Michael B Fessler

Michael B Fessler

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Michael B Fessler

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Alveolar Macrophage ABCG1 Deficiency Promotes Pulmonary Granulomatous Inflammation.

Am J Respir Cell Mol Biol 2019 Sep;61(3):332-340

Program in Lung Cell Biology and Translational Research, Division of Pulmonary, Critical Care and Sleep Medicine.

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http://dx.doi.org/10.1165/rcmb.2018-0365OCDOI Listing
September 2019

Cross-linking Proteomics Indicates Effects of Simvastatin on the TLR2 Interactome and Reveals ACTR1A as a Novel Regulator of the TLR2 Signal Cascade.

Mol Cell Proteomics 2019 Sep 20;18(9):1732-1744. Epub 2019 Jun 20.

‡Department of Chemistry and Biochemistry, University of Texas at Arlington, Texas 76019

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http://dx.doi.org/10.1074/mcp.RA119.001377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731082PMC
September 2019

Influenza-Mediated Lung Infection Models.

Methods Mol Biol 2019 ;1960:191-205

Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.

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http://dx.doi.org/10.1007/978-1-4939-9167-9_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675590PMC
July 2019

Drugging the Mighty Neutrophil in Chronic Obstructive Pulmonary Disease.

Am J Respir Cell Mol Biol 2019 Apr;60(4):382-383

1 National Institute of Environmental Health Sciences National Institutes of Health Research Triangle Park, North Carolina.

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http://dx.doi.org/10.1165/rcmb.2018-0370EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444626PMC
April 2019

Cholestenoic acid is a prognostic biomarker in acute respiratory distress syndrome.

J Allergy Clin Immunol 2019 Jan 5;143(1):440-442.e8. Epub 2018 Oct 5.

Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183136
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http://dx.doi.org/10.1016/j.jaci.2018.09.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322978PMC
January 2019

Crohn's disease IRGM risk alleles are associated with altered gene expression in human tissues.

Am J Physiol Gastrointest Liver Physiol 2019 Jan 18;316(1):G95-G105. Epub 2018 Oct 18.

Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health , Research Triangle Park, North Carolina.

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http://dx.doi.org/10.1152/ajpgi.00196.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383377PMC
January 2019

Sulfite-induced protein radical formation in LPS aerosol-challenged mice: Implications for sulfite sensitivity in human lung disease.

Redox Biol 2018 05 29;15:327-334. Epub 2017 Dec 29.

Free Radical Biology Group, Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.redox.2017.12.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756054PMC
May 2018

Comparative and network-based proteomic analysis of low dose ethanol- and lipopolysaccharide-induced macrophages.

PLoS One 2018 26;13(2):e0193104. Epub 2018 Feb 26.

Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0193104PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826526PMC
May 2018

The challenges and promise of targeting the Liver X Receptors for treatment of inflammatory disease.

Pharmacol Ther 2018 01 16;181:1-12. Epub 2017 Jul 16.

National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, P.O. Box 12233, MD D2-01, Research Triangle Park, NC 27709, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01637258173019
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http://dx.doi.org/10.1016/j.pharmthera.2017.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743771PMC
January 2018

CO as a Potential Obesogen: A Gas That Will Stick to Your Ribs.

Am J Respir Cell Mol Biol 2017 11;57(5):499-500

1 National Institute of Environmental Health Sciences National Institutes of Health Research Triangle Park, North Carolina.

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http://dx.doi.org/10.1165/rcmb.2017-0222EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705909PMC
November 2017

A New Frontier in Immunometabolism. Cholesterol in Lung Health and Disease.

Ann Am Thorac Soc 2017 Nov;14(Supplement_5):S399-S405

Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.

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http://dx.doi.org/10.1513/AnnalsATS.201702-136AWDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711269PMC
November 2017

Effects of Orally Ingested Arsenic on Respiratory Epithelial Permeability to Bacteria and Small Molecules in Mice.

Environ Health Perspect 2017 09 28;125(9):097024. Epub 2017 Sep 28.

Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services , Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1289/EHP1878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915208PMC
September 2017

Roles of the Mevalonate Pathway and Cholesterol Trafficking in Pulmonary Host Defense.

Curr Mol Pharmacol 2017 ;10(1):27-45

Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, P.O. Box 12233, Maildrop D2-01, Research Triangle Park, NC 27709, United States.

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http://dx.doi.org/10.2174/1874467209666160112123603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026538PMC
June 2017

House Dust Endotoxin and Peripheral Leukocyte Counts: Results from Two Large Epidemiologic Studies.

Environ Health Perspect 2017 05 31;125(5):057010. Epub 2017 May 31.

Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA

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http://dx.doi.org/10.1289/EHP661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730525PMC
May 2017

TAK1 regulates resident macrophages by protecting lysosomal integrity.

Cell Death Dis 2017 02 9;8(2):e2598. Epub 2017 Feb 9.

Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695-7633, USA.

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http://dx.doi.org/10.1038/cddis.2017.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386472PMC
February 2017

The novel p53 target TNFAIP8 variant 2 is increased in cancer and offsets p53-dependent tumor suppression.

Cell Death Differ 2017 01 11;24(1):181-191. Epub 2016 Nov 11.

Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA.

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http://www.nature.com/articles/cdd2016130
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http://dx.doi.org/10.1038/cdd.2016.130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260499PMC
January 2017

The Intracellular Cholesterol Landscape: Dynamic Integrator of the Immune Response.

Trends Immunol 2016 12 28;37(12):819-830. Epub 2016 Sep 28.

Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, P.O. Box 12233, MD D2-01 Research Triangle Park, NC 27709, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14714906163012
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http://dx.doi.org/10.1016/j.it.2016.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135597PMC
December 2016

Ozone-derived Oxysterols Affect Liver X Receptor (LXR) Signaling: A POTENTIAL ROLE FOR LIPID-PROTEIN ADDUCTS.

J Biol Chem 2016 Nov 4;291(48):25192-25206. Epub 2016 Oct 4.

From the Curriculum in Toxicology, Departments of Pediatrics and Microbiology and Immunology, Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina, Chapel Hill, North Carolina 27599,

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http://dx.doi.org/10.1074/jbc.M116.732362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122785PMC
November 2016

Role for phospholipid acyl chains and cholesterol in pulmonary infections and inflammation.

J Leukoc Biol 2016 11 10;100(5):985-997. Epub 2016 Jun 10.

Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA;

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http://dx.doi.org/10.1189/jlb.4VMR0316-103RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069085PMC
November 2016

Differential Tandem Mass Spectrometry-Based Cross-Linker: A New Approach for High Confidence in Identifying Protein Cross-Linking.

Anal Chem 2016 10 28;88(20):10215-10222. Epub 2016 Sep 28.

Laboratory of Bioanalysis, Washington State University , Pullman, Washington 98195, United States.

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http://dx.doi.org/10.1021/acs.analchem.6b02886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316473PMC
October 2016

MicroRNA-33 Regulates the Innate Immune Response via ATP Binding Cassette Transporter-mediated Remodeling of Membrane Microdomains.

J Biol Chem 2016 09 28;291(37):19651-60. Epub 2016 Jul 28.

From the Immunity, Inflammation and Disease Laboratory, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709,

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http://dx.doi.org/10.1074/jbc.M116.723056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016698PMC
September 2016

A Non-invasive and Technically Non-intensive Method for Induction and Phenotyping of Experimental Bacterial Pneumonia in Mice.

J Vis Exp 2016 09 28(115). Epub 2016 Sep 28.

Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health;

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http://dx.doi.org/10.3791/54508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5092067PMC
September 2016

Elevated MicroRNA-33 in Sarcoidosis and a Carbon Nanotube Model of Chronic Granulomatous Disease.

Am J Respir Cell Mol Biol 2016 06;54(6):865-71

1 Division of Pulmonary, Critical Care, and Sleep Medicine, East Carolina University, Greenville, North Carolina.

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http://dx.doi.org/10.1165/rcmb.2015-0332OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942222PMC
June 2016

A new inflammatory role for p53 in human macrophages.

Cell Cycle 2014 ;13(19):2983-4

a Laboratory of Respiratory Biology ; National Institute of Environmental Health Sciences ; NIH ; Research Triangle Park , NC USA.

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http://dx.doi.org/10.4161/15384101.2014.959852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614039PMC
May 2016

Surfactant Lipids at the Host-Environment Interface. Metabolic Sensors, Suppressors, and Effectors of Inflammatory Lung Disease.

Am J Respir Cell Mol Biol 2016 05;54(5):624-35

2 Center for Translational Medicine and Jane and Leonard Korman Lung Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

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http://www.atsjournals.org/doi/10.1165/rcmb.2016-0011PS
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http://dx.doi.org/10.1165/rcmb.2016-0011PSDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942198PMC
May 2016

Rosuvastatin Alters the Proteome of High Density Lipoproteins: Generation of alpha-1-antitrypsin Enriched Particles with Anti-inflammatory Properties.

Mol Cell Proteomics 2015 Dec 19;14(12):3247-57. Epub 2015 Oct 19.

From the ‡Lipoprotein Metabolism Section, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland;

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http://dx.doi.org/10.1074/mcp.M115.054031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762624PMC
December 2015

Regulation of Adaptive Immunity in Health and Disease by Cholesterol Metabolism.

Curr Allergy Asthma Rep 2015 Aug;15(8):48

Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, Maildrop D2-01, P.O. Box 12233, Research Triangle Park, NC, 27709, USA,

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http://dx.doi.org/10.1007/s11882-015-0548-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567252PMC
August 2015

Revisiting "Good" and "Bad" Cholesterol. The Battle over Flow through Arteries Now Shifts to Flow through Airways.

Am J Respir Crit Care Med 2015 May;191(9):969-70

1 National Institute of Environmental Health Sciences National Institutes of Health Research Triangle Park, North Carolina.

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http://www.atsjournals.org/doi/10.1164/rccm.201502-0413ED
Publisher Site
http://dx.doi.org/10.1164/rccm.201502-0413EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435461PMC
May 2015

Palmitoylation of the immunity related GTPase, Irgm1: impact on membrane localization and ability to promote mitochondrial fission.

PLoS One 2014 21;9(4):e95021. Epub 2014 Apr 21.

Geriatric Research, Education, and Clinical Center, VA Medical Center, Durham, North Carolina, United States of America; Departments of Medicine; Molecular Genetics and Microbiology; and Immunology; Division of Geriatrics, and Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0095021PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994021PMC
January 2015

APOε4 is associated with enhanced in vivo innate immune responses in human subjects.

J Allergy Clin Immunol 2014 Jul 18;134(1):127-34. Epub 2014 Mar 18.

Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.01.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125509PMC
July 2014

p53 and NF-κB coregulate proinflammatory gene responses in human macrophages.

Cancer Res 2014 Apr;74(8):2182-92

Authors' Affiliations: Laboratory of Molecular Genetics, Biostatistics Branch, Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle Park; and Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994464PMC
April 2014

ABCG1-mediated generation of extracellular cholesterol microdomains.

J Lipid Res 2014 Jan 8;55(1):115-27. Epub 2013 Nov 8.

Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M044552
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http://dx.doi.org/10.1194/jlr.M044552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927477PMC
January 2014

Relationship between serum cholesterol and indices of erythrocytes and platelets in the US population.

J Lipid Res 2013 Nov 2;54(11):3177-88. Epub 2013 Sep 2.

Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709.

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http://www.jlr.org/lookup/doi/10.1194/jlr.P037614
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http://dx.doi.org/10.1194/jlr.P037614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793622PMC
November 2013

Emerging roles for cholesterol and lipoproteins in lung disease.

Pulm Pharmacol Ther 2013 Aug 15;26(4):430-7. Epub 2012 Jun 15.

Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, PO Box 12233, MD D2-01, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.pupt.2012.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466369PMC
August 2013

Effects of acute and chronic low density lipoprotein exposure on neutrophil function.

Pulm Pharmacol Ther 2013 Aug 17;26(4):405-11. Epub 2012 Oct 17.

Department of Medicine, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1016/j.pupt.2012.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573240PMC
August 2013

Preferential invasion of mitotic cells by Salmonella reveals that cell surface cholesterol is maximal during metaphase.

J Cell Sci 2013 Jul 17;126(Pt 14):2990-6. Epub 2013 May 17.

Section of Microbiology, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, UK.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.115253
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http://dx.doi.org/10.1242/jcs.115253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711197PMC
July 2013

CD11b/CD18 (Mac-1) is a novel surface receptor for extracellular double-stranded RNA to mediate cellular inflammatory responses.

J Immunol 2013 Jan 3;190(1):115-25. Epub 2012 Dec 3.

Laboratory of Toxicology and Pharmacology, National Institutes of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1202136
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http://dx.doi.org/10.4049/jimmunol.1202136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529770PMC
January 2013

Greasing the way: the ABCs of HSPC efflux from the marrow.

Cell Stem Cell 2012 Aug;11(2):143-4

Vermont Lung Center, University of Vermont College of Medicine, Burlington, VT 05405, USA.

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http://dx.doi.org/10.1016/j.stem.2012.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429340PMC
August 2012

ATP binding cassette transporter G1 deletion induces IL-17-dependent dysregulation of pulmonary adaptive immunity.

J Immunol 2012 Jun 25;188(11):5327-36. Epub 2012 Apr 25.

Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.4049/jimmunol.1101605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358405PMC
June 2012

Crosstalk between reverse cholesterol transport and innate immunity.

Trends Endocrinol Metab 2012 Apr 10;23(4):169-78. Epub 2012 Mar 10.

Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.tem.2012.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338129PMC
April 2012

Proteomic profiling of S-acylated macrophage proteins identifies a role for palmitoylation in mitochondrial targeting of phospholipid scramblase 3.

Mol Cell Proteomics 2011 Oct 23;10(10):M110.006007. Epub 2011 Jul 23.

Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA.

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http://www.mcponline.org/lookup/doi/10.1074/mcp.M110.006007
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http://dx.doi.org/10.1074/mcp.M110.006007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205854PMC
October 2011

Intracellular lipid flux and membrane microdomains as organizing principles in inflammatory cell signaling.

J Immunol 2011 Aug;187(4):1529-35

Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1100253
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http://dx.doi.org/10.4049/jimmunol.1100253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151145PMC
August 2011

The Toll-like receptor gene family is integrated into human DNA damage and p53 networks.

PLoS Genet 2011 Mar 31;7(3):e1001360. Epub 2011 Mar 31.

Chromosome Stability Group, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1001360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069118PMC
March 2011

Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress.

Mol Cell Biol 2010 Oct 20;30(19):4712-21. Epub 2010 Jul 20.

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.00657-10
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http://dx.doi.org/10.1128/MCB.00657-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950528PMC
October 2010

ATP-binding cassette transporter G1 deficiency dysregulates host defense in the lung.

Am J Respir Crit Care Med 2010 Aug 15;182(3):404-12. Epub 2010 Apr 15.

National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1164/rccm.200910-1580OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921600PMC
August 2010

Mechanisms of neutrophil accumulation in the lungs against bacteria.

Am J Respir Cell Mol Biol 2010 Jul 8;43(1):5-16. Epub 2009 Sep 8.

D.V.M., Pathobiolgical Sciences and Center for Experimental Infectious Disease Research, LSU, Baton Rouge, LA 70803, USA.

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http://dx.doi.org/10.1165/rcmb.2009-0047TRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911570PMC
July 2010

The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins.

J Allergy Clin Immunol 2010 Apr 11;125(4):909-917.e4. Epub 2010 Mar 11.

Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.1016/j.jaci.2009.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885876PMC
April 2010

Novel relationship of serum cholesterol with asthma and wheeze in the United States.

J Allergy Clin Immunol 2009 Nov 3;124(5):967-74.e1-15. Epub 2009 Oct 3.

Department of Health and Human Services, Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.jaci.2009.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936400PMC
November 2009

Simvastatin as a potential therapeutic for acute respiratory distress syndrome.

Am J Respir Crit Care Med 2009 Nov;180(10):1031; author reply 1031-2

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http://dx.doi.org/10.1164/ajrccm.180.10.1031DOI Listing
November 2009

Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome.

Curr Opin Lipidol 2009 Oct;20(5):379-85

Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1040, USA.

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http://dx.doi.org/10.1097/MOL.0b013e32832fa5c4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099529PMC
October 2009

Epitope mapping by proteolysis of antigen-antibody complexes.

Methods Mol Biol 2009 ;524:87-101

Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, 111 T.W. Alexander Drive, PO Box 12233, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1007/978-1-59745-450-6_7DOI Listing
July 2009

Epitope mapping by differential chemical modification of antigens.

Methods Mol Biol 2009 ;524:119-34

Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, 111 T.W. Alexander Drive, PO Box 12233, Research Triangle Park, NC 27709, USA.

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July 2009

Quantitative proteomics analysis of macrophage rafts reveals compartmentalized activation of the proteasome and of proteasome-mediated ERK activation in response to lipopolysaccharide.

Mol Cell Proteomics 2009 Jan 23;8(1):201-13. Epub 2008 Sep 23.

Laboratories of Respiratory Biology, NIEHS, National Institutes of Health, United States Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1074/mcp.M800286-MCP200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621002PMC
January 2009

Liver X Receptor: Crosstalk Node for the Signaling of Lipid Metabolism, Carbohydrate Metabolism, and Innate Immunity.

Curr Signal Transduct Ther 2008 May;3(2):75-81

Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931522PMC
May 2008

Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense.

J Immunol 2008 Mar;180(5):3305-12

Laboratory of Respiratory Biology, Department of Health and Human Services, Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430066PMC
http://dx.doi.org/10.4049/jimmunol.180.5.3305DOI Listing
March 2008

The IL-1 type 1 receptor is required for the development of LPS-induced airways disease.

J Allergy Clin Immunol 2007 Jul 18;120(1):121-7. Epub 2007 May 18.

National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.jaci.2007.03.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570244PMC
July 2007

Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling contributes to innate immune responses in the lung during Escherichia coli pneumonia.

J Immunol 2007 Mar;178(5):3153-60

Division of Respiratory Infections, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street Neustadt D-403, Denver, CO 80206, USA.

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March 2007

A 70-year-old man with migratory pulmonary infiltrates.

Chest 2006 Oct;130(4):1269-74

Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Ave, Box C-272, Denver, CO 80262, USA.

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October 2006

Statins enhance clearance of apoptotic cells through modulation of Rho-GTPases.

Proc Am Thorac Soc 2006 Aug;3(6):516-7

Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Ave, C272, Denver, 80220, USA.

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August 2006

Lovastatin enhances clearance of apoptotic cells (efferocytosis) with implications for chronic obstructive pulmonary disease.

J Immunol 2006 Jun;176(12):7657-65

COPD Center, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, 80262, USA.

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June 2006

Genetic polymorphisms and sepsis.

Shock 2005 Oct;24(4):300-12

Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.

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http://dx.doi.org/10.1097/01.shk.0000180621.52058.e1DOI Listing
October 2005

Inhibition of c-Jun N-terminal kinase limits lipopolysaccharide-induced pulmonary neutrophil influx.

Am J Respir Crit Care Med 2005 May 25;171(9):978-86. Epub 2005 Feb 25.

Division of Pulmonary and Critical Care Medicine, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80206, USA.

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http://www.atsjournals.org/doi/abs/10.1164/rccm.200406-712OC
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May 2005

A role for hydroxy-methylglutaryl coenzyme a reductase in pulmonary inflammation and host defense.

Am J Respir Crit Care Med 2005 Mar 10;171(6):606-15. Epub 2004 Dec 10.

Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, D403 Neustadt, Denver, CO 80206, USA.

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March 2005

Lipid rafts regulate lipopolysaccharide-induced activation of Cdc42 and inflammatory functions of the human neutrophil.

J Biol Chem 2004 Sep 15;279(38):39989-98. Epub 2004 Jul 15.

Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA.

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September 2004

Idiopathic diffuse hyperplasia of pulmonary neuroendocrine cells in a patient with acromegaly.

Respirology 2004 Jun;9(2):274-7

Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.

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June 2004

Phospholipid flip-flop and phospholipid scramblase 1 (PLSCR1) co-localize to uropod rafts in formylated Met-Leu-Phe-stimulated neutrophils.

J Biol Chem 2004 Apr 6;279(17):17625-33. Epub 2004 Feb 6.

Department of Pediatrics, Division of Cell Biology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA.

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April 2004

Right-to-left shunting through a patent foramen ovale in right ventricular infarction: improvement of hypoxemia and hemodynamics with inhaled nitric oxide.

J Clin Anesth 2003 Aug;15(5):371-4

Cardiology Division, Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114-2696, USA.

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http://dx.doi.org/10.1016/s0952-8180(03)00053-9DOI Listing
August 2003

A genomic and proteomic analysis of activation of the human neutrophil by lipopolysaccharide and its mediation by p38 mitogen-activated protein kinase.

J Biol Chem 2002 Aug 9;277(35):31291-302. Epub 2002 Apr 9.

Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center and National Jewish Medical and Research Center, Denver, Colorado 80262, USA.

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August 2002

Lipopolysaccharide stimulation of the human neutrophil: an analysis of changes in gene transcription and protein expression by oligonucleotide microarrays and proteomics.

Chest 2002 Mar;121(3 Suppl):75S-76S

Department of Medicine, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, 80262, USA.

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March 2002