Michael A J Ferguson

Michael A J Ferguson

UNVERIFIED PROFILE

Are you Michael A J Ferguson?   Register this Author

Register author
Michael A J Ferguson

Michael A J Ferguson

Publications by authors named "Michael A J Ferguson"

Are you Michael A J Ferguson?   Register this Author

99Publications

1412Reads

46Profile Views

CAP-MAP: cap analysis protocol with minimal analyte processing, a rapid and sensitive approach to analysing mRNA cap structures.

Open Biol 2020 Feb 26;10(2):190306. Epub 2020 Feb 26.

Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1098/rsob.190306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058934PMC
February 2020

Organizational Innovation for Developing New Medicines That Target Aging and Age-Related Conditions.

J Gerontol A Biol Sci Med Sci 2020 Jan;75(1):87-88

Charles Perkins Centre, Centre for Education and Research on Ageing and ANZAC Research Institute, University of Sydney and Concord Hospital, Australia.

View Article

Download full-text PDF

Source
https://academic.oup.com/biomedgerontology/advance-article/d
Publisher Site
http://dx.doi.org/10.1093/gerona/glz062DOI Listing
January 2020

Phosphomannomutase and Guanosine Diphosphate-Mannose Pyrophosphorylase Ligandability Assessment.

Antimicrob Agents Chemother 2019 10 23;63(10). Epub 2019 Sep 23.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.01082-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761512PMC
October 2019

Proteome turnover in the bloodstream and procyclic forms of measured by quantitative proteomics.

Wellcome Open Res 2019 9;4:152. Epub 2019 Oct 9.

The Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12688/wellcomeopenres.15421.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816455PMC
October 2019

Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei.

PLoS Pathog 2018 12 27;14(12):e1007475. Epub 2018 Dec 27.

The Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1007475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307712PMC
December 2018

Author Correction: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.

Nat Rev Microbiol 2018 Nov;16(11):714

Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, DD1 5EH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41579-018-0085-1DOI Listing
November 2018

N-glycan microheterogeneity regulates interactions of plasma proteins.

Proc Natl Acad Sci U S A 2018 08 15;115(35):8763-8768. Epub 2018 Aug 15.

Department of Chemistry, University of Oxford, Oxford OX1 3QZ, United Kingdom;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1807439115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126716PMC
August 2018

Proteomic Analysis of the Cell Cycle of Procylic Form .

Mol Cell Proteomics 2018 06 19;17(6):1184-1195. Epub 2018 Mar 19.

§Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/mcp.RA118.000650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986242PMC
June 2018

Single-subunit oligosaccharyltransferases of display different and predictable peptide acceptor specificities.

J Biol Chem 2017 12 19;292(49):20328-20341. Epub 2017 Sep 19.

From the Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M117.810945
Publisher Site
http://dx.doi.org/10.1074/jbc.M117.810945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724017PMC
December 2017

Prediction of Protein Complexes in by Protein Correlation Profiling Mass Spectrometry and Machine Learning.

Mol Cell Proteomics 2017 Dec 17;16(12):2254-2267. Epub 2017 Oct 17.

From the ‡Division of Biological Chemistry and Drug Discovery and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/mcp.O117.068122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724185PMC
December 2017

Genetic metabolic complementation establishes a requirement for GDP-fucose in .

J Biol Chem 2017 06 2;292(25):10696-10708. Epub 2017 May 2.

From the Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M117.778480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481574PMC
June 2017

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.

Nat Rev Microbiol 2017 Feb 27;15(4):217-231. Epub 2017 Feb 27.

Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee DD1 5EH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrmicro.2016.193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582623PMC
February 2017

Global Membrane Protein Interactome Analysis using In vivo Crosslinking and Mass Spectrometry-based Protein Correlation Profiling.

Mol Cell Proteomics 2016 07 25;15(7):2476-90. Epub 2016 Apr 25.

From the ‡Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee, United Kingdom;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/mcp.O115.055467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937518PMC
July 2016

A Gene of the β3-Glycosyltransferase Family Encodes N-Acetylglucosaminyltransferase II Function in Trypanosoma brucei.

J Biol Chem 2016 Jun 4;291(26):13834-45. Epub 2016 May 4.

From the Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M116.733246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919465PMC
June 2016

Parasite Glycobiology: A Bittersweet Symphony.

PLoS Pathog 2015 12;11(11):e1005169. Epub 2015 Nov 12.

ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1005169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642930PMC
April 2016

Leishmania major UDP-sugar pyrophosphorylase salvages galactose for glycoconjugate biosynthesis.

Int J Parasitol 2015 Oct 26;45(12):783-90. Epub 2015 Jul 26.

Hannover Medical School, Department of Cellular Chemistry OE4330, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpara.2015.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722067PMC
October 2015

Molecular control of irreversible bistability during trypanosome developmental commitment.

J Cell Biol 2015 Oct 19;211(2):455-68. Epub 2015 Oct 19.

Centre for Immunity, Infection and Evolution, Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, Scotland, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1083/jcb.201506114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621835PMC
October 2015

Evaluation of the diagnostic accuracy of prototype rapid tests for human African trypanosomiasis.

PLoS Negl Trop Dis 2014 Dec 18;8(12):e3373. Epub 2014 Dec 18.

Foundation for Innovative New Diagnostics (FIND) Campus Biotech, Geneva, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0003373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270746PMC
December 2014

Serum proteome of nonalcoholic fatty liver disease: a multimodal approach to discovery of biomarkers of nonalcoholic steatohepatitis.

J Gastroenterol Hepatol 2014 Oct;29(10):1839-47

Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jgh.12614DOI Listing
October 2014

Identification of sVSG117 as an immunodiagnostic antigen and evaluation of a dual-antigen lateral flow test for the diagnosis of human African trypanosomiasis.

PLoS Negl Trop Dis 2014 Jul 17;8(7):e2976. Epub 2014 Jul 17.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0002976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102454PMC
July 2014

High-confidence glycosome proteome for procyclic form Trypanosoma brucei by epitope-tag organelle enrichment and SILAC proteomics.

J Proteome Res 2014 Jun 13;13(6):2796-806. Epub 2014 May 13.

Division of Biological Chemistry and Drug Discovery and ‡Centre for Advanced Scientific Technologies, College of Life Sciences, University of Dundee , Dow Street, Dundee DD1 5EH, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/pr401209wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052807PMC
June 2014

Proteomic selection of immunodiagnostic antigens for Trypanosoma congolense.

PLoS Negl Trop Dis 2014 Jun 12;8(6):e2936. Epub 2014 Jun 12.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0002936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055490PMC
June 2014

Exploring the Trypanosoma brucei Hsp83 potential as a target for structure guided drug design.

PLoS Negl Trop Dis 2013 17;7(10):e2492. Epub 2013 Oct 17.

The Structural Genomics Consortium (SGC), University of Toronto, Toronto, Ontario, Canada ; Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, United States of America.

View Article

Download full-text PDF

Source
http://www.drugdiscovery.dundee.ac.uk/sites/www.drugdiscover
Web Search
http://dx.plos.org/10.1371/journal.pntd.0002492
Publisher Site
http://dx.doi.org/10.1371/journal.pntd.0002492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798429PMC
May 2014

Probing the substrate specificity of Trypanosoma brucei GlcNAc-PI de-N-acetylase with synthetic substrate analogues.

Org Biomol Chem 2014 Mar 12;12(12):1919-34. Epub 2014 Feb 12.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c3ob42164cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326964PMC
March 2014

Identification and functional characterization of a highly divergent N-acetylglucosaminyltransferase I (TbGnTI) in Trypanosoma brucei.

J Biol Chem 2014 Mar 18;289(13):9328-39. Epub 2014 Feb 18.

From the Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M114.555029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979372PMC
March 2014

Fragment screening reveals salicylic hydroxamic acid as an inhibitor of Trypanosoma brucei GPI GlcNAc-PI de-N-acetylase.

Carbohydr Res 2014 Mar 30;387:54-8. Epub 2013 Dec 30.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.carres.2013.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991331PMC
March 2014

Creation and characterization of glycosyltransferase mutants of Trypanosoma brucei.

Methods Mol Biol 2013 ;1022:249-75

Barcelona Centre for International Health Research, (CRESIB, Hospital Clinic-Universitat de Barcelona), Barcelona, Spain.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/978-1-62703-465-4_19
Publisher Site
http://dx.doi.org/10.1007/978-1-62703-465-4_19DOI Listing
January 2014

A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei.

ACS Chem Biol 2013 Sep 18;8(9):1981-7. Epub 2013 Jul 18.

Division of Biological Chemistry and Drug Discovery, ‡Division of Molecular Microbiology, and §MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee , Dundee DD1 5EH, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/cb400411xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780468PMC
September 2013

Genetic and structural validation of Aspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as an antifungal target.

Mol Microbiol 2013 Aug 5;89(3):479-93. Epub 2013 Jul 5.

Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, Scotland, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/mmi.12290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888555PMC
August 2013

Structure of a complex phosphoglycan epitope from gp72 of Trypanosoma cruzi.

J Biol Chem 2013 Apr 22;288(16):11093-105. Epub 2013 Feb 22.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M113.452763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630849PMC
April 2013

Chemical proteomic analysis reveals the drugability of the kinome of Trypanosoma brucei.

ACS Chem Biol 2012 Nov 23;7(11):1858-65. Epub 2012 Aug 23.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/cb300326zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621575PMC
November 2012

Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages.

PLoS One 2012 4;7(5):e36619. Epub 2012 May 4.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, United Kingdom.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036619PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344917PMC
September 2012

Modeling of the N-glycosylated transferrin receptor suggests how transferrin binding can occur within the surface coat of Trypanosoma brucei.

PLoS Pathog 2012 5;8(4):e1002618. Epub 2012 Apr 5.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1002618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320590PMC
August 2012

Deep evolutionary conservation of an intramolecular protein kinase activation mechanism.

PLoS One 2012 3;7(1):e29702. Epub 2012 Jan 3.

Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029702PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250476PMC
May 2012

The lipid-linked oligosaccharide donor specificities of Trypanosoma brucei oligosaccharyltransferases.

Glycobiology 2012 May 12;22(5):696-703. Epub 2012 Jan 12.

Division of Biological Chemistry and Drug Discovery, The College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

View Article

Download full-text PDF

Source
https://academic.oup.com/glycob/article-lookup/doi/10.1093/g
Publisher Site
http://dx.doi.org/10.1093/glycob/cws003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311286PMC
May 2012

The de novo and salvage pathways of GDP-mannose biosynthesis are both sufficient for the growth of bloodstream-form Trypanosoma brucei.

Mol Microbiol 2012 Apr 21;84(2):340-51. Epub 2012 Mar 21.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1365-2958.2012.08026.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-2958.2012.08026.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412276PMC
April 2012

Protein O-GlcNAcylation is required for fibroblast growth factor signaling in Drosophila.

Sci Signal 2011 Dec 20;4(204):ra89. Epub 2011 Dec 20.

Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scisignal.2002335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660836PMC
December 2011

Investigation of copper(II) tetrafluoroborate catalysed epoxide opening.

Tetrahedron Lett 2011 Dec;52(52):7091-7094

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee DD1 5EH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tetlet.2011.10.090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314918PMC
December 2011

Chemical structure of Trichomonas vaginalis surface lipoglycan: a role for short galactose (β1-4/3) N-acetylglucosamine repeats in host cell interaction.

J Biol Chem 2011 Nov 7;286(47):40494-508. Epub 2011 Sep 7.

Department of Microbiology, Immunology, and Molecular Genetics, UCLA, Los Angeles, California 90095-1489, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M111.280578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220458PMC
November 2011

Characterization, localization, essentiality, and high-resolution crystal structure of glucosamine 6-phosphate N-acetyltransferase from Trypanosoma brucei.

Eukaryot Cell 2011 Jul 29;10(7):985-97. Epub 2011 Apr 29.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/EC.05025-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147419PMC
July 2011

Probing elongating and branching β-D-galactosyltransferase activities in Leishmania parasites by making use of synthetic phosphoglycans.

ACS Chem Biol 2011 Jun 11;6(6):648-57. Epub 2011 Apr 11.

College of Life Sciences, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/cb100416jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659391PMC
June 2011

Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei.

Carbohydr Res 2011 May 24;346(6):708-14. Epub 2011 Feb 24.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, The University of Dundee, DD1 5EH Dundee, Scotland, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.carres.2011.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125106PMC
May 2011

Systematic review of performance of non-invasive biomarkers in the evaluation of non-alcoholic fatty liver disease.

Liver Int 2011 Apr 1;31(4):461-73. Epub 2011 Feb 1.

Biomedical Research Institute, University of Dundee, Ninewells Hospital, Dundee, UK.

View Article

Download full-text PDF

Source
https://www.researchgate.net/profile/Michael_Ferguson4/publi
Web Search
http://doi.wiley.com/10.1111/j.1478-3231.2011.02451.x
Publisher Site
http://dx.doi.org/10.1111/j.1478-3231.2011.02451.xDOI Listing
April 2011

Identification, subcellular localization, biochemical properties, and high-resolution crystal structure of Trypanosoma brucei UDP-glucose pyrophosphorylase.

Glycobiology 2010 Dec 19;20(12):1619-30. Epub 2010 Aug 19.

Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/glycob/cwq115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270307PMC
December 2010

Glycotyping of Trypanosoma brucei variant surface glycoprotein MITat1.8.

Mol Biochem Parasitol 2010 Nov 15;174(1):74-7. Epub 2010 Jun 15.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molbiopara.2010.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935967PMC
November 2010

Prophossi: automating expert validation of phosphopeptide-spectrum matches from tandem mass spectrometry.

Bioinformatics 2010 Sep 22;26(17):2153-9. Epub 2010 Jul 22.

Division of Biological Chemistry and Drug Discovery, College of LifeSciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/btq341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922888PMC
September 2010

Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4'-epimerase inhibitors: toward the development of novel therapies for African sleeping sickness.

J Med Chem 2010 Jul;53(13):5025-32

Biomedical Sciences Program, University of California San Diego, 9500 Gilman Drive, Mail Code 0365, La Jolla, California 92093-0365, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm100456aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895357PMC
July 2010

Application of electrospray mass spectrometry to the structural determination of glycosylphosphatidylinositol membrane anchors.

Glycobiology 2010 May 24;20(5):576-85. Epub 2010 Jan 24.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/glycob/cwq007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850939PMC
May 2010

Stoichiometric quantification of Akt phosphorylation using LC-MS/MS.

J Proteome Res 2010 Feb;9(2):743-51

Translational Medicine Research Collaboration, Dundee DD1 9SY, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/pr900572hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816933PMC
February 2010

Myristoyl-CoA:protein N-myristoyltransferase depletion in trypanosomes causes avirulence and endocytic defects.

Mol Biochem Parasitol 2010 Jan 24;169(1):55-8. Epub 2009 Sep 24.

Centre for Immunology and Infection, Department of Biology, University of York, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molbiopara.2009.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789243PMC
January 2010

Proteomic scale high-sensitivity analyses of GPI membrane anchors.

Glycoconj J 2009 Nov;26(8):915-21

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10719-008-9116-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791486PMC
November 2009

Distinct donor and acceptor specificities of Trypanosoma brucei oligosaccharyltransferases.

EMBO J 2009 Sep 23;28(17):2650-61. Epub 2009 Jul 23.

Division of Biological Chemistry and Drug Discovery, The College of Life Sciences, University of Dundee, Dundee, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/emboj.2009.203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722254PMC
September 2009

The phosphoproteome of bloodstream form Trypanosoma brucei, causative agent of African sleeping sickness.

Mol Cell Proteomics 2009 Jul 4;8(7):1527-38. Epub 2009 Apr 4.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.

View Article

Download full-text PDF

Source
http://www.mcponline.org/lookup/doi/10.1074/mcp.M800556-MCP2
Publisher Site
http://dx.doi.org/10.1074/mcp.M800556-MCP200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716717PMC
July 2009

Identification and specific localization of tyrosine-phosphorylated proteins in Trypanosoma brucei.

Eukaryot Cell 2009 Apr 30;8(4):617-26. Epub 2009 Jan 30.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/EC.00366-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669198PMC
April 2009

Trypanosoma brucei UDP-glucose:glycoprotein glucosyltransferase has unusual substrate specificity and protects the parasite from stress.

Eukaryot Cell 2009 Feb 29;8(2):230-40. Epub 2008 Dec 29.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/EC.00361-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643610PMC
February 2009

Identification of a glycosylphosphatidylinositol anchor-modifying beta1-3 N-acetylglucosaminyl transferase in Trypanosoma brucei.

Mol Microbiol 2009 Jan 21;71(2):478-91. Epub 2008 Nov 21.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1365-2958.2008.06542.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-2958.2008.06542.xDOI Listing
January 2009

Probing enzymes late in the trypanosomal glycosylphosphatidylinositol biosynthetic pathway with synthetic glycosylphosphatidylinositol analogues.

ACS Chem Biol 2008 Oct;3(10):625-34

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/cb800143wDOI Listing
October 2008

Phosphatidylethanolamine in Trypanosoma brucei is organized in two separate pools and is synthesized exclusively by the Kennedy pathway.

J Biol Chem 2008 Aug 28;283(35):23636-44. Epub 2008 Jun 28.

Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, Bern, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M803600200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259767PMC
August 2008

Probing Trypanosoma brucei glycosylphosphatidylinositol biosynthesis using novel precursor-analogues.

Chem Biol Drug Des 2008 Aug 15;72(2):127-32. Epub 2008 Jul 15.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1747-0285.2008.00688.x
Publisher Site
http://dx.doi.org/10.1111/j.1747-0285.2008.00688.xDOI Listing
August 2008

Synthesis of 1-D-6-O-[2-(N-hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate): a potential metalloenzyme inhibitor of glycosylphosphatidylinositol biosynthesis.

Carbohydr Res 2008 Jul 30;343(9):1478-81. Epub 2008 Mar 30.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, The University of Dundee, DD1 5EH Dundee, Scotland, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.carres.2008.03.028DOI Listing
July 2008

Deletion of the TbALG3 gene demonstrates site-specific N-glycosylation and N-glycan processing in Trypanosoma brucei.

Glycobiology 2008 May 8;18(5):367-83. Epub 2008 Feb 8.

The Division of Biological Chemistry and Drug Discovery, The Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/glycob/cwn014DOI Listing
May 2008

GPIs on a chip.

Nat Chem Biol 2008 Apr;4(4):223-4

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nchembio0408-223DOI Listing
April 2008

The de novo synthesis of GDP-fucose is essential for flagellar adhesion and cell growth in Trypanosoma brucei.

J Biol Chem 2007 Sep 19;282(39):28853-63. Epub 2007 Jul 19.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD15EH, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M704742200DOI Listing
September 2007

Sugar nucleotide pools of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major.

Eukaryot Cell 2007 Aug 8;6(8):1450-63. Epub 2007 Jun 8.

Division of Biological Chemistry and Drug Discovery, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dow St., Dundee DD1 5EH, Scotland, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/EC.00175-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1951125PMC
August 2007

Structure of the glycosylphosphatidylinositol anchor of the Trypanosoma brucei transferrin receptor.

Mol Biochem Parasitol 2007 Feb 27;151(2):220-3. Epub 2006 Nov 27.

Division of Biological Chemistry and Molecular Microbiology, Faculty of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molbiopara.2006.11.001DOI Listing
February 2007

GPI-anchored proteins and free GPI glycolipids of procyclic form Trypanosoma brucei are nonessential for growth, are required for colonization of the tsetse fly, and are not the only components of the surface coat.

Mol Biol Cell 2006 Dec 11;17(12):5265-74. Epub 2006 Oct 11.

Division of Biological Chemistry and Molecular Microbiology, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1091/mbc.e06-08-0702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1679689PMC
December 2006

Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness.

Bioorg Med Chem Lett 2006 Nov 7;16(22):5744-7. Epub 2006 Sep 7.

Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2006.08.091DOI Listing
November 2006

Galactose starvation in a bloodstream form Trypanosoma brucei UDP-glucose 4'-epimerase conditional null mutant.

Eukaryot Cell 2006 Nov;5(11):1906-13

Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/EC.00156-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1694802PMC
November 2006

Characterization of the glycosylphosphatidylinositol anchor of the immunodominant Cryptosporidium parvum 17-kDa antigen.

Mol Biochem Parasitol 2006 Sep 17;149(1):108-12. Epub 2006 May 17.

Division of Parasitic Diseases, Centers for Disease Control and Prevention, 4770 Buford Hwy, NE, Mail Stop F-13, Atlanta, GA 30341, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molbiopara.2006.04.006DOI Listing
September 2006

Trypanosoma brucei UDP-galactose-4'-epimerase in ternary complex with NAD+ and the substrate analogue UDP-4-deoxy-4-fluoro-alpha-D-galactose.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 Sep 11;62(Pt 9):829-34. Epub 2006 Aug 11.

Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S1744309106028740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2242870PMC
September 2006

Synthetic glycovaccine protects against the bite of leishmania-infected sand flies.

J Infect Dis 2006 Aug 3;194(4):512-8. Epub 2006 Jul 3.

Liverpool School of Tropical Medicine, University of Liverpool, Pembroke Place, Liverpool L3 5QA, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1086/505584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839923PMC
August 2006

The suppression of galactose metabolism in Trypanosoma cruzi epimastigotes causes changes in cell surface molecular architecture and cell morphology.

Mol Biochem Parasitol 2006 May 9;147(1):126-36. Epub 2006 Mar 9.

Division of Biological Chemistry & Molecular Microbiology, The School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molbiopara.2006.02.011DOI Listing
May 2006

Recombinant human PPAR-beta/delta ligand-binding domain is locked in an activated conformation by endogenous fatty acids.

J Mol Biol 2006 Mar 4;356(4):1005-13. Epub 2006 Jan 4.

Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmb.2005.12.047DOI Listing
March 2006