Publications by authors named "Michael A Hollingsworth"

100Publications

Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.

Authors:
Ayuko Hoshino Han Sang Kim Linda Bojmar Kofi Ennu Gyan Michele Cioffi Jonathan Hernandez Constantinos P Zambirinis Gonçalo Rodrigues Henrik Molina Søren Heissel Milica Tesic Mark Loïc Steiner Alberto Benito-Martin Serena Lucotti Angela Di Giannatale Katharine Offer Miho Nakajima Caitlin Williams Laura Nogués Fanny A Pelissier Vatter Ayako Hashimoto Alexander E Davies Daniela Freitas Candia M Kenific Yonathan Ararso Weston Buehring Pernille Lauritzen Yusuke Ogitani Kei Sugiura Naoko Takahashi Maša Alečković Kayleen A Bailey Joshua S Jolissant Huajuan Wang Ashton Harris L Miles Schaeffer Guillermo García-Santos Zoe Posner Vinod P Balachandran Yasmin Khakoo G Praveen Raju Avigdor Scherz Irit Sagi Ruth Scherz-Shouval Yosef Yarden Moshe Oren Mahathi Malladi Mary Petriccione Kevin C De Braganca Maria Donzelli Cheryl Fischer Stephanie Vitolano Geraldine P Wright Lee Ganshaw Mariel Marrano Amina Ahmed Joe DeStefano Enrico Danzer Michael H A Roehrl Norman J Lacayo Theresa C Vincent Martin R Weiser Mary S Brady Paul A Meyers Leonard H Wexler Srikanth R Ambati Alexander J Chou Emily K Slotkin Shakeel Modak Stephen S Roberts Ellen M Basu Daniel Diolaiti Benjamin A Krantz Fatima Cardoso Amber L Simpson Michael Berger Charles M Rudin Diane M Simeone Maneesh Jain Cyrus M Ghajar Surinder K Batra Ben Z Stanger Jack Bui Kristy A Brown Vinagolu K Rajasekhar John H Healey Maria de Sousa Kim Kramer Sujit Sheth Jeanine Baisch Virginia Pascual Todd E Heaton Michael P La Quaglia David J Pisapia Robert Schwartz Haiying Zhang Yuan Liu Arti Shukla Laurence Blavier Yves A DeClerck Mark LaBarge Mina J Bissell Thomas C Caffrey Paul M Grandgenett Michael A Hollingsworth Jacqueline Bromberg Bruno Costa-Silva Hector Peinado Yibin Kang Benjamin A Garcia Eileen M O'Reilly David Kelsen Tanya M Trippett David R Jones Irina R Matei William R Jarnagin David Lyden

Cell 2020 Aug 13;182(4):1044-1061.e18. Epub 2020 Aug 13.

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.07.009DOI Listing
August 2020

Sulfation modulates the targeting properties of hyaluronic acid to P-selectin and CD44.

ACS Biomater Sci Eng 2020 Jun 4;6(6):3585-3598. Epub 2020 May 4.

Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, United States.

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http://dx.doi.org/10.1021/acsbiomaterials.0c00115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331950PMC
June 2020

Local and systemic immunosuppression in pancreatic cancer: Targeting the stalwarts in tumor's arsenal.

Biochim Biophys Acta Rev Cancer 2020 Aug 21;1874(1):188387. Epub 2020 Jun 21.

The Eppley Institute for Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2020.188387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483650PMC
August 2020

Comparative phenotypes of peripheral blood and spleen cells from cancer patients.

Int Immunopharmacol 2020 Aug 7;85:106655. Epub 2020 Jun 7.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA. Electronic address:

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http://dx.doi.org/10.1016/j.intimp.2020.106655DOI Listing
August 2020

Targeting the Tumor Core: Hypoxia-Responsive Nanoparticles for the Delivery of Chemotherapy to Pancreatic Tumors.

Mol Pharm 2020 08 22;17(8):2849-2863. Epub 2020 Jul 22.

Pharmaceutical Sciences Department, North Dakota State University, Fargo, North Dakota 58105, United States.

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http://dx.doi.org/10.1021/acs.molpharmaceut.0c00247DOI Listing
August 2020

Development of a MUC16-Targeted Near-Infrared Fluorescent Antibody Conjugate for Intraoperative Imaging of Pancreatic Cancer.

Mol Cancer Ther 2020 08 13;19(8):1670-1681. Epub 2020 May 13.

Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska.

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http://dx.doi.org/10.1158/1535-7163.MCT-20-0033DOI Listing
August 2020

Macrophages potentiate STAT3 signaling in skeletal muscles and regulate pancreatic cancer cachexia.

Cancer Lett 2020 Aug 25;484:29-39. Epub 2020 Apr 25.

The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2020.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286478PMC
August 2020

A rapid and sensitive bioanalytical LC-MS/MS method for the quantitation of a novel CDK5 inhibitor 20-223 (CP668863) in plasma: Application to in vitro metabolism and plasma protein-binding studies.

Biomed Chromatogr 2020 Aug 18;34(8):e4859. Epub 2020 May 18.

Clinical Pharmacology Laboratory, Department of Pharmacy Practice and Science, University of Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.1002/bmc.4859DOI Listing
August 2020

Tuned near infrared fluorescent hyaluronic acid conjugates for delivery to pancreatic cancer for intraoperative imaging.

Theranostics 2020 10;10(8):3413-3429. Epub 2020 Feb 10.

Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.

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http://dx.doi.org/10.7150/thno.40688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069077PMC
February 2020

Invasive phenotype induced by low extracellular pH requires mitochondria dependent metabolic flexibility.

Biochem Biophys Res Commun 2020 Feb 18. Epub 2020 Feb 18.

The Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198, USA; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198, USA; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA; Department of Genetics Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, 68198, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2020.02.018DOI Listing
February 2020

Predicted Prognosis of Patients with Pancreatic Cancer by Machine Learning.

Clin Cancer Res 2020 May 28;26(10):2411-2421. Epub 2020 Jan 28.

Department of Pathology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-1247DOI Listing
May 2020

CDK5 Inhibitor Downregulates Mcl-1 and Sensitizes Pancreatic Cancer Cell Lines to Navitoclax.

Mol Pharmacol 2019 10;96(4):419-429

Eppley Institute for Research in Cancer and Allied Diseases (S.Ko., S.R., J.I.C., H.M.K., C.M.R., Y.A.S., M.B., A.J.C., C.J.B., S.Ki., X.L., M.A.H., A.N.), Departments of Pharmaceutical Sciences (A.N.) and Genetics Cell Biology and Anatomy (A.N.), and Fred & Pamela Buffett Cancer Center (X.L., M.A.H., A.N.), University of Nebraska Medical Center, Omaha, Nebraska

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http://dx.doi.org/10.1124/mol.119.116855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726458PMC
October 2019

Mucin-1 is required for Coxsackie Virus B3-induced inflammation in pancreatitis.

Sci Rep 2019 07 23;9(1):10656. Epub 2019 Jul 23.

Division of Surgical Oncology, Department of Surgery, Fred and Pamela Buffet Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.1038/s41598-019-46933-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650496PMC
July 2019

The glycoprotein mucin-1 negatively regulates GalNAc transferase 5 expression in pancreatic cancer.

FEBS Lett 2019 10 21;593(19):2751-2761. Epub 2019 Jul 21.

Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffet Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.1002/1873-3468.13532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048170PMC
October 2019

Integration of Genomic and Transcriptional Features in Pancreatic Cancer Reveals Increased Cell Cycle Progression in Metastases.

Cancer Cell 2019 02 24;35(2):267-282.e7. Epub 2019 Jan 24.

PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Department of Surgery, University of Toronto, Toronto, ON M5T 1P5, Canada; Hepatobiliary/Pancreatic Surgical Oncology Program, University Health Network, Toronto, ON M5G 2M9, Canada; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108183058
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http://dx.doi.org/10.1016/j.ccell.2018.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398439PMC
February 2019

A Polymeric Nanogel-Based Treatment Regimen for Enhanced Efficacy and Sequential Administration of Synergistic Drug Combination in Pancreatic Cancer.

J Pharmacol Exp Ther 2019 09 25;370(3):894-901. Epub 2019 Jan 25.

Department of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine, College of Pharmacy (K.S.S., F.L., T.K.B.), Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center (D.T., T.C., K.M., K.A.O., S.S., M.A.H., P.R.), and Department of Pathology and Microbiology (S.M.L.), University of Nebraska Medical Center, Omaha, Nebraska

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http://dx.doi.org/10.1124/jpet.118.255372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6807295PMC
September 2019

Met receptor inhibitor SU11274 localizes in the endoplasmic reticulum.

Biochem Biophys Res Commun 2018 07 19;501(4):858-862. Epub 2018 May 19.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA; Eppley Institute, Fred and Pamela Buffet Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2018.05.034DOI Listing
July 2018

Indocyanine green loaded hyaluronan-derived nanoparticles for fluorescence-enhanced surgical imaging of pancreatic cancer.

Nanomedicine 2018 04 9;14(3):769-780. Epub 2018 Jan 9.

Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2017.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899013PMC
April 2018

TET1-mediated DNA hypomethylation regulates the expression of MUC4 in lung cancer.

Genes Cancer 2017 Mar;8(3-4):517-527

Department of Pathology, Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area, Research and Education Assembly, Kagoshima University, Sakuragoaka, Japan.

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http://dx.doi.org/10.18632/genesandcancer.139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489649PMC
March 2017

Emerging roles of the CXCL12/CXCR4 axis in pancreatic cancer progression and therapy.

Pharmacol Ther 2017 Nov 23;179:158-170. Epub 2017 May 23.

Department of Pharmaceutical Sciences, University of Nebraska Medical Center, 985830 Nebraska Medical Center, Omaha, NE, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2017.05.012DOI Listing
November 2017

Identification of FRA-1 as a novel player in pancreatic cancer in cooperation with a MUC1: ERK signaling axis.

Oncotarget 2016 Jun;7(26):39996-40011

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.

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http://dx.doi.org/10.18632/oncotarget.9557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129987PMC
June 2016

Functional Consequences of Differential O-glycosylation of MUC1, MUC4, and MUC16 (Downstream Effects on Signaling).

Biomolecules 2016 07 30;6(3). Epub 2016 Jul 30.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039420PMC
http://dx.doi.org/10.3390/biom6030034DOI Listing
July 2016

SOX2 functions as a molecular rheostat to control the growth, tumorigenicity and drug responses of pancreatic ductal adenocarcinoma cells.

Oncotarget 2016 Jun;7(23):34890-906

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198-5950, USA.

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http://dx.doi.org/10.18632/oncotarget.8994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085197PMC
June 2016

Proteomic mapping of p53 immunogenicity in pancreatic, ovarian, and breast cancers.

Proteomics Clin Appl 2016 07 17;10(7):720-31. Epub 2016 May 17.

Virginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.

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http://dx.doi.org/10.1002/prca.201500096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553208PMC
July 2016

Mucins and associated glycan signatures in colon adenoma-carcinoma sequence: Prospective pathological implication(s) for early diagnosis of colon cancer.

Cancer Lett 2016 May 16;374(2):304-14. Epub 2016 Feb 16.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA; Fred and Pamela Buffett Cancer Center, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2016.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881851PMC
May 2016

The lymphatic system and pancreatic cancer.

Cancer Lett 2016 10 29;381(1):217-36. Epub 2015 Dec 29.

Eppley Institute, University of Nebraska Medical Center, Omaha, NE 68198-5950, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2015.11.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969225PMC
October 2016

Advances in Biomedical Imaging, Bioengineering, and Related Technologies for the Development of Biomarkers of Pancreatic Disease: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases and National Institute of Biomedical Imaging and Bioengineering Workshop.

Pancreas 2015 Nov;44(8):1185-94

From the *Department of Biomedical Engineering, University of Virginia, Charlottesville, VA; †Eppley Cancer Institute, University of Nebraska School of Medicine, Omaha, NE; ‡Division of Gastroenterology, Hepatology and Nutrition, Departments of Medicine and Anesthesiology and Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA; §Office of Cancer Nanotechnology Research and the Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD; ∥Division of Gastroenterology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; ¶Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD; and #Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1097/MPA.0000000000000552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608388PMC
November 2015

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver.

Nat Cell Biol 2015 Jun 18;17(6):816-26. Epub 2015 May 18.

1] Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medical College, New York, New York 10021, USA [2] Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/ncb3169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769922PMC
June 2015

Early detection of sporadic pancreatic cancer: summative review.

Pancreas 2015 Jul;44(5):693-712

From the *Department of Medicine, Mayo Clinic, Rochester, MN; †Department of Biomedical Engineering, University of Virginia, Charlottesville, VA; Departments of ‡Biochemistry and Molecular Biology, §Pathology and Microbiology, and ∥Surgery, Fred & Pamela Buffett Cancer Center, University of Nebraska, Omaha, NE; ¶Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD; #Division of Gastroenterology, University of Washington, Seattle, WA; **Division of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, MD; ††Sawgrass Leadership Institute, Ponte Vedra Beach, FL; ‡‡Department of Surgery, University of Utah, Salt Lake City, UT; §§Department of Radiology, Stanford University School of Medicine, Stanford; ∥∥Department of Medicine, David Geffen School of Medicine, and ¶¶General Surgery, University of California Los Angeles, Los Angeles, CA; ##Kenner Family Research Fund; ***Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY; †††Department of Internal Medicine, University of Greifswald, Greifswald, Germany; ‡‡‡Division of Pathology and Laboratory Medicine, University of Texas MD Anderson Cancer Center, Houston, TX; §§§Department of Health Sciences Research, Mayo Clinic, Rochester, MN; ∥∥∥Gastroenterology Division, Department of Internal Medicine and Comprehensive Cancer Center, and ¶¶¶Department of Surgery, School of Medicine, University of Michigan, Ann Arbor, MI; ###Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, Rockville, MD; ****Departments of Surgery and Oncology, Kyushu University, Fukuoka, Japan; ††††Department of Medicine, Eastern Virginia Medical School, Norfolk, VA; and ‡‡‡‡Division of Oral Biology and Medicine, CLA School of Dentistry, Jonnson Comprehensive Cancer Center, University of California Los Angeles, L

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http://dx.doi.org/10.1097/MPA.0000000000000368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467589PMC
July 2015

Loss of E-cadherin and epithelial to mesenchymal transition is not required for cell motility in tissues or for metastasis.

Tissue Barriers 2014 8;2(4):e969112. Epub 2014 Aug 8.

Eppley Institute For Research in Cancer and Allied Disease; University of Nebraska Medical Center ; Omaha, NE USA.

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http://dx.doi.org/10.4161/21688362.2014.969112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292045PMC
January 2015

Nerve growth factor regulates neurolymphatic remodeling during corneal inflammation and resolution.

PLoS One 2014 10;9(11):e112737. Epub 2014 Nov 10.

Boys Town National Research Hospital, Department of Genetics, 555 North 30th Street, Omaha, Nebraska 68131, United States of America; Boys Town National Research Hospital, Department of Otolaryngology, 555 North 30th Street, Omaha, Nebraska 68131, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0112737PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226611PMC
December 2015

Spatiotemporal proteomic analyses during pancreas cancer progression identifies serine/threonine stress kinase 4 (STK4) as a novel candidate biomarker for early stage disease.

Mol Cell Proteomics 2014 Dec 15;13(12):3484-96. Epub 2014 Sep 15.

From the ‡Translational Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109; **Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109; ‡‡Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington 98195

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http://dx.doi.org/10.1074/mcp.M113.036517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256499PMC
December 2014

Context-dependent function of the deubiquitinating enzyme USP9X in pancreatic ductal adenocarcinoma.

Cancer Biol Ther 2014 Aug 19;15(8):1042-52. Epub 2014 May 19.

Eppley Institute for Research in Cancer and Allied Diseases; Fred & Pamela Buffett Cancer Center; University of Nebraska Medical Center; Omaha, NE USA.

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http://dx.doi.org/10.4161/cbt.29182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119071PMC
August 2014

Microfluidic immunocapture of circulating pancreatic cells using parallel EpCAM and MUC1 capture: characterization, optimization and downstream analysis.

Lab Chip 2014 May 28;14(10):1775-84. Epub 2014 Mar 28.

Department of Biomedical Engineering, College of Engineering, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1039/c4lc00041bDOI Listing
May 2014

Interactions between MUC1 and p120 catenin regulate dynamic features of cell adhesion, motility, and metastasis.

Cancer Res 2014 Mar 26;74(5):1609-20. Epub 2013 Dec 26.

Authors' Affiliations: Eppley Institute for Research in Cancer and Allied Disease; Department of Oral Biology, University of Nebraska Medical Center, Omaha, Nebraska; Department of Gynecologic Oncology and Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas; and Department of Translational Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, California.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-2444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076167PMC
March 2014

MUC4-mediated regulation of acute phase protein lipocalin 2 through HER2/AKT/NF-κB signaling in pancreatic cancer.

Clin Cancer Res 2014 Feb 15;20(3):688-700. Epub 2013 Nov 15.

Authors' Affiliations: Departments of Biochemistry and Molecular Biology, Statistics, Pathology, Surgery; Buffett Cancer Center, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska; and Division of Gastroenterology, Hepatology and Nutrition, UT Health-UT Health Science Center and Medical School at Houston, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946494PMC
February 2014

MUC1 regulates expression of multiple microRNAs involved in pancreatic tumor progression, including the miR-200c/141 cluster.

PLoS One 2013 15;8(10):e73306. Epub 2013 Oct 15.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0073306PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797065PMC
June 2014

Expression of core 3 synthase in human pancreatic cancer cells suppresses tumor growth and metastasis.

Int J Cancer 2013 Dec 5;133(12):2824-33. Epub 2013 Aug 5.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE.

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http://dx.doi.org/10.1002/ijc.28322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873636PMC
December 2013

Aberrant expression of mucin core proteins and o-linked glycans associated with progression of pancreatic cancer.

Clin Cancer Res 2013 Apr 27;19(8):1981-93. Epub 2013 Feb 27.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-2662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873635PMC
April 2013

Overexpression of ecdysoneless in pancreatic cancer and its role in oncogenesis by regulating glycolysis.

Clin Cancer Res 2012 Nov 12;18(22):6188-98. Epub 2012 Sep 12.

Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-12-1789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551465PMC
November 2012

Relevance of amyloid precursor-like protein 2 C-terminal fragments in pancreatic cancer cells.

Int J Oncol 2012 Oct 13;41(4):1464-74. Epub 2012 Jul 13.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.

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http://dx.doi.org/10.3892/ijo.2012.1553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482291PMC
October 2012

Tumor suppression by collagen XV is independent of the restin domain.

Matrix Biol 2012 Jun 16;31(5):285-9. Epub 2012 Apr 16.

Human Molecular Genetics Program, Children's Memorial Research Center, and Department of Pediatrics, Northwestern University Feinberg School of Medicine, 2300 Children's Plaza #211, Chicago, IL 60614, USA.

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http://dx.doi.org/10.1016/j.matbio.2012.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373166PMC
June 2012

Molecular pathology of early pancreatic cancer.

Cancer Biomark 2010 ;9(1-6):421-40

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.3233/CBM-2011-0168DOI Listing
July 2012

The N-terminal domain of G3BP enhances cell motility and invasion by posttranscriptional regulation of BART.

Mol Cancer Res 2011 Jul 10;9(7):856-66. Epub 2011 Jun 10.

Eppley Institute for Research in Cancer and Allied Diseases, and Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-10-0574DOI Listing
July 2011

Intracellular CD24 inhibits cell invasion by posttranscriptional regulation of BART through interaction with G3BP.

Cancer Res 2011 Feb 25;71(3):895-905. Epub 2011 Jan 25.

Eppley Institute for Research in Cancer and Allied Diseases, Omaha, Nebraska, USA.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-10-2743DOI Listing
February 2011

Regulation of Aerobic Glycolysis by microRNAs in Cancer.

Mol Cell Pharmacol 2011 ;3(3):125-134

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392682PMC
January 2011

Cancer biomarkers defined by autoantibody signatures to aberrant O-glycopeptide epitopes.

Cancer Res 2010 Feb 2;70(4):1306-13. Epub 2010 Feb 2.

Center for Glycomics, Departments of Cellular and Molecular Medicine and Oral Diagnostics, University of Copenhagen, Blegdamsvej 3, Copenhagen 2200 N, Denmark.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-2893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538776PMC
February 2010

What a fish can learn from a mouse: principles and strategies for modeling human cancer in mice.

Zebrafish 2009 Dec;6(4):329-37

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA.

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http://dx.doi.org/10.1089/zeb.2009.0626DOI Listing
December 2009

The human RNA polymerase II-associated factor 1 (hPaf1): a new regulator of cell-cycle progression.

PLoS One 2009 Sep 22;4(9):e7077. Epub 2009 Sep 22.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007077PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740866PMC
September 2009

Comparison of ras-responsive gene enhancers in pancreatic tumor cells that express either wild-type or mutant K-ras.

Biochem Biophys Res Commun 2009 Apr 28;381(4):706-11. Epub 2009 Feb 28.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, 68198-6805, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0900406
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http://dx.doi.org/10.1016/j.bbrc.2009.02.126DOI Listing
April 2009

Sonic hedgehog promotes desmoplasia in pancreatic cancer.

Clin Cancer Res 2008 Oct;14(19):5995-6004

Eppley Institute, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-0291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782957PMC
October 2008

Phosphorylation of MUC1 by Met modulates interaction with p53 and MMP1 expression.

J Biol Chem 2008 Oct 14;283(40):26985-95. Epub 2008 Jul 14.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198-6805, USA.

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http://dx.doi.org/10.1074/jbc.M805036200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556014PMC
October 2008