Publications by authors named "Michael C Deblock"

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Anti-tumor activity of lipophilic imidazolium salts on select NSCLC cell lines.

Med Chem Res 2015 Jul 13;24(7):2838-2861. Epub 2015 Feb 13.

Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA.

The anti-tumor activity of imidazolium salts is highly dependent upon the substituents on the nitrogen atoms of the imidazolium cation. We have synthesized and characterized a series of naphthalene-substituted imidazolium salts and tested them against a variety of non-smallcell lung cancer cell lines. Several of these complexes displayed anticancer activity comparable to cisplatin. These compounds induced apoptosis in the NCI-H460 cell line as determined by Annexin V staining, caspase-3, and PARP cleavage. These results strongly suggest that this class of compounds can serve as potent chemotherapeutic agents.
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July 2015