Michael Brownlee

Michael Brownlee

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Michael Brownlee

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Hemoglobin A1c Targets for Glycemic Control With Pharmacologic Therapy.

Ann Intern Med 2018 10;169(7):512-513

Montefiore Medical Center and Albert Einstein College of Medicine, New York, New York (J.Z., M.B.).

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http://annals.org/article.aspx?doi=10.7326/L18-0372
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http://dx.doi.org/10.7326/L18-0372DOI Listing
October 2018

Development and innovation of system resources to optimize patient care.

Am J Health Syst Pharm 2018 Apr;75(7):465-472

University of Iowa Health Care, Iowa City, IA.

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http://dx.doi.org/10.2146/ajhp170402DOI Listing
April 2018

Vascular toxicity of urea, a new "old player" in the pathogenesis of chronic renal failure induced cardiovascular diseases.

Turk Pediatri Ars 2017 Dec 1;52(4):187-193. Epub 2017 Dec 1.

Department of Pediatrics. Scientific Institute "Casa Sollievo della Sofferenza", University of Foggia, Italy.

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http://dx.doi.org/10.5152/TurkPediatriArs.2017.6314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819855PMC
December 2017

Pharmacy informatics: A call to action for educators, administrators, and residency directors.

Curr Pharm Teach Learn 2017 09 30;9(5):746-749. Epub 2017 Jun 30.

Unity Point Health, St. Luke's Hospital, 1026 A Ave. NE, Cedar Rapids, IA 52402, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cptl.2017.05.003DOI Listing
September 2017

Urea-induced ROS accelerate senescence in endothelial progenitor cells.

Atherosclerosis 2017 Aug 15;263:127-136. Epub 2017 Jun 15.

Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2017.06.028DOI Listing
August 2017

Methylglyoxal-Induced Endothelial Cell Loss and Inflammation Contribute to the Development of Diabetic Cardiomyopathy.

Diabetes 2016 06 8;65(6):1699-713. Epub 2016 Mar 8.

Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada Department of Cellular & Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada

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http://dx.doi.org/10.2337/db15-0568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878427PMC
June 2016

Molecular and Cellular Mechanisms of Cardiovascular Disorders in Diabetes.

Circ Res 2016 May;118(11):1808-29

From the Diabetes Research Center (M.S.S., M.B.), Departments of Medicine (M.S.S., M.B.), and Pathology (M.B.), Albert Einstein College of Medicine, Bronx, New York, NY.

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http://dx.doi.org/10.1161/CIRCRESAHA.116.306923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888901PMC
May 2016

Response to Comment on Giacco et al. GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop. Diabetes 2015;64:3273-3284.

Authors:
Michael Brownlee

Diabetes 2016 Feb;65(2):e6-7

Einstein-Mount Sinai Diabetes Research Center and Departments of Medicine and Pathology, Albert Einstein College of Medicine, Bronx, NY

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http://dx.doi.org/10.2337/dbi15-0031DOI Listing
February 2016

GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop.

Diabetes 2015 Sep;64(9):3273-84

Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY Department of Medicine, Albert Einstein College of Medicine, Bronx, NY Department of Pathology, Albert Einstein College of Medicine, Bronx, NY

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db15
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http://dx.doi.org/10.2337/db15-0084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542449PMC
September 2015

Diabetic kidney disease.

Nat Rev Dis Primers 2015 07 30;1:15018. Epub 2015 Jul 30.

Baker IDI Heart &Diabetes Institute, 75 Commercial Road, Melbourne, Victoria 3004, Australia.

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http://dx.doi.org/10.1038/nrdp.2015.18DOI Listing
July 2015

Urea-induced ROS cause endothelial dysfunction in chronic renal failure.

Atherosclerosis 2015 Apr 31;239(2):393-400. Epub 2015 Jan 31.

Department of Clinical and Experimental Medicine, University of Foggia, Viale Pinto 1, O.O.R.R., Foggia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.01.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361277PMC
April 2015

Increased peritoneal damage in glyoxalase 1 knock-down mice treated with peritoneal dialysis.

Nephrol Dial Transplant 2015 Mar 11;30(3):401-9. Epub 2014 Nov 11.

Department of Nephrology, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1093/ndt/gfu346DOI Listing
March 2015

Mitochondrial reactive oxygen species in the pathogenesis of early diabetic nephropathy.

J Diabetes Investig 2015 Mar 25;6(2):137-9. Epub 2014 Jul 25.

Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University Kumamoto, Japan.

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http://dx.doi.org/10.1111/jdi.12258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364847PMC
March 2015

Transdermal deferoxamine prevents pressure-induced diabetic ulcers.

Proc Natl Acad Sci U S A 2015 Jan 22;112(1):94-9. Epub 2014 Dec 22.

Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1413445112
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http://dx.doi.org/10.1073/pnas.1413445112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291638PMC
January 2015

Differential effects of glyoxalase 1 overexpression on diabetic atherosclerosis and renal dysfunction in streptozotocin-treated, apolipoprotein E-deficient mice.

Physiol Rep 2014 Jun 11;2(6). Epub 2014 Jun 11.

Atherosclerosis, Genetics and Cell Biology Group, University of Ottawa Heart Institute, Ottawa, Ontario, Canada Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.14814/phy2.12043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208644PMC
June 2014

Knockdown of glyoxalase 1 mimics diabetic nephropathy in nondiabetic mice.

Diabetes 2014 Jan 23;63(1):291-9. Epub 2013 Sep 23.

Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY.

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http://dx.doi.org/10.2337/db13-0316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868051PMC
January 2014

Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetes.

Diabetologia 2014 Jan 26;57(1):224-35. Epub 2013 Oct 26.

Laboratory for Metabolism and Vascular Medicine, Division of General Internal Medicine, Department of Internal Medicine, Maastricht University Medical Center, Universiteitssingel 50, P.O. Box 616 (box 14), 6200 MD, Maastricht, the Netherlands,

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http://dx.doi.org/10.1007/s00125-013-3088-5DOI Listing
January 2014

Hyperglycemia-stimulated myelopoiesis causes impaired regression of atherosclerosis in type 1 diabetes.

Authors:
Michael Brownlee

Cell Metab 2013 May;17(5):631-3

Diabetes Research Center and Departments of Internal Medicine and Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/j.cmet.2013.04.015DOI Listing
May 2013

Overexpression of glyoxalase-I reduces hyperglycemia-induced levels of advanced glycation end products and oxidative stress in diabetic rats.

J Biol Chem 2011 Jan 5;286(2):1374-80. Epub 2010 Nov 5.

Department of Internal Medicine, Division of General Internal Medicine, Laboratory for Metabolism and Vascular Medicine, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M110.144097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020745PMC
January 2011

Diabetic retinopathy: targeting vasoregression.

Diabetes 2011 Jan;60(1):9-16

University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.2337/db10-0454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012202PMC
January 2011

Oxidative stress and diabetic complications.

Circ Res 2010 Oct;107(9):1058-70

Diabetes Research Center, Departments of Medicine/Endocrinology, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, New York 10461-1602, USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.110.223545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996922PMC
October 2010

Beyond hemoglobin A1c--need for additional markers of risk for diabetic microvascular complications.

JAMA 2010 Jun;303(22):2291-2

Division of Metabolism, Endocrinology, and Nutrition, School of Medicine, and Diabetes Care Center, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1001/jama.2010.785DOI Listing
June 2010

Hyperglycemia impairs proteasome function by methylglyoxal.

Diabetes 2010 Mar 15;59(3):670-8. Epub 2009 Dec 15.

School of Medicine, Institute of Biochemistry, Justus-Liebig-University, Giessen, Germany.

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http://dx.doi.org/10.2337/db08-1565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828656PMC
March 2010

Hyperglycemia-induced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands.

Diabetes 2010 Jan 15;59(1):249-55. Epub 2009 Oct 15.

Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA.

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http://dx.doi.org/10.2337/db09-0801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797929PMC
January 2010

HIF-1alpha dysfunction in diabetes.

Cell Cycle 2010 Jan;9(1):75-9

Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.

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http://dx.doi.org/10.4161/cc.9.1.10371DOI Listing
January 2010

The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues.

Proc Natl Acad Sci U S A 2009 Aug 28;106(32):13505-10. Epub 2009 Jul 28.

Department of Surgery, Stanford University School of Medicine, 257 Campus Drive, GK-201, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1073/pnas.0906670106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726398PMC
August 2009

Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function.

Endocrinology 2009 Jul 26;150(7):3040-8. Epub 2009 Feb 26.

Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2008-1642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703519PMC
July 2009

RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes.

J Am Soc Nephrol 2009 Apr 21;20(4):742-52. Epub 2009 Jan 21.

Juvenile Diabetes Research Foundation Einstein Centre for Diabetes Complications, Division of Diabetes Complications, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia.

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http://www.jasn.org/cgi/doi/10.1681/ASN.2008050514
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http://dx.doi.org/10.1681/ASN.2008050514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663823PMC
April 2009

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia.

J Exp Med 2008 Sep 22;205(10):2409-17. Epub 2008 Sep 22.

Diabetes and Metabolism Division, Baker Epigenetics in Human Health and Disease, Baker IDI Heart and Diabetes Institute, Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia.

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http://dx.doi.org/10.1084/jem.20081188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556800PMC
September 2008

PANIC-ATTAC: a mouse model for inducible and reversible beta-cell ablation.

Diabetes 2008 Aug 9;57(8):2137-48. Epub 2008 May 9.

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA.

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http://dx.doi.org/10.2337/db07-1631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494693PMC
August 2008

Decreasing intracellular superoxide corrects defective ischemia-induced new vessel formation in diabetic mice.

J Biol Chem 2008 Apr 28;283(16):10930-8. Epub 2008 Jan 28.

Department of Surgery, Stanford University School of Medicine, Stanford, California 94305-5148, USA.

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http://dx.doi.org/10.1074/jbc.M707451200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447622PMC
April 2008

High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A.

J Biol Chem 2007 Oct 1;282(42):31038-45. Epub 2007 Aug 1.

Juvenile Diabetes Research Foundation International Center for Diabetic Complications Research, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M704703200
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http://dx.doi.org/10.1074/jbc.M704703200DOI Listing
October 2007

Method for chronological recording of antigen appearance in human head-hair shafts and its use for monitoring glycation products in diabetes.

J Immunol Methods 2007 Mar 27;320(1-2):1-17. Epub 2006 Nov 27.

Myers Skin Biology and Biochemistry Laboratory, Department of Biological Chemistry, Institute of Life Sciences, Givat Ram - Hebrew University of Jerusalem, Jerusalem 91904, Israel.

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http://linkinghub.elsevier.com/retrieve/pii/S002217590600305
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http://dx.doi.org/10.1016/j.jim.2006.10.014DOI Listing
March 2007

The effect of glucose variability on the risk of microvascular complications in type 1 diabetes.

Diabetes Care 2007 Jan;30(1):186-7; author reply 188-9

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http://dx.doi.org/10.2337/dc06-1610DOI Listing
January 2007

Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation.

J Clin Invest 2006 Apr 9;116(4):1071-80. Epub 2006 Mar 9.

Diabetes Research Center, Albert Einstein College of Medicine, New York, New York 10461, USA.

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http://dx.doi.org/10.1172/JCI23354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1395482PMC
April 2006

Methylglyoxal modification of mSin3A links glycolysis to angiopoietin-2 transcription.

Cell 2006 Jan 12;124(2):275-86. Epub 2006 Jan 12.

JDRF International Center for Diabetic Complications Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/j.cell.2005.11.024DOI Listing
January 2006

Should minimal blood glucose variability become the gold standard of glycemic control?

J Diabetes Complications 2005 May-Jun;19(3):178-81

University of Washington Medical Center, Box 356176, 1959 NE Pacific Street, PO Seattle, WA 98105-6176, United States.

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http://dx.doi.org/10.1016/j.jdiacomp.2004.10.001DOI Listing
September 2005

Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation.

Am J Physiol Renal Physiol 2005 Aug 5;289(2):F420-30. Epub 2005 Apr 5.

Deparment of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1152/ajprenal.00415.2004DOI Listing
August 2005

The pathobiology of diabetic complications: a unifying mechanism.

Authors:
Michael Brownlee

Diabetes 2005 Jun;54(6):1615-25

Departments of Medicine and Pathology, Albert Einstein College of Medicine, F-531 1300 Morris Park Ave., Bronx, NY 10461-1602, USA.

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http://dx.doi.org/10.2337/diabetes.54.6.1615DOI Listing
June 2005

Susceptibility to apoptosis in insulin-like growth factor-I receptor-deficient brown adipocytes.

Mol Biol Cell 2004 Nov 8;15(11):5101-17. Epub 2004 Sep 8.

Departamento de Bioquímica y Biología Molecular II, Centro Mixto Consejo Superior de Investigaciones Cientificas, Universidad Complutense de Madrid, Facultad de Farmacia, Ciudad Universitaria, 28040-Madrid, Spain.

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http://dx.doi.org/10.1091/mbc.e03-11-0853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC524782PMC
November 2004

A novel action of minocycline: inhibition of human immunodeficiency virus type 1 infection in microglia.

J Neurovirol 2004 Oct;10(5):284-92

Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://link.springer.com/10.1080/13550280490499533
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http://dx.doi.org/10.1080/13550280490499533DOI Listing
October 2004

Angiopoietin-2 causes pericyte dropout in the normal retina: evidence for involvement in diabetic retinopathy.

Diabetes 2004 Apr;53(4):1104-10

5th Medical Clinic, University-Clinic Mannheim, Medical Faculty of the University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.2337/diabetes.53.4.1104DOI Listing
April 2004

Uncoupling proteins prevent glucose-induced neuronal oxidative stress and programmed cell death.

Diabetes 2004 Mar;53(3):726-34

Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.2337/diabetes.53.3.726DOI Listing
March 2004

A radical explanation for glucose-induced beta cell dysfunction.

Authors:
Michael Brownlee

J Clin Invest 2003 Dec;112(12):1788-90

Diabetes Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, New York, New York 10461, USA.

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http://dx.doi.org/10.1172/JCI20501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC297003PMC
December 2003

Enhanced vascularization and survival of neural transplants with ex vivo angiogenic gene transfer.

Cell Transplant 2002 ;11(4):331-49

Department of Neurological Surgery, Montefiore Medical Center, Bronx, NY 10467, USA.

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February 2003

Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic beta-cells.

Biochem Biophys Res Commun 2003 Jan;300(1):216-22

Department of Metabolic Medicine, Kumamoto University School of Medicine, 1-1-1 Honjo, Japan.

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http://dx.doi.org/10.1016/s0006-291x(02)02832-2DOI Listing
January 2003

Pericytes and the pathogenesis of diabetic retinopathy.

Diabetes 2002 Oct;51(10):3107-12

Fifth Medical Clinic, Medical Faculty of the University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.2337/diabetes.51.10.3107DOI Listing
October 2002

Oxidative stress and programmed cell death in diabetic neuropathy.

Ann N Y Acad Sci 2002 Apr;959:368-83

Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2002.tb02108.xDOI Listing
April 2002