Michael Buchert

IL33 and Mast Cells-The Key Regulators of Immune Responses in Gastrointestinal Cancers?

Authors:

Moritz F Eissmann Michael Buchert Matthias Ernst

Front Immunol 2020 3;11:1389. Epub 2020 Jul 3.

Olivia Newton-John Cancer Research Institute, and La Trobe University School of Cancer Medicine, Heidelberg, VIC, Australia.

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July 2020

IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization.

Authors:

Moritz F Eissmann Christine Dijkstra Andrew Jarnicki Toby Phesse Jamina Brunnberg Ashleigh R Poh Nima Etemadi Evelyn Tsantikos Stefan Thiem Nicholas D Huntington Margaret L Hibbs Alex Boussioutas Michele A Grimbaldeston Michael Buchert Robert J J O'Donoghue Frederick Masson Matthias Ernst

Nat Commun 2019 06 21;10(1):2735. Epub 2019 Jun 21.

Cancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe University, Heidelberg, VIC, 3084, Australia.

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June 2019

Repurposing the selective estrogen receptor modulator to suppress gastrointestinal cancer growth.

Authors:

Pathum Thilakasiri Jennifer Huynh Ashleigh R Poh Chin Wee Tan Tracy L Nero Kelly Tran Adam C Parslow Shoukat Afshar-Sterle David Baloyan Natalie J Hannan Michael Buchert Andrew Mark Scott Michael Dw Griffin Frederic Hollande Michael W Parker Tracy L Putoczki Matthias Ernst Ashwini L Chand

EMBO Mol Med 2019 04;11(4)

Olivia Newton-John Cancer Research Institute, School of Cancer Medicine, La Trobe University, Heidelberg, Vic., Australia

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April 2019

Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors.

Cancer Discov 2018 08 7;8(8):988-1005. Epub 2018 Jun 7.

Systems Biology and Personalised Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

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August 2018

The JAK/STAT3 axis: A comprehensive drug target for solid malignancies.

Authors:

Jennifer Huynh Nima Etemadi Frédéric Hollande Matthias Ernst Michael Buchert

Semin Cancer Biol 2017 08 21;45:13-22. Epub 2017 Jun 21.

Olivia Newton-John Cancer Research Institute and La Trobe University School of Cancer Medicine, 145 Studely Rd, Heidelberg VIC, 3084, Australia.

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August 2017

Generation of an inducible mouse model to reversibly silence Stat3.

Authors:

Mariah G Alorro Thomas P Pierce Moritz F Eissmann Christine Dijkstra Ross A Dickins Matthias Ernst Michael Buchert Frederic Masson

Genesis 2017 04 23;55(4). Epub 2017 Feb 23.

Cancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute and La Trobe University School of Cancer Medicine, Heidelberg, Victoria, 3084, Australia.

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April 2017

Inducible gene modification in the gastric epithelium of Tff1-CreERT2, Tff2-rtTA, Tff3-luc mice.

Authors:

Stefan Thiem Moritz F Eissmann Emma Stuart Joachim Elzer Anna Jonas Michael Buchert Matthias Ernst

Genesis 2016 Dec 25;54(12):626-635. Epub 2016 Oct 25.

Cancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute and School of Cancer Medicine La Trobe University, Heidelberg, Australia.

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December 2016

Biochemical and Structural Insights into Doublecortin-like Kinase Domain 1.

Authors:

Onisha Patel Weiwen Dai Mareike Mentzel Michael D W Griffin Juliette Serindoux Yoann Gay Stefanie Fischer Shoukat Sterle Ashleigh Kropp Christopher J Burns Matthias Ernst Michael Buchert Isabelle S Lucet

Structure 2016 09 18;24(9):1550-61. Epub 2016 Aug 18.

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia. Electronic address:

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September 2016

Stomach-Specific Activation of Oncogenic KRAS and STAT3-Dependent Inflammation Cooperatively Promote Gastric Tumorigenesis in a Preclinical Model.

Authors:

Stefan Thiem Moritz F Eissmann Joachim Elzer Anna Jonas Tracy L Putoczki Ashleigh Poh Paul Nguyen Adele Preaudet Dustin Flanagan Elizabeth Vincan Paul Waring Michael Buchert Andrew Jarnicki Matthias Ernst

Cancer Res 2016 04 2;76(8):2277-87. Epub 2016 Feb 2.

Cancer and Inflammation, Olivia Newton-John Cancer Research Institute and School of Cancer Medicine La Trobe University, Heidelberg, Australia.

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April 2016

A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations.

Authors:

Michael Buchert Franziska Rohde Moritz Eissmann Niall Tebbutt Ben Williams Chin Wee Tan Alexander Owen Yumiko Hirokawa Alexandra Gnann Gertraud Orend Gayle Orner Rod H Dashwood Joan K Heath Matthias Ernst Klaus-Peter Janssen

Dis Model Mech 2015 Nov 6;8(11):1361-73. Epub 2015 Aug 6.

Department of Surgery, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany

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November 2015

Glycoprotein A33 deficiency: a new mouse model of impaired intestinal epithelial barrier function and inflammatory disease.

Authors:

Benjamin B Williams Niall C Tebbutt Michael Buchert Tracy L Putoczki Karen Doggett Shisan Bao Cameron N Johnstone Frederick Masson Frederic Hollande Antony W Burgess Andrew M Scott Matthias Ernst Joan K Heath

Dis Model Mech 2015 Aug 8;8(8):805-15. Epub 2015 May 8.

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia Department of Medical Biology, University of Melbourne, Parkville, Victoria 3052, Australia Ludwig Institute for Cancer Research, Melbourne-Parkville Branch, Parkville, Victoria 3050, Australia

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August 2015

Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.

Sci Signal 2014 Sep 30;7(345):ra92. Epub 2014 Sep 30.

Ludwig Institute for Cancer Research, Melbourne, Victoria 3052, Australia. Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia. Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3052, Australia.

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September 2014

Therapeutic inhibition of Jak activity inhibits progression of gastrointestinal tumors in mice.

Authors:

Emma Stuart Michael Buchert Tracy Putoczki Stefan Thiem Ryan Farid Joachim Elzer Dennis Huszar Paul M Waring Toby J Phesse Matthias Ernst

Mol Cancer Ther 2014 Feb 7;13(2):468-74. Epub 2014 Jan 7.

Corresponding Author: Matthias Ernst, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.

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February 2014

mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice.

Authors:

Stefan Thiem Thomas P Pierce Michelle Palmieri Tracy L Putoczki Michael Buchert Adele Preaudet Ryan O Farid Chris Love Bruno Catimel Zhengdeng Lei Steve Rozen Veena Gopalakrishnan Fred Schaper Michael Hallek Alex Boussioutas Patrick Tan Andrew Jarnicki Matthias Ernst

J Clin Invest 2013 Feb 16;123(2):767-81. Epub 2013 Jan 16.

Ludwig Institute for Cancer Research, Melbourne-Parkville Branch, Parkville, Victoria, Australia.

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February 2013

Methods to examine tight junction physiology in cancer stem cells: TEER, paracellular permeability, and dilution potential measurements.

Authors:

Michael Buchert Kursad Turksen Frédéric Hollande

Stem Cell Rev Rep 2012 Sep;8(3):1030-4

Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Australia.

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September 2012

Symplekin promotes tumorigenicity by up-regulating claudin-2 expression.

Authors:

Michael Buchert Marina Papin Caroline Bonnans Charbel Darido Warren S Raye Véronique Garambois André Pélegrin Jean-François Bourgaux Julie Pannequin Dominique Joubert Frédéric Hollande

Proc Natl Acad Sci U S A 2010 Feb 25;107(6):2628-33. Epub 2010 Jan 25.

Institut de Génomique Fonctionnelle, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5203, Institut National de la Santé et de la Recherche Médicale U661, and Université Montpellier 1 and 2, Montpellier F-34094, France.

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February 2010

Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo.

Authors:

Michael Buchert Dimitris Athineos Helen E Abud Zoe D Burke Maree C Faux Michael S Samuel Andrew G Jarnicki Catherine E Winbanks Ian P Newton Valerie S Meniel Hiromu Suzuki Steven A Stacker Inke S Näthke David Tosh Joerg Huelsken Alan R Clarke Joan K Heath Owen J Sansom Matthias Ernst

PLoS Genet 2010 Jan 15;6(1):e1000816. Epub 2010 Jan 15.

Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Australia.

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January 2010

Elevated Dnmt3a activity promotes polyposis in Apc(Min) mice by relaxing extracellular restraints on Wnt signaling.

Authors:

Michael S Samuel Hiromu Suzuki Michael Buchert Tracy L Putoczki Niall C Tebbutt Therése Lundgren-May Aliki Christou Melissa Inglese Minoru Toyota Joan K Heath Robyn L Ward Paul M Waring Matthias Ernst

Gastroenterology 2009 Sep 18;137(3):902-13, 913.e1-11. Epub 2009 May 18.

Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia.

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September 2009

The symplekin/ZONAB complex inhibits intestinal cell differentiation by the repression of AML1/Runx1.

Authors:

Michael Buchert Charbel Darido Ebba Lagerqvist Anna Sedello Chantal Cazevieille Frank Buchholz Jean-Francois Bourgaux Julie Pannequin Dominique Joubert Frédéric Hollande

Gastroenterology 2009 Jul 27;137(1):156-64, 164.e1-3. Epub 2009 Mar 27.

CNRS, UMR 5203, Institut de Génomique Fonctionnelle, Montpellier, France.

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July 2009

Defective claudin-7 regulation by Tcf-4 and Sox-9 disrupts the polarity and increases the tumorigenicity of colorectal cancer cells.

Authors:

Charbel Darido Michael Buchert Julie Pannequin Pauline Bastide Hassan Zalzali Theo Mantamadiotis Jean-François Bourgaux Véronique Garambois Philippe Jay Philippe Blache Dominique Joubert Frédéric Hollande

Cancer Res 2008 Jun;68(11):4258-68

Centre National de la Recherche Scientifique, UMR 5203, Institut de Génomique Fonctionnelle, INSERM U661, Université Montpellier 1, 2, Montpellier, France.

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June 2008