Michael Borges

Michael Borges

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Michael Borges

Michael Borges

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Gene Variants That Affect Levels of Circulating Tumor Markers Increase Identification of Patients with Pancreatic Cancer.

Clin Gastroenterol Hepatol 2019 Oct 29. Epub 2019 Oct 29.

Department of Pathology The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD; Department of Medicine The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD; Department of Oncology The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2019.10.036DOI Listing
October 2019

Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.

Authors:
Alison P Klein Brian M Wolpin Harvey A Risch Rachael Z Stolzenberg-Solomon Evelina Mocci Mingfeng Zhang Federico Canzian Erica J Childs Jason W Hoskins Ashley Jermusyk Jun Zhong Fei Chen Demetrius Albanes Gabriella Andreotti Alan A Arslan Ana Babic William R Bamlet Laura Beane-Freeman Sonja I Berndt Amanda Blackford Michael Borges Ayelet Borgida Paige M Bracci Lauren Brais Paul Brennan Hermann Brenner Bas Bueno-de-Mesquita Julie Buring Daniele Campa Gabriele Capurso Giulia Martina Cavestro Kari G Chaffee Charles C Chung Sean Cleary Michelle Cotterchio Frederike Dijk Eric J Duell Lenka Foretova Charles Fuchs Niccola Funel Steven Gallinger J Michael M Gaziano Maria Gazouli Graham G Giles Edward Giovannucci Michael Goggins Gary E Goodman Phyllis J Goodman Thilo Hackert Christopher Haiman Patricia Hartge Manal Hasan Peter Hegyi Kathy J Helzlsouer Joseph Herman Ivana Holcatova Elizabeth A Holly Robert Hoover Rayjean J Hung Eric J Jacobs Krzysztof Jamroziak Vladimir Janout Rudolf Kaaks Kay-Tee Khaw Eric A Klein Manolis Kogevinas Charles Kooperberg Matthew H Kulke Juozas Kupcinskas Robert J Kurtz Daniel Laheru Stefano Landi Rita T Lawlor I-Min Lee Loic LeMarchand Lingeng Lu Núria Malats Andrea Mambrini Satu Mannisto Roger L Milne Beatrice Mohelníková-Duchoňová Rachel E Neale John P Neoptolemos Ann L Oberg Sara H Olson Irene Orlow Claudio Pasquali Alpa V Patel Ulrike Peters Raffaele Pezzilli Miquel Porta Francisco X Real Nathaniel Rothman Ghislaine Scelo Howard D Sesso Gianluca Severi Xiao-Ou Shu Debra Silverman Jill P Smith Pavel Soucek Malin Sund Renata Talar-Wojnarowska Francesca Tavano Mark D Thornquist Geoffrey S Tobias Stephen K Van Den Eeden Yogesh Vashist Kala Visvanathan Pavel Vodicka Jean Wactawski-Wende Zhaoming Wang Nicolas Wentzensen Emily White Herbert Yu Kai Yu Anne Zeleniuch-Jacquotte Wei Zheng Peter Kraft Donghui Li Stephen Chanock Ofure Obazee Gloria M Petersen Laufey T Amundadottir

Nat Commun 2018 02 8;9(1):556. Epub 2018 Feb 8.

Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1038/s41467-018-02942-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805680PMC
February 2018

Using an endoscopic distal cap to collect pancreatic fluid from the ampulla (with video).

Gastrointest Endosc 2017 Dec 1;86(6):1152-1156.e2. Epub 2017 Mar 1.

Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA; Department of Medicine, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA; Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1016/j.gie.2017.02.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581309PMC
December 2017

IL2RG, identified as overexpressed by RNA-seq profiling of pancreatic intraepithelial neoplasia, mediates pancreatic cancer growth.

Oncotarget 2017 Oct 3;8(48):83370-83383. Epub 2017 Aug 3.

Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.18632/oncotarget.19848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663522PMC
October 2017

Lack of association between the pancreatitis risk allele CEL-HYB and pancreatic cancer.

Oncotarget 2017 Aug 7;8(31):50824-50831. Epub 2017 Feb 7.

Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.18632/oncotarget.15137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584208PMC
August 2017

Overexpression of ankyrin1 promotes pancreatic cancer cell growth.

Oncotarget 2016 Jun;7(23):34977-87

Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.18632/oncotarget.9009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085203PMC
June 2016

Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer.

Nat Genet 2015 Aug 22;47(8):911-6. Epub 2015 Jun 22.

1] Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. [2] Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/ng.3341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520746PMC
August 2015

KRAS and guanine nucleotide-binding protein mutations in pancreatic juice collected from the duodenum of patients at high risk for neoplasia undergoing endoscopic ultrasound.

Clin Gastroenterol Hepatol 2015 May 4;13(5):963-9.e4. Epub 2014 Dec 4.

Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland; Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland; Department of Medicine, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2014.11.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404180PMC
May 2015

Mutant KRAS and GNAS DNA Concentrations in Secretin-Stimulated Pancreatic Fluid Collected from the Pancreatic Duct and the Duodenal Lumen.

Clin Transl Gastroenterol 2014 Nov 13;5:e62. Epub 2014 Nov 13.

1] Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA [2] Department of Medicine, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA [3] Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/ctg.2014.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543403PMC
November 2014

Having pancreatic cancer with tumoral loss of ATM and normal TP53 protein expression is associated with a poorer prognosis.

Clin Cancer Res 2014 Apr 31;20(7):1865-72. Epub 2014 Jan 31.

Authors' Affiliations: Departments of Pathology, Medicine, Oncology, Surgery and Radiation Oncology, and Molecular Radiation Sciences, The Sol Goldman Pancreatic Cancer Research Center; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins Medical Institutions, Baltimore, Maryland; Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, South Korea; and Department of Pathology, Emory University Hospital, Atlanta, Georgia.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975663PMC
April 2014

Mutant GNAS detected in duodenal collections of secretin-stimulated pancreatic juice indicates the presence or emergence of pancreatic cysts.

Gut 2013 Jul 2;62(7):1024-33. Epub 2012 Aug 2.

Johns Hopkins Medical Institutions, Department of Pathology, Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, 1550 Orleans Street, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1136/gutjnl-2012-302823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893110PMC
July 2013

Mutant TP53 in duodenal samples of pancreatic juice from patients with pancreatic cancer or high-grade dysplasia.

Clin Gastroenterol Hepatol 2013 Jun 28;11(6):719-30.e5. Epub 2012 Nov 28.

Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1016/j.cgh.2012.11.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600161PMC
June 2013

Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia.

Gastroenterology 2012 Apr 5;142(4):730-733.e9. Epub 2012 Jan 5.

Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1053/j.gastro.2011.12.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321090PMC
April 2012

Pancreatic cancers epigenetically silence SIP1 and hypomethylate and overexpress miR-200a/200b in association with elevated circulating miR-200a and miR-200b levels.

Cancer Res 2010 Jul 15;70(13):5226-37. Epub 2010 Jun 15.

Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-4227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130565PMC
July 2010

Cyclooxygenase-deficient pancreatic cancer cells use exogenous sources of prostaglandins.

Mol Cancer Res 2010 Jun 8;8(6):821-32. Epub 2010 Jun 8.

The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, CRBII Room 342, 1550 Orleans Street, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-09-0336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888921PMC
June 2010

Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts.

Clin Cancer Res 2010 Mar 9;16(6):1781-9. Epub 2010 Mar 9.

Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-09-1913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846609PMC
March 2010

Absence of deleterious palladin mutations in patients with familial pancreatic cancer.

Cancer Epidemiol Biomarkers Prev 2009 Apr 31;18(4):1328-30. Epub 2009 Mar 31.

Department of Pathology, The John Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-09-0056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824557PMC
April 2009

Absence of germline BRCA1 mutations in familial pancreatic cancer patients.

Cancer Biol Ther 2009 Jan 4;8(2):131-5. Epub 2009 Feb 4.

Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, Maryland, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684337PMC
http://dx.doi.org/10.4161/cbt.8.2.7136DOI Listing
January 2009

Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor cells by notch signaling.

J Clin Endocrinol Metab 2005 Jul 3;90(7):4350-6. Epub 2005 May 3.

Department of Surgery, University of California, San Francisco, California 94115, USA.

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http://dx.doi.org/10.1210/jc.2005-0540DOI Listing
July 2005

Notch signaling induces rapid degradation of achaete-scute homolog 1.

Mol Cell Biol 2002 May;22(9):3129-39

Program in Cellular and Molecular Medicine, Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC133746PMC
http://dx.doi.org/10.1128/mcb.22.9.3129-3139.2002DOI Listing
May 2002