Michael C Irizarry

Michael C Irizarry

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Michael C Irizarry

Michael C Irizarry

Publications by authors named "Michael C Irizarry"

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57Publications

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Severity dependent distribution of impairments in PSP and CBS: Interactive visualizations.

Parkinsonism Relat Disord 2019 Mar 4;60:138-145. Epub 2018 Sep 4.

Memory and Aging Center, Department of Neurology, University of California, 675 Nelson Rising Lane, Suite 193, San Francisco, CA, 94158, USA.

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http://dx.doi.org/10.1016/j.parkreldis.2018.08.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399076PMC
March 2019

Topographic staging of tau positron emission tomography images.

Alzheimers Dement (Amst) 2018 14;10:221-231. Epub 2018 Feb 14.

Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://dx.doi.org/10.1016/j.dadm.2018.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956800PMC
February 2018

Incidence of type 2 diabetes among patients exposed to the combination of pravastatin and paroxetine.

Curr Drug Saf 2015 ;10(2):152-8

Bristol-Myers Squibb Co., 311 Pennington-Rocky Hill Road, Pennington, NJ 08534, USA.

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February 2016

Lipoprotein-associated phospholipase A2 and risk of dementia in the Cardiovascular Health Study.

Atherosclerosis 2014 Aug 22;235(2):384-91. Epub 2014 May 22.

WW Epidemiology, GlaxoSmithKline, Research Triangle Park, NC and Upper Merion, PA, USA.

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http://dx.doi.org/10.1016/j.atherosclerosis.2014.04.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096578PMC
August 2014

Risk of cancer in patients exposed to gabapentin in two electronic medical record systems.

Pharmacoepidemiol Drug Saf 2012 Feb 6;21(2):214-25. Epub 2011 Dec 6.

WW Epidemiology, GlaxoSmithKline, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.1002/pds.2266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314779PMC
February 2012

Modeling Alzheimer's disease progression using the disease system analysis approach.

Alzheimers Dement 2012 Jan 22;8(1):39-50. Epub 2011 Jul 22.

Pharmacometrics, GlaxoSmithKline R&D, Upper Merion, PA, USA.

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http://dx.doi.org/10.1016/j.jalz.2010.12.012DOI Listing
January 2012

Risk factors for antiepileptic drug regimen change in patients with newly diagnosed epilepsy.

Epilepsy Behav 2011 Jun 30;21(2):168-72. Epub 2011 Apr 30.

Worldwide Epidemiology, GlaxoSmithKline, Middlesex, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S152550501100121
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http://dx.doi.org/10.1016/j.yebeh.2011.03.017DOI Listing
June 2011

Effects of simvastatin on cholesterol metabolism and Alzheimer disease biomarkers.

Alzheimer Dis Assoc Disord 2010 Jul-Sep;24(3):220-6

Memory Disorders Unit, Department of Neurology and Massachusetts Alzheimer's Disease Research Center, Massachusetts General Hospital, Harvard Medical School, Boston , MA 02114, USA.

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http://dx.doi.org/10.1097/WAD.0b013e3181d61feaDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694274PMC
January 2011

Caffeine protects against combined paraquat and maneb-induced dopaminergic neuron degeneration.

Exp Neurol 2010 Jun 24;223(2):657-61. Epub 2010 Feb 24.

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00144886100006
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http://dx.doi.org/10.1016/j.expneurol.2010.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864327PMC
June 2010

Performance characteristics of plasma amyloid-beta 40 and 42 assays.

J Alzheimers Dis 2009 ;16(2):277-85

Division of Aging, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA.

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/JAD-2009-0948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737811PMC
June 2009

Plasma urate and progression of mild cognitive impairment.

Neurodegener Dis 2009 5;6(1-2):23-8. Epub 2008 Nov 5.

Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1159/000170883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745303PMC
February 2009

Plasma amyloid beta-protein and C-reactive protein in relation to the rate of progression of Alzheimer disease.

Arch Neurol 2008 Jun;65(6):776-85

Massachusetts Alzheimer's Disease Research Center, Wang Ambulatory Care Center, Suite 720, Room 731-G, Massachusetts General Hospital, 15 Parkman St, Boston, MA 02114, USA.

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http://archneur.jamanetwork.com/article.aspx?doi=10.1001/arc
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http://dx.doi.org/10.1001/archneur.65.6.776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662621PMC
June 2008

Shorter telomeres may mark early risk of dementia: preliminary analysis of 62 participants from the nurses' health study.

PLoS One 2008 Feb 13;3(2):e1590. Epub 2008 Feb 13.

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001590PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2536511PMC
February 2008

The normal equilibrium between CSF and plasma amyloid beta levels is disrupted in Alzheimer's disease.

Neurosci Lett 2007 Nov 20;427(3):127-31. Epub 2007 Sep 20.

Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.neulet.2007.09.023DOI Listing
November 2007

Expression of APP pathway mRNAs and proteins in Alzheimer's disease.

Brain Res 2007 Aug 5;1161:116-23. Epub 2007 Jun 5.

Alzheimer Disease Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.brainres.2007.05.050DOI Listing
August 2007

Plasma Abeta levels do not reflect brain Abeta levels.

J Neuropathol Exp Neurol 2007 Apr;66(4):264-71

C. S. Kubik Laboratory for Neuropathology, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA.

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http://dx.doi.org/10.1097/NEN.0b013e31803d3ae4DOI Listing
April 2007

Prospective study of plasma folate, vitamin B12, and cognitive function and decline.

Epidemiology 2006 Nov;17(6):650-7

Department of Medicine, Channing Laboratory, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1097/01.ede.0000239727.59575.daDOI Listing
November 2006

Prevalence and effects of lobar microhemorrhages in early-stage dementia.

Neurodegener Dis 2005 ;2(6):305-12

Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1159/000092317DOI Listing
October 2006

Coordinated expression of caspase 8, 3 and 7 mRNA in temporal cortex of Alzheimer disease: relationship to formic acid extractable abeta42 levels.

J Neuropathol Exp Neurol 2006 May;65(5):508-15

Alzheimer Research Unit, Mass General Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1097/01.jnen.0000229238.05748.12DOI Listing
May 2006

Relation of quantitative indexes of concurrent alpha-synuclein abnormalities to clinical outcome in autopsy-proven Alzheimer disease.

Arch Neurol 2006 Feb;63(2):226-30

Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

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http://dx.doi.org/10.1001/archneur.63.2.226DOI Listing
February 2006

Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms.

Exp Neurol 2005 Jul;194(1):91-6

Harvard Medical School, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.expneurol.2005.01.026DOI Listing
July 2005

Autoantibodies to redox-modified oligomeric Abeta are attenuated in the plasma of Alzheimer's disease patients.

J Biol Chem 2005 Apr 21;280(17):17458-63. Epub 2005 Feb 21.

Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129-4404, USA.

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http://dx.doi.org/10.1074/jbc.M414176200DOI Listing
April 2005

Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy.

J Cell Sci 2004 Oct 5;117(Pt 22):5437-45. Epub 2004 Oct 5.

Alzheimer Disease Research Laboratory, Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1242/jcs.01422DOI Listing
October 2004

Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein.

J Neurochem 2004 Sep;90(5):1132-43

Alzheimer Disease Research Unit, Massachusetts General Hospital-East, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2004.02581.xDOI Listing
September 2004

Lack of association of the cholesterol 24-hydroxylase (CYP46) intron 2 polymorphism with Alzheimer's disease.

Neurosci Lett 2004 Sep;367(2):228-31

Harvard Medical School, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.neulet.2004.06.011DOI Listing
September 2004

Biomarkers of Alzheimer disease in plasma.

NeuroRx 2004 Apr;1(2):226-34

Alzheimer Disease Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC534932PMC
http://dx.doi.org/10.1602/neurorx.1.2.226DOI Listing
April 2004

Beta-secretase activity increases with aging in human, monkey, and mouse brain.

Am J Pathol 2004 Feb;164(2):719-25

Department of Neurology, Alzheimer Disease Research Unit, Massachusetts General Hospital-East, Charlestown, Massachusetts 02129, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1602259PMC
http://dx.doi.org/10.1016/s0002-9440(10)63159-8DOI Listing
February 2004

Genotyping of apolipoprotein E: comparative evaluation of different protocols.

Curr Protoc Hum Genet 2003 Nov;Chapter 9:Unit9.14

Harvard Medical School/Massachusetts General Hospital, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1002/0471142905.hg0914s38DOI Listing
November 2003

FGF-2 regulates neurogenesis and degeneration in the dentate gyrus after traumatic brain injury in mice.

J Clin Invest 2003 Oct;112(8):1202-10

Neuroscience Center, Radiology Department, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI16618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC213483PMC
October 2003

Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes.

J Cell Sci 2003 Aug 26;116(Pt 16):3339-46. Epub 2003 Jun 26.

Alzheimer Disease Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1242/jcs.00643DOI Listing
August 2003

A turn of the sulfatide in Alzheimer's disease.

Ann Neurol 2003 Jul;54(1):7-8

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http://dx.doi.org/10.1002/ana.10642DOI Listing
July 2003

Age but not diagnosis is the main predictor of plasma amyloid beta-protein levels.

Arch Neurol 2003 Jul;60(7):958-64

Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.

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http://dx.doi.org/10.1001/archneur.60.7.958DOI Listing
July 2003

Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels.

J Biol Chem 2002 Dec 15;277(50):48508-13. Epub 2002 Oct 15.

Alzheimer Research Unit, Massachusetts General Hospital, Charlestown 02129, USA.

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http://dx.doi.org/10.1074/jbc.M209085200DOI Listing
December 2002

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease.

Arch Neurol 2002 Sep;59(9):1381-9

Alzheimer Disease Research Unit, Center for Aging, Genetics, and Neurodegeneration, Massachusetts General Hospital-East, Bldg 114, Room 2010, 114 16th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1001/archneur.59.9.1381DOI Listing
September 2002

LRP and senile plaques in Alzheimer's disease: colocalization with apolipoprotein E and with activated astrocytes.

Brain Res Mol Brain Res 2002 Jul;104(1):38-46

Alzheimer Research Unit, Department of Neurology, Massachusetts General Hospital, 114 16th Street, Room 2009, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/s0169-328x(02)00203-6DOI Listing
July 2002