Michael A Lobritz

Michael A Lobritz

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Michael A Lobritz

Michael A Lobritz

Publications by authors named "Michael A Lobritz"

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21Publications

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Bacterial Metabolism and Antibiotic Efficacy.

Cell Metab 2019 Aug 3;30(2):251-259. Epub 2019 Jul 3.

Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Infectious Disease & Microbiome Program, Broad Institute of MIT & Harvard, Cambridge, MA 02142, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.06.009DOI Listing
August 2019

Understanding and Sensitizing Density-Dependent Persistence to Quinolone Antibiotics.

Mol Cell 2017 12 7;68(6):1147-1154.e3. Epub 2017 Dec 7.

Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.11.012DOI Listing
December 2017

Carbon Sources Tune Antibiotic Susceptibility in Pseudomonas aeruginosa via Tricarboxylic Acid Cycle Control.

Cell Chem Biol 2017 Feb 19;24(2):195-206. Epub 2017 Jan 19.

Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Department of Biological Engineering, Institute for Medical Engineering & Science, Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard-MIT Program, Health Sciences and Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2016.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426816PMC
February 2017

Bactericidal Antibiotics Induce Toxic Metabolic Perturbations that Lead to Cellular Damage.

Cell Rep 2015 Nov 22;13(5):968-80. Epub 2015 Oct 22.

Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, 3 Blackfan Circle, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.09.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648786PMC
November 2015

Engineered Phagemids for Nonlytic, Targeted Antibacterial Therapies.

Nano Lett 2015 Jul 8;15(7):4808-13. Epub 2015 Jun 8.

†Institute for Medical Engineering and Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/acs.nanolett.5b01943DOI Listing
July 2015

Antibiotic efficacy is linked to bacterial cellular respiration.

Proc Natl Acad Sci U S A 2015 Jul 22;112(27):8173-80. Epub 2015 Jun 22.

Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115; Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139; Broad Institute of MIT and Harvard, Cambridge, MA 02139; Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA 02139

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http://dx.doi.org/10.1073/pnas.1509743112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500273PMC
July 2015

Antibiotics induce redox-related physiological alterations as part of their lethality.

Proc Natl Acad Sci U S A 2014 May 6;111(20):E2100-9. Epub 2014 May 6.

Howard Hughes Medical Institute,Departments of Biomedical Engineering andCenter of Synthetic Biology, Boston University, Boston, MA 02215;Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115;Department of Medicine, Boston University School of Medicine, Boston, MA 02118

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http://dx.doi.org/10.1073/pnas.1401876111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034191PMC
May 2014

Multifaceted mechanisms of HIV inhibition and resistance to CCR5 inhibitors PSC-RANTES and Maraviroc.

Antimicrob Agents Chemother 2013 Jun 25;57(6):2640-50. Epub 2013 Mar 25.

Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1128/AAC.02511-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716150PMC
June 2013

Microbial persistence and the road to drug resistance.

Cell Host Microbe 2013 Jun;13(6):632-42

Howard Hughes Medical Institute, Boston University, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.chom.2013.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695397PMC
June 2013

A flexible model of HIV-1 latency permitting evaluation of many primary CD4 T-cell reservoirs.

PLoS One 2012 24;7(1):e30176. Epub 2012 Jan 24.

Gladstone Institute of Virology and Immunology, San Francisco, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030176PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265466PMC
June 2012

HIV-1 replicative fitness in elite controllers.

Curr Opin HIV AIDS 2011 May;6(3):214-20

Department of Medicine, Stanford University Hospital and Clinics, Palo Alto, USA.

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http://dx.doi.org/10.1097/COH.0b013e3283454cf5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730053PMC
May 2011

Identification of two APOBEC3F splice variants displaying HIV-1 antiviral activity and contrasting sensitivity to Vif.

J Biol Chem 2010 Sep 12;285(38):29326-35. Epub 2010 Jul 12.

Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.154054
Publisher Site
http://dx.doi.org/10.1074/jbc.M110.154054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937965PMC
September 2010

HIV-1 Entry, Inhibitors, and Resistance.

Viruses 2010 May 29;2(5):1069-105. Epub 2010 Apr 29.

Department of Molecular Biology and Microbiology and Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA; E-Mails: (M.A.L.); (A.N.R.).

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http://dx.doi.org/10.3390/v2051069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187606PMC
May 2010

Elite suppressor-derived HIV-1 envelope glycoproteins exhibit reduced entry efficiency and kinetics.

PLoS Pathog 2009 Apr 10;5(4):e1000377. Epub 2009 Apr 10.

Department of Molecular Biology and Microbiology, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.

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http://dx.doi.org/10.1371/journal.ppat.1000377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661022PMC
April 2009

Targets of small interfering RNA restriction during human immunodeficiency virus type 1 replication.

J Virol 2008 Mar 16;82(6):2938-51. Epub 2008 Jan 16.

Division of Infectious Diseases, BRB 1034, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1128/JVI.02126-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2259002PMC
March 2008

Natural variation in the V3 crown of human immunodeficiency virus type 1 affects replicative fitness and entry inhibitor sensitivity.

J Virol 2007 Aug 23;81(15):8258-69. Epub 2007 May 23.

Department of Molecular Biology and Microbiology, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1128/JVI.02739-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1951322PMC
August 2007