Michael A Newton

Michael A Newton

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Michael A Newton

Michael A Newton

Publications by authors named "Michael A Newton"

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Predicting kinase inhibitors using bioactivity matrix derived informer sets.

PLoS Comput Biol 2019 Aug 5;15(8):e1006813. Epub 2019 Aug 5.

Department of Statistics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1006813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695194PMC
August 2019

Notch signaling activation induces cell death in MAPKi-resistant melanoma cells.

Pigment Cell Melanoma Res 2019 07 3;32(4):528-539. Epub 2019 Feb 3.

Comparative Biomedical Sciences Graduate Program, University of Wisconsin, Madison, Wisconsin.

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http://dx.doi.org/10.1111/pcmr.12764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581614PMC
July 2019

Melanoma Progression Inhibits Pluripotency and Differentiation of Melanoma-Derived iPSCs Produces Cells with Neural-like Mixed Dysplastic Phenotype.

Stem Cell Reports 2019 Jul 20;13(1):177-192. Epub 2019 Jun 20.

Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2019.05.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627006PMC
July 2019

Enrichment of melanoma-associated T cells in 6-thioguanine-resistant T cells from metastatic melanoma patients.

Melanoma Res 2019 May 23. Epub 2019 May 23.

University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health.

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http://dx.doi.org/10.1097/CMR.0000000000000625DOI Listing
May 2019

4-HPR Is an Endoplasmic Reticulum Stress Aggravator and Sensitizes Breast Cancer Cells Resistant to TRAIL/Apo2L.

Anticancer Res 2018 Aug;38(8):4403-4416

Biochemistry Department, University of Wisconsin-Madison, Madison, WI, U.S.A.

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http://dx.doi.org/10.21873/anticanres.12742DOI Listing
August 2018

RNA expression profiling in sulfamethoxazole-treated patients with a range of in vitro lymphocyte cytotoxicity phenotypes.

Pharmacol Res Perspect 2018 04 2;6(2):e00388. Epub 2018 Mar 2.

Department of Medical Sciences School of Veterinary Medicine University of Wisconsin-Madison Madison WI USA.

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http://dx.doi.org/10.1002/prp2.388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832900PMC
April 2018

Machine Learning Consensus Scoring Improves Performance Across Targets in Structure-Based Virtual Screening.

J Chem Inf Model 2017 07 12;57(7):1579-1590. Epub 2017 Jul 12.

Center for High Throughput Computing, Department of Computer Sciences, University of Wisconsin-Madison , 1210 W. Dayton St., Madison, Wisconsin 53706, United States.

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http://dx.doi.org/10.1021/acs.jcim.7b00153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872818PMC
July 2017

Dual PI3K/mTOR Inhibition in Colorectal Cancers with and Mutations.

Mol Cancer Res 2017 02 9;15(3):317-327. Epub 2017 Feb 9.

Division of Hematology and Oncology, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin.

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http://dx.doi.org/10.1158/1541-7786.MCR-16-0256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550373PMC
February 2017

A statistical approach for identifying differential distributions in single-cell RNA-seq experiments.

Genome Biol 2016 10 25;17(1):222. Epub 2016 Oct 25.

Department of Biostatistics, University of Wisconsin, Madison, 53706, WI, USA.

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http://dx.doi.org/10.1186/s13059-016-1077-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080738PMC
October 2016

Making the cut: improved ranking and selection for large-scale inference.

J R Stat Soc Series B Stat Methodol 2016 Sep 8;78(4):781-804. Epub 2015 Nov 8.

Departments of Statistics and of Biostatistics and Medical Informatics, University of Wisconsin, Madison, USA.

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http://dx.doi.org/10.1111/rssb.12131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996506PMC
September 2016

Further support for aneuploidy tolerance in wild yeast and effects of dosage compensation on gene copy-number evolution.

Elife 2016 Mar 7;5:e14409. Epub 2016 Mar 7.

Department of Statistics, University of Wisconsin-Madison, Madison, United States.

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http://dx.doi.org/10.7554/eLife.14409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798956PMC
March 2016

Heterochromatin Protein 1 Binding Protein 3 Expression as a Candidate Marker of Intrinsic 5-Fluorouracil Resistance.

Anticancer Res 2016 Mar;36(3):845-52

Department of Medicine, Division of Gastroenterology and Hepatology, K4/532 Clinical Science Center, Madison, WI, U.S.A. Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, U.S.A.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876978PMC
March 2016

A conserved transcriptional signature of delayed aging and reduced disease vulnerability is partially mediated by SIRT3.

PLoS One 2015 1;10(4):e0120738. Epub 2015 Apr 1.

LifeGen Technologies LLC, Madison, Wisconsin, United States of America; Department of Medicine, SMPH, University of Wisconsin, Madison, Wisconsin, United States of America; Geriatric Research, Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120738PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382298PMC
December 2015

Molecular transitions from papillomavirus infection to cervical precancer and cancer: Role of stromal estrogen receptor signaling.

Proc Natl Acad Sci U S A 2015 Jun 8;112(25):E3255-64. Epub 2015 Jun 8.

Morgridge Institute for Research, University of Wisconsin-Madison, Madison, WI 53715; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI 53792; Institute for Molecular Virology, University of Wisconsin-Madison, Madison, WI 53706; Howard Hughes Medical Institute, University of Wisconsin-Madison, Madison, WI 53706;

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http://dx.doi.org/10.1073/pnas.1509322112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485108PMC
June 2015

Single-molecule analysis reveals widespread structural variation in multiple myeloma.

Proc Natl Acad Sci U S A 2015 Jun 8;112(25):7689-94. Epub 2015 Jun 8.

Biophysics Graduate Program, University of Wisconsin-Madison, Madison, WI 53706; Laboratory for Molecular and Computational Genomics, Department of Chemistry, Laboratory of Genetics and Biotechnology Center, University of Wisconsin-Madison, Madison, WI 53706; University of Wisconsin Carbone Cancer Center, Madison, WI 53705;

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http://dx.doi.org/10.1073/pnas.1418577112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485118PMC
June 2015

Dosage compensation can buffer copy-number variation in wild yeast.

Elife 2015 May 8;4. Epub 2015 May 8.

Laboratory of Genetics, University of Wisconsin-Madison, Madison, United States.

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http://dx.doi.org/10.7554/eLife.05462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448642PMC
May 2015

Multiset Statistics for Gene Set Analysis.

Annu Rev Stat Appl 2015 Apr;2:95-111

Department of Statistics, University of Wisconsin, Madison, Wisconsin 53706.

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http://dx.doi.org/10.1146/annurev-statistics-010814-020335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405258PMC
April 2015

Limited agreement of independent RNAi screens for virus-required host genes owes more to false-negative than false-positive factors.

PLoS Comput Biol 2013 19;9(9):e1003235. Epub 2013 Sep 19.

Institute of Molecular Virology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America ; Howard Hughes Medical Institute, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1003235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777922PMC
April 2014

Statistical significance of optical map alignments.

J Comput Biol 2012 May 16;19(5):478-92. Epub 2012 Apr 16.

Theoretical Statistics and Mathematics Unit, Indian Statistical Institute, New Delhi, India.

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http://www.liebertpub.com/doi/10.1089/cmb.2011.0221
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http://dx.doi.org/10.1089/cmb.2011.0221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342520PMC
May 2012

Systematic identification of novel, essential host genes affecting bromovirus RNA replication.

PLoS One 2011 22;6(8):e23988. Epub 2011 Aug 22.

Institute for Molecular Virology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0023988PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161824PMC
April 2012

Mutations in protein-binding hot-spots on the hub protein Smad3 differentially affect its protein interactions and Smad3-regulated gene expression.

PLoS One 2011 19;6(9):e25021. Epub 2011 Sep 19.

McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0025021PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176292PMC
February 2012

Monoallelic silencing and haploinsufficiency in early murine intestinal neoplasms.

Proc Natl Acad Sci U S A 2012 Feb 23;109(6):2060-5. Epub 2012 Jan 23.

McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, Madison, WI 53706, USA.

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http://dx.doi.org/10.1073/pnas.1120753109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277532PMC
February 2012

A model-based analysis to infer the functional content of a gene list.

Stat Appl Genet Mol Biol 2012 Jan 6;11(2). Epub 2012 Jan 6.

University of Wisconsin, Madison, WI, USA.

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http://dx.doi.org/10.2202/1544-6115.1716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351831PMC
January 2012

GAMMA-BASED CLUSTERING VIA ORDERED MEANS WITH APPLICATION TO GENE-EXPRESSION ANALYSIS.

Ann Stat 2010 Dec;38(6):3217-3244

Department of Statistics, University of Wisconsin, Madison, 1300 University Ave, Madison, Wisconsin 53706-1532, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990889PMC
December 2010

High-resolution human genome structure by single-molecule analysis.

Proc Natl Acad Sci U S A 2010 Jun 1;107(24):10848-53. Epub 2010 Jun 1.

The Laboratory for Molecular and Computational Genomics, Department of Chemistry, Laboratory of Genetics and Biotechnology Center, University of Wisconsin, 425 Henry Mall, Madison, WI 53706-1580, USA.

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http://dx.doi.org/10.1073/pnas.0914638107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890719PMC
June 2010

Longitudinal assessment of colonic tumor fate in mice by computed tomography and optical colonoscopy.

Acad Radiol 2009 Dec;16(12):1475-82

Department of Medical Physics, University of Wisconsin - Madison, 1400 University Avenue, Madison, WI 53706, USA.

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http://dx.doi.org/10.1016/j.acra.2009.07.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818525PMC
December 2009

Statistical use of argonaute expression and RISC assembly in microRNA target identification.

PLoS Comput Biol 2009 Sep 25;5(9):e1000516. Epub 2009 Sep 25.

Department of Statistics, University of Wisconsin-Madison, Madison, Wisconsin, USA.

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http://dx.doi.org/10.1371/journal.pcbi.1000516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739424PMC
September 2009

Clonal expansions of 6-thioguanine resistant T lymphocytes in the blood and tumor of melanoma patients.

Environ Mol Mutagen 2008 Dec;49(9):676-87

Medical Service, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA.

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http://dx.doi.org/10.1002/em.20417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037545PMC
December 2008

MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins.

Proc Natl Acad Sci U S A 2008 Apr 4;105(15):5874-8. Epub 2008 Apr 4.

Institute for Molecular Virology, Howard Hughes Medical Institute, McArdle Laboratory for Cancer Research, Departments of Statistics and Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI 53076, USA.

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http://dx.doi.org/10.1073/pnas.0801130105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2311339PMC
April 2008

Reproducibility of tumor volume measurement at microCT colonography in living mice.

Acad Radiol 2008 Mar;15(3):334-41

Department of Medical Physics, 1400 University Avenue, University of Wisconsin, Madison, WI 53706, USA.

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http://dx.doi.org/10.1016/j.acra.2007.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409002PMC
March 2008

On estimating the polyclonal fraction in lineage-marker studies of tumor origin.

Authors:
Michael A Newton

Biostatistics 2006 Oct 16;7(4):503-14. Epub 2006 Feb 16.

Department of Statistics, University of Wisconsin-Madison, Madison, WI 53706, USA.

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http://biostatistics.oxfordjournals.org/content/7/4/503.full
Web Search
http://www.stat.wisc.edu/~newton/papers/abstracts/bmk.pdf
Web Search
http://biostatistics.oxfordjournals.org/cgi/doi/10.1093/bios
Publisher Site
http://dx.doi.org/10.1093/biostatistics/kxj022DOI Listing
October 2006

A statistical test of the hypothesis that polyclonal intestinal tumors arise by random collision of initiated clones.

Biometrics 2006 Sep;62(3):721-7

Department of Statistics, University of Wisconsin-Madison, 1300 University Avenue, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1111/j.1541-0420.2006.00522.xDOI Listing
September 2006

Genome-wide expression profiling reveals EBV-associated inhibition of MHC class I expression in nasopharyngeal carcinoma.

Cancer Res 2006 Aug;66(16):7999-8006

Institute for Molecular Virology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI 53706, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-4399DOI Listing
August 2006

Polyclonality of familial murine adenomas: analyses of mouse chimeras with low tumor multiplicity suggest short-range interactions.

Proc Natl Acad Sci U S A 2005 May 3;102(19):6960-5. Epub 2005 May 3.

McArdle Laboratory for Cancer Research, Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53706, USA.

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http://dx.doi.org/10.1073/pnas.0502662102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1100801PMC
May 2005

Lack of association between EBV and breast carcinoma.

Cancer Epidemiol Biomarkers Prev 2005 Apr;14(4):809-14

Department of Oncology, University of Wisconsin-Madison, 814 McArdle Laboratory for Cancer Research, 1400 University Avenue, Madison, WI 53706, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-04-0763DOI Listing
April 2005

Detecting differential gene expression with a semiparametric hierarchical mixture method.

Biostatistics 2004 Apr;5(2):155-76

Department of Statistics, University of Wisconsin-Madison, 1210 West Dayton St, Madison, WI 53706-1685, USA.

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http://dx.doi.org/10.1093/biostatistics/5.2.155DOI Listing
April 2004