Michael Benatar

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Neurofilaments in pre-symptomatic ALS and the impact of genotype.

Amyotroph Lateral Scler Frontotemporal Degener 2019 Nov 21;20(7-8):538-548. Epub 2019 Aug 21.

Neuroscience Center, Blizard, Institute of Cell and Molecular Medicine, Barts & the London School of Medicine & Dentistry , London , UK.

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http://dx.doi.org/10.1080/21678421.2019.1646769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768722PMC
November 2019

Defining pre-symptomatic amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2019 Aug 20;20(5-6):303-309. Epub 2019 Mar 20.

a Department of Neurology , University of Miami , Miami , FL , USA and.

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http://dx.doi.org/10.1080/21678421.2019.1587634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613999PMC
August 2019

Editorial: We may need large trials to find treatments for neurodegenerative diseases.

Clin Trials 2019 Apr 10;16(2):120-121. Epub 2019 Jan 10.

2 Miller School of Medicine, University of Miami, Miami, USA.

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http://dx.doi.org/10.1177/1740774518820814DOI Listing
April 2019

Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials.

Neurology 2019 Apr 8;92(14):e1610-e1623. Epub 2019 Mar 8.

From the Department of Neurology (L.H.v.d.B.), Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands; Department of Neurology (E.S.), Mayo Clinic, Rochester, MN; Department of Neurology (G.G.), University of Kansas Medical Center, Kansas City; Department of Medicine (E.A.M.), Massachusetts General Hospital, Biostatistics Center, Harvard Medical School, Boston; Department of Neurology (J.A., H.M.), Columbia University, Eleanor and Lou Gehrig ALS Center, New York, NY; Department of Neurology (R.H.B.), Cedars-Sinai Medical Center, Los Angeles, CA; Department of Neurology (M.B.), University of Miami, FL; Neurological Clinical Research Institute (J.D.B.), Massachusetts General Hospital, Boston; Rita Levi Montalcini Department of Neuroscience (A.C.), University of Torino, Italy; Centre Constitutif SLA (P.C.), Université de Tours, France; Department of Neurology (A.G.), Clinical Research Unit, Montreal Neurological Institute, Neurosurgery, McGill University, Montreal, Canada; National Institute of Neurological Disorders and Stroke (A.K.G.), National Institutes of Health, Bethesda, MD; ALS Center (C.L.-H.), University of California San Francisco; Department of Neuroscience (C.J.M.), Sheffield Institute for Translational Neuroscience, University of Sheffield, UK; Department of Neurology (E.P.P.), Section of ALS & Related Disorders, Cleveland Clinic, OH; Department of Neurology (J.R.), The Center for Restorative Neurology, Loma Linda University School of Medicine, CA; Department of Neurology and Laboratory of Neuroscience (V.S.), Istituto Auxologico Italiano, IRCCS, Milan; Department of Pathophysiology and Transplantation (V.S.), "Dino Ferrari" Centre, Università degli Studi di Milano, Milan, Italy; Nuffield Department of Clinical Neurosciences (M.R.T.), University of Oxford, UK; Neuromuscular Diseases Unit/ALS Clinic (M.W.), Kantonsspital St. Gallen, Switzerland; Carolinas Neuromuscular/ALS-MDA Care Center (B.R.B.), Charlotte; Department of Neurology (B.R.B.), Carolinas Medical Center, University of North Carolina School of Medicine, Charlotte; Forbes Norris ALS Treatment and Research Center (R.G.M.), California Pacific Medical Center San Francisco; and Department of Neurosciences (R.G.M.), Stanford University, CA.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000007242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448453PMC
April 2019

Impaired corticomuscular and interhemispheric cortical beta oscillation coupling in amyotrophic lateral sclerosis.

Clin Neurophysiol 2018 07 6;129(7):1479-1489. Epub 2018 Apr 6.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Oxford Centre for Human Brain Activity, University of Oxford, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.clinph.2018.03.019DOI Listing
July 2018

Neurofilament light: A candidate biomarker of presymptomatic amyotrophic lateral sclerosis and phenoconversion.

Ann Neurol 2018 07 16;84(1):130-139. Epub 2018 Aug 16.

Neuroscience Center, Blizard, Institute of Cell and Molecular Medicine, Barts & the London School of Medicine & Dentistry, London, United Kingdom.

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http://dx.doi.org/10.1002/ana.25276DOI Listing
July 2018

Ocular Myasthenia.

Neurol Clin 2018 05;36(2):241-251

Department of Neurology, George Washington University, 2150 Pennsylvania Avenue, Northwest, Washington, DC 20037, USA; Department of Neurology, 1150 Northwest 14th Street #715, Miami, FL 33136, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ncl.2018.01.003DOI Listing
May 2018

The state of clinical research in neurology.

Neurology 2018 04 16;90(15):e1347-e1354. Epub 2018 Mar 16.

From the Department of Neurological Sciences (D.H.), Rush University, Chicago, IL; Department of Neurology (A.R.R., M.B.), University of Miami, FL; Department of Neurology (J.M.G.), University of California San Francisco; Massachusetts General Hospital (A.V.), Boston; Member Insights Department (C.C.), American Academy of Neurology, Minneapolis, MN; Department of Neurology (B.M.K.), University of Colorado, Denver; and Department of Neurology (M.G.), University of Virginia, Charlottesville.

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http://dx.doi.org/10.1212/WNL.0000000000005295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894931PMC
April 2018

Increased cerebral functional connectivity in ALS: A resting-state magnetoencephalography study.

Neurology 2018 04 21;90(16):e1418-e1424. Epub 2018 Mar 21.

From the Nuffield Department of Clinical Neurosciences (M.P., K.T., M.R.T.), and Oxford Centre for Human Brain Activity (M.P., G.L.C., A.Q., A.C.N., M.W.W., M.R.T.), University of Oxford, UK; and Miller School of Medicine (J.W., M.B.), University of Miami, FL.

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http://dx.doi.org/10.1212/WNL.0000000000005333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902786PMC
April 2018

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Authors:
Aude Nicolas Kevin P Kenna Alan E Renton Nicola Ticozzi Faraz Faghri Ruth Chia Janice A Dominov Brendan J Kenna Mike A Nalls Pamela Keagle Alberto M Rivera Wouter van Rheenen Natalie A Murphy Joke J F A van Vugt Joshua T Geiger Rick A Van der Spek Hannah A Pliner Shankaracharya Bradley N Smith Giuseppe Marangi Simon D Topp Yevgeniya Abramzon Athina Soragia Gkazi John D Eicher Aoife Kenna Gabriele Mora Andrea Calvo Letizia Mazzini Nilo Riva Jessica Mandrioli Claudia Caponnetto Stefania Battistini Paolo Volanti Vincenzo La Bella Francesca L Conforti Giuseppe Borghero Sonia Messina Isabella L Simone Francesca Trojsi Fabrizio Salvi Francesco O Logullo Sandra D'Alfonso Lucia Corrado Margherita Capasso Luigi Ferrucci Cristiane de Araujo Martins Moreno Sitharthan Kamalakaran David B Goldstein Aaron D Gitler Tim Harris Richard M Myers Hemali Phatnani Rajeeva Lochan Musunuri Uday Shankar Evani Avinash Abhyankar Michael C Zody Julia Kaye Steven Finkbeiner Stacia K Wyman Alex LeNail Leandro Lima Ernest Fraenkel Clive N Svendsen Leslie M Thompson Jennifer E Van Eyk James D Berry Timothy M Miller Stephen J Kolb Merit Cudkowicz Emily Baxi Michael Benatar J Paul Taylor Evadnie Rampersaud Gang Wu Joanne Wuu Giuseppe Lauria Federico Verde Isabella Fogh Cinzia Tiloca Giacomo P Comi Gianni Sorarù Cristina Cereda Philippe Corcia Hannu Laaksovirta Liisa Myllykangas Lilja Jansson Miko Valori John Ealing Hisham Hamdalla Sara Rollinson Stuart Pickering-Brown Richard W Orrell Katie C Sidle Andrea Malaspina John Hardy Andrew B Singleton Janel O Johnson Sampath Arepalli Peter C Sapp Diane McKenna-Yasek Meraida Polak Seneshaw Asress Safa Al-Sarraj Andrew King Claire Troakes Caroline Vance Jacqueline de Belleroche Frank Baas Anneloor L M A Ten Asbroek José Luis Muñoz-Blanco Dena G Hernandez Jinhui Ding J Raphael Gibbs Sonja W Scholz Mary Kay Floeter Roy H Campbell Francesco Landi Robert Bowser Stefan M Pulst John M Ravits Daniel J L MacGowan Janine Kirby Erik P Pioro Roger Pamphlett James Broach Glenn Gerhard Travis L Dunckley Christopher B Brady Neil W Kowall Juan C Troncoso Isabelle Le Ber Kevin Mouzat Serge Lumbroso Terry D Heiman-Patterson Freya Kamel Ludo Van Den Bosch Robert H Baloh Tim M Strom Thomas Meitinger Aleksey Shatunov Kristel R Van Eijk Mamede de Carvalho Maarten Kooyman Bas Middelkoop Matthieu Moisse Russell L McLaughlin Michael A Van Es Markus Weber Kevin B Boylan Marka Van Blitterswijk Rosa Rademakers Karen E Morrison A Nazli Basak Jesús S Mora Vivian E Drory Pamela J Shaw Martin R Turner Kevin Talbot Orla Hardiman Kelly L Williams Jennifer A Fifita Garth A Nicholson Ian P Blair Guy A Rouleau Jesús Esteban-Pérez Alberto García-Redondo Ammar Al-Chalabi Ekaterina Rogaeva Lorne Zinman Lyle W Ostrow Nicholas J Maragakis Jeffrey D Rothstein Zachary Simmons Johnathan Cooper-Knock Alexis Brice Stephen A Goutman Eva L Feldman Summer B Gibson Franco Taroni Antonia Ratti Cinzia Gellera Philip Van Damme Wim Robberecht Pietro Fratta Mario Sabatelli Christian Lunetta Albert C Ludolph Peter M Andersen Jochen H Weishaupt William Camu John Q Trojanowski Vivianna M Van Deerlin Robert H Brown Leonard H van den Berg Jan H Veldink Matthew B Harms Jonathan D Glass David J Stone Pentti Tienari Vincenzo Silani Adriano Chiò Christopher E Shaw Bryan J Traynor John E Landers

Neuron 2018 03;97(6):1268-1283.e6

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867896PMC
March 2018

Randomized, double-blind, placebo-controlled trial of arimoclomol in rapidly progressive ALS.

Neurology 2018 02 24;90(7):e565-e574. Epub 2018 Jan 24.

From the Department of Neurology (M.B., J.W.), University of Miami, FL; Department of Pharmacology and Clinical Neuroscience (P.M.A.), Umeå University, Sweden; Department of Neurology (N.A., W.D., M.C.), Massachusetts General Hospital (D.S.), Harvard Medical School; and Department of Biostatistics (D.S.), Harvard Chan School of Public Health, Boston, MA.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000004960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818014PMC
February 2018

Learning from the past: reflections on recently completed myasthenia gravis trials.

Ann N Y Acad Sci 2018 01 24;1412(1):5-13. Epub 2017 Oct 24.

Department of Biostatistics, University of Alabama Birmingham, Birmingham, Alabama.

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http://dx.doi.org/10.1111/nyas.13501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790606PMC
January 2018

Rituximab as treatment for anti-MuSK myasthenia gravis: Multicenter blinded prospective review.

Neurology 2017 Sep 11;89(10):1069-1077. Epub 2017 Aug 11.

From the Larner College of Medicine at the University of Vermont (M.K.H., D.H., S.M.G.), Burlington; Duke University School of Medicine (L.D.H.-W.), Durham, NC; University of Miami Health System (M.B., M.A.F.), FL; University of Toronto School of Medicine (C.B.), Canada; SUNY Buffalo Jacobs School of Medicine (N.J.S.), NY; UNC School of Medicine (J.F.H.), Chapel Hill, NC; Mayo Clinic (A.V., B.A.C.), Rochester, MN; Yale School of Medicine (R.N., R.B., A.K.), New Haven, CT; Medical University of South Carolina (K.R., I.-H.A.C.), Columbia; University of Florida (M.T.P., S.M.L., Gainesville; University of Kansas Medical Center (M.P.), Kansas City; and University of Virginia School of Medicine (T.M.B.), Charlottesville.

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http://dx.doi.org/10.1212/WNL.0000000000004341DOI Listing
September 2017

Abnormal expression of homeobox genes and transthyretin in expansion carriers.

Neurol Genet 2017 Aug 7;3(4):e161. Epub 2017 Jun 7.

Department of Neuroscience (N.A.F., M.C.B., T.F.G., K.F.B., M.D.-H., P.H.B., J.C., K.R.J.-W., L.M.D., A.M.N., M.E.M., L.P., D.W.D., R.R., M.v.B.), Department of Health Sciences Research (X.W., Y.W.A.), Department of Neurology (N.R.G.-R., K.B.B.), Division of Biomedical Statistics and Informatics (M.G.H.), Mayo Clinic, Jacksonville, FL; Department of Neurology (J.W., M.B.), University of Miami, FL; Department of Neurology (K.A.J., J.E.P., D.S.K., R.C.P., B.F.B.), Mayo Clinic, Rochester, MN; and Divisions of Neurology and Neurobiology (R.B.), Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ.

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http://dx.doi.org/10.1212/NXG.0000000000000161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479438PMC
August 2017

A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD.

Mol Neurodegener 2017 06 12;12(1):46. Epub 2017 Jun 12.

Department of Psychiatry & Behavioral Sciences, Center for Therapeutic Innovation, University of Miami Miller School of Medicine, 1501 NW 10th Ave, BRB-413, Miami, FL, 33136, USA.

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http://dx.doi.org/10.1186/s13024-017-0185-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468954PMC
June 2017

Amyotrophic lateral sclerosis - frontotemporal spectrum disorder (ALS-FTSD): Revised diagnostic criteria.

Amyotroph Lateral Scler Frontotemporal Degener 2017 05 5;18(3-4):153-174. Epub 2017 Jan 5.

n Nuffield Department of Clinical Neurosciences , University of Oxford , Oxford , UK.

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http://dx.doi.org/10.1080/21678421.2016.1267768DOI Listing
May 2017

Urinary p75: A prognostic, disease progression, and pharmacodynamic biomarker in ALS.

Neurology 2017 Mar 22;88(12):1137-1143. Epub 2017 Feb 22.

From the Department of Human Physiology & Centre for Neuroscience (S.R.S., L.W., T.C., M.-L.R.), Department of Gastroenterology and Surgery, Flinders Medical Centre (P.G.D.), and Department of Human Physiology, Centre for Neuroscience (P.G.D.), Flinders University, Adelaide, South Australia; Department of Neurology (J.W., M.B.), Miller School of Medicine, University of Miami, FL; and Neurology Department and MND Clinic (D.S.), Flinders Medical Centre, Bedford Park, South Australia.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000003741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373786PMC
March 2017

Poly(GP) proteins are a useful pharmacodynamic marker for -associated amyotrophic lateral sclerosis.

Sci Transl Med 2017 03;9(383)

Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.

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http://dx.doi.org/10.1126/scitranslmed.aai7866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576451PMC
March 2017

Getting Rid of Weakness in the ICU: An Updated Approach to the Acute Management of Myasthenia Gravis and Guillain-Barré Syndrome.

Semin Neurol 2016 Dec 1;36(6):615-624. Epub 2016 Dec 1.

Department of Neurology, University of Miami School of Medicine, Miami, Florida.

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http://dx.doi.org/10.1055/s-0036-1592106DOI Listing
December 2016

Mind the gap: the mismatch between clinical and imaging metrics in ALS.

Amyotroph Lateral Scler Frontotemporal Degener 2015 24;16(7-8):524-9. Epub 2015 Sep 24.

e Department of Neurology , University of Miami Miller School of Medicine , Miami, Florida , USA.

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http://dx.doi.org/10.3109/21678421.2015.1051989DOI Listing
August 2016

Randomized Trial of Thymectomy in Myasthenia Gravis.

N Engl J Med 2016 08;375(6):511-22

From the Department of Neurology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo (G.I.W.), the Department of Neurology, University of Rochester Medical Center, Rochester (E.C.), and the Section of General Thoracic Surgery, Columbia University Medical Center, New York (J.R.S., A.J.) - all in New York; the Department of Neurology, George Washington University School of Medicine and Health Sciences, Washington, DC (H.J.K.); the Department of Biostatistics, University of Alabama at Birmingham, Birmingham (I.B.A., G.M., H.-C.K., G.R.C.); the Institute of Pathology, University Medical Center Mannheim, University of Heidelberg, Mannheim (A.M.), the Institute of Pathology, University of Göttingen, Göttingen (P.S.), and the Department of Neurology, Johannes Gutenberg University, Mainz (W.N.) - all in Germany; the Department of Neurology, University of Buenos Aires, Buenos Aires (C.M.); the Division of Neurology, University of British Columbia, Vancouver (J. Oger), and the Department of Neurology, McGill University, Montreal (C.H.C.) - both in Canada; the Department of Neurology, University of Chile, Santiago (J.G.C.); the Division of Neurology, Department of Medicine, University of Cape Town, Cape Town, South Africa (J.M.H.); the Department of Neurology, Catholic University (A.E.), and the Department of Neurosciences, Mental Health and Sensory Organs, Sapienza University of Rome (G.A.) - both in Rome; the Division of Neurology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand (R.W.); the Department of Neurology, University of Melbourne, Melbourne, VIC, Australia (J.O.K.); the Department of Neurology, University of Southern California, Los Angeles (S.R.B.), and the Department of Neurology, University of California Irvine Medical Center, Orange (T.M.) - both in California; the Department of Neurology, Medical College of Wisconsin, Milwaukee (A.C.B.); the Department of Neurology, Harvard Medical School, Boston (A.A.A.); Nerve and M

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http://dx.doi.org/10.1056/NEJMoa1602489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5189669PMC
August 2016

A randomized controlled trial of methotrexate for patients with generalized myasthenia gravis.

Neurology 2016 Jul 15;87(1):57-64. Epub 2016 Jun 15.

From the Department of Biostatistics (J.H.), University of Kansas Medical Center (M.P., J.H., L.H., M.M.D., J.M.S., R.J.B.), Kansas City; University of Virginia (T.M.B.), Charlottesville; University of Texas Southwestern (S.N.), Dallas; University of Toronto (V.B.), Canada; University of California-Irvine (A.K.W., T.M.), Orange; Ohio State University (B.H.E., J.T.K.), Columbus; Phoenix Neurological Associates (D.S.), AZ; Nerve and Muscle Center of Texas (J.A.S.), Houston; University of Texas Health Science Center (C.J.), San Antonio; University of Iowa (A.S.), Iowa City; University of North Carolina (J.F.H.), Chapel Hill; Massachusetts General Hospital (N.G., W.D.), Boston; Penn State Hershey Medical Center (M.W.), Hershey, PA; University of Florida-Jacksonville (M.P.); Children's Mercy Hospital and Clinics (M. Becker), Kansas City, MO; University of Miami (M. Benatar), FL; Indiana University (R.P.), Indianapolis; Methodist Hospital System (E.S.), Houston, TX; and University of San Francisco (J.R.), CA.

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http://www.neurology.org/content/early/2016/06/15/WNL.000000
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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
Publisher Site
http://dx.doi.org/10.1212/WNL.0000000000002795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932232PMC
July 2016

International consensus guidance for management of myasthenia gravis: Executive summary.

Neurology 2016 Jul 29;87(4):419-25. Epub 2016 Jun 29.

From the Department of Neurology (D.B.S., J.M.M.), Duke University Medical Center, Durham, NC; Department of Neurology (G.I.W.), University at Buffalo School of Medicine and Biomedical Sciences, State University of New York; Department of Neurology (M.B.), University of Miami, Miller School of Medicine, FL; Department of Neurology (A.E.), Catholic University, Rome, Italy; Department of Clinical Medicine (N.E.G.), University of Bergen, Norway; Department of Neurology (I.I.), Hospital Santa Creu i Sant Pau, Universitat Autònoma de Barcelona; CIBERER U762 (I.I.), Barcelona, Spain; Departments of Pediatrics and Neurology (N.K.), Northwestern Feinberg School of Medicine, Chicago, IL; Neurologische Klinik (A.M.), Universitätsklinikum Erlangen; Hertie Institute for Clinical Research (A.M.), University of Tübingen, Germany; Department of Neurological Therapeutics (H.M.), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Clinical Neurological Sciences (M.N.), Western University, London, Canada; Department of Clinical Neurology (J.P.), John Radcliffe Hospital, Oxford University Hospitals Trust, Oxford, UK; Department of Neurology (D.P.R.), University of California, Davis, CA; Department of Neurology (J.V.), Leiden University Medical Centre, Leiden, the Netherlands; and Department of Neurology, Beth Israel Deaconess Medical Center/Harvard Medical School (P.N.), Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000002790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977114PMC
July 2016

Increased functional connectivity common to symptomatic amyotrophic lateral sclerosis and those at genetic risk.

J Neurol Neurosurg Psychiatry 2016 06 5;87(6):580-8. Epub 2016 Jan 5.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK FMRIB Centre, John Radcliffe Hospital, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1136/jnnp-2015-311945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893149PMC
June 2016

Presymptomatic ALS genetic counseling and testing: Experience and recommendations.

Neurology 2016 06 18;86(24):2295-302. Epub 2016 May 18.

From the Department of Neurology (M.B., E.R., S.H., A.C., M.C.F., D.D.D., S.-C.M., J.W.), University of Miami, FL; Winship Cancer Institute and Department of Human Genetics (C.S.), Emory University, Atlanta, GA; and Department of Pharmacology and Clinical Neuroscience (P.M.A.), Umeå University, Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000002773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909562PMC
June 2016

Efficacy of prednisone for the treatment of ocular myasthenia (EPITOME): A randomized, controlled trial.

Muscle Nerve 2016 Mar 27;53(3):363-9. Epub 2016 Jan 27.

Department of Neurology, Miller School of Medicine, University of Miami, 1120 NW 14th Street, CRB 1318, Miami, Florida, 33136, USA.

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http://dx.doi.org/10.1002/mus.24769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038933PMC
March 2016

C9orf72 promoter hypermethylation is reduced while hydroxymethylation is acquired during reprogramming of ALS patient cells.

Exp Neurol 2016 Mar 31;277:171-177. Epub 2015 Dec 31.

Center for Therapeutic Innovation, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2015.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761318PMC
March 2016

How Neurologists and Neuro-Ophthalmologists Think.

Authors:
Michael Benatar

J Neuroophthalmol 2016 Mar;36(1):4-5

Professor of Neurology and Public Health Sciences, Department of Neurology, Miller School of Medicine, Miami, Florida.

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https://insights.ovid.com/crossref?an=00041327-201603000-000
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http://dx.doi.org/10.1097/WNO.0000000000000353DOI Listing
March 2016

Editorial by concerned physicians: Unintended effect of the orphan drug act on the potential cost of 3,4-diaminopyridine.

Authors:
Ted M Burns Gordon A Smith Jeffrey A Allen Anthony A Amato W David Arnold Richard Barohn Michael Benatar Shawn J Bird Mark Bromberg Nizar Chahin Emma Ciafaloni Jeffrey A Cohen Andrea Corse Brian A Crum William S David Elliot Dimberg Eduardo A De Sousa Peter D Donofrio P James B Dyck Andrew G Engel Erik R Ensrud Mark Ferrante Miriam Freimer Karissa L Gable Summer Gibson James M Gilchrist Jonathan M Goldstein Clifton L Gooch Brent P Goodman Dmitri Gorelov Sidney M Gospe Namita A Goyal Amanda C Guidon Jeffrey T Guptill Laurie Gutmann Ludwig Gutmann Kelly Gwathmey Yadollah Harati C Michel Harper Michael K Hehir Lisa D Hobson-Webb James F Howard Carlayne E Jackson Nicholas Johnson Sarah M Jones Vern C Juel Henry J Kaminski Chafic Karam Kathleen D Kennelly Sami Khella Julie Khoury John C Kincaid John T Kissel Noah Kolb David Lacomis Shafeeq Ladha Daniel Larriviere Richard A Lewis Yuebing Li William J Litchy Eric Logigian Jau-Shin Lou Daniel J L MacGowen Ricardo Maselli Janice M Massey Michelle L Mauermann Katherine D Mathews Matthew N Meriggioli Robert G Miller Joon-Shik Moon Tahseen Mozaffar Sharon P Nations Richard J Nowak Lyle W Ostrow Robert M Pascuzzi Amanda Peltier Katherine Ruzhansky David P Richman Mark A Ross Devon I Rubin James A Russell George M Sachs Mohammad Kian Salajegheh David S Saperstein Stephen Scelsa Duygu Selcen Aziz Shaibani Perry B Shieh Nicholas J Silvestri J Rob Singleton Benn E Smith Yuen T So Guillermo Solorzano Eric J Sorenson Jayashri Srinivasen Jinny Tavee Rabi Tawil Pariwat Thaisetthawatkul Charles Thornton Jaya Trivedi Steven Vernino Annabel K Wang Tyler A Webb Michael D Weiss Anthony J Windebank Gil I Wolfe

Muscle Nerve 2016 Feb 21;53(2):165-8. Epub 2015 Dec 21.

Department of Neurology, University of Buffalo, Buffalo, New York, USA.

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http://dx.doi.org/10.1002/mus.25009DOI Listing
February 2016

Reply.

Ann Neurol 2016 Feb 19;79(2):334. Epub 2016 Jan 19.

Department of Neurology, University of Miami, Miami, FL.

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http://dx.doi.org/10.1002/ana.24586DOI Listing
February 2016

To travel or not to travel: The modern day struggle of the academic researcher.

Ann Neurol 2015 Nov 18;78(5):667-9. Epub 2015 Sep 18.

Department of Neurology, University of Miami, Miller School of Medicine, Miami, FL.

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November 2015

Bromodomain inhibitors regulate the C9ORF72 locus in ALS.

Exp Neurol 2015 Sep 20;271:241-50. Epub 2015 Jun 20.

Center for Therapeutic Innovation and Department of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2015.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586400PMC
September 2015

How clinical trials of myasthenia gravis can inform pre-clinical drug development.

Exp Neurol 2015 Aug 13;270:78-81. Epub 2015 Jan 13.

Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1016/j.expneurol.2014.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466144PMC
August 2015

Progress towards a neuroimaging biomarker for amyotrophic lateral sclerosis.

Lancet Neurol 2015 Aug;14(8):786-788

Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK.

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August 2015

Evidence-based guideline summary: Evaluation, diagnosis, and management of facioscapulohumeral muscular dystrophy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the Practice Issues Review Panel of the American Association of Neuromuscular & Electrodiagnostic Medicine.

Neurology 2015 Jul;85(4):357-64

From the MDA Neuromuscular Disease Clinic (R.T.) and the Department of Neurology (C.H., S.P.), School of Medicine and Dentistry, University of Rochester Medical Center, NY; the Department of Neurology (J.T.K.), Wexner Medical Center, Ohio State University, Columbus; the Department of Neurology (G.G.), University of Kansas School of Medicine, Kansas City; and the Department of Neurology (M.B.), Miller School of Medicine, University of Miami, OH.

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http://dx.doi.org/10.1212/WNL.0000000000001783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520817PMC
July 2015

A genome-wide association study of myasthenia gravis.

JAMA Neurol 2015 Apr;72(4):396-404

Neuromuscular Diseases Research Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Porter Neuroscience Research Center, Bethesda, Maryland11Department of Neurology, Johns Hopkins School of Medicine, Baltimore, M.

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http://dx.doi.org/10.1001/jamaneurol.2014.4103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856525PMC
April 2015

A case of familial ALS due to multi-system proteinopathy 1 and Huntington disease.

Amyotroph Lateral Scler Frontotemporal Degener 2015 Mar 10;16(1-2):124-6. Epub 2014 Sep 10.

University of California , Davis, California.

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http://dx.doi.org/10.3109/21678421.2014.952238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664522PMC
March 2015

Novel mutations expand the clinical spectrum of DYNC1H1-associated spinal muscular atrophy.

Neurology 2015 Feb 21;84(7):668-79. Epub 2015 Jan 21.

From the Dubowitz Neuromuscular Center (M.S., M.C., S.R., A.Y.M., A.R.F., C.S., R.P., F.M.) and MRC Center for Neuromuscular Diseases (F.M.), UCL Institute of Child Health, London; MRC Center for Neuromuscular Diseases (A.M.R., M.M.R.), UCL Institute of Neurology, Queen Square, London, UK; Neuromuscular Division (M.B.H., A.M.C., M.T.A.-L.), Department of Neurology, Washington University School of Medicine, St. Louis, MO; Research Center for Genetic Medicine (S.C.), Children's National Medical Center, Washington, DC; Galdakao-Usansolo Hospital (A.M.A., A.R.S.), Department of Neurology, Barrio Labeaga s/n, Usansolo, Vizcaya, Spain; St George's NHS Health Care Trust (S.M., P.F., I.H.), London, UK; Department of Paediatric Neurology (A.K.), University Children's Hospital, Zurich, Switzerland; Department of Pediatrics (M.Y.), University of Colorado Denver; Department of Neurology (M.D.V., W.C.G.O.-P., F.B.), Academic Medical Center, University of Amsterdam, the Netherlands; Human Genetics Unit (C.M.), Ninewells Hospital, Dundee; Center for Inherited Neuromuscular Diseases (C.S.), RJAH Orthopaedic NHS Foundation Trust, Oswestry; School of Life Sciences (M.H.), University of Sussex, John Maynard Smith Building, Brighton; Radiology Department (W.K.C.) and Neurophysiology Department (M.P.), Great Ormond Street Hospital, London, UK; Paediatric Neurology Unit (E.M.), Policlinico Gemelli, Rome, Italy; Department of Neurology (R.H.B.), Cedars Sinai Medical Center, Los Angeles, CA; Department of Developmental Neurobiology (J.P.T.), St. Jude Children's Research Hospital, Memphis, TN; Neurology Department (M.B.), University of Miami Miller School of Medicine, FL; and Department of Neurology (J.N., C.G.E.L.d.G.), Royal Preston Hospital, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336105PMC
February 2015

Ensuring continued progress in biomarkers for amyotrophic lateral sclerosis.

Muscle Nerve 2015 01 24;51(1):14-8. Epub 2014 Nov 24.

Oxford University, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, West Wing Level 3, Oxford, OX3 9DU, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270289PMC
January 2015

An ¹⁸F-FDG PET study of cervical muscle in parkinsonian anterocollis.

J Neurol Sci 2014 May 18;340(1-2):174-7. Epub 2014 Mar 18.

Department of Neurology, Movement Disorders Program, Emory University School of Medicine, Atlanta, GA, United States.

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http://dx.doi.org/10.1016/j.jns.2014.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305331PMC
May 2014

Electrical impedance myography correlates with standard measures of ALS severity.

Muscle Nerve 2014 Mar 19;49(3):441-3. Epub 2013 Dec 19.

Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, TCC-810, Boston, Massachusetts, USA, 02215.

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March 2014

Thymectomy for non-thymomatous myasthenia gravis.

Cochrane Database Syst Rev 2013 Oct 14(10):CD008111. Epub 2013 Oct 14.

Departamento de Neurosciencias, Hospital del Salvador, Universidad de Chile, Avda Salvador 364, Providencia, Santiago, Chile, 6640517.

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October 2013

C9ORF72 intermediate repeat copies are a significant risk factor for Parkinson disease.

Ann Hum Genet 2013 Sep 12;77(5):351-63. Epub 2013 Jul 12.

University of Miami, Miller School of Medicine, John P. Hussman Institute for Human Genomics, Biomedical Research building, 1501 NW 10th Ave, Miami, FL, 33136, USA.

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http://dx.doi.org/10.1111/ahg.12033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815478PMC
September 2013

Utility of capture-recapture methodology to assess completeness of amyotrophic lateral sclerosis case ascertainment.

Neuroepidemiology 2013 24;40(2):133-41. Epub 2012 Oct 24.

Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA.

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July 2013

A randomized, double-blind, placebo-controlled phase II study of eculizumab in patients with refractory generalized myasthenia gravis.

Muscle Nerve 2013 Jul 30;48(1):76-84. Epub 2013 Apr 30.

Department of Neurology, University of North Carolina, 2200 Physicians Office Building, CB 7025, 170 Manning Drive, Chapel Hill, North Carolina, 27599-7025, USA.

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July 2013

ALS Untangled No. 20: the Deanna protocol.

Amyotroph Lateral Scler Frontotemporal Degener 2013 May 2;14(4):319-23. Epub 2013 May 2.

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http://dx.doi.org/10.3109/21678421.2013.788405DOI Listing
May 2013

Reply: To PMID 22581550.

Muscle Nerve 2013 Jan 5;47(1):145-6. Epub 2012 Oct 5.

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January 2013

Medical and surgical treatment for ocular myasthenia.

Cochrane Database Syst Rev 2012 Dec 12;12:CD005081. Epub 2012 Dec 12.

Department of Neurology, University of Miami, Miami, Florida, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485481PMC
December 2012

Design of the efficacy of prednisone in the treatment of ocular myasthenia (EPITOME) trial.

Ann N Y Acad Sci 2012 Dec;1275:17-22

Department of Neurology, University of Miami, Miller School of Medicine, Miami, Florida, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2012.06780.xDOI Listing
December 2012

Presymptomatic studies in ALS: rationale, challenges, and approach.

Neurology 2012 Oct;79(16):1732-9

Neuromuscular, Department of Neurology, University of Miami, Miami, FL, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468777PMC
October 2012

Valosin-containing protein (VCP) mutations in sporadic amyotrophic lateral sclerosis.

Neurobiol Aging 2012 Sep 8;33(9):2231.e1-2231.e6. Epub 2012 May 8.

Neuromuscular Diseases Research Unit, Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2012.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391327PMC
September 2012

Recommendations for myasthenia gravis clinical trials.

Muscle Nerve 2012 Jun;45(6):909-17

Department of Neurology, University of Miami School of Medicine, Miami, Florida, USA.

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http://doi.wiley.com/10.1002/mus.23330
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June 2012

Clinical subtypes of anterocollis in parkinsonian syndromes.

J Neurol Sci 2012 Apr 30;315(1-2):100-3. Epub 2011 Nov 30.

Department of Neurosciences, Division of Neurology, Movement Disorder Program, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1016/j.jns.2011.11.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495550PMC
April 2012

Mutational analysis of the VCP gene in Parkinson's disease.

Neurobiol Aging 2012 Jan 13;33(1):209.e1-2. Epub 2011 Sep 13.

Laboratory of Neurogenetics, National Institute of Aging, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2011.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221929PMC
January 2012

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD.

Neuron 2011 Oct 21;72(2):257-68. Epub 2011 Sep 21.

Neuromuscular Diseases Research Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.neuron.2011.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200438PMC
October 2011

Magnetic resonance spectroscopy of the cervical cord in amyotrophic lateral sclerosis.

Amyotroph Lateral Scler 2011 May 14;12(3):185-91. Epub 2010 Dec 14.

R. Stuart Dickson Institute for Health Studies, Carolinas HealthCare System, Charlotte, North Carolina 28232-2861, USA.

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http://dx.doi.org/10.3109/17482968.2010.515223DOI Listing
May 2011

Towards a neuroimaging biomarker for amyotrophic lateral sclerosis.

Lancet Neurol 2011 May;10(5):400-3

Nuffield Department of Clinical Neurosciences and Centre for Functional Magnetic Resonance of the Brain, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/S1474-4422(11)70049-7DOI Listing
May 2011

Preparing for a U.S. National ALS Registry: Lessons from a pilot project in the State of Georgia.

Amyotroph Lateral Scler 2011 Mar 15;12(2):130-5. Epub 2010 Sep 15.

Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.3109/17482968.2010.515224DOI Listing
March 2011

Enteral tube feeding for amyotrophic lateral sclerosis/motor neuron disease.

Cochrane Database Syst Rev 2011 Jan 19(1):CD004030. Epub 2011 Jan 19.

University of Toronto Toronto General Hospital / UHN, 200 Elizabeth Street, 5EC-306 Toronto, Canada, ON M5G 2C4.

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http://dx.doi.org/10.1002/14651858.CD004030.pub3DOI Listing
January 2011

Diffusion tensor imaging reveals regional differences in the cervical spinal cord in amyotrophic lateral sclerosis.

Neuroimage 2010 Nov 28;53(2):576-83. Epub 2010 Jun 28.

Biomedical Imaging Technology Center, Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA.

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http://dx.doi.org/10.1016/j.neuroimage.2010.06.060DOI Listing
November 2010

Utility of axial and radial diffusivity from diffusion tensor MRI as markers of neurodegeneration in amyotrophic lateral sclerosis.

Brain Res 2010 Aug 1;1348:156-64. Epub 2010 Jun 1.

The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, GA, USA.

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http://dx.doi.org/10.1016/j.brainres.2010.05.067DOI Listing
August 2010

HIV neuropathy in South Africans: frequency, characteristics, and risk factors.

Muscle Nerve 2010 May;41(5):599-606

Division of Neurology, Department of Medicine, University of Cape Town, Observatory 7925, Cape Town, South Africa.

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http://dx.doi.org/10.1002/mus.21535DOI Listing
May 2010

Pearls: myasthenia.

Authors:
Michael Benatar

Semin Neurol 2010 Feb 1;30(1):35-7. Epub 2010 Feb 1.

Emory University School of Medicine and School of Public Health, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1055/s-0029-1244999DOI Listing
February 2010

Developing reference data for nerve conduction studies: an application of quantile regression.

Muscle Nerve 2009 Nov;40(5):763-71

Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, Georgia, USA.

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November 2009

Reference data for commonly used sensory and motor nerve conduction studies.

Muscle Nerve 2009 Nov;40(5):772-94

Department of Neurology, Emory University School of Medicine, Woodruff Memorial Building, Suite 6000, 101 Woodruff Circle, Atlanta, Georgia 30322, USA.

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November 2009

Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trials.

Stroke 2009 Feb 12;40(2):577-81. Epub 2008 Dec 12.

Department of Neurology, University of Texas Houston Medical School, Houston, TX 77030, USA.

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February 2009

Treatment for familial amyotrophic lateral sclerosis/motor neuron disease.

Cochrane Database Syst Rev 2009 Jan 21(1):CD006153. Epub 2009 Jan 21.

Neurology Department, Emory University, Department of Neurology, Woodruff Memorial Building , Suite 6000, 100 Woodruff Circle, Atlanta, GA 30322, USA.

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January 2009

Sensory nerve conduction slowing is a specific marker for CIDP.

Muscle Nerve 2008 Dec;38(6):1599-603

Department of Neurology, Emory University, School of Medicine, Atlanta, Georgia 30322, USA.

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December 2008

Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choices.

Cerebrovasc Dis 2008 17;26(2):156-62. Epub 2008 Jun 17.

Department of Neurology, University of Texas Houston Medical School, Houston, TX 77030, USA.

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October 2008

Treatment of ocular symptoms in myasthenia gravis.

Neurology 2008 Oct;71(17):1335-41

Emory University, Department of Neurology, Atlanta, GA 30322, USA.

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http://www.neurology.org/cgi/doi/10.1212/01.wnl.0000327669.7
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October 2008

Levetiracetam versus carbamazepine monotherapy for partial epilepsy in children less than 16 years of age.

J Child Neurol 2008 May 8;23(5):515-9. Epub 2008 Jan 8.

Department of Pediatrics, Division of Child Neurology, Emory University, Atlanta, GA 30322, USA.

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http://journals.sagepub.com/doi/10.1177/0883073807309784
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May 2008

Treatment of pyridostigmine-induced AV block with hyoscyamine in a patient with myasthenia gravis.

J Cardiovasc Electrophysiol 2008 Feb 16;19(2):214-6. Epub 2007 Aug 16.

Section of Cardiac Electrophysiology, Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1111/j.1540-8167.2007.00938.xDOI Listing
February 2008

What zebras and mice can teach us about familial ALS.

Authors:
Michael Benatar

Neuromuscul Disord 2007 Oct 12;17(9-10):671-2. Epub 2007 Jul 12.

Department of Neurology, Emory University, Woodruff Memorial Building, 101 Woodruff Circle, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/j.nmd.2007.06.005DOI Listing
October 2007

Diagnostic accuracy of thoracic paraspinal electromyography in amyotrophic lateral sclerosis.

J Clin Neurophysiol 2007 Jun;24(3):298-300

Department of Neurology, Emory University, Atlanta, GA 30322, USA.

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June 2007