Publications by authors named "Michael Andreeff"

100Publications

MDM2 inhibition: an important step forward in cancer therapy.

Leukemia 2020 Jul 10. Epub 2020 Jul 10.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1038/s41375-020-0949-zDOI Listing
July 2020

LGALS1 acts as a pro-survival molecule in AML.

Biochim Biophys Acta Mol Cell Res 2020 Oct 23;1867(10):118785. Epub 2020 Jun 23.

Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States of America; Section of Molecular Hematology and Therapy, University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States of America.

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http://dx.doi.org/10.1016/j.bbamcr.2020.118785DOI Listing
October 2020

Combinatorial Inhibition of Focal Adhesion Kinase and BCL-2 Enhances Antileukemia Activity of Venetoclax in Acute Myeloid Leukemia.

Mol Cancer Ther 2020 Aug 13;19(8):1636-1648. Epub 2020 May 13.

Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1535-7163.MCT-19-0841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416436PMC
August 2020

Fatty Acid Metabolism, Bone Marrow Adipocytes, and AML.

Front Oncol 2020 18;10:155. Epub 2020 Feb 18.

Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

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http://dx.doi.org/10.3389/fonc.2020.00155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040225PMC
February 2020

Bone marrow niches in haematological malignancies.

Nat Rev Cancer 2020 05 28;20(5):285-298. Epub 2020 Feb 28.

Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Medicine, Frankfurt, Germany.

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http://dx.doi.org/10.1038/s41568-020-0245-2DOI Listing
May 2020

Updates on the hematologic tumor microenvironment and its therapeutic targeting.

Haematologica 2019 10 12;104(10):1928-1934. Epub 2019 Sep 12.

Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute and Department of Haematology, University of Cambridge, Cambridge, UK

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http://dx.doi.org/10.3324/haematol.2018.195396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886423PMC
October 2019

Combined inhibition of MDM2 and BCR-ABL1 tyrosine kinase targets chronic myeloid leukemia stem/progenitor cells in a murine model.

Haematologica 2020 May 1;105(5):1274-1284. Epub 2019 Aug 1.

Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

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http://dx.doi.org/10.3324/haematol.2019.219261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193504PMC
May 2020

LGALS3 is connected to CD74 in a previously unknown protein network that is associated with poor survival in patients with AML.

EBioMedicine 2019 Jun 16;44:126-137. Epub 2019 May 16.

Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA; Division of Molecular Hematology and Therapy, University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.05.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604360PMC
June 2019

Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality.

Cancer Cell 2019 05 2;35(5):721-737.e9. Epub 2019 May 2.

The University of Texas MD Anderson Cancer Center, Molecular Hematology and Therapy, Department of Leukemia, Houston, TX 77030, USA; The University of Texas MD Anderson Cancer Center; Department of Leukemia, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.03.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620028PMC
May 2019

An ARC-Regulated IL1β/Cox-2/PGE2/β-Catenin/ARC Circuit Controls Leukemia-Microenvironment Interactions and Confers Drug Resistance in AML.

Cancer Res 2019 03 23;79(6):1165-1177. Epub 2019 Jan 23.

Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-0921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420856PMC
March 2019

Osteogenic niche in the regulation of normal hematopoiesis and leukemogenesis.

Haematologica 2018 12 18;103(12):1945-1955. Epub 2018 Oct 18.

Section of Molecular Hematology and Therapy, Leukemia Department, The University of Texas MD Anderson Cancer Center, Houston, TX

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http://www.haematologica.org/lookup/doi/10.3324/haematol.201
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http://dx.doi.org/10.3324/haematol.2018.197004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269284PMC
December 2018

ST8SIA1 Regulates Tumor Growth and Metastasis in TNBC by Activating the FAK-AKT-mTOR Signaling Pathway.

Mol Cancer Ther 2018 12 20;17(12):2689-2701. Epub 2018 Sep 20.

Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1535-7163.MCT-18-0399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279518PMC
December 2018

NSG-S mice for acute myeloid leukemia, yes. For myelodysplastic syndrome, no.

Haematologica 2018 06;103(6):921-923

Section of Molecular Hematology and Therapy, Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA

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http://dx.doi.org/10.3324/haematol.2018.193847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058791PMC
June 2018

Clearance of Somatic Mutations at Remission and the Risk of Relapse in Acute Myeloid Leukemia.

J Clin Oncol 2018 06 27;36(18):1788-1797. Epub 2018 Apr 27.

Kiyomi Morita, Hagop M. Kantarjian, Feng Wang, Yuanqing Yan, Carlos Bueso-Ramos, Koji Sasaki, Ghayas C. Issa, Sa Wang, Jeffrey Jorgensen, Xingzhi Song, Jianhua Zhang, Samantha Tippen, Rebecca Thornton, Marcus Coyle, Latasha Little, Curtis Gumbs, Naveen Pemmaraju, Naval Daver, Courtney D. DiNardo, Marina Konopleva, Michael Andreeff, Farhad Ravandi, Jorge E. Cortes, Tapan Kadia, Elias Jabbour, Guillermo Garcia-Manero, Keyur P. Patel, P. Andrew Futreal, and Koichi Takahash, The University of Texas MD Anderson Cancer Center, Houston, TX; Kiyomi Morita, The University of Tokyo, Tokyo; and Koichi Takahashi, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1200/JCO.2017.77.6757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008108PMC
June 2018

Role of MSC-derived galectin 3 in the AML microenvironment.

Biochim Biophys Acta Mol Cell Res 2018 07 12;1865(7):959-969. Epub 2018 Apr 12.

Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, United States; Section of Molecular Hematology, University of Texas MD Anderson Cancer Center, Houston, TX, United States.

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http://dx.doi.org/10.1016/j.bbamcr.2018.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936474PMC
July 2018

Predictive Gene Signatures Determine Tumor Sensitivity to MDM2 Inhibition.

Cancer Res 2018 05 28;78(10):2721-2731. Epub 2018 Feb 28.

Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955838PMC
May 2018

Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy.

Cancer Cell 2017 Dec;32(6):748-760.e6

Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730338PMC
December 2017

Tumor status and genotype affect the bone marrow microenvironment in acute myeloid leukemia.

Oncotarget 2017 Oct 6;8(48):83354-83369. Epub 2017 Jul 6.

Department of Leukemia, Section of Molecular Hematology and Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.18632/oncotarget.19042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663521PMC
October 2017

The Imipridone ONC201 Induces Apoptosis and Overcomes Chemotherapy Resistance by Up-Regulation of Bim in Multiple Myeloma.

Neoplasia 2017 Oct 30;19(10):772-780. Epub 2017 Aug 30.

Department of Lymphoma/Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou 511436, China. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2017.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577403PMC
October 2017

Single-Cell Mass Cytometry of Acute Myeloid Leukemia and Leukemia Stem/Progenitor Cells.

Methods Mol Biol 2017 ;1633:75-86

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1007/978-1-4939-7142-8_5DOI Listing
May 2018

IKK inhibition by BMS-345541 suppresses breast tumorigenesis and metastases by targeting GD2+ cancer stem cells.

Oncotarget 2017 Jun;8(23):36936-36949

Department of Leukemia, Section of Molecular Hematology and Therapy, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://www.oncotarget.com/fulltext/16294
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http://dx.doi.org/10.18632/oncotarget.16294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514883PMC
June 2017

Jab1/Csn5-Thioredoxin Signaling in Relapsed Acute Monocytic Leukemia under Oxidative Stress.

Clin Cancer Res 2017 Aug 7;23(15):4450-4461. Epub 2017 Mar 7.

Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-2426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861712PMC
August 2017

Focal Adhesion Kinase as a Potential Target in AML and MDS.

Mol Cancer Ther 2017 06 7;16(6):1133-1144. Epub 2017 Mar 7.

Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1535-7163.MCT-16-0719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457713PMC
June 2017

Mesenchymal stromal cells for the delivery of oncolytic viruses in gliomas.

Cytotherapy 2017 04 21;19(4):445-457. Epub 2017 Feb 21.

Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; The Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jcyt.2017.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410175PMC
April 2017

The authors reply.

Crit Care Med 2017 03;45(3):e328-e329

Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany; Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany, and IRCCS San Martino IST, Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy; Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany, and Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany, and IRCCS San Martino IST, Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy; Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany; Institute of Nuclear Medicine, University Hospital Dresden, Dresden, Germany; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard University, Boston, MA; IRCCS San Martino IST, Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy; Institute of Nuclear Medicine, University Hospital Dresden, Dresden, Germany; Department of Anesthesiology and Intensive Care Medicine, Pulmonary Engineering Group, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany.

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http://dx.doi.org/10.1097/CCM.0000000000002225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500205PMC
March 2017

Eradication of CML stem cells.

Oncoscience 2016 23;3(11-12):313-315. Epub 2016 Nov 23.

Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.18632/oncoscience.327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5235917PMC
November 2016

Targeting autophagy to overcome chemoresistance in acute myleogenous leukemia.

Autophagy 2017 Jan 31;13(1):214-215. Epub 2016 Oct 31.

a Department of Leukemia , Section of Molecular Hematology and Therapy, MD Anderson Cancer Center , Houston , TX USA.

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http://dx.doi.org/10.1080/15548627.2016.1245263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240828PMC
January 2017

Editorial.

Cytotherapy 2016 11 26;18(11):1349-1350. Epub 2016 Sep 26.

Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/j.jcyt.2016.09.004DOI Listing
November 2016

Combined targeting of BCL-2 and BCR-ABL tyrosine kinase eradicates chronic myeloid leukemia stem cells.

Sci Transl Med 2016 09;8(355):355ra117

Section of Molecular Hematology and Therapy, Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1126/scitranslmed.aag1180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111086PMC
September 2016

Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML.

Blood 2016 10 18;128(15):1944-1958. Epub 2016 Aug 18.

Department of Biochemistry and Molecular Biology and Hollings Cancer Center, Medical University of South Carolina, Charleston, SC; and.

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http://dx.doi.org/10.1182/blood-2016-04-708750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064718PMC
October 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.

Authors:
Elizabeth C Townsend Mark A Murakami Alexandra Christodoulou Amanda L Christie Johannes Köster Tiffany A DeSouza Elizabeth A Morgan Scott P Kallgren Huiyun Liu Shuo-Chieh Wu Olivia Plana Joan Montero Kristen E Stevenson Prakash Rao Raga Vadhi Michael Andreeff Philippe Armand Karen K Ballen Patrizia Barzaghi-Rinaudo Sarah Cahill Rachael A Clark Vesselina G Cooke Matthew S Davids Daniel J DeAngelo David M Dorfman Hilary Eaton Benjamin L Ebert Julia Etchin Brant Firestone David C Fisher Arnold S Freedman Ilene A Galinsky Hui Gao Jacqueline S Garcia Francine Garnache-Ottou Timothy A Graubert Alejandro Gutierrez Ensar Halilovic Marian H Harris Zachary T Herbert Steven M Horwitz Giorgio Inghirami Andrew M Intlekofer Moriko Ito Shai Izraeli Eric D Jacobsen Caron A Jacobson Sébastien Jeay Irmela Jeremias Michelle A Kelliher Raphael Koch Marina Konopleva Nadja Kopp Steven M Kornblau Andrew L Kung Thomas S Kupper Nicole R LeBoeuf Ann S LaCasce Emma Lees Loretta S Li A Thomas Look Masato Murakami Markus Muschen Donna Neuberg Samuel Y Ng Oreofe O Odejide Stuart H Orkin Rachel R Paquette Andrew E Place Justine E Roderick Jeremy A Ryan Stephen E Sallan Brent Shoji Lewis B Silverman Robert J Soiffer David P Steensma Kimberly Stegmaier Richard M Stone Jerome Tamburini Aaron R Thorner Paul van Hummelen Martha Wadleigh Marion Wiesmann Andrew P Weng Jens U Wuerthner David A Williams Bruce M Wollison Andrew A Lane Anthony Letai Monica M Bertagnolli Jerome Ritz Myles Brown Henry Long Jon C Aster Margaret A Shipp James D Griffin David M Weinstock

Cancer Cell 2016 07 11;30(1):183. Epub 2016 Jul 11.

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http://dx.doi.org/10.1016/j.ccell.2016.06.008DOI Listing
July 2016

Bone marrow niche-mediated survival of leukemia stem cells in acute myeloid leukemia: Yin and Yang.

Cancer Biol Med 2016 Jun;13(2):248-59

Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.20892/j.issn.2095-3941.2016.0023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944541PMC
June 2016

[Therapy of bone metastases with radium-223. German guidelines].

Nuklearmedizin 2016 Sep 15;55(5):177-86. Epub 2016 Jul 15.

Dr. Thorsten Pöppel, Universitätsklinikum Essen, Klinik für Nuklearmedizin, Hufelandstr. 55, 45122 Essen,

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http://dx.doi.org/10.3413/Nukmed-2016050001DOI Listing
September 2016

DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia.

Blood 2016 08 22;128(7):971-81. Epub 2016 Jun 22.

Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX; Dan L. Duncan Cancer Center, Department of Molecular and Human Genetics, Stem Cells and Regenerative Medicine Center, and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX;

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http://www.bloodjournal.org/content/bloodjournal/early/2016/
Web Search
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2015-11-68
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http://dx.doi.org/10.1182/blood-2015-11-684225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990856PMC
August 2016

Pharmacological activation of wild-type p53 in the therapy of leukemia.

Exp Hematol 2016 09 18;44(9):791-798. Epub 2016 Jun 18.

Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062953PMC
http://dx.doi.org/10.1016/j.exphem.2016.05.014DOI Listing
September 2016

On the Reliability of Automatic Volume Delineation in Low-Contrast [(18)F]FMISO-PET Imaging.

Recent Results Cancer Res 2016;198:175-87

OncoRay, National Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, TU Dresden, Fetscherstraße 74, 01307, Dresden, Germany.

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http://dx.doi.org/10.1007/978-3-662-49651-0_9DOI Listing
July 2017

GD2 and GD3 synthase: novel drug targets for cancer therapy.

Mol Cell Oncol 2015 Jul-Sep;2(3):e975068. Epub 2015 Mar 9.

Department of Translational Molecular Pathology; The University of Texas MD Anderson Cancer Center; Houston, TX USA; Metastasis Research Center; The University of Texas MD Anderson Cancer Center; Houston, TX USA; Center for Stem Cells and Developmental Biology; The University of Texas MD Anderson Cancer Center; Houston, TX USA.

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http://dx.doi.org/10.4161/23723556.2014.975068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905286PMC
June 2016

Mixed-phenotype acute leukemia (MPAL) exhibits frequent mutations in DNMT3A and activated signaling genes.

Exp Hematol 2016 08 18;44(8):740-4. Epub 2016 May 18.

Cancer and Hematology Centers, Texas Children's Hospital/Baylor College of Medicine, Houston, TX. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2016.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956537PMC
August 2016