Michael A Schwarzschild

Michael A Schwarzschild

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Michael A Schwarzschild

Michael A Schwarzschild

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Physical activity and prodromal features of Parkinson disease.

Neurology 2019 Dec 12;93(23):e2157-e2169. Epub 2019 Nov 12.

From the Department of Nutrition (K.C.H., A.A.), Harvard T. H. Chan School of Public Health, Boston, MA; Department of Nutritional Health (X.G.), The Pennsylvania State University, University Park; Population Health Sciences Program (S.M.), Harvard University, Cambridge, MA; Department of Biostatistics (L.V.), Columbia University Mailman School of Public Health, New York, NY; MassGeneral Institute for Neurodegenerative Disease (M.A.S.), Massachusetts General Hospital, Boston; Department of Epidemiology (A.A.), Harvard T. H. Chan School of Public Health, Boston, MA; and Channing Division of Network Medicine, Department of Medicine (A.A.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000008567DOI Listing
December 2019

Sex differences by design and outcome in the Safety of Urate Elevation in PD (SURE-PD) trial.

Neurology 2019 Oct 4;93(14):e1328-e1338. Epub 2019 Sep 4.

From the Departments of Neurology (M.A.S., R.B., S.B., R.L., A.Y.H., G.B.) and Medicine (E.A.M.), Massachusetts General Hospital, Boston; University of Cincinnati (A.J.E.), OH; Rush University (C.G.G.), Chicago, IL; Michigan State University (J.L.G.), East Lansing; Struthers Parkinson's Center (S.A.P.), Minneapolis, MN; Boston University (M.H.S.-H.), MA; University of Rochester (A.R.), NY; University of Miami (J.M.H.), FL; Brigham and Women's Hospital (G.C.C.), Boston, MA; Yale University School of Medicine (D.S.R.), New Haven, CT; and Department of Nutrition (A.A.), Harvard School of Public Health, Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000008194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814412PMC
October 2019

Reply to "Mitochondrial DNA deletions discriminate affected from unaffected LRRK2 mutation carriers".

Ann Neurol 2019 Aug 12;86(2):326-327. Epub 2019 Jun 12.

Department of Neurology, Massachusetts General Hospital, Boston, MA.

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http://dx.doi.org/10.1002/ana.25509DOI Listing
August 2019

Prediagnostic plasma branched-chain amino acids and the risk of amyotrophic lateral sclerosis.

Neurology 2019 04 14;92(18):e2081-e2088. Epub 2018 Nov 14.

From the Departments of Nutrition (K.B., É.J.O., Z.Z., A.A.) and Epidemiology (J.E.M., A.A.), Harvard T.H. Chan School of Public Health, Boston, MA; School of Public Health (É.J.O.), College of Medicine, University College Cork, Ireland; Department of Neurology (J.D.B., M.A.S.), Massachusetts General Hospital (S.P.), Boston; Metabolomics Platform (C.B.C., S.J.), Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge; Department of Oncology (I.K.), Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI; Epidemiology Program (L.N.K., L.L.M.), University of Hawaii Cancer Center, Honolulu; Epidemiology Research Program (M.L.M.), American Cancer Society, Atlanta, GA; Department of Physical Medicine and Rehabilitation (S.P.), Spaulding Rehabilitation Hospital, Charlestown; Harvard Medical School (S.P., M.A.S.), Boston, MA; Department of Epidemiology (E.O.T.), Graduate School of Public Health, University of Pittsburgh, PA; Department of Epidemiology (R.B.W.), College of Public Health, University of Iowa, Iowa City; and Department of Medicine (J.E.M.) and Channing Division of Network Medicine (A.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000006669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512885PMC
April 2019

Higher urate in LRRK2 mutation carriers resistant to Parkinson disease.

Ann Neurol 2019 Apr 3;85(4):593-599. Epub 2019 Mar 3.

Department of Neurology, Massachusetts General Hospital.

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http://dx.doi.org/10.1002/ana.25436DOI Listing
April 2019

Prediagnostic plasma metabolomics and the risk of amyotrophic lateral sclerosis.

Neurology 2019 04 29;92(18):e2089-e2100. Epub 2019 Mar 29.

From the Departments of Nutrition (K.B., Z.Z., É.J.O., D.D.W., A.A.) and Epidemiology (L.L., J.E.M., A.A.), Harvard T.H. Chan School of Public Health, Boston, MA; School of Public Health (É.J.O.), College of Medicine, University College Cork, Ireland; Department of Neurology (J.D.B., M.A.S.), Massachusetts General Hospital, Boston; Metabolomics Platform (C.B.C., A.D., S.J., K.A.P.), Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA; Department of Oncology (I.K.), Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI; Channing Division of Network Medicine (R.S.K., A.A.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Epidemiology Program (L.N.K., L.L.M.), University of Hawaii Cancer Center, Honolulu; Behavioral and Epidemiology Research Group (M.L.M.), American Cancer Society, Atlanta, GA; Department of Physical Medicine and Rehabilitation (S.P.), Spaulding Rehabilitation Hospital and Massachusetts General Hospital; Harvard Medical School (S.P., M.A.S.), Boston, MA; Family Medicine and Public Health (A.H.S.), School of Medicine, University of California San Diego; Epidemiology and Environmental Health, Public Health and Health Professions (J.W.-W.), University at Buffalo, NY; Behavioral and Epidemiology Research Group (Y.W.), American Cancer Society, Atlanta, GA; and Department of Medicine (J.E.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000007401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512888PMC
April 2019

Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases.

Neurology 2019 02;92(7):329-337

From the UC Gardner Neuroscience Institute and Gardner Family Center for Parkinson's Disease and Movement Disorders (A.J.E., J.A.V., L.M., A.M.), Department of Neurology, University of Cincinnati, OH; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic (A.E.L., A.F.), Toronto Western Hospital, University of Toronto; Krembil Research Institute (A.E.L., A.F.), Toronto, Canada; Parkinson's Disease and Movement Disorders Center (D.K.S.), Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA; College of Medicine (K.A.J.), Mayo Clinic, Rochester, MN; Institute of Molecular and Clinical Sciences (F.M.), St George's University of London, UK; Division of Movement Disorders (R.S.), Department of Neurology and Department of Health Science Research, Mayo Clinic College of Medicine, Rochester, MN; Department of Neurology and the Pittsburgh Institute for Neurodegenerative Diseases (J.T.G., F.C.), University of Pittsburgh, PA; Department of Neurology (T.R.Y.), University of Kentucky, Lexington; Parkinson's Disease Research, Education and Clinical Center (C.M.T.), Neurology, San Francisco Veterans Affairs Medical Center; Department of Neurology (C.M.T.), University of California-San Francisco; Department of Neurology & Neurosurgery, Montreal Neurological Institute, and Department of Human Genetics (Z.G.-O.), McGill University, Canada; Parkinson & Other Movement Disorders Center UC San Diego (I.L.), Department of Neurosciences, Altman Clinical Translational Research Institute, La Jolla, CA; VA Puget Sound Health Care System and Department of Neurology (I.F.M., CP.Z.), University of Washington, Seattle; Department of Neurology (I.F.M.), University of Washington School of Medicine, Seattle; Center for Neurodegenerative Science (P.B.), Van Andel Research Institute, Grand Rapids, MI; Center for Neurological Restoration (H.H.F.) and Lou Ruvo Center for Brain Health, Neurological Institute (J.B.L.), Cleveland Clinic, OH; Department of Neurology (D.G.S.), University of Alabama at Birmingham; Consultorio y Laboratorio de Neurogenética (M.A.K.), Centro Universitario de Neurología "José María Ramos Mejía" y División Neurología, Hospital JM Ramos Mejía, Facultad de Medicina, UBA; Programa de Medicina de Precision y Genomica Clinica (M.A.K.), Instituto de Investigaciones en Medicina Traslacional, Facultad de Ciencias Biomédicas, Universidad Austral-CONICET, Buenos Aires, Argentina; Department of Neurology (M.A.S.), Massachusetts General Hospital, Boston; Division of Neuroscience (S.P.S.), Sanofi-Genzyme, Framingham, MA; Michael J. Fox Foundation for Parkinson's Research (T.S.), New York, NY; and College of Sciences (G.P.), University of Texas at San Antonio.

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http://dx.doi.org/10.1212/WNL.0000000000006926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382364PMC
February 2019

Lifestyle and Parkinson's disease progression.

Mov Disord 2019 01;34(1):7-8

Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/mds.27566DOI Listing
January 2019

Non-motor features of Parkinson's disease in a nested case-control study of US men.

J Neurol Neurosurg Psychiatry 2018 12 3;89(12):1288-1295. Epub 2018 Aug 3.

Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1136/jnnp-2018-318275DOI Listing
December 2018

The association between restless legs syndrome and premotor symptoms of Parkinson's disease.

J Neurol Sci 2018 11 1;394:41-44. Epub 2018 Sep 1.

Department of Nutrition, Harvard School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.jns.2018.08.028DOI Listing
November 2018

Urate mitigates oxidative stress and motor neuron toxicity of astrocytes derived from ALS-linked SOD1 mutant mice.

Mol Cell Neurosci 2018 10 18;92:12-16. Epub 2018 Jun 18.

Molecular Neurobiology Laboratory, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.mcn.2018.06.002DOI Listing
October 2018

Cardiovascular Safety of Febuxostat.

N Engl J Med 2018 10;379(16):1582

Massachusetts General Hospital, Boston, MA

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http://dx.doi.org/10.1056/NEJMc1809736DOI Listing
October 2018

Appendectomy and risk of Parkinson's disease in two large prospective cohorts of men and women.

Mov Disord 2018 09 14;33(9):1492-1496. Epub 2018 Sep 14.

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/mds.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310901PMC
September 2018

Genetic variants related to urate and risk of Parkinson's disease.

Parkinsonism Relat Disord 2018 08 1;53:4-9. Epub 2018 May 1.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.parkreldis.2018.04.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120767PMC
August 2018

Differences in Parkinson's Disease Risk with Caffeine Intake and Postmenopausal Hormone Use.

J Parkinsons Dis 2017 ;7(4):677-684

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.3233/JPD-171175DOI Listing
June 2018

Pre-diagnostic plasma urate and the risk of amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2018 05 26;19(3-4):194-200. Epub 2017 Dec 26.

b Department of Nutrition , Harvard TH Chan School of Public Health , Boston , MA , USA.

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http://dx.doi.org/10.1080/21678421.2017.1418005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423442PMC
May 2018

Integration of risk factors for Parkinson disease in 2 large longitudinal cohorts.

Neurology 2018 05 11;90(19):e1646-e1653. Epub 2018 Apr 11.

From the Departments of Epidemiology (I.Y.K., A.A.), Nutrition (É.J.O., K.C.H., A.A.), and Biostatistics (R.A.B.), Harvard T.H. Chan School of Public Health, Boston, MA; School of Public Health (É.J.O.), University College Cork, Ireland; Channing Division of Network Medicine (A.A.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Nutritional Sciences (X.G.), The Pennsylvania State University, University Park; MassGeneral Institute for Neurodegenerative Disease (M.A.S.), Massachusetts General Hospital, Boston; The Institute for Aging Research (M.T.H.), Hebrew Senior Life, Boston; and Department of Medicine (M.T.H.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000005473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952970PMC
May 2018

Bimolecular Fluorescence Complementation of Alpha-synuclein Demonstrates its Oligomerization with Dopaminergic Phenotype in Mice.

EBioMedicine 2018 Mar 31;29:13-22. Epub 2018 Jan 31.

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA; Shanghai Huashan Hospital, Fudan University, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.01.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925445PMC
March 2018

Targeting urate to reduce oxidative stress in Parkinson disease.

Exp Neurol 2017 12 13;298(Pt B):210-224. Epub 2017 Jun 13.

Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.expneurol.2017.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693633PMC
December 2017

Dietary antioxidants and Parkinson's disease.

Mov Disord 2017 11 4;32(11):1501-1503. Epub 2017 Oct 4.

Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/mds.27194DOI Listing
November 2017

Air Pollution and Risk of Parkinson's Disease in a Large Prospective Study of Men.

Environ Health Perspect 2017 08 18;125(8):087011. Epub 2017 Aug 18.

Department of Environmental Health, Harvard T. H. Chan School of Public Health , Boston, Massachusetts, USA.

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http://dx.doi.org/10.1289/EHP259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783632PMC
August 2017

Intake of dairy foods and risk of Parkinson disease.

Neurology 2017 Jul 8;89(1):46-52. Epub 2017 Jun 8.

From the Departments of Epidemiology (K.C.H., I.Y.K., M.W., M.G.W., A.A.), Nutrition (K.C.H., A.A.), Biostatistics (M.W.), and Environmental Health (M.G.W.), Harvard T.H. Chan School of Public Health, Boston, MA; Department of Nutritional Health (X.G.), Pennsylvania State University, University Park; Channing Laboratory (M.W., A.A.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; and MassGeneral Institute for Neurodegenerative Disease (M.A.S.), Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000004057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496517PMC
July 2017

The melanoma-linked "redhead" MC1R influences dopaminergic neuron survival.

Ann Neurol 2017 Mar 23;81(3):395-406. Epub 2017 Jan 23.

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA.

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http://dx.doi.org/10.1002/ana.24852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085083PMC
March 2017

Biomarker-driven phenotyping in Parkinson's disease: A translational missing link in disease-modifying clinical trials.

Mov Disord 2017 03 24;32(3):319-324. Epub 2017 Feb 24.

Morton and Gloria Shulman Movement Disorders Center, Toronto Western Hospital and The Edmond J. Safra Program in PD, Toronto, Ontario, Canada, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/mds.26913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359057PMC
March 2017

Red hair, variants, and risk for Parkinson's disease - a meta-analysis.

Ann Clin Transl Neurol 2017 03 24;4(3):212-216. Epub 2017 Feb 24.

Department of Nutritional Sciences The Pennsylvania State University University Park 16802 Pennsylvania.

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http://dx.doi.org/10.1002/acn3.381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338132PMC
March 2017

Serum urate at trial entry and ALS progression in EMPOWER.

Amyotroph Lateral Scler Frontotemporal Degener 2017 02 28;18(1-2):120-125. Epub 2016 Sep 28.

e Department of Epidemiology and Nutrition , Harvard TH Chan School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Harvard Medical School and Brigham and Women's Hospital , Boston , Massachusetts , USA.

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http://dx.doi.org/10.1080/21678421.2016.1214733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531275PMC
February 2017

Urate as a Marker of Risk and Progression of Neurodegenerative Disease.

Neurotherapeutics 2017 01;14(1):148-153

Harvard Medical School, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1007/s13311-016-0497-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233635PMC
January 2017

Intake of antioxidant vitamins and risk of Parkinson's disease.

Mov Disord 2016 12 27;31(12):1909-1914. Epub 2016 Oct 27.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/mds.26819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154924PMC
December 2016

The epidemiology of Parkinson's disease: risk factors and prevention.

Lancet Neurol 2016 Nov 11;15(12):1257-1272. Epub 2016 Oct 11.

Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1016/S1474-4422(16)30230-7DOI Listing
November 2016

Purines: forgotten mediators in traumatic brain injury.

J Neurochem 2016 Apr 25;137(2):142-53. Epub 2016 Feb 25.

Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1111/jnc.13551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828259PMC
April 2016

Oral Inosine Persistently Elevates Plasma antioxidant capacity in Parkinson's disease.

Mov Disord 2016 Mar 25;31(3):417-21. Epub 2016 Jan 25.

Department of Neurology, Molecular Neurobiology Lab, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/mds.26483DOI Listing
March 2016

Prospective study of plasma urate and risk of Parkinson disease in men and women.

Neurology 2016 Feb 13;86(6):520-6. Epub 2016 Jan 13.

From the Department of Nutritional Health (X.G.), The Pennsylvania State University, University Park; Department of Nutrition (E.J.O., A.A.), Harvard School of Public Health; Channing Division of Network Medicine (E.J.O., A.A.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; and Department of Neurology (M.A.S.), Massachusetts General Hospital and Harvard Medical School, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000002351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753729PMC
February 2016

Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease.

Brain 2015 Sep 28;138(Pt 9):2659-71. Epub 2015 Jul 28.

1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women's Hospital, Cambridge, MA 02139, USA 2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA 4 Ann Romney Centre for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA 5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA 7 Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA

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http://dx.doi.org/10.1093/brain/awv202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643625PMC
September 2015

Mendelian randomization of serum urate and parkinson disease progression.

Ann Neurol 2014 Dec 3;76(6):862-8. Epub 2014 Oct 3.

Department of Nutrition, Harvard School of Public Health, Boston, MA; Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1002/ana.24281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245314PMC
December 2014

Urate and neuroprotection trials.

Lancet Neurol 2014 Aug;13(8):758

Harvard School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/S1474-4422(14)70138-3DOI Listing
August 2014

Allopurinol reduces levels of urate and dopamine but not dopaminergic neurons in a dual pesticide model of Parkinson's disease.

Brain Res 2014 May 26;1563:103-9. Epub 2014 Mar 26.

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.

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http://dx.doi.org/10.1016/j.brainres.2014.03.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146456PMC
May 2014

Postmortem brain levels of urate and precursors in Parkinson's disease and related disorders.

Neurodegener Dis 2013 28;12(4):189-98. Epub 2013 Feb 28.

Center for Translational Research in Neurodegenerative Disease, Department of Neurology, University of Florida College of Medicine, Gainesville, Fla., USA.

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http://dx.doi.org/10.1159/000346370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809155PMC
April 2014

Restless legs syndrome: an early clinical feature of Parkinson disease in men.

Sleep 2014 Feb 1;37(2):369-72. Epub 2014 Feb 1.

Department of Nutrition, Harvard School of Public Health, Boston, MA ; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA ; School of Public Health, Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.5665/sleep.3416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900617PMC
February 2014

Treatment of Parkinson's disease: what's in the non-dopaminergic pipeline?

Neurotherapeutics 2014 Jan;11(1):34-46

Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA,

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http://dx.doi.org/10.1007/s13311-013-0239-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899482PMC
January 2014

Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study.

Neurology 2013 Oct 25;81(17):1531-7. Epub 2013 Sep 25.

From the Neurogenomics Laboratory (H.D., K.D., K.C.L., A.N.H., K.D., A.T.-L., C.R.S.), Harvard Medical School and Brigham & Women's Hospital, Cambridge; Biomarkers Program (K.D., K.C.L., A.N.H., K.D., A.T.-L., M.T.H., U.S.S., B.M., N.M., V.K., S.N.G., D.J.S., M.A.S., M.G.S., B.T.H., J.H.G., C.R.S.), Harvard NeuroDiscovery Center, Boston; Department of Neurology (J.J.L., U.S.S., A.-M.W., A.W.F., A.Y.H., N.M., V.K., S.N.G., M.A.S., B.T.H., J.H.G., C.R.S.), Massachusetts General Hospital, Boston; Department of Neurology (M.T.H., A.Y.H., D.J.S., L.R.S., C.R.S.), Brigham and Women's Hospital, Boston, MA; Paracelsus-Elena-Klinik (B.M.), Kassel, Germany; and Division of Neurology, the Ottawa Hospital, University of Ottawa (M.G.S.), Canada.

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http://dx.doi.org/10.1212/WNL.0b013e3182a95818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888173PMC
October 2013

Efficient determination of purine metabolites in brain tissue and serum by high-performance liquid chromatography with electrochemical and UV detection.

Biomed Chromatogr 2013 Jan 5;27(1):122-9. Epub 2012 Jun 5.

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 114 16th, Charlestown, MA 02129, USA.

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http://doi.wiley.com/10.1002/bmc.2760
Publisher Site
http://dx.doi.org/10.1002/bmc.2760DOI Listing
January 2013

Disrupted and transgenic urate oxidase alter urate and dopaminergic neurodegeneration.

Proc Natl Acad Sci U S A 2013 Jan 17;110(1):300-5. Epub 2012 Dec 17.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.

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http://dx.doi.org/10.1073/pnas.1217296110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538212PMC
January 2013

Urate and its transgenic depletion modulate neuronal vulnerability in a cellular model of Parkinson's disease.

PLoS One 2012 14;7(5):e37331. Epub 2012 May 14.

Neurology Department, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0037331PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351394PMC
October 2012

Protection of dopaminergic cells by urate requires its accumulation in astrocytes.

J Neurochem 2012 Oct 22;123(1):172-81. Epub 2012 Aug 22.

Molecular Neurobiology Laboratory, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, MA 02129, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2012.07820.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438313PMC
October 2012

Caffeine and risk of Parkinson's disease in a large cohort of men and women.

Mov Disord 2012 Sep 27;27(10):1276-82. Epub 2012 Aug 27.

Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.1002/mds.25076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554265PMC
September 2012

Urate in Parkinson's disease: more than a biomarker?

Curr Neurol Neurosci Rep 2012 Aug;12(4):367-75

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1007/s11910-012-0282-7DOI Listing
August 2012

Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes.

Glia 2012 May 1;60(5):702-16. Epub 2012 Feb 1.

Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.

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http://dx.doi.org/10.1002/glia.22290DOI Listing
May 2012

Prospective study of statin use and risk of Parkinson disease.

Arch Neurol 2012 Mar;69(3):380-4

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1001/archneurol.2011.1060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398841PMC
March 2012

Adenosine A2A receptor gene disruption protects in an α-synuclein model of Parkinson's disease.

Ann Neurol 2012 Feb;71(2):278-82

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Boston, USA.

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http://dx.doi.org/10.1002/ana.22630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292742PMC
February 2012

Obesity, diabetes, and risk of Parkinson's disease.

Mov Disord 2011 Oct 7;26(12):2253-9. Epub 2011 Jul 7.

Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/mds.23855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627531PMC
October 2011

A prospective study of bowel movement frequency and risk of Parkinson's disease.

Am J Epidemiol 2011 Sep 30;174(5):546-51. Epub 2011 Jun 30.

Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/aje/kwr119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202149PMC
September 2011

Serum urate and probability of dopaminergic deficit in early "Parkinson's disease".

Mov Disord 2011 Aug 29;26(10):1864-8. Epub 2011 Apr 29.

Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/mds.23741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150627PMC
August 2011

Preclinical jockeying on the translational track of adenosine A2A receptors.

Exp Neurol 2011 Apr 4;228(2):160-4. Epub 2011 Jan 4.

Dept of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.expneurol.2010.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073659PMC
April 2011

Use of ibuprofen and risk of Parkinson disease.

Neurology 2011 Mar 2;76(10):863-9. Epub 2011 Mar 2.

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, 181 Longwood Ave., Boston, MA 02115, USA.

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http://dx.doi.org/10.1212/WNL.0b013e31820f2d79DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059148PMC
March 2011

Deletion of adenosine A₁ or A(₂A) receptors reduces L-3,4-dihydroxyphenylalanine-induced dyskinesia in a model of Parkinson's disease.

Brain Res 2011 Jan 7;1367:310-8. Epub 2010 Sep 7.

MassGeneral Institute for Neurolodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA.

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http://dx.doi.org/10.1016/j.brainres.2010.08.099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005012PMC
January 2011

Pathophysiological roles for purines: adenosine, caffeine and urate.

Prog Brain Res 2010 ;183:183-208

Department of Toxicology, University of Cagliari, Cagliari, Italy.

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http://dx.doi.org/10.1016/S0079-6123(10)83010-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102301PMC
December 2010

Restless legs syndrome and Parkinson's disease in men.

Mov Disord 2010 Nov;25(15):2654-7

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/mds.23256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114885PMC
November 2010

Urate: a novel biomarker of Parkinson's disease risk, diagnosis and prognosis.

Biomark Med 2010 Oct;4(5):701-12

Massachusetts General Hospital, 114 16th Street, Boston, MA 02129, USA.

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http://dx.doi.org/10.2217/bmm.10.94DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049925PMC
October 2010

Calcium channel blocker use and risk of Parkinson's disease.

Mov Disord 2010 Sep;25(12):1818-22

Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1002/mds.23191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939261PMC
September 2010

Plasma urate and Parkinson's disease in women.

Am J Epidemiol 2010 Sep 2;172(6):666-70. Epub 2010 Aug 2.

Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1093/aje/kwq195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950819PMC
September 2010

Prenatal and early life factors and risk of Parkinson's disease.

Mov Disord 2010 Aug;25(11):1560-7

Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/mds.23339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132935PMC
August 2010

Caffeine protects against combined paraquat and maneb-induced dopaminergic neuron degeneration.

Exp Neurol 2010 Jun 24;223(2):657-61. Epub 2010 Feb 24.

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00144886100006
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http://dx.doi.org/10.1016/j.expneurol.2010.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864327PMC
June 2010

Rasagiline in Parkinson's disease.

N Engl J Med 2010 Feb;362(7):658; author reply 658-9

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February 2010

Restless legs syndrome and erectile dysfunction.

Sleep 2010 Jan;33(1):75-9

Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802250PMC
http://dx.doi.org/10.1093/sleep/33.1.75DOI Listing
January 2010

Reproductive factors, exogenous estrogen use, and risk of Parkinson's disease.

Mov Disord 2009 Jul;24(9):1359-65

Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/mds.22619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751573PMC
July 2009

Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease.

J Neuropathol Exp Neurol 2009 May;68(5):515-24

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129-4404, USA.

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http://dx.doi.org/10.1097/NEN.0b013e3181a24b53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753269PMC
May 2009

Obesity and restless legs syndrome in men and women.

Neurology 2009 Apr;72(14):1255-61

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1212/01.wnl.0000345673.35676.1cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677487PMC
April 2009

Smoking and Parkinson's disease: using parental smoking as a proxy to explore causality.

Am J Epidemiol 2009 Mar 8;169(6):678-82. Epub 2009 Jan 8.

Department of Epidemiology and Nutrition, Harvard School of Public Health, Boston, MA 02215, USA.

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http://dx.doi.org/10.1093/aje/kwn388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727210PMC
March 2009

Plasma urate and progression of mild cognitive impairment.

Neurodegener Dis 2009 5;6(1-2):23-8. Epub 2008 Nov 5.

Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1159/000170883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745303PMC
February 2009

Dual-target-directed drugs that block monoamine oxidase B and adenosine A(2A) receptors for Parkinson's disease.

Neurotherapeutics 2009 Jan;6(1):141-51

Pharmaceutical Chemistry, School of Pharmacy, North-West University, Potchefstroom, 2520, South Africa.

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http://dx.doi.org/10.1016/j.nurt.2008.10.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084262PMC
January 2009

Genetic determinants of hair color and Parkinson's disease risk.

Ann Neurol 2009 Jan;65(1):76-82

Department of Nutrition, Harvard University School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1002/ana.21535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639631PMC
January 2009

Adenosine A1 and A2A receptor regulation of protein phosphatase 2A in the murine heart.

J Cell Physiol 2008 Jul;216(1):83-90

Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.

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http://dx.doi.org/10.1002/jcp.21375DOI Listing
July 2008

Diet, urate, and Parkinson's disease risk in men.

Am J Epidemiol 2008 Apr 7;167(7):831-8. Epub 2008 Mar 7.

Department of Nutrition, School of Public Health, Harvard University, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/aje/kwm385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367211PMC
April 2008

Perceived imbalance and risk of Parkinson's disease.

Mov Disord 2008 Mar;23(4):613-6

Department of Nutrition, Harvard University School of Public Health, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1002/mds.21919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2385782PMC
March 2008