5.

Lipid Research Group, Gastroenterology, Hepatology and Nutrition Division, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4318, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S138819811100145
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http://dx.doi.org/10.1016/j.bbalip.2011.07.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227795PMC
March 2012

Cytoskeleton disruption in J774 macrophages: consequences for lipid droplet formation and cholesterol flux.

Biochim Biophys Acta 2012 Mar 8;1821(3):464-72. Epub 2011 Oct 8.

Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA 19104-4318, USA.

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http://dx.doi.org/10.1016/j.bbalip.2011.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274585PMC
March 2012

Novel in vivo method for measuring cholesterol mass flux in peripheral macrophages.

Arterioscler Thromb Vasc Biol 2011 Dec 22;31(12):2865-71. Epub 2011 Sep 22.

Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://dx.doi.org/10.1161/ATVBAHA.111.236406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220789PMC
December 2011

A sensitive assay for ABCA1-mediated cholesterol efflux using BODIPY-cholesterol.

J Lipid Res 2011 Dec 27;52(12):2332-40. Epub 2011 Sep 27.

Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1194/jlr.D018051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220299PMC
December 2011

Influence of apolipoprotein A-I domain structure on macrophage reverse cholesterol transport in mice.

Arterioscler Thromb Vasc Biol 2011 Feb 11;31(2):320-7. Epub 2010 Nov 11.

Children's Hospital of Philadelphia, 3615 Civic Center Blvd., Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1161/ATVBAHA.110.216226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024460PMC
February 2011

Influence of N-terminal helix bundle stability on the lipid-binding properties of human apolipoprotein A-I.

Biochim Biophys Acta 2011 Jan 30;1811(1):25-30. Epub 2010 Oct 30.

Department of Biophysical Chemistry, Kobe Pharmaceutical University, Kobe 658-8558, Japan.

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http://dx.doi.org/10.1016/j.bbalip.2010.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003738PMC
January 2011

Molecular basis for the differences in lipid and lipoprotein binding properties of human apolipoproteins E3 and E4.

Biochemistry 2010 Dec 3;49(51):10881-9. Epub 2010 Dec 3.

Lipid Research Group, Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4318, United States.

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http://dx.doi.org/10.1021/bi1017655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025481PMC
December 2010

Influence of apolipoprotein (Apo) A-I structure on nascent high density lipoprotein (HDL) particle size distribution.

J Biol Chem 2010 Oct 2;285(42):31965-73. Epub 2010 Aug 2.

Lipid Research Group, Gastroenterology, Hepatology, and Nutrition Division, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4318, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.126292
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http://dx.doi.org/10.1074/jbc.M110.126292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952197PMC
October 2010

High-density lipoprotein heterogeneity and function in reverse cholesterol transport.

Curr Opin Lipidol 2010 Jun;21(3):229-38

Gastroenterology, Hepatology and Nutrition Division, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4318, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215082PMC
June 2010

High density lipoprotein structure-function and role in reverse cholesterol transport.

Subcell Biochem 2010 ;51:183-227

Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4318, USA.

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http://dx.doi.org/10.1007/978-90-481-8622-8_7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215094PMC
May 2010

Surface plasmon resonance analysis of the mechanism of binding of apoA-I to high density lipoprotein particles.

J Lipid Res 2010 Mar 28;51(3):606-17. Epub 2009 Sep 28.

Lipid Research Group, Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4318, USA.

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http://dx.doi.org/10.1194/jlr.M002055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817590PMC
March 2010

Pathways by which reconstituted high-density lipoprotein mobilizes free cholesterol from whole body and from macrophages.

Arterioscler Thromb Vasc Biol 2010 Mar 17;30(3):526-32. Epub 2009 Dec 17.

Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Maloney Building, Room 8039, 3600 Spruce Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1161/ATVBAHA.109.196105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842952PMC
March 2010

Influence of class B scavenger receptors on cholesterol flux across the brush border membrane and intestinal absorption.

J Lipid Res 2009 Nov 19;50(11):2235-44. Epub 2009 May 19.

Gastroenterology, Hepatology, and Nutrition Division, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4318, USA.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M900036-JLR200
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http://dx.doi.org/10.1194/jlr.M900036-JLR200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759829PMC
November 2009

Helical structure and stability in human apolipoprotein A-I by hydrogen exchange and mass spectrometry.

Proc Natl Acad Sci U S A 2009 Nov 22;106(45):19005-10. Epub 2009 Oct 22.

Lipid Research Group, Gastroenterology, Hepatology and Nutrition Division, Children's Hospital of Philadelphia, Philadelphia, PA 19104-4318, USA.

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http://dx.doi.org/10.1073/pnas.0909708106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776417PMC
November 2009

Macrophage reverse cholesterol transport in mice expressing ApoA-I Milano.

Arterioscler Thromb Vasc Biol 2009 Oct 6;29(10):1496-501. Epub 2009 Aug 6.

Lipid Research Group, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://dx.doi.org/10.1161/ATVBAHA.109.191379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943867PMC
October 2009

Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture.

J Neurosci Res 2009 Aug;87(11):2498-508

Department of Alzheimer's Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.

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http://dx.doi.org/10.1002/jnr.22073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065888PMC
August 2009

Structural and functional consequences of the Milano mutation (R173C) in human apolipoprotein A-I.

J Lipid Res 2009 Jul 24;50(7):1409-19. Epub 2009 Mar 24.

Gastroenterology/Nutrition/Hepatology Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4318, USA.

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http://dx.doi.org/10.1194/jlr.M800578-JLR200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694339PMC
July 2009

Molecular mechanism of apolipoprotein E binding to lipoprotein particles.

Biochemistry 2009 Apr;48(13):3025-32

Lipid Research Group, Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4318, USA.

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http://dx.doi.org/10.1021/bi9000694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765560PMC
April 2009

Interaction between the N- and C-terminal domains modulates the stability and lipid binding of apolipoprotein A-I.

Biochemistry 2009 Mar;48(11):2529-37

Department of Biophysical Chemistry, Kobe Pharmaceutical University, 4-19-1 Motoyamakitamachi, Higashinada-ku, Kobe 658-8558, Japan.

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http://dx.doi.org/10.1021/bi802317vDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936823PMC
March 2009

Characterization and properties of pre beta-HDL particles formed by ABCA1-mediated cellular lipid efflux to apoA-I.

J Lipid Res 2008 May 5;49(5):1006-14. Epub 2008 Feb 5.

Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4318, USA.

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http://www.jlr.org/content/49/5/1006.full.pdf
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http://www.jlr.org/cgi/doi/10.1194/jlr.M700506-JLR200
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http://dx.doi.org/10.1194/jlr.M700506-JLR200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2311446PMC
May 2008

Influence of tertiary structure domain properties on the functionality of apolipoprotein A-I.

Biochemistry 2008 Feb 19;47(7):2172-80. Epub 2008 Jan 19.

Department of Biophysical Chemistry, Kobe Pharmaceutical University, Kobe 658-8558, Japan.

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http://dx.doi.org/10.1021/bi702332bDOI Listing
February 2008

Structure-function properties of the apoE-dependent COX-2 pathway in vascular smooth muscle cells.

Atherosclerosis 2008 Jan 25;196(1):201-9. Epub 2007 May 25.

Institute for Translational Medicine and Therapeutics, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.1016/j.atherosclerosis.2007.03.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328805PMC
January 2008

The roles of different pathways in the release of cholesterol from macrophages.

J Lipid Res 2007 Nov 29;48(11):2453-62. Epub 2007 Aug 29.

Gastroenterology, Hepatology, and Nutrition Division, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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November 2007

Wild-type ApoA-I and the Milano variant have similar abilities to stimulate cellular lipid mobilization and efflux.

Arterioscler Thromb Vasc Biol 2007 Sep 5;27(9):2022-9. Epub 2007 Jul 5.

Division of Gasteroenterology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA 19104-4399, USA.

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http://dx.doi.org/10.1161/ATVBAHA.107.148403DOI Listing
September 2007

Mechanism of ATP-binding cassette transporter A1-mediated cellular lipid efflux to apolipoprotein A-I and formation of high density lipoprotein particles.

J Biol Chem 2007 Aug 29;282(34):25123-30. Epub 2007 Jun 29.

Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4318, USA.

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August 2007

ABCA1-induced cell surface binding sites for ApoA-I.

Arterioscler Thromb Vasc Biol 2007 Jul 3;27(7):1603-9. Epub 2007 May 3.

Division of GI/Nutrition, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4318, USA.

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July 2007

Effects of amino acid substitutions at glycine 420 on SR-BI cholesterol transport function.

J Lipid Res 2007 Jun 19;48(6):1386-95. Epub 2007 Mar 19.

Department of Pharmacological Sciences, University Medical Center, Stony Brook University, Stony Brook, NY 11794-8651, USA.

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June 2007

The C-terminal lipid-binding domain of apolipoprotein E is a highly efficient mediator of ABCA1-dependent cholesterol efflux that promotes the assembly of high-density lipoproteins.

Biochemistry 2007 Mar 17;46(10):2583-93. Epub 2007 Feb 17.

GI/Nutrition Division, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4318, USA.

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http://dx.doi.org/10.1021/bi602407rDOI Listing
March 2007

Contributions of the N- and C-terminal helical segments to the lipid-free structure and lipid interaction of apolipoprotein A-I.

Biochemistry 2006 Aug;45(34):10351-8

Department of Biophysical Chemistry, Kobe Pharmaceutical University, Kobe 658-8558, Japan.

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http://dx.doi.org/10.1021/bi060726tDOI Listing
August 2006

Characterization of nascent HDL particles and microparticles formed by ABCA1-mediated efflux of cellular lipids to apoA-I.

J Lipid Res 2006 Apr 17;47(4):832-43. Epub 2006 Jan 17.

Division of GI/Nutrition, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4318, USA.

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April 2006

Effect of carboxyl-terminal truncation on structure and lipid interaction of human apolipoprotein E4.

Biochemistry 2006 Apr;45(13):4240-7

Department of Biophysical Chemistry, Kobe Pharmaceutical University, Kobe 658-8558, Japan.

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April 2006

Structural analysis of lipoprotein E particles.

Biochemistry 2005 Sep;44(37):12525-34

University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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September 2005

Mechanisms of cholesterol-lowering effects of dietary insoluble fibres: relationships with intestinal and hepatic cholesterol parameters.

Br J Nutr 2005 Sep;94(3):331-7

Department of GI/Nutrition, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, 3615 Civic Center Blvd, Philadelphia, PA 19104-4318, USA.

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September 2005

Effects of the core lipid on the energetics of binding of ApoA-I to model lipoprotein particles of different sizes.

Biochemistry 2005 Aug;44(31):10689-95

The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4318, USA.

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August 2005

New HIV Drugs in Development, 2005.

Curr Infect Dis Rep 2005 May;7(3):221-226

Tampa General Hospital, Department of Infectious Diseases, G318, 2 Columbia Drive, Tampa, FL 33606, USA.

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May 2005

Class B scavenger receptor-mediated intestinal absorption of dietary beta-carotene and cholesterol.

Biochemistry 2005 Mar;44(11):4517-25

Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4318, USA.

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March 2005

Two-step mechanism of binding of apolipoprotein E to heparin: implications for the kinetics of apolipoprotein E-heparan sulfate proteoglycan complex formation on cell surfaces.

J Biol Chem 2005 Feb 6;280(7):5414-22. Epub 2004 Dec 6.

Lipid Research Group, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4318, USA.

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February 2005

Influence of ApoA-I structure on the ABCA1-mediated efflux of cellular lipids.

J Biol Chem 2004 Nov 21;279(48):49931-9. Epub 2004 Sep 21.

Division of GI/Nutrition, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4318, USA.

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November 2004

Structure of human apolipoprotein A-IV: a distinct domain architecture among exchangeable apolipoproteins with potential functional implications.

Biochemistry 2004 Aug;43(33):10719-29

Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA.

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August 2004

Contributions of domain structure and lipid interaction to the functionality of exchangeable human apolipoproteins.

Prog Lipid Res 2004 Jul;43(4):350-80

Lipid Research Group, The Children's Hospital of Philadelphia, Abramson Research Center, Suite 1102, 3615 Civic Center Boulevard, University of Pennsylvania School of Medicine, Philadelphia, 19104-4318, USA.

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July 2004

Identification of an apolipoprotein A-I structural element that mediates cellular cholesterol efflux and stabilizes ATP binding cassette transporter A1.

J Biol Chem 2004 Jun 29;279(23):24044-52. Epub 2004 Mar 29.

Lawrence Berkeley National Laboratory, Donner Laboratory MS1-224, University of California at Berkeley, California 94720, USA.

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June 2004

Alpha-helix formation is required for high affinity binding of human apolipoprotein A-I to lipids.

J Biol Chem 2004 May 12;279(20):20974-81. Epub 2004 Mar 12.

Division of Gastroenterology and Nutrition, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Abramson Research Center, 3625 Civic Center Boulevard, Philadelphia, PA 19104-4318, USA.

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May 2004

Helix orientation of the functional domains in apolipoprotein e in discoidal high density lipoprotein particles.

J Biol Chem 2004 Apr 21;279(14):14273-9. Epub 2004 Jan 21.

Lipid Biology in Health and Disease Research Group, Children's Hospital Oakland Research Institute, Oakland, California 94609, USA.

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April 2004

Scavenger receptor class B type I-mediated cholesteryl ester-selective uptake and efflux of unesterified cholesterol. Influence of high density lipoprotein size and structure.

J Biol Chem 2004 Mar 12;279(13):12448-55. Epub 2004 Jan 12.

Division of GI/Nutrition, Lipid Research Group, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, 3615 Civic Center Boulevard, Philadelphia, PA 19104-4318, USA.

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March 2004

Scavenger receptor BI (SR-BI) clustered on microvillar extensions suggests that this plasma membrane domain is a way station for cholesterol trafficking between cells and high-density lipoprotein.

Mol Biol Cell 2004 Jan 3;15(1):384-96. Epub 2003 Oct 3.

Department of Pharmacological Sciences, University Medical Center, State University of New York at Stony Brook, Stony Brook, New York 11794, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC307555PMC
January 2004

Effects of polymorphism on the lipid interaction of human apolipoprotein E.

J Biol Chem 2003 Oct 12;278(42):40723-9. Epub 2003 Aug 12.

National Institute of Health Sciences, Osaka Branch, Osaka 540-0006, Japan.

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October 2003

Effects of apolipoprotein A-I on ATP-binding cassette transporter A1-mediated efflux of macrophage phospholipid and cholesterol: formation of nascent high density lipoprotein particles.

J Biol Chem 2003 Oct 19;278(44):42976-84. Epub 2003 Aug 19.

Gastrointestinal/Nutrition Division, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4318, USA.

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http://dx.doi.org/10.1074/jbc.M308420200DOI Listing
October 2003

A quantitative analysis of apolipoprotein binding to SR-BI: multiple binding sites for lipid-free and lipid-associated apolipoproteins.

J Lipid Res 2003 Jun 1;44(6):1132-42. Epub 2003 Apr 1.

Division of GI/Nutrition, Lipid Research Group, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, 19104-4318, USA.

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June 2003

Domain structure and lipid interaction in human apolipoproteins A-I and E, a general model.

J Biol Chem 2003 Jun 22;278(26):23227-32. Epub 2003 Apr 22.

National Institute of Health Sciences, Osaka Branch, Osaka 540-0006, Japan.

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June 2003

Importance of different pathways of cellular cholesterol efflux.

Arterioscler Thromb Vasc Biol 2003 May 23;23(5):712-9. Epub 2003 Jan 23.

Division of Gastroenterology and Nutrition, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4318, USA.

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May 2003

High density lipoprotein structure.

Front Biosci 2003 May 1;8:d1044-54. Epub 2003 May 1.

GI/Nutrition Division, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4318, USA.

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May 2003

Characterization of the heparin binding sites in human apolipoprotein E.

J Biol Chem 2003 Apr 14;278(17):14782-7. Epub 2003 Feb 14.

Joseph Stokes, Jr. Research Institute, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4318, USA.

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April 2003

Increased low-density lipoprotein oxidation and impaired high-density lipoprotein antioxidant defense are associated with increased macrophage homing and atherosclerosis in dyslipidemic obese mice: LCAT gene transfer decreases atherosclerosis.

Circulation 2003 Apr 24;107(12):1640-6. Epub 2003 Mar 24.

Cardiovascular Research Unit at the Center for Experimental Surgery and Anesthesiology, Katholieke Universiteit Leuven, Campus Gasthuisberg, O&N, Herestraat 49, B-3000 Leuven, Belgium.

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April 2003

Influence of apoE domain structure and polymorphism on the kinetics of phospholipid vesicle solubilization.

J Lipid Res 2002 Oct;43(10):1688-700

Joseph Stokes Jr. Research Institute, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4318, USA.

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October 2002

Comparison of the stabilities and unfolding pathways of human apolipoprotein E isoforms by differential scanning calorimetry and circular dichroism.

Biochim Biophys Acta 2002 Sep;1584(1):9-19

Department of Chemistry and Biochemistry, University of the Sciences in Philadelphia, Philadelphia, PA 19104, USA.

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September 2002