Publications by authors named "Michael Boutros"

100Publications

Wnt10b-GSK3β-dependent Wnt/STOP signaling prevents aneuploidy in human somatic cells.

Life Sci Alliance 2021 01 30;4(1). Epub 2020 Nov 30.

Georg-August University Göttingen, Göttingen Center for Molecular Biosciences (GZMB) and University Medical Center Göttingen (UMG), Institute of Molecular Oncology, Section for Cellular Oncology, Göttingen, Germany

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January 2021

Genome-scale CRISPR screening at high sensitivity with an empirically designed sgRNA library.

BMC Biol 2020 11 23;18(1):174. Epub 2020 Nov 23.

German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Heidelberg University, BioQuant and Medical Faculty Mannheim, D-69120, Heidelberg, Germany.

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November 2020

Extracellular vesicles and oncogenic signaling.

Mol Oncol 2021 Jan 6;15(1):3-26. Epub 2020 Dec 6.

Division Signaling and Functional Genomics, German Cancer Research Center (DKFZ) and Heidelberg University, Germany.

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January 2021

Multi-omics integration identifies a selective vulnerability of colorectal cancer subtypes to YM155.

Int J Cancer 2020 Nov 13. Epub 2020 Nov 13.

Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Department of Cell and Molecular Biology, Faculty of Medicine Mannheim, Heidelberg University, Heidelberg, Germany.

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November 2020

Cloud-Based Design of Short Guide RNA (sgRNA) Libraries for CRISPR Experiments.

Methods Mol Biol 2021 ;2162:3-22

Division Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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January 2021

Multiplexed conditional genome editing with Cas12a in .

Proc Natl Acad Sci U S A 2020 09 25;117(37):22890-22899. Epub 2020 Aug 25.

Division Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Department for Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, D-69120 Heidelberg, Germany

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September 2020

Cancer-Associated Mutations in Normal Colorectal Mucosa Adjacent to Sporadic Neoplasia.

Clin Transl Gastroenterol 2020 Jul;11(7):e00212

1Department Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; 2German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany; 3Central Interdisciplinary Endoscopy (ZIE), University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; 4Institute of Pathology, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; 5German Cancer Consortium (DKTK), Heidelberg, Germany.

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July 2020

Ageing, metabolism and the intestine.

EMBO Rep 2020 07 21;21(7):e50047. Epub 2020 Jun 21.

Division Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg University, Heidelberg, Germany.

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July 2020

Pooled In Vitro and In Vivo CRISPR-Cas9 Screening Identifies Tumor Suppressors in Human Colon Organoids.

Cell Stem Cell 2020 05 28;26(5):782-792.e7. Epub 2020 Apr 28.

German Cancer Consortium (DKTK), 69120 Heidelberg, Germany; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, 60596 Frankfurt am Main, Germany; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Frankfurt Cancer Institute, Goethe University, 60596 Frankfurt am Main, Germany. Electronic address:

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May 2020

JNK-dependent intestinal barrier failure disrupts host-microbe homeostasis during tumorigenesis.

Proc Natl Acad Sci U S A 2020 04 10;117(17):9401-9412. Epub 2020 Apr 10.

Division Signaling and Functional Genomics, Department for Cell and Molecular Biology, Medical Faculty Mannheim, German Cancer Research Center and Heidelberg University, D-69120 Heidelberg, Germany

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April 2020

'Corrigendum to "Ataxin-10 is part of a cachexokine cocktail triggering cardiac metabolic dysfunction in cancer cachexia" [Molecular Metabolism 5 (2) (2015) 67-78]'.

Mol Metab 2020 05 4;35:100970. Epub 2020 Mar 4.

Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich, 85764, Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine I, Heidelberg University Hospital, 69120, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), Partner site Heidelberg/Mannheim, 69120, Heidelberg, Germany; German Center for Diabetes Research (DZD), 85764, Neuherberg, Germany. Electronic address:

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May 2020

Exocyst-mediated apical Wg secretion activates signaling in the Drosophila wing epithelium.

PLoS Genet 2019 09 17;15(9):e1008351. Epub 2019 Sep 17.

German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Heidelberg University, Department of Cell and Molecular Biology, Im Neuenheimer Feld, Heidelberg, Germany.

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September 2019

Robust Wnt signaling is maintained by a Wg protein gradient and Fz2 receptor activity in the developing wing.

Development 2019 08 9;146(15). Epub 2019 Aug 9.

German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany

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August 2019

Editorial overview: Functionalizing cancer genomes in the era of big data.

Curr Opin Genet Dev 2019 02 20;54:iii-vi. Epub 2019 Jul 20.

Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Germany. Electronic address:

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February 2019

Context-dependent genetic interactions in cancer.

Curr Opin Genet Dev 2019 02 23;54:73-82. Epub 2019 Apr 23.

Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ) and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany. Electronic address:

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February 2019

Time-resolved mapping of genetic interactions to model rewiring of signaling pathways.

Elife 2018 12 28;7. Epub 2018 Dec 28.

Division Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany.

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December 2018

Stem Cell Intrinsic Hexosamine Metabolism Regulates Intestinal Adaptation to Nutrient Content.

Dev Cell 2018 10 13;47(1):112-121.e3. Epub 2018 Sep 13.

German Cancer Research Center, Division of Signaling and Functional Genomics and Heidelberg University, Heidelberg 69120, Germany. Electronic address:

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October 2018

Decoding the Regulatory Logic of the Drosophila Male Stem Cell System.

Cell Rep 2018 09;24(11):3072-3086

Centre for Organismal Studies (COS) Heidelberg, Heidelberg University, 69120 Heidelberg, Germany. Electronic address:

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September 2018

Machine learning and image-based profiling in drug discovery.

Curr Opin Syst Biol 2018 Aug;10:43-52

German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Heidelberg University, Department of Cell and Molecular Biology, Medical Faculty Mannheim, D-69120 Heidelberg, Germany.

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August 2018

CRISPR/Cas9 for cancer research and therapy.

Semin Cancer Biol 2019 04 16;55:106-119. Epub 2018 Apr 16.

German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics, and Heidelberg University, Department Cell and Molecular Biology, Faculty of Medicine Mannheim, Heidelberg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany. Electronic address:

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April 2019

The Role of Mitotic Cell-Substrate Adhesion Re-modeling in Animal Cell Division.

Dev Cell 2018 04;45(1):132-145.e3

MRC - Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK; Institute for the Physics of Living Systems, University College London, London WC1E 6BT, UK. Electronic address:

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April 2018

Systematic characterization of pan-cancer mutation clusters.

Mol Syst Biol 2018 03 23;14(3):e7974. Epub 2018 Mar 23.

Division Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany

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March 2018

RNA Interference (RNAi) Screening in .

Genetics 2018 03;208(3):853-874

Division of Signaling and Functional Genomics, German Cancer Research Center, and Department of Cell and Molecular Biology, Heidelberg University, Medical Faculty Mannheim, D-69120, Germany

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March 2018

Toward an integrated map of genetic interactions in cancer cells.

Mol Syst Biol 2018 02 21;14(2):e7656. Epub 2018 Feb 21.

Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany

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February 2018

β-catenin-independent regulation of Wnt target genes by RoR2 and ATF2/ATF4 in colon cancer cells.

Sci Rep 2018 02 16;8(1):3178. Epub 2018 Feb 16.

German Cancer Research Center (DKFZ), Division of Signaling and Functional Genomics and Heidelberg University, Department of Cell and Molecular Biology, Medical Faculty Mannheim, 69120, Heidelberg, Germany.

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February 2018

ERAD-dependent control of the Wnt secretory factor Evi.

EMBO J 2018 02 29;37(4). Epub 2018 Jan 29.

Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ) and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany

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February 2018

Widespread Rewiring of Genetic Networks upon Cancer Signaling Pathway Activation.

Cell Syst 2018 Jan 30;6(1):52-64.e4. Epub 2017 Nov 30.

German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Heidelberg University, Department of Cell and Molecular Biology, Faculty of Medicine Mannheim, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany. Electronic address:

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January 2018

Neutral sphingomyelinases control extracellular vesicles budding from the plasma membrane.

J Extracell Vesicles 2017 26;6(1):1378056. Epub 2017 Sep 26.

Hematology and Oncology/Developmental Biochemistry, University Medical Center Goettingen, Goettingen, Germany.

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September 2017

Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice.

Hepatology 2018 08 1;68(2):707-722. Epub 2018 Feb 1.

Department of Dermatology, Venereology, and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, Mannheim, Germany.

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August 2018

An RNAi Screen Reveals an Essential Role for HIPK4 in Human Skin Epithelial Differentiation from iPSCs.

Stem Cell Reports 2017 10 28;9(4):1234-1245. Epub 2017 Sep 28.

Skin Cancer Unit (G300), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69121 Heidelberg, Germany; Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Heidelberg University, 68167 Mannheim, Germany. Electronic address:

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October 2017

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.

FASEB J 2017 11 21;31(11):4832-4844. Epub 2017 Jul 21.

Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany; and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany

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November 2017

Splicing stimulates siRNA formation at Drosophila DNA double-strand breaks.

PLoS Genet 2017 Jun 19;13(6):e1006861. Epub 2017 Jun 19.

Gene Center and Dept. of Biochemistry, Ludwig-Maximilians-Universität München, München, Germany.

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June 2017

Phenotype databases for genetic screens in human cells.

J Biotechnol 2017 Nov 16;261:63-69. Epub 2017 Jun 16.

Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ) and Heidelberg University, 69120 Heidelberg, Germany. Electronic address:

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November 2017

HTSvis: a web app for exploratory data analysis and visualization of arrayed high-throughput screens.

Bioinformatics 2017 Sep;33(18):2960-2962

Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ) and Heidelberg University, 69120 Heidelberg, Germany.

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September 2017

ATF3 acts as a rheostat to control JNK signalling during intestinal regeneration.

Nat Commun 2017 03 8;8:14289. Epub 2017 Mar 8.

German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Heidelberg University, Department for Cell and Molecular Biology, Medical Faculty Mannheim, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany.

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March 2017

The lncRNA VELUCT strongly regulates viability of lung cancer cells despite its extremely low abundance.

Nucleic Acids Res 2017 May;45(9):5458-5469

Division of RNA Biology & Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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May 2017

Systematic epistatic mapping of cellular processes.

Cell Div 2017 6;12. Epub 2017 Jan 6.

German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Heidelberg University, Department of Cell and Molecular Biology, Faculty of Medicine Mannheim, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany ; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.

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January 2017

Autocrine Wnt regulates the survival and genomic stability of embryonic stem cells.

Sci Signal 2017 01 10;10(461). Epub 2017 Jan 10.

German Cancer Research Center (DKFZ), Division of Signaling and Functional Genomics, and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Heidelberg 69120, Germany.

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January 2017

Immune cell recruitment in teratomas is impaired by increased Wnt secretion.

Stem Cell Res 2016 11 29;17(3):607-615. Epub 2016 Oct 29.

German Cancer Research Center (DKFZ), Div. of Signaling and Functional Genomics, and Heidelberg University, Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Heidelberg 69120, Germany.

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November 2016

Pharmacological Inhibition of Centrosome Clustering by Slingshot-Mediated Cofilin Activation and Actin Cortex Destabilization.

Cancer Res 2016 11 13;76(22):6690-6700. Epub 2016 Sep 13.

Max-Eder Research Group "Experimental Therapies for Hematologic Malignancies", German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.

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November 2016

GenomeCRISPR - a database for high-throughput CRISPR/Cas9 screens.

Nucleic Acids Res 2017 01 26;45(D1):D679-D686. Epub 2016 Oct 26.

German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Heidelberg University, Department of Cell and Molecular Biology, Medical Faculty Mannheim, 69120 Heidelberg, Germany

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January 2017

Methods for High-Throughput RNAi Screening in Drosophila Cells.

Methods Mol Biol 2016 ;1478:95-116

Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg University, Im Neuenheimer Feld 580, D-69120, Heidelberg, Germany.

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January 2018

Biochemical Methods to Analyze Wnt Protein Secretion.

Methods Mol Biol 2016 ;1481:17-28

Haematology and Oncology and Developmental Biochemistry, University Medicine Göttingen, Göttingen Center for Molecular Biosciences (GZMB), Justus-von-Liebig Weg 11, 37077, Göttingen, Germany.

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January 2018

A Protocol for a High-Throughput Multiplex Cell Viability Assay.

Methods Mol Biol 2016 ;1470:75-84

Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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December 2017

Refining Pathways: A Model Comparison Approach.

PLoS One 2016 1;11(6):e0155999. Epub 2016 Jun 1.

Department of Statistical Bioinformatics, Institute of Functional Genomics, University of Regensburg, Regensburg, Germany.

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July 2017

Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein.

PLoS Genet 2016 05 27;12(5):e1006072. Epub 2016 May 27.

Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York, United States of America.

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May 2016

CRISPR library designer (CLD): software for multispecies design of single guide RNA libraries.

Genome Biol 2016 Mar 24;17:55. Epub 2016 Mar 24.

Division Signaling and Functional Genomics, German Cancer Research Center (DKFZ) and Heidelberg University, Im Neuenheimer Feld 580, Heidelberg, 69120, Germany.

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March 2016

eIF4A inactivates TORC1 in response to amino acid starvation.

EMBO J 2016 05 17;35(10):1058-76. Epub 2016 Mar 17.

Division of Signal Transduction in Cancer and Metabolism, German Cancer Research Center (DKFZ), Heidelberg, Germany

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May 2016

Sticking Around: Short-Range Activity of Wnt Ligands.

Dev Cell 2016 Mar;36(5):485-6

Division of Molecular Embryology, German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany; Institute of Molecular Biology (IMB), 55128 Mainz, Germany.

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March 2016

A genetic interaction map of cell cycle regulators.

Mol Biol Cell 2016 Apr 24;27(8):1397-407. Epub 2016 Feb 24.

Division of Signaling and Functional Genomics, German Cancer Research Center, and Department of Cell and Molecular Biology, Heidelberg University, 69120 Heidelberg, Germany

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April 2016

Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes.

Sci Rep 2016 Feb 25;6:21455. Epub 2016 Feb 25.

Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA.

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February 2016

Ataxin-10 is part of a cachexokine cocktail triggering cardiac metabolic dysfunction in cancer cachexia.

Mol Metab 2016 Feb 26;5(2):67-78. Epub 2015 Nov 26.

Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich, 85764 Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine I, Heidelberg University Hospital, 69120 Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), Partner site Heidelberg/Mannheim, 69120 Heidelberg, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany. Electronic address:

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February 2016

Endothelial RSPO3 Controls Vascular Stability and Pruning through Non-canonical WNT/Ca(2+)/NFAT Signaling.

Dev Cell 2016 Jan;36(1):79-93

Division of Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg (DKFZ-ZMBH Alliance), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Department of Vascular Biology and Tumor Angiogenesis (CBTM), Medical Faculty Mannheim, Heidelberg University, Ludolf-Krehl-Straße 13-17, 68167 Mannheim, Germany; German Cancer Consortium, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Electronic address:

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January 2016

Cytokine Diedel and a viral homologue suppress the IMD pathway in Drosophila.

Proc Natl Acad Sci U S A 2016 Jan 6;113(3):698-703. Epub 2016 Jan 6.

Institut de Biologie Moleculaire et Cellulaire, CNRS-Unité Propre de Recherche 9022, 67084 Strasbourg, France; University of Strasbourg Institute for Advanced Studies, Université de Strasbourg, 67084 Strasbourg, France; Faculté des Sciences de la Vie, Université de Strasbourg, 67083 Strasbourg, France

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January 2016

A chemical-genetic interaction map of small molecules using high-throughput imaging in cancer cells.

Mol Syst Biol 2015 Dec 23;11(12):846. Epub 2015 Dec 23.

Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany Department of Cell and Molecular Biology, Heidelberg University, Heidelberg, Germany

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December 2015

Microscopy-Based High-Content Screening.

Cell 2015 Dec;163(6):1314-25

Division Signaling and Functional Genomics, German Cancer Research Center (DKFZ) and Department of Cell and Molecular Biology, Heidelberg University, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany.

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December 2015

Towards a compendium of essential genes - From model organisms to synthetic lethality in cancer cells.

Crit Rev Biochem Mol Biol 2016 1;51(2):74-85. Epub 2015 Dec 1.

a Department of Cell and Molecular Biology , Division of Signaling and Functional Genomics, Medical Faculty Mannheim, German Cancer Research Center (DKFZ), Heidelberg University , Heidelberg , Germany and.

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November 2016

Thymic Epithelial Cells Are a Nonredundant Source of Wnt Ligands for Thymus Development.

J Immunol 2015 Dec 28;195(11):5261-71. Epub 2015 Oct 28.

Division of Developmental Immunology, Tumor Immunology Program, German Cancer Research Center, 69120 Heidelberg, Germany;

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December 2015

caRpools: an R package for exploratory data analysis and documentation of pooled CRISPR/Cas9 screens.

Bioinformatics 2016 Feb 27;32(4):632-4. Epub 2015 Oct 27.

German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Heidelberg University, Heidelberg, Germany and.

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February 2016

Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening.

Genome Med 2015 17;7(1):46. Epub 2015 May 17.

German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Heidelberg University, Department of Cell and Molecular Biology, Medical Faculty Mannheim, Im Neuenheimer Feld 580, D-69120 Heidelberg, Germany.

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June 2015

Amplicon sequencing of colorectal cancer: variant calling in frozen and formalin-fixed samples.

PLoS One 2015 26;10(5):e0127146. Epub 2015 May 26.

Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ) and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.

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April 2016

REPTOR and REPTOR-BP Regulate Organismal Metabolism and Transcription Downstream of TORC1.

Dev Cell 2015 May 23;33(3):272-84. Epub 2015 Apr 23.

German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. Electronic address:

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May 2015

A map of directional genetic interactions in a metazoan cell.

Elife 2015 Mar 6;4. Epub 2015 Mar 6.

Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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March 2015

A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia.

Blood 2015 Apr 6;125(14):2265-75. Epub 2015 Feb 6.

Department of Pediatric Hematology, Oncology and Immunology, University of Heidelberg, Heidelberg, Germany; Molecular Medicine Partnership Unit, Heidelberg, Germany;

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April 2015

Dpp/Gbb signaling is required for normal intestinal regeneration during infection.

Dev Biol 2015 Mar 29;399(2):189-203. Epub 2014 Dec 29.

German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Heidelberg University, Department for Cell and Molecular Biology, Medical Faculty Mannheim, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany. Electronic address:

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March 2015

Measuring genetic interactions in human cells by RNAi and imaging.

Nat Protoc 2014 Oct 11;9(10):2341-53. Epub 2014 Sep 11.

1] German Cancer Research Center (DKFZ), Division of Signaling and Functional Genomics, Heidelberg, Germany. [2] Department of Cell and Molecular Biology, Heidelberg University, Heidelberg, Germany.

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October 2014

Functional analysis of the Drosophila embryonic germ cell transcriptome by RNA interference.

PLoS One 2014 4;9(6):e98579. Epub 2014 Jun 4.

Institute of Genetics, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary.

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August 2015

Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity.

BMC Biol 2014 May 30;12:44. Epub 2014 May 30.

Centre for Organismal Studies, Department of Molecular Evolution and Genomics, University of Heidelberg, Im Neuenheimer Feld 329, 69120 Heidelberg, Germany.

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May 2014

Endothelial cell-derived non-canonical Wnt ligands control vascular pruning in angiogenesis.

Development 2014 Apr;141(8):1757-66

Division of Vascular Oncology and Metastasis, German Cancer Research Center (DKFZ-ZMBH Alliance), Heidelberg 69221, Germany.

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April 2014

E-CRISP: fast CRISPR target site identification.

Nat Methods 2014 Feb;11(2):122-3

1] Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany. [2] Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.

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February 2014

A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis.

EMBO J 2014 Feb 17;33(3):181-97. Epub 2014 Jan 17.

German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Heidelberg University, Department for Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg, Germany.

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February 2014

A novel phenotypic dissimilarity method for image-based high-throughput screens.

BMC Bioinformatics 2013 Nov 21;14:336. Epub 2013 Nov 21.

German Cancer Research Center (DKFZ), Div, Signaling and Functional Genomics and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Im Neuenheimer Feld 580, D-69120 Heidelberg, Germany.

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November 2013

Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells.

Nat Commun 2013 ;4:2610

1] German Cancer Research Center (DKFZ), Div. Signalling and Functional Genomics, and Heidelberg University, Dept. Cell and Molecular Biology, Faculty of Medicine Mannheim, Im Neuenheimer Feld 580, D-69120 Heidelberg, Germany [2].

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June 2014