Publications by authors named "Michael A Caligiuri"

100Publications

Enriched environment enhances NK cell maturation through hypothalamic BDNF in male mice.

Eur J Immunol 2020 Nov 10. Epub 2020 Nov 10.

Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University, Columbus, Ohio, 43210, United States.

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http://dx.doi.org/10.1002/eji.201948358DOI Listing
November 2020

Editorial: Natural Killer Cells in Tissue Compartments.

Front Immunol 2020 20;11:258. Epub 2020 Feb 20.

Department of Experimental Medicine, University of Genoa, Genoa, Italy.

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http://dx.doi.org/10.3389/fimmu.2020.00258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044183PMC
February 2020

CSF1R inhibitor PLX5622 and environmental enrichment additively improve metabolic outcomes in middle-aged female mice.

Aging (Albany NY) 2020 02 2;12(3):2101-2122. Epub 2020 Feb 2.

Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.18632/aging.102724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041757PMC
February 2020

The Mechanism of Anti-PD-L1 Antibody Efficacy against PD-L1-Negative Tumors Identifies NK Cells Expressing PD-L1 as a Cytolytic Effector.

Cancer Discov 2019 10 24;9(10):1422-1437. Epub 2019 Jul 24.

Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California.

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http://dx.doi.org/10.1158/2159-8290.CD-18-1259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253691PMC
October 2019

Adipocytes: A Novel Target for IL-15/IL-15Rα Cancer Gene Therapy.

Mol Ther 2019 05 16;27(5):922-932. Epub 2019 Feb 16.

The Ohio State University Comprehensive Cancer Center, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA; Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2019.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520519PMC
May 2019

Cellular pathways in the development of human and murine innate lymphoid cells.

Curr Opin Immunol 2019 02 19;56:100-106. Epub 2018 Dec 19.

Department of Hematology, City of Hope National Medical Center, Los Angeles, CA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2018.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285385PMC
February 2019

An oncolytic herpesvirus expressing E-cadherin improves survival in mouse models of glioblastoma.

Nat Biotechnol 2018 Nov 26. Epub 2018 Nov 26.

Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio, USA.

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http://dx.doi.org/10.1038/nbt.4302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535376PMC
November 2018

Enriched environment regulates thymocyte development and alleviates experimental autoimmune encephalomyelitis in mice.

Brain Behav Immun 2019 01 1;75:137-148. Epub 2018 Oct 1.

Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210, United States; The Ohio State University Comprehensive Cancer Center, The James Cancer Hospital and Solove Research Institute, Columbus, OH 43210, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08891591183064
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http://dx.doi.org/10.1016/j.bbi.2018.09.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279528PMC
January 2019

CD56 Expression Marks Human Group 2 Innate Lymphoid Cell Divergence from a Shared NK Cell and Group 3 Innate Lymphoid Cell Developmental Pathway.

Immunity 2018 09 4;49(3):464-476.e4. Epub 2018 Sep 4.

Department of Pathology, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210 USA; Comprehensive Cancer Center, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210 USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613183035
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http://dx.doi.org/10.1016/j.immuni.2018.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148384PMC
September 2018

SMAD4 promotes TGF-β-independent NK cell homeostasis and maturation and antitumor immunity.

J Clin Invest 2018 11 15;128(11):5123-5136. Epub 2018 Oct 15.

Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio, USA.

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http://dx.doi.org/10.1172/JCI121227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205382PMC
November 2018

Dependence of innate lymphoid cell 1 development on NKp46.

PLoS Biol 2018 04 27;16(4):e2004867. Epub 2018 Apr 27.

The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.2004867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922978PMC
April 2018

Complex role of NK cells in regulation of oncolytic virus-bortezomib therapy.

Proc Natl Acad Sci U S A 2018 05 23;115(19):4927-4932. Epub 2018 Apr 23.

Mathematical Biosciences Institute, The Ohio State University, Columbus, OH 43210;

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http://dx.doi.org/10.1073/pnas.1715295115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948955PMC
May 2018

Fratricide of NK Cells in Daratumumab Therapy for Multiple Myeloma Overcome by -Expanded Autologous NK Cells.

Clin Cancer Res 2018 08 17;24(16):4006-4017. Epub 2018 Apr 17.

The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-3117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095810PMC
August 2018

Erratum: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells.

Authors:
Nimitha R Mathew Francis Baumgartner Lukas Braun David O'Sullivan Simone Thomas Miguel Waterhouse Tony A Müller Kathrin Hanke Sanaz Taromi Petya Apostolova Anna L Illert Wolfgang Melchinger Sandra Duquesne Annette Schmitt-Graeff Lena Osswald Kai-Li Yan Arnim Weber Sonia Tugues Sabine Spath Dietmar Pfeifer Marie Follo Rainer Claus Michael Lübbert Christoph Rummelt Hartmut Bertz Ralph Wäsch Johanna Haag Andrea Schmidts Michael Schultheiss Dominik Bettinger Robert Thimme Evelyn Ullrich Yakup Tanriver Giang Lam Vuong Renate Arnold Philipp Hemmati Dominik Wolf Markus Ditschkowski Cordula Jilg Konrad Wilhelm Christian Leiber Sabine Gerull Jörg Halter Claudia Lengerke Thomas Pabst Thomas Schroeder Guido Kobbe Wolf Rösler Soroush Doostkam Stephan Meckel Kathleen Stabla Stephan K Metzelder Sebastian Halbach Tilman Brummer Zehan Hu Joern Dengjel Björn Hackanson Christoph Schmid Udo Holtick Christof Scheid Alexandros Spyridonidis Friedrich Stölzel Rainer Ordemann Lutz P Müller Flore Sicre-de-Fontbrune Gabriele Ihorst Jürgen Kuball Jan E Ehlert Daniel Feger Eva-Maria Wagner Jean-Yves Cahn Jacqueline Schnell Florian Kuchenbauer Donald Bunjes Ronjon Chakraverty Simon Richardson Saar Gill Nicolaus Kröger Francis Ayuk Luca Vago Fabio Ciceri Antonia M Müller Takeshi Kondo Takanori Teshima Susan Klaeger Bernhard Kuster Dennis Dong Hwan Kim Daniel Weisdorf Walter van der Velden Daniela Dörfel Wolfgang Bethge Inken Hilgendorf Andreas Hochhaus Geoffroy Andrieux Melanie Börries Hauke Busch John Magenau Pavan Reddy Myriam Labopin Joseph H Antin Andrea S Henden Geoffrey R Hill Glen A Kennedy Merav Bar Anita Sarma Donal McLornan Ghulam Mufti Betul Oran Katayoun Rezvani Omid Shah Robert S Negrin Arnon Nagler Marco Prinz Andreas Burchert Andreas Neubauer Dietrich Beelen Andreas Mackensen Nikolas von Bubnoff Wolfgang Herr Burkhard Becher Gerard Socié Michael A Caligiuri Eliana Ruggiero Chiara Bonini Georg Häcker Justus Duyster Jürgen Finke Erika Pearce Bruce R Blazar Robert Zeiser

Nat Med 2018 Apr;24(4):526

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http://dx.doi.org/10.1038/nm0418-526cDOI Listing
April 2018

Patient Enrichment for Precision-Based Cancer Clinical Trials: Using Prospective Cohort Surveillance as an Approach to Improve Clinical Trials.

Clin Pharmacol Ther 2018 07 23;104(1):23-26. Epub 2018 Mar 23.

Ohio State University Comprehensive Cancer Center; The James Cancer Hospital and Solove Research Institute, Ohio State University, Columbus, Ohio, USA.

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http://dx.doi.org/10.1002/cpt.1051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032821PMC
July 2018

Molecular Basis for the Recognition of Herpes Simplex Virus Type 1 Infection by Human Natural Killer Cells.

Front Immunol 2018 12;9:183. Epub 2018 Feb 12.

The Ohio State University Comprehensive Cancer Center, The James Cancer Hospital and Solove Research Institute, Columbus, OH, United States.

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http://dx.doi.org/10.3389/fimmu.2018.00183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816072PMC
April 2019

Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells.

Authors:
Nimitha R Mathew Francis Baumgartner Lukas Braun David O'Sullivan Simone Thomas Miguel Waterhouse Tony A Müller Kathrin Hanke Sanaz Taromi Petya Apostolova Anna L Illert Wolfgang Melchinger Sandra Duquesne Annette Schmitt-Graeff Lena Osswald Kai-Li Yan Arnim Weber Sonia Tugues Sabine Spath Dietmar Pfeifer Marie Follo Rainer Claus Michael Lübbert Christoph Rummelt Hartmut Bertz Ralph Wäsch Johanna Haag Andrea Schmidts Michael Schultheiss Dominik Bettinger Robert Thimme Evelyn Ullrich Yakup Tanriver Giang Lam Vuong Renate Arnold Philipp Hemmati Dominik Wolf Markus Ditschkowski Cordula Jilg Konrad Wilhelm Christian Leiber Sabine Gerull Jörg Halter Claudia Lengerke Thomas Pabst Thomas Schroeder Guido Kobbe Wolf Rösler Soroush Doostkam Stephan Meckel Kathleen Stabla Stephan K Metzelder Sebastian Halbach Tilman Brummer Zehan Hu Joern Dengjel Björn Hackanson Christoph Schmid Udo Holtick Christof Scheid Alexandros Spyridonidis Friedrich Stölzel Rainer Ordemann Lutz P Müller Flore Sicre-de-Fontbrune Gabriele Ihorst Jürgen Kuball Jan E Ehlert Daniel Feger Eva-Maria Wagner Jean-Yves Cahn Jacqueline Schnell Florian Kuchenbauer Donald Bunjes Ronjon Chakraverty Simon Richardson Saar Gill Nicolaus Kröger Francis Ayuk Luca Vago Fabio Ciceri Antonia M Müller Takeshi Kondo Takanori Teshima Susan Klaeger Bernhard Kuster Dennis Dong Hwan Kim Daniel Weisdorf Walter van der Velden Daniela Dörfel Wolfgang Bethge Inken Hilgendorf Andreas Hochhaus Geoffroy Andrieux Melanie Börries Hauke Busch John Magenau Pavan Reddy Myriam Labopin Joseph H Antin Andrea S Henden Geoffrey R Hill Glen A Kennedy Merav Bar Anita Sarma Donal McLornan Ghulam Mufti Betul Oran Katayoun Rezvani Omid Shah Robert S Negrin Arnon Nagler Marco Prinz Andreas Burchert Andreas Neubauer Dietrich Beelen Andreas Mackensen Nikolas von Bubnoff Wolfgang Herr Burkhard Becher Gerard Socié Michael A Caligiuri Eliana Ruggiero Chiara Bonini Georg Häcker Justus Duyster Jürgen Finke Erika Pearce Bruce R Blazar Robert Zeiser

Nat Med 2018 03 12;24(3):282-291. Epub 2018 Feb 12.

Department of Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1038/nm.4484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029618PMC
March 2018

Epigenetic and Posttranscriptional Regulation of CD16 Expression during Human NK Cell Development.

J Immunol 2018 01 11;200(2):565-572. Epub 2017 Dec 11.

The Ohio State University Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH 43210;

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http://dx.doi.org/10.4049/jimmunol.1701128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881939PMC
January 2018

The Broad Spectrum of Human Natural Killer Cell Diversity.

Immunity 2017 11;47(5):820-833

Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA; Comprehensive Cancer Center and The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728700PMC
November 2017

Addressing Disparities: The 10th Anniversary of the AACR Cancer Health Disparities Conference.

Cancer Epidemiol Biomarkers Prev 2017 09;26(9):1359

The Ohio State University, Columbus, Ohio.

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http://dx.doi.org/10.1158/1055-9965.EPI-17-0670DOI Listing
September 2017

The Fc Domain of Immunoglobulin Is Sufficient to Bridge NK Cells with Virally Infected Cells.

Immunity 2017 07;47(1):159-170.e10

The Ohio State University Comprehensive Cancer Center, The James Cancer Hospital and Solove Research Institute, Columbus, OH 43210, USA; Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH 43205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.06.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568648PMC
July 2017

Amplification of mixed lineage leukemia gene perturbs hematopoiesis and cooperates with partial tandem duplication to induce acute myeloid leukemia.

Haematologica 2017 08 18;102(8):e300-e304. Epub 2017 May 18.

Leukemia and Stem Cell Biology Group, Department of Haematological Medicine, Division of Cancer Studies, King's College London, UK

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http://dx.doi.org/10.3324/haematol.2016.161406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643733PMC
August 2017

Modeling Human Natural Killer Cell Development in the Era of Innate Lymphoid Cells.

Front Immunol 2017 27;8:360. Epub 2017 Mar 27.

Comprehensive Cancer Center, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH, USA; Division of Hematology and Oncology, Department of Internal Medicine, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH, USA.

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http://dx.doi.org/10.3389/fimmu.2017.00360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366880PMC
March 2017

Bortezomib Treatment Sensitizes Oncolytic HSV-1-Treated Tumors to NK Cell Immunotherapy.

Clin Cancer Res 2016 Nov 7;22(21):5265-5276. Epub 2016 Jul 7.

Department of Neurological Surgery, Dardinger Laboratory for Neuro-oncology and Neurosciences, The Ohio State University Wexner Medical Center, Columbus, Ohio.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-1003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093037PMC
November 2016

Increased Levels of Plasma Epstein Barr Virus DNA Identify a Poor-Risk Subset of Patients With Advanced Stage Cutaneous T-Cell Lymphoma.

Clin Lymphoma Myeloma Leuk 2016 08;16 Suppl:S181-S190.e4

The Comprehensive Cancer Center and The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH; Division of Hematology, The Ohio State University, Columbus, OH. Electronic address:

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http://dx.doi.org/10.1016/j.clml.2016.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999299PMC
August 2016

Mechanism, Consequences, and Therapeutic Targeting of Abnormal IL15 Signaling in Cutaneous T-cell Lymphoma.

Cancer Discov 2016 09 15;6(9):986-1005. Epub 2016 Jul 15.

Comprehensive Cancer Center, James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, Ohio. Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio.

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http://dx.doi.org/10.1158/2159-8290.CD-15-1297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388135PMC
September 2016

NKp80 Defines a Critical Step during Human Natural Killer Cell Development.

Cell Rep 2016 07 30;16(2):379-391. Epub 2016 Jun 30.

Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA; Comprehensive Cancer Center and The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1016/j.celrep.2016.05.095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970225PMC
July 2016

Obesity, Inflammation, and Cancer.

Annu Rev Pathol 2016 05;11:421-49

The Diabetes and Metabolism Research Center, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, The Ohio State University, Columbus, Ohio 43210; email:

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http://dx.doi.org/10.1146/annurev-pathol-012615-044359DOI Listing
May 2016

A Progenitor Cell Expressing Transcription Factor RORγt Generates All Human Innate Lymphoid Cell Subsets.

Immunity 2016 05 10;44(5):1140-50. Epub 2016 May 10.

Department of Pathology, The Ohio State University, Columbus, OH 43210, USA; Comprehensive Cancer Center, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893782PMC
May 2016

Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype.

Cancer Immunol Res 2016 06 4;4(6):488-497. Epub 2016 Apr 4.

Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio 43210.

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http://dx.doi.org/10.1158/2326-6066.CIR-15-0297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891265PMC
June 2016

TGFβ Treatment Enhances Glioblastoma Virotherapy by Inhibiting the Innate Immune Response.

Cancer Res 2015 Dec 2;75(24):5273-82. Epub 2015 Dec 2.

Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio. The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681611PMC
December 2015

The Raf Kinase Inhibitor Sorafenib Inhibits JAK-STAT Signal Transduction in Human Immune Cells.

J Immunol 2015 Sep 3;195(5):1995-2005. Epub 2015 Aug 3.

Department of Surgery, The Ohio State University, Columbus, OH 43210; Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210; Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH 43210

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http://www.jimmunol.org/content/early/2015/08/01/jimmunol.14
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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1400084
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http://dx.doi.org/10.4049/jimmunol.1400084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546911PMC
September 2015

Rapid Column-Free Enrichment of Mononuclear Cells from Solid Tissues.

Sci Rep 2015 Jul 30;5:12490. Epub 2015 Jul 30.

1] Division of Hematopathology, Department of Pathology, The Ohio State University, Columbus, Ohio 43210, USA [2] The Ohio State University Comprehensive Cancer Center, The James Cancer Hospital &Solove Research Center, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1038/srep12490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519776PMC
July 2015

Promoter-Specific Hypomethylation Is Associated with Overexpression of PLS3, GATA6, and TWIST1 in the Sezary Syndrome.

J Invest Dermatol 2015 Aug 25;135(8):2084-2092. Epub 2015 Mar 25.

Division of Dermatology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA; The Comprehensive Cancer Center and The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, Ohio, USA; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA; Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, USA. Electronic address:

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http://dx.doi.org/10.1038/jid.2015.116DOI Listing
August 2015

Transcription factor Foxo1 is a negative regulator of natural killer cell maturation and function.

Immunity 2015 Mar 10;42(3):457-70. Epub 2015 Mar 10.

Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH 43210, USA; The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA; The James Cancer Hospital, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400836PMC
March 2015

The Epstein-Barr Virus Lytic Protein BZLF1 as a Candidate Target Antigen for Vaccine Development.

Cancer Immunol Res 2015 Jul 3;3(7):787-94. Epub 2015 Mar 3.

The Comprehensive Cancer Center and Arthur G. James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, Ohio. Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio.

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http://dx.doi.org/10.1158/2326-6066.CIR-14-0242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491000PMC
July 2015

MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition.

Haematologica 2015 May 16;100(5):e190-3. Epub 2015 Jan 16.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA

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http://dx.doi.org/10.3324/haematol.2014.115337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420229PMC
May 2015

PTEN is a negative regulator of NK cell cytolytic function.

J Immunol 2015 Feb 16;194(4):1832-40. Epub 2015 Jan 16.

Medical Scientist Training Program and Biomedical Sciences Graduate Program, The Ohio State University, Columbus, OH 43210; The Comprehensive Cancer Center and Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Columbus, OH 43210; Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210; and Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210.

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http://dx.doi.org/10.4049/jimmunol.1401224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319309PMC
February 2015

Human leukocyte antigen type and posttransplant lymphoproliferative disorder.

Transplantation 2015 Jun;99(6):1220-5

1 Division of Infectious Diseases, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH. 2 Division of Transplantation Surgery, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH. 3 Division of Hematology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH. 4 The Ohio State University Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH.

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http://dx.doi.org/10.1097/TP.0000000000000487DOI Listing
June 2015

The natural product phyllanthusmin C enhances IFN-γ production by human NK cells through upregulation of TLR-mediated NF-κB signaling.

J Immunol 2014 Sep 13;193(6):2994-3002. Epub 2014 Aug 13.

Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH 43210; The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210;

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http://dx.doi.org/10.4049/jimmunol.1302600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162489PMC
September 2014

Echinomycin protects mice against relapsed acute myeloid leukemia without adverse effect on hematopoietic stem cells.

Blood 2014 Aug 3;124(7):1127-35. Epub 2014 Jul 3.

Center for Cancer and Immunology Research, Children's Research Institute, Children's National Medical Center, Washington, DC;

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http://dx.doi.org/10.1182/blood-2013-12-544221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133485PMC
August 2014

The transcription Factor AHR prevents the differentiation of a stage 3 innate lymphoid cell subset to natural killer cells.

Cell Rep 2014 Jul 19;8(1):150-62. Epub 2014 Jun 19.

Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA; Integrated Biomedical Graduate Program, Medical Scientist Program, The Ohio State University, Columbus, OH 43210, USA; Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA; The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.05.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133146PMC
July 2014

Role of cysteine-rich 61 protein (CCN1) in macrophage-mediated oncolytic herpes simplex virus clearance.

Mol Ther 2014 Sep 4;22(9):1678-87. Epub 2014 Jun 4.

Department of Neurological Surgery, Dardinger Laboratory for Neuro-oncology and Neurosciences, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

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http://dx.doi.org/10.1038/mt.2014.101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435480PMC
September 2014

Molecular pathways: interleukin-15 signaling in health and in cancer.

Clin Cancer Res 2014 Apr;20(8):2044-50

Authors' Affiliation: The Divisions of Dermatology and Hematology, Department of Internal Medicine, The Comprehensive Cancer Center, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, Ohio.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-3603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989546PMC
April 2014

Human natural killer cell development in secondary lymphoid tissues.

Semin Immunol 2014 Apr 21;26(2):132-7. Epub 2014 Mar 21.

Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA; Comprehensive Cancer Center and The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2014.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010312PMC
April 2014

Epigenetics meets genetics in acute myeloid leukemia: clinical impact of a novel seven-gene score.

J Clin Oncol 2014 Feb 30;32(6):548-56. Epub 2013 Dec 30.

Guido Marcucci, Pearlly Yan, Kati Maharry, David Frankhouser, Deedra Nicolet, Klaus H. Metzeler, Jessica Kohlschmidt, Krzysztof Mrózek, Yue-Zhong Wu, Donna Bucci, John P. Curfman, Susan P. Whitman, Ann-Kathrin Eisfeld, Jason H. Mendler, Sebastian Schwind, Heiko Becker, John C. Byrd, Ramiro Garzon, Michael A. Caligiuri, Stefano Volinia, and Clara D. Bloomfield, The Ohio State University Comprehensive Cancer Center; Ralf Bundschuh, The Ohio State University, Columbus, OH; Kati Maharry, Deedra Nicolet, and Jessica Kohlschmidt, Alliance for Clinical Trials in Oncology Statistics and Data Center, Mayo Clinic, Rochester, MN; Andrew J. Carroll, University of Alabama at Birmingham, Birmingham, AL; Maria R. Baer, Greenebaum Cancer Center, University of Maryland, Baltimore, MD; Meir Wetzler, Roswell Park Cancer Institute, Buffalo; Jonathan E. Kolitz, Monter Cancer Center, Lake Success, NY; Thomas H. Carter, University of Iowa, Iowa City, IA; Bayard L. Powell, The Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC; Richard M. Stone, Dana-Farber Cancer Institute, Boston, MA; Constance Bär and Christoph Plass, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1200/JCO.2013.50.6337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918538PMC
February 2014

Location and cellular stages of natural killer cell development.

Trends Immunol 2013 Dec 19;34(12):573-82. Epub 2013 Sep 19.

Division of Hematology, Department of Internal Medicine, College of Medicine, Ohio State University, Columbus, OH 43210, USA; Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA; James Cancer Hospital and Solove Research Institute, Ohio State University, Columbus, OH 43210, USA. Electronic address:

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http://dx.doi.org/10.1016/j.it.2013.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852183PMC
December 2013

Uncovering a novel mechanism whereby NK cells interfere with glioblastoma virotherapy.

Oncoimmunology 2013 Apr;2(4):e23658

Medical Scientist Training Program; The Ohio State University Medical Center; Columbus, OH USA ; Dardinger Laboratory for Neuro-Oncology and Neurosciences; Department of Neurological Surgery; The Ohio State University Medical Center; Columbus, OH USA.

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http://dx.doi.org/10.4161/onci.23658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654589PMC
April 2013

Axl/Gas6 pathway positively regulates FLT3 activation in human natural killer cell development.

Eur J Immunol 2013 Oct 8;43(10):2750-5. Epub 2013 Jul 8.

The Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.

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http://dx.doi.org/10.1002/eji.201243116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829002PMC
October 2013