Michael A Hollingsworth

Michael A Hollingsworth

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Michael A Hollingsworth

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CDK5 Inhibitor Downregulates Mcl-1 and Sensitizes Pancreatic Cancer Cell Lines to Navitoclax.

Mol Pharmacol 2019 Oct;96(4):419-429

Eppley Institute for Research in Cancer and Allied Diseases (S.Ko., S.R., J.I.C., H.M.K., C.M.R., Y.A.S., M.B., A.J.C., C.J.B., S.Ki., X.L., M.A.H., A.N.), Departments of Pharmaceutical Sciences (A.N.) and Genetics Cell Biology and Anatomy (A.N.), and Fred & Pamela Buffett Cancer Center (X.L., M.A.H., A.N.), University of Nebraska Medical Center, Omaha, Nebraska

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http://dx.doi.org/10.1124/mol.119.116855DOI Listing
October 2019

A Polymeric Nanogel-Based Treatment Regimen for Enhanced Efficacy and Sequential Administration of Synergistic Drug Combination in Pancreatic Cancer.

J Pharmacol Exp Ther 2019 Sep 25;370(3):894-901. Epub 2019 Jan 25.

Department of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine, College of Pharmacy (K.S.S., F.L., T.K.B.), Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center (D.T., T.C., K.M., K.A.O., S.S., M.A.H., P.R.), and Department of Pathology and Microbiology (S.M.L.), University of Nebraska Medical Center, Omaha, Nebraska

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http://dx.doi.org/10.1124/jpet.118.255372DOI Listing
September 2019

The glycoprotein mucin-1 negatively regulates GalNAc transferase 5 expression in pancreatic cancer.

FEBS Lett 2019 Jul 8. Epub 2019 Jul 8.

Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffet Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.1002/1873-3468.13532DOI Listing
July 2019

Mucin-1 is required for Coxsackie Virus B3-induced inflammation in pancreatitis.

Sci Rep 2019 Jul 23;9(1):10656. Epub 2019 Jul 23.

Division of Surgical Oncology, Department of Surgery, Fred and Pamela Buffet Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.1038/s41598-019-46933-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650496PMC
July 2019

Integration of Genomic and Transcriptional Features in Pancreatic Cancer Reveals Increased Cell Cycle Progression in Metastases.

Cancer Cell 2019 Feb 24;35(2):267-282.e7. Epub 2019 Jan 24.

PanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Department of Surgery, University of Toronto, Toronto, ON M5T 1P5, Canada; Hepatobiliary/Pancreatic Surgical Oncology Program, University Health Network, Toronto, ON M5G 2M9, Canada; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108183058
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http://dx.doi.org/10.1016/j.ccell.2018.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398439PMC
February 2019

Met receptor inhibitor SU11274 localizes in the endoplasmic reticulum.

Biochem Biophys Res Commun 2018 07 19;501(4):858-862. Epub 2018 May 19.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA; Eppley Institute, Fred and Pamela Buffet Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2018.05.034DOI Listing
July 2018

Indocyanine green loaded hyaluronan-derived nanoparticles for fluorescence-enhanced surgical imaging of pancreatic cancer.

Nanomedicine 2018 04 9;14(3):769-780. Epub 2018 Jan 9.

Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2017.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899013PMC
April 2018

Combination of mAb-AR20.5, anti-PD-L1 and PolyICLC inhibits tumor progression and prolongs survival of MUC1.Tg mice challenged with pancreatic tumors.

Cancer Immunol Immunother 2018 Mar 4;67(3):445-457. Epub 2017 Dec 4.

The Eppley Institute for Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE, 68198-6805, USA.

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http://dx.doi.org/10.1007/s00262-017-2095-7DOI Listing
March 2018

Emerging roles of the CXCL12/CXCR4 axis in pancreatic cancer progression and therapy.

Pharmacol Ther 2017 Nov 23;179:158-170. Epub 2017 May 23.

Department of Pharmaceutical Sciences, University of Nebraska Medical Center, 985830 Nebraska Medical Center, Omaha, NE, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2017.05.012DOI Listing
November 2017

TET1-mediated DNA hypomethylation regulates the expression of MUC4 in lung cancer.

Genes Cancer 2017 Mar;8(3-4):517-527

Department of Pathology, Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area, Research and Education Assembly, Kagoshima University, Sakuragoaka, Japan.

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http://dx.doi.org/10.18632/genesandcancer.139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489649PMC
March 2017

The lymphatic system and pancreatic cancer.

Cancer Lett 2016 10 29;381(1):217-36. Epub 2015 Dec 29.

Eppley Institute, University of Nebraska Medical Center, Omaha, NE 68198-5950, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2015.11.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969225PMC
October 2016

Proteomic mapping of p53 immunogenicity in pancreatic, ovarian, and breast cancers.

Proteomics Clin Appl 2016 07 17;10(7):720-31. Epub 2016 May 17.

Virginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.

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http://dx.doi.org/10.1002/prca.201500096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553208PMC
July 2016

Functional Consequences of Differential O-glycosylation of MUC1, MUC4, and MUC16 (Downstream Effects on Signaling).

Biomolecules 2016 07 30;6(3). Epub 2016 Jul 30.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039420PMC
http://dx.doi.org/10.3390/biom6030034DOI Listing
July 2016

SOX2 functions as a molecular rheostat to control the growth, tumorigenicity and drug responses of pancreatic ductal adenocarcinoma cells.

Oncotarget 2016 Jun;7(23):34890-906

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198-5950, USA.

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http://dx.doi.org/10.18632/oncotarget.8994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085197PMC
June 2016

Identification of FRA-1 as a novel player in pancreatic cancer in cooperation with a MUC1: ERK signaling axis.

Oncotarget 2016 Jun;7(26):39996-40011

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.

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http://dx.doi.org/10.18632/oncotarget.9557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129987PMC
June 2016

Mucins and associated glycan signatures in colon adenoma-carcinoma sequence: Prospective pathological implication(s) for early diagnosis of colon cancer.

Cancer Lett 2016 May 16;374(2):304-14. Epub 2016 Feb 16.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA; Fred and Pamela Buffett Cancer Center, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2016.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881851PMC
May 2016

Nerve growth factor regulates neurolymphatic remodeling during corneal inflammation and resolution.

PLoS One 2014 10;9(11):e112737. Epub 2014 Nov 10.

Boys Town National Research Hospital, Department of Genetics, 555 North 30th Street, Omaha, Nebraska 68131, United States of America; Boys Town National Research Hospital, Department of Otolaryngology, 555 North 30th Street, Omaha, Nebraska 68131, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0112737PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226611PMC
December 2015

Advances in Biomedical Imaging, Bioengineering, and Related Technologies for the Development of Biomarkers of Pancreatic Disease: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases and National Institute of Biomedical Imaging and Bioengineering Workshop.

Pancreas 2015 Nov;44(8):1185-94

From the *Department of Biomedical Engineering, University of Virginia, Charlottesville, VA; †Eppley Cancer Institute, University of Nebraska School of Medicine, Omaha, NE; ‡Division of Gastroenterology, Hepatology and Nutrition, Departments of Medicine and Anesthesiology and Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA; §Office of Cancer Nanotechnology Research and the Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD; ∥Division of Gastroenterology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; ¶Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD; and #Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1097/MPA.0000000000000552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608388PMC
November 2015

Early detection of sporadic pancreatic cancer: summative review.

Pancreas 2015 Jul;44(5):693-712

From the *Department of Medicine, Mayo Clinic, Rochester, MN; †Department of Biomedical Engineering, University of Virginia, Charlottesville, VA; Departments of ‡Biochemistry and Molecular Biology, §Pathology and Microbiology, and ∥Surgery, Fred & Pamela Buffett Cancer Center, University of Nebraska, Omaha, NE; ¶Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD; #Division of Gastroenterology, University of Washington, Seattle, WA; **Division of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, MD; ††Sawgrass Leadership Institute, Ponte Vedra Beach, FL; ‡‡Department of Surgery, University of Utah, Salt Lake City, UT; §§Department of Radiology, Stanford University School of Medicine, Stanford; ∥∥Department of Medicine, David Geffen School of Medicine, and ¶¶General Surgery, University of California Los Angeles, Los Angeles, CA; ##Kenner Family Research Fund; ***Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY; †††Department of Internal Medicine, University of Greifswald, Greifswald, Germany; ‡‡‡Division of Pathology and Laboratory Medicine, University of Texas MD Anderson Cancer Center, Houston, TX; §§§Department of Health Sciences Research, Mayo Clinic, Rochester, MN; ∥∥∥Gastroenterology Division, Department of Internal Medicine and Comprehensive Cancer Center, and ¶¶¶Department of Surgery, School of Medicine, University of Michigan, Ann Arbor, MI; ###Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, Rockville, MD; ****Departments of Surgery and Oncology, Kyushu University, Fukuoka, Japan; ††††Department of Medicine, Eastern Virginia Medical School, Norfolk, VA; and ‡‡‡‡Division of Oral Biology and Medicine, CLA School of Dentistry, Jonnson Comprehensive Cancer Center, University of California Los Angeles, L

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http://dx.doi.org/10.1097/MPA.0000000000000368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467589PMC
July 2015

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver.

Nat Cell Biol 2015 Jun 18;17(6):816-26. Epub 2015 May 18.

1] Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medical College, New York, New York 10021, USA [2] Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/ncb3169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769922PMC
June 2015

Loss of E-cadherin and epithelial to mesenchymal transition is not required for cell motility in tissues or for metastasis.

Tissue Barriers 2014 8;2(4):e969112. Epub 2014 Aug 8.

Eppley Institute For Research in Cancer and Allied Disease; University of Nebraska Medical Center ; Omaha, NE USA.

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http://dx.doi.org/10.4161/21688362.2014.969112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292045PMC
January 2015

Spatiotemporal proteomic analyses during pancreas cancer progression identifies serine/threonine stress kinase 4 (STK4) as a novel candidate biomarker for early stage disease.

Mol Cell Proteomics 2014 Dec 15;13(12):3484-96. Epub 2014 Sep 15.

From the ‡Translational Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109; **Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109; ‡‡Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington 98195

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http://dx.doi.org/10.1074/mcp.M113.036517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256499PMC
December 2014

Context-dependent function of the deubiquitinating enzyme USP9X in pancreatic ductal adenocarcinoma.

Cancer Biol Ther 2014 Aug 19;15(8):1042-52. Epub 2014 May 19.

Eppley Institute for Research in Cancer and Allied Diseases; Fred & Pamela Buffett Cancer Center; University of Nebraska Medical Center; Omaha, NE USA.

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http://dx.doi.org/10.4161/cbt.29182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119071PMC
August 2014

MUC1 regulates expression of multiple microRNAs involved in pancreatic tumor progression, including the miR-200c/141 cluster.

PLoS One 2013 15;8(10):e73306. Epub 2013 Oct 15.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0073306PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797065PMC
June 2014

Microfluidic immunocapture of circulating pancreatic cells using parallel EpCAM and MUC1 capture: characterization, optimization and downstream analysis.

Lab Chip 2014 May 28;14(10):1775-84. Epub 2014 Mar 28.

Department of Biomedical Engineering, College of Engineering, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1039/c4lc00041bDOI Listing
May 2014

Interactions between MUC1 and p120 catenin regulate dynamic features of cell adhesion, motility, and metastasis.

Cancer Res 2014 Mar 26;74(5):1609-20. Epub 2013 Dec 26.

Authors' Affiliations: Eppley Institute for Research in Cancer and Allied Disease; Department of Oral Biology, University of Nebraska Medical Center, Omaha, Nebraska; Department of Gynecologic Oncology and Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas; and Department of Translational Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, California.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-2444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076167PMC
March 2014

MUC4-mediated regulation of acute phase protein lipocalin 2 through HER2/AKT/NF-κB signaling in pancreatic cancer.

Clin Cancer Res 2014 Feb 15;20(3):688-700. Epub 2013 Nov 15.

Authors' Affiliations: Departments of Biochemistry and Molecular Biology, Statistics, Pathology, Surgery; Buffett Cancer Center, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska; and Division of Gastroenterology, Hepatology and Nutrition, UT Health-UT Health Science Center and Medical School at Houston, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946494PMC
February 2014

Expression of core 3 synthase in human pancreatic cancer cells suppresses tumor growth and metastasis.

Int J Cancer 2013 Dec 5;133(12):2824-33. Epub 2013 Aug 5.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE.

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http://dx.doi.org/10.1002/ijc.28322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873636PMC
December 2013

Aberrant expression of mucin core proteins and o-linked glycans associated with progression of pancreatic cancer.

Clin Cancer Res 2013 Apr 27;19(8):1981-93. Epub 2013 Feb 27.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-2662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873635PMC
April 2013

Overexpression of ecdysoneless in pancreatic cancer and its role in oncogenesis by regulating glycolysis.

Clin Cancer Res 2012 Nov 12;18(22):6188-98. Epub 2012 Sep 12.

Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-12-1789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551465PMC
November 2012

Relevance of amyloid precursor-like protein 2 C-terminal fragments in pancreatic cancer cells.

Int J Oncol 2012 Oct 13;41(4):1464-74. Epub 2012 Jul 13.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.

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http://dx.doi.org/10.3892/ijo.2012.1553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482291PMC
October 2012

Molecular pathology of early pancreatic cancer.

Cancer Biomark 2010 ;9(1-6):421-40

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.3233/CBM-2011-0168DOI Listing
July 2012

Tumor suppression by collagen XV is independent of the restin domain.

Matrix Biol 2012 Jun 16;31(5):285-9. Epub 2012 Apr 16.

Human Molecular Genetics Program, Children's Memorial Research Center, and Department of Pediatrics, Northwestern University Feinberg School of Medicine, 2300 Children's Plaza #211, Chicago, IL 60614, USA.

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http://dx.doi.org/10.1016/j.matbio.2012.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373166PMC
June 2012

The N-terminal domain of G3BP enhances cell motility and invasion by posttranscriptional regulation of BART.

Mol Cancer Res 2011 Jul 10;9(7):856-66. Epub 2011 Jun 10.

Eppley Institute for Research in Cancer and Allied Diseases, and Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-10-0574DOI Listing
July 2011

Intracellular CD24 inhibits cell invasion by posttranscriptional regulation of BART through interaction with G3BP.

Cancer Res 2011 Feb 25;71(3):895-905. Epub 2011 Jan 25.

Eppley Institute for Research in Cancer and Allied Diseases, Omaha, Nebraska, USA.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-10-2743DOI Listing
February 2011

Regulation of Aerobic Glycolysis by microRNAs in Cancer.

Mol Cell Pharmacol 2011 ;3(3):125-134

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392682PMC
January 2011

Cancer biomarkers defined by autoantibody signatures to aberrant O-glycopeptide epitopes.

Cancer Res 2010 Feb 2;70(4):1306-13. Epub 2010 Feb 2.

Center for Glycomics, Departments of Cellular and Molecular Medicine and Oral Diagnostics, University of Copenhagen, Blegdamsvej 3, Copenhagen 2200 N, Denmark.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-2893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538776PMC
February 2010

What a fish can learn from a mouse: principles and strategies for modeling human cancer in mice.

Zebrafish 2009 Dec;6(4):329-37

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA.

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http://dx.doi.org/10.1089/zeb.2009.0626DOI Listing
December 2009

The human RNA polymerase II-associated factor 1 (hPaf1): a new regulator of cell-cycle progression.

PLoS One 2009 Sep 22;4(9):e7077. Epub 2009 Sep 22.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007077PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740866PMC
September 2009

Comparison of ras-responsive gene enhancers in pancreatic tumor cells that express either wild-type or mutant K-ras.

Biochem Biophys Res Commun 2009 Apr 28;381(4):706-11. Epub 2009 Feb 28.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, 68198-6805, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0900406
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http://dx.doi.org/10.1016/j.bbrc.2009.02.126DOI Listing
April 2009

Phosphorylation of MUC1 by Met modulates interaction with p53 and MMP1 expression.

J Biol Chem 2008 Oct 14;283(40):26985-95. Epub 2008 Jul 14.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198-6805, USA.

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http://dx.doi.org/10.1074/jbc.M805036200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556014PMC
October 2008

Sonic hedgehog promotes desmoplasia in pancreatic cancer.

Clin Cancer Res 2008 Oct;14(19):5995-6004

Eppley Institute, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-0291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782957PMC
October 2008

ADH-1 suppresses N-cadherin-dependent pancreatic cancer progression.

Int J Cancer 2008 Jan;122(1):71-7

Department of Oral Biology, University of Nebraska Medical Center, Omaha, NE 68198-7696, USA.

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http://dx.doi.org/10.1002/ijc.23027DOI Listing
January 2008

Complete suppression of tumor formation by high levels of basement membrane collagen.

Mol Cancer Res 2007 Dec;5(12):1241-5

Weatherall Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital, Oxford, United Kingdom.

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http://dx.doi.org/10.1158/1541-7786.MCR-07-0200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822624PMC
December 2007

Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, Notch, and bone morphogenic proteins.

J Cell Biochem 2007 Nov;102(4):829-39

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198-6805, USA.

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http://doi.wiley.com/10.1002/jcb.21509
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http://dx.doi.org/10.1002/jcb.21509DOI Listing
November 2007

MUC1 is a counter-receptor for myelin-associated glycoprotein (Siglec-4a) and their interaction contributes to adhesion in pancreatic cancer perineural invasion.

Cancer Res 2007 Nov;67(21):10222-9

Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-6805, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-2483DOI Listing
November 2007

Loss of fibulin-2 expression is associated with breast cancer progression.

Am J Pathol 2007 May;170(5):1535-45

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198-6805, USA.

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http://dx.doi.org/10.2353/ajpath.2007.060478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1854949PMC
May 2007

The lectin domains of polypeptide GalNAc-transferases exhibit carbohydrate-binding specificity for GalNAc: lectin binding to GalNAc-glycopeptide substrates is required for high density GalNAc-O-glycosylation.

Glycobiology 2007 Apr 10;17(4):374-87. Epub 2007 Jan 10.

Department of Medical Biochemistry and Genetics, Dental School, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.1093/glycob/cwl082DOI Listing
April 2007

Flt3 ligand delivered in a pluronic formulation prolongs the survival of mice with orthotopic pancreatic adenocarcinoma.

Cancer Biother Radiopharm 2007 Apr;22(2):235-8

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198-6805, USA.

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http://www.liebertpub.com/doi/10.1089/cbr.2007.336
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http://dx.doi.org/10.1089/cbr.2007.336DOI Listing
April 2007

CCL21 induces extensive intratumoral immune cell infiltration and specific anti-tumor cellular immunity.

Int J Oncol 2007 Mar;30(3):631-9

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.

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March 2007

Cell surface-associated mucins in signal transduction.

Trends Cell Biol 2006 Sep 9;16(9):467-76. Epub 2006 Aug 9.

Eppley Institute for Research in Cancer and Allied Diseases, Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-6805, USA.

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http://dx.doi.org/10.1016/j.tcb.2006.07.006DOI Listing
September 2006

RNA interference suppression of MUC1 reduces the growth rate and metastatic phenotype of human pancreatic cancer cells.

Clin Cancer Res 2006 May;12(10):2976-87

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198-6805, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-1197DOI Listing
May 2006

The role of the SEA (sea urchin sperm protein, enterokinase and agrin) module in cleavage of membrane-tethered mucins.

FEBS J 2005 Jun;272(11):2901-11

Paediatric Molecular Genetics, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1111/j.1742-4658.2005.04711.xDOI Listing
June 2005