Publications by authors named "Miaomiao Ye"

37 Publications

g-CN/MoS based floating solar still for clean water production by thermal/light activation of persulfate.

Chemosphere 2021 Apr 27;280:130618. Epub 2021 Apr 27.

Zhejiang Key Laboratory of Drinking Water Safety and Distribution Technology, College of Civil Engineering and Architecture, Zhejiang University, Hangzhou, 310058, PR China. Electronic address:

Currently, seawater desalination based on air-water interface solar heating has triggered significant research interests because it effectively makes use of the solar energy and avoids fossil fuel consumption. However, to prevent the volatile organic compounds (VOCs) from volatilizing with water vapor which later will liquefy and enter the condensed freshwater is still a challenge. In this work, a g-CN/MoS based floating solar still (CM-FSS) combined with thermal/light activation of persulfate (PS) at air-water interface was applied for clean freshwater production for the first time. The CM-FSS was composed of a g-CN/MoS top layer for solar absorption, simultaneous thermal/light activation of PS and then VOCs degradation at air-water interface, a floating layer of expandable polyethylene (EPE) foam for heat isolation, and a transport channel of air-laid paper (ALP) for seawater and PS solution delivery. The water evaporation rate of the CM-FSS was measured at 1.23 kg m h under 1 kW m, which is 4.09 times higher than that of pure water without an evaporator. With the assistance of g-CN/MoS photocatalytic degradation and thermal/light activation of PS at the air-water interface, a high removal efficiency of a selected model VOCs pollutant of nitrobenzene (NB) could reach to 98.2% in condensed freshwater. Finally, when real seawater samples were employed as source water for solar distillation, the typical water-quality indices such as salinity, turbidity, anions, cations and organics of the condensed freshwater were below the limit values of the Standards for Drinking Water Quality in WHO, US EPA and China.
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http://dx.doi.org/10.1016/j.chemosphere.2021.130618DOI Listing
April 2021

Interfacial Solar Distillation for Freshwater Production: Fate of Volatile and Semivolatile Organic Contaminants.

Environ Sci Technol 2021 05 8;55(9):6248-6256. Epub 2021 Apr 8.

Zhejiang Key Laboratory of Drinking Water Safety and Distribution Technology, College of Civil Engineering and Architecture, Zhejiang University, Hangzhou 310058, P. R. China.

Interfacial solar distillation (ISD) is an approach with low cost and low energy demand useful for seawater desalination and freshwater production. However, the commercial potential of ISD for applications such as polluted seawater desalination or industrial wastewater reuse may be hindered by low rejection of volatile and semivolatile contaminants. For the first time, the results of this study showed that the transport (from bulk water (B) to distilled water (D)) of volatile and semivolatile contaminants during the solar desalination process was highly correlated with compound volatility ( = 0.858). The obtained relationship was verified to be capable of predicting the distillation concentration ratio (/) of different contaminants ( = 6.29 × 10-2.94 × 10 atm·m·mol) during the ISD process. Compounds such as phenols, which have relatively high volatilization and condensation rates, deserve the most attention as potential contaminants in the distilled water. Meanwhile, other compounds that are more volatile than phenol condensed less in distilled water. Adding an activated carbon adsorbent or a photothermal oxidant is a promising strategy to effectively mitigate the distillation of contaminants and ensure water safety. These results fill the knowledge gap in understanding the transport of volatile and semivolatile compounds in ISD for the treatment of complex source waters.
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http://dx.doi.org/10.1021/acs.est.0c07191DOI Listing
May 2021

UV-activated permanganate process for micro-organic pollutant degradation: efficiency, mechanism and influencing factors.

Water Sci Technol 2021 Mar;83(6):1278-1285

Zhejiang Key Laboratory of Drinking Water Safety and Distribution Technology, Zhejiang University, Hangzhou 310058, China E-mail:

Ultraviolet-activated permanganate (UV/PM) process is a novel advanced oxidation process (AOP), but its application potential remains to be evaluated. This work investigates the degradation of refractory organic pollutant by UV/PM in terms of efficiency, mechanism, and influencing factors. The target compound benzoic acid (BA), which is a micro-organic pollutant and is resistant to PM and UV treatment, can be efficiently degraded by UV/PM. The electron paramagnetic resonance spectra directly supported the formation of hydroxyl radical (HO•) and superoxide radical (O) from UV photolysis of PM. Competitive kinetics experiments verified that O acted as precursor of HO• and the good degradation performance of BA was due to the involvement of HO• and manganese(V). The rate constants of BA degradation showed a positive linear relationship with PM dosage in the range of 0.5-20 mg·L, and the degradation process was significantly influenced by solution pH and natural organic matters but insensitive to chloride and bicarbonate at environmentally relevant concentrations. Compared to the typical UV-based AOP UV/hydrogen peroxide, UV/PM is a little inferior, indicating that optimization and enhancement is needed for this process before its possible practical application.
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http://dx.doi.org/10.2166/wst.2021.068DOI Listing
March 2021

An Ultralocalized Cas13a Assay Enables Universal and Nucleic Acid Amplification-Free Single-Molecule RNA Diagnostics.

ACS Nano 2021 01 17;15(1):1167-1178. Epub 2020 Dec 17.

School of Life Sciences, South China Normal University, Guangzhou 510631, China.

Existing methods for RNA diagnostics, such as reverse transcription PCR (RT-PCR), mainly rely on nucleic acid amplification (NAA) and RT processes, which are known to introduce substantial issues, including amplification bias, cross-contamination, and sample loss. To address these problems, we introduce a confinement effect-inspired Cas13a assay for single-molecule RNA diagnostics, eliminating the need for NAA and RT. This assay involves confining the RNA-triggered Cas13a catalysis system in cell-like-sized reactors to enhance local concentrations of target and reporter simultaneously, droplet microfluidics. It achieves >10 000-fold enhancement in sensitivity when compared to the bulk Cas13a assay and enables absolute digital single-molecule RNA quantitation. We experimentally demonstrate its broad applicability for precisely counting microRNAs, 16S rRNAs, and SARS-CoV-2 RNA from synthetic sequences to clinical samples with excellent accuracy. Notably, this direct RNA diagnostic technology enables detecting a wide range of RNA molecules at the single-molecule level. Moreover, its simplicity, universality, and excellent quantification capability might render it to be a dominant rival to RT-qPCR.
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http://dx.doi.org/10.1021/acsnano.0c08165DOI Listing
January 2021

The clinical effectiveness and safety of alprostadil combined with alpha lipoic acid in the treatment of diabetic peripheral neuropathy: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2020 Dec;99(50):e23507

Department of Traditional Chinese Medicine, The Second Affiliated Hospital of Hainan Medical University, Longhua District, Haikou City, Hainan Province, P.R. China.

Background: The pathogenesis of diabetic peripheral neuropathy is more complex and it is not yet clear, but studies have shown that microangiopathy and oxidative stress responses are closely related to their pathogenesis. At present, the treatment of improving microcirculation and antioxidant stress is mainly used in clinical. Alprostadil is a commonly used vasodilator, and alpha lipoic acid is an antioxidant, which can effectively reduce oxidative stress responses and delay the progression of diabetes mellitus and its complications. However, there is a lack of evidence-based medical evidence for alprostadil combined with alpha lipoic acid in the treatment of diabetic peripheral neuropathy, and this article aims to understand the clinical effectiveness and safety of alprostadil combined with alpha lipoic acid in the treatment of diabetic peripheral neuropath by a meta-analysis of published randomized controlled trials.

Methods: In this study, we obtain the relevant literature by retrieving 8 electronic databases, including PubMed, EMBASE, Web of Science, the Cochrane Library, CBM, CNKI, VIP, and WanFang Database. Retrieving a randomized controlled study of alprostadil combined with alpha lipoic acid in the treatment of diabetic peripheral neuropath, while the language of the literature is restricted and it only includes Chinese and English literature. For the publication of literature, the time is from the beginning of the database to August 31, 2020. In the English database, using the retrieval method of subject word combined free word. The two researchers read the titles and abstracts of all the literature independently based on the inclusion and exclusion criteria. If it cannot be determined whether the literature is included by reading the title and abstract, then download and read the full text of the literature. If there is a dispute between the two researchers about the literature, so it should discuss the dispute with the third researcher in order to reach a conclusion. Using the bias risk assessment tool of randomized controlled trials in Cochrane systematic review to evaluate the bias risk of the included literature; Using RevMan 5.3 software to conduct statistical analysis; Using funnel plot analysis to analyze the situation of literature publication bias.

Results: This study will provide a high-quality evidence on the effects of hydrolyzed protein formula milk on gastrointestinal diseases and physical development of premature infants.

Conclusion: This study will draw reliable evidence-based medical evidence for alprostadil combined with Alpha lipoic acid in the treatment of diabetic peripheral neuropathy, thus providing help for the clinical treatment of diabetic peripheral neuropathy.

Registration Number: Open Science Framework (OSF), registration number: DOI 10.17605/OSF.IO/7S46G.
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http://dx.doi.org/10.1097/MD.0000000000023507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738071PMC
December 2020

The prognostic value of the lysyl oxidase family in ovarian cancer.

J Clin Lab Anal 2020 Dec 15;34(12):e23538. Epub 2020 Oct 15.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Background: Our study intended to evaluate the prognostic value of lysyl oxidase (LOX) and its four relevant members, the lysyl oxidase-like genes (LOXL1-4), in ovarian cancer (OC) patients.

Material And Methods: The Kaplan-Meier plotter (KM plotter) database was used to investigate the prognostic power of the LOX family for OC patients. Overall survival (OS) and progression-free survival (PFS) were the clinical endpoints. The prognostic roles of the LOX family in OC patients were also analyzed according to various clinicopathological characteristics, including histological subtypes, clinical stages, pathological grades, and chemotherapeutic treatments.

Results: Overexpression of LOX, LOXL1, LOXL2, and LOXL3 mRNA indicated poor OS and PFS in OC patients, particularly in serous and grade II + III OC patients. Overexpression of LOXL4 mRNA resulted in worse PFS in OC patients. Overexpression of LOX and LOXL1 mRNA showed worse OS and PFS in stage III + IV OC patients, and overexpression of LOXL3 mRNA indicated worse OS and PFS in stage I + II OC patients. Overexpression of LOX, LOXL3, and LOXL4 mRNA indicated worse OS and PFS among OC patients who received platinum, taxol, and taxol + platinum chemotherapy. Overexpression of LOXL1 and LOXL2 mRNA was related to lower OS and PFS in OC patients who received platinum chemotherapy.

Conclusion: LOX, LOXL1, LOXL2, and LOXL3 may become potential predictive markers for negative outcomes in OC patients. Moreover, the LOX family can serve as new molecular predictors for the efficiency of platinum-based chemotherapy in OC patients.
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http://dx.doi.org/10.1002/jcla.23538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7755792PMC
December 2020

Evolving roles of lysyl oxidase family in tumorigenesis and cancer therapy.

Pharmacol Ther 2020 11 18;215:107633. Epub 2020 Jul 18.

Departmant of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China. Electronic address:

The lysyl oxidase (LOX) family is comprised of LOX and four LOX-like proteins (LOXL1, LOXL2, LOXL3, and LOXL4), and mainly functions in the remodeling of extracellular matrix (ECM) and the cross-linking of collagen and elastic fibers. Recently, a growing body of research has demonstrated that LOX family is critically involved in the regulation of cancer cell proliferation, migration, invasion and metastasis. In this review, we discuss the roles of LOX family members in the development and progression of different types of human cancers. Furthermore, we also describe the potential inhibitors of LOX family proteins and highlight that LOX family might be an important therapeutic target for cancer therapy.
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http://dx.doi.org/10.1016/j.pharmthera.2020.107633DOI Listing
November 2020

TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2.

Protein Cell 2020 12 19;11(12):894-914. Epub 2020 Jun 19.

State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.

Tripartite motif (TRIM) family proteins are important effectors of innate immunity against viral infections. Here we identified TRIM35 as a regulator of TRAF3 activation. Deficiency in or inhibition of TRIM35 suppressed the production of type I interferon (IFN) in response to viral infection. Trim35-deficient mice were more susceptible to influenza A virus (IAV) infection than were wild-type mice. TRIM35 promoted the RIG-I-mediated signaling by catalyzing Lys63-linked polyubiquitination of TRAF3 and the subsequent formation of a signaling complex with VISA and TBK1. IAV PB2 polymerase countered the innate antiviral immune response by impeding the Lys63-linked polyubiquitination and activation of TRAF3. TRIM35 mediated Lys48-linked polyubiquitination and proteasomal degradation of IAV PB2, thereby antagonizing its suppression of TRAF3 activation. Our in vitro and in vivo findings thus reveal novel roles of TRIM35, through catalyzing Lys63- or Lys48-linked polyubiquitination, in RIG-I antiviral immunity and mechanism of defense against IAV infection.
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http://dx.doi.org/10.1007/s13238-020-00734-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719147PMC
December 2020

Analysis of hidden blood loss and its influential factors in myomectomy.

J Int Med Res 2020 May;48(5):300060520920417

Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Objective: This study was performed to quantify hidden blood loss (HBL) and explore its influential factors in myomectomy.

Methods: Two hundred nine patients who underwent myomectomy by laparotomy or laparoscopy from 1 January 2017 to 31 December 2018 were analyzed. Each patient's estimated blood volume and total blood loss (TBL) were calculated by the Nadler formula and Gross formula, respectively. The HBL was calculated by subtracting the visible blood loss (VBL) from the TBL. A multivariate linear stepwise analysis was applied to identify the influential factors of HBL in myomectomy.

Results: The mean perioperative VBL and estimated TBL during myomectomy were 137.81 ±104.43 and 492.24 ± 225.00 mL, respectively. The mean HBL was 354.39 ± 177.69 mL, which accounted for 71.52% ± 15.75% of the TBL and was two to three times higher than the VBL. The duration of surgery, number of removed leiomyomas, and location of removed leiomyomas were independent risk factors for HBL in myomectomy.

Conclusions: HBL accounted for a significant percentage of TBL in myomectomy. A full understanding of the HBL in perioperative blood management may improve patients' postoperative rehabilitation.
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http://dx.doi.org/10.1177/0300060520920417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223209PMC
May 2020

The diverse roles of SPOP in prostate cancer and kidney cancer.

Nat Rev Urol 2020 Jun 30;17(6):339-350. Epub 2020 Apr 30.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Multiple studies have confirmed that speckle-type pox virus and zinc finger (POZ) protein (SPOP) functions as a substrate adaptor of cullin 3-based E3 ligase and has a crucial role in various cellular processes via specific targeting of proteins for ubiquitination and subsequent proteasomal degradation. Dysregulation of SPOP-mediated proteolysis might be involved in the development and progression of human prostate and kidney cancers. In prostate cancer, SPOP seems to function as a tumour suppressor by targeting several proteins, including androgen receptor (AR), steroid receptor coactivator 3 (SRC3) and BRD4, for degradation, whereas it might function as an oncoprotein in kidney cancer, for example, by targeting phosphatase and tensin homologue (PTEN) for proteasomal degradation. In addition, nuclear SPOP targets AR for degradation and has a role as a tumour suppressor in prostate cancer; however, in kidney cancer, SPOP largely accumulates in the cytoplasm and fails to promote degradation of AR located in the nucleus, resulting in activation of AR-driven pathways and cancer progression. Owing to the context-dependent function of SPOP in human malignancies, further assessment of the molecular mechanisms involving SPOP in prostate and kidney cancers is needed to improve our understanding of its role in the development of these cancer types. Treatments that target SPOP might become therapeutic strategies in these malignancies in the future.
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http://dx.doi.org/10.1038/s41585-020-0314-zDOI Listing
June 2020

Prognostic Values of Transforming Growth Factor-Beta Subtypes in Ovarian Cancer.

Biomed Res Int 2020 12;2020:2170606. Epub 2020 Apr 12.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.

Purpose: To explore the potential role of the transforming growth factor-beta (TGF-) subtypes in the prognosis of ovarian cancer patients. . The prognostic roles of individual TGF- subtypes in women with ovarian cancer were retrieved from the Kaplan-Meier plotter (KM plotter) database. In addition, the Oncomine database and immunohistochemistry were used to observe the mRNA and protein expression of TGF- subtypes between human ovarian carcinoma and normal ovarian samples, respectively.

Results: TGF-1 and TGF-4 were totally uncorrelated with survival outcomes in women with ovarian cancer. Increased TGF-2 and TGF-3 mRNA expression was markedly related to unfavorable prognosis, especially in women with serous, poorly differentiated, and late-stage ovarian carcinoma. High expression levels of TGF-2 were related to worse progression-free survival (PFS) while TGF-3 was linked to unfavorable overall survival (OS) and PFS in women with TP53-mutated ovarian cancer. TGF-2 was associated with poor OS and PFS from treatment with chemotherapy with platins, Taxol, or a platin+Taxol. However, overexpression of TGF-3 was associated with poor OS from the use of platins and poor PFS of Taxol or a platin+Taxol in women with ovarian carcinoma. Furthermore, the expression of TGF-2 mRNA and protein was higher but only TGF-3 mRNA expression was higher in cancerous tissues than in normal ovarian samples.

Conclusion: Higher expression of TGF-2 functioned as a significant predictor of poor prognosis in women with ovarian cancer, especially those with TP53 mutations or who were undergoing chemotherapy with platins, Taxol, or a platin+Taxol.
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http://dx.doi.org/10.1155/2020/2170606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174935PMC
February 2021

NEDD4 E3 ligase: Functions and mechanism in human cancer.

Semin Cancer Biol 2020 12 11;67(Pt 2):92-101. Epub 2020 Apr 11.

Department of Gastrointestinal Surgery, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China. Electronic address:

A growing amount of evidence indicates that the neuronally expressed developmentally downregulated 4 (NEDD4, also known as NEDD4-1) E3 ligase plays a critical role in a variety of cellular processes via the ubiquitination-mediated degradation of multiple substrates. The abnormal regulation of NEDD4 protein has been implicated in cancer development and progression. In this review article, we briefly delineate the downstream substrates and upstream regulators of NEDD4, which are involved in carcinogenesis. Moreover, we succinctly elucidate the functions of NEDD4 protein in tumorigenesis and progression, including cell proliferation, apoptosis, cell cycle, migration, invasion, epithelial mesenchymal transition (EMT), cancer stem cells, and drug resistance. The findings regarding NEDD4 functions are further supported by knockout mouse models and human tumor tissue studies. This review could provide a promising and optimum anticancer therapeutic strategy via targeting the NEDD4 protein.
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http://dx.doi.org/10.1016/j.semcancer.2020.03.006DOI Listing
December 2020

Design of magnetic nanoparticles with high magnetic separation efficiencies and durability for Cu adsorption.

Nanotechnology 2019 Nov 8;31(8):085710. Epub 2019 Nov 8.

Zhejiang Key Laboratory of Drinking Water Safety and Distribution Technology, College of Civil Engineering and Architecture, Zhejiang University, Hangzhou 310058, Zhejiang, People's Republic of China. Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, 199 Ren'ai Road, Suzhou, 215123, Jiangsu, People's Republic of China.

[email protected] core-shell structured nanoparticles are promising candidates for adsorption of heavy metal ions from waste water due to their high adsorption capacities and feasible recycling process. However, their practical applications have been hindered by the trade-off between the magnetic separation efficiency and durability. In this study, we demonstrate the preparation of amino-functionalized [email protected] absorbents with both high magnetic separation efficiencies and durability in strong acidic environment. Our key strategy was to use a thin but highly protective silica layer by manipulating the sol-gel chemistry. With the protection of a thin but poorly permeable silica shell, the durability of the FeO in strong acid solution was significantly enhanced while its magnetic separation efficiency was maintained. We also demonstrated the adsorption of Cu from aqueous solution corresponded well with the pseudo-second-order kinetic model and the Langmuir adsorption isotherm. The adsorption capacity can be further improved by coating an additional layer of mesoporous SiO outside [email protected] The design of highly durable magnetic absorbents without sacrificing the magnetic separation efficiency greatly facilitates the practical applications of magnetic nanoparticles in adsorption of heavy metal ions.
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http://dx.doi.org/10.1088/1361-6528/ab55c2DOI Listing
November 2019

Prognostic values of transketolase family genes in ovarian cancer.

Oncol Lett 2019 Nov 6;18(5):4845-4857. Epub 2019 Sep 6.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China.

Transketolase genes are key rate-limiting enzymes in the non-oxidative part of the pentose phosphate pathway, which is an important metabolic pathway in ribose-5-phosphate production. Three human transketolase genes have been identified: Transketolase (TKT), transketolase-like gene 1 (TKTL1) and transketolase-like gene 2 (TKTL2). Transketolase genes serve crucial roles in the tumorigenesis, metastasis and outcome of multiple types of cancer. However, the expression levels and prognostic values of transketolase family genes in patients with ovarian cancer remain unclear. The purpose of the study was to analyze the expression level and prognostic significance of transketolase family genes in ovarian cancer. In the present study, the mRNA expression levels of three transketolase genes in ovarian cancer and normal ovarian tissue were compared by Oncomine. The prognostic values of these genes were systemically assessed using the Kaplan-Meier plotter database. In addition, the associations between the mRNA levels of these transketolase genes and the clinicopathological characteristics of patients with ovarian cancer, such as histological subtype, clinical stage, grade, tumor protein p53 (TP53) mutation status and chemotherapy history were studied. The prognostic roles of transketolase genes were also evaluated in a validation dataset. The results demonstrated that TKT and TKTL1 expression in ovarian cancer tissues was elevated compared with that in normal ovarian tissues. In addition, high mRNA expression of the three transketolase genes was identified to be associated with poorer progression-free survival (PFS) in patients with serous ovarian cancer, especially in patients at an advanced stage. TKTL2 was significantly associated with poor overall survival in all patients with ovarian cancer. Additionally, transketolase family genes served a role in predicting PFS in patients with ovarian cancer treated with platinum and/or taxol. High expression of the three transketolase genes was associated with unfavorable PFS in patients with TP53-mutated ovarian cancer, but not in patients with TP53 wild-type ovarian cancer. These results suggested that transketolase family genes may serve important roles in the prognosis of patients with ovarian cancer.
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http://dx.doi.org/10.3892/ol.2019.10818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781755PMC
November 2019

Targeting E-cadherin expression with small molecules for digestive cancer treatment.

Am J Transl Res 2019 15;11(7):3932-3944. Epub 2019 Jul 15.

Departmant of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University Wenzhou 325027, Zhejiang, China.

Digestive system cancers, mainly including gastric cancer, hepatocellular carcinoma, pancreatic cancer, and colorectal cancer, are major public health problems and lead to serious cancer-related deaths worldwide. Clinically, treatment strategies of these cancers include surgery, chemotherapy, and immunotherapy. Although successful resection and chemotherapeutic drugs have improved the treatment level, the survival rate of patients with advanced digestive system cancers remains still low primarily due to tumor metastasis. E-cadherin, the prototypical member of the type-1 classical cadherins, has been characrized as an important molecule in epithelial-mesenchymal transition (EMT) process. Loss of E-cadherin is able to induce EMT process, which is associated with cancer stem cells and drug resistance in human cancer. Therefore, restoring E-cadherin could be a useful strategy for reversal of EMT and overcoming drug resistance. In this review, we describe pharmacological small molecules targeting E-cadherin expression for the treatment of digestive system cancers, which have emerged in the recent 5 years. We hope these compounds could be potentially used for treating cancer in the near future.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684918PMC
July 2019

Effects of dynein light chain Tctex-type 3 on the biological behavior of ovarian cancer.

Cancer Manag Res 2019 1;11:5925-5938. Epub 2019 Jul 1.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, People's Republic of China.

Objective: To investigate dynein light chain Tctex-type 3 (DYNLT3) protein expression in ovarian epithelial lesions and explore the effects and related mechanisms of DYNLT3 in terms of the biological behavior of ovarian cancer.

Materials And Methods: Initially, expression of the DYNLT3 protein in ovarian epithelial lesions was detected by immunohistochemical staining, and the prognostic value of DYNLT3 mRNA expression in ovarian cancer patients was assessed using the Kaplan-Meier plotter database. Then, the mRNA and protein expression of DYNLT3 in IOSE80 normal ovarian epithelial cells and SKOV3 ovarian cancer cells was evaluated by quantitative real-time polymerase chain reaction and Western blotting respectively, and the proliferation, apoptosis, migration and invasion of SKOV3 cells after DYNLT3 over-expression and under-expression were investigated by CCK-8 assays and immunofluorescence staining, flow cytometry, wound healing assays and Transwell invasion assays, respectively. Furthermore, the expression of the proliferation-related proteins PCNA and Ki-67 and the invasion- and migration-related proteins Ezrin, Fascin, MMP2 and MMP9 in cells was examined by Western blotting.

Results: The protein expression of DYNLT3 gradually increased during the progression of ovarian epithelial lesions, and was related to the development of ovarian cancer. High expression of DYNLT3 mRNA was related to poor overall survival and progression free survival, especially in serous ovarian cancer patients. In addition, overexpression of DYNLT3 promoted SKOV3 cell proliferation, invasion and migration. The corresponding results were also verified by a DYNLT3 knockdown assay. Moreover, DYNLT3 increased cell proliferation, which was related to Ki-67 expression. Besides, DYNLT3 enhanced cell invasion and migration through regulating Ezrin, but not Fascin, MMP2 or MMP9.

Conclusion: DYNLT3 exerts pro-tumoral effects on ovarian cancer through promoting cell proliferation, migration and invasion, possibly via regulating the protein expression of Ki-67 and Ezrin. DYNLT3 may be a potential prognostic predictor in ovarian cancer.
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http://dx.doi.org/10.2147/CMAR.S205158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612992PMC
July 2019

Restoring E-cadherin Expression by Natural Compounds for Anticancer Therapies in Genital and Urinary Cancers.

Mol Ther Oncolytics 2019 Sep 17;14:130-138. Epub 2019 May 17.

Departmant of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.

E-cadherin plays a pivotal role in cancer progression, including the epithelial-mesenchymal transition (EMT) process and tumor metastasis. Loss of E-cadherin contributes to enhanced invasion and metastasis in human cancers. Therefore, restoring E-cadherin could be a potential approach for cancer therapy. Multiple natural compounds have been shown to possess anti-tumor activities through the regulation of key molecules in signaling pathways, including E-cadherin. In this review, we describe the numerous compounds that restore the expression of E-cadherin in genital and urinary malignancies. We further discuss the potential anti-tumor molecular mechanisms of these agents as the activators of E-cadherin in genital and urinary cancers. Although these compounds exhibit their potential to inhibit the development and progression of cancers, there are several challenges to developing them as therapeutic drugs for cancer patients. Poor bioavailability is the main disadvantage of these compounds. Modification of compound structures has produced actual improvements in bioavailability. Nanoparticle-based delivery systems could be useful to deliver the agents to targeted organs. These compounds could be new promising therapeutic agents for the treatment of human genital and urinary cancers. Further investigations are required to determine the safety and side effects of natural compounds using animal models prior to clinical trials.
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http://dx.doi.org/10.1016/j.omto.2019.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551504PMC
September 2019

Formation of odorant haloanisoles and variation of microorganisms during microbial O-methylation in annular reactors equipped with different coupon materials.

Sci Total Environ 2019 Aug 24;679:1-11. Epub 2019 Apr 24.

College of Civil Engineering and Architecture, Zhejiang University, Hangzhou 310058, Zhejiang, China.

Taste and odor (T & O) issues in drinking water have become serious problems which cannot be ignored by customers. Several studies have confirmed that microbes in water can biotransform halophenols (HPs) to haloanisoles (HAs) with earthy and musty flavors via microbial O-methylation. In this paper, the formation of 2-chloroanisole (2-CA), 2,4-dichloroanisole (2,4-DCA), 2,4,6-trichloroanisole (2,4,6-TCA), 2,3,6-trichloroanisole (2,3,6-TCA) and 2,4,6-tribromoanisole (2,4,6-TBA), and the microbial variation during the microbial O-methylation were investigated in annular reactors (ARs) with three coupon materials. For precursors, 42.5% of 2-CP and 68.9% of 2,4-DCP decayed during the reaction. Among the five HAs, the formation rate constant followed an order of 2,4,6-TCA > 2-CA > 2,4,6-TBA > 2,4-DCA ~ 2,3,6-TCA, while [HA] followed a totally opposite one. The simulated flow velocity had no significant effect (p > 0.05) on HA formation. Ductile iron (DI) AR could produce more HAs than stainless steel (SS) and polyvinyl chloride (PVC) ARs. The final HA molar concentration followed an order of 2,3,6-TCA > 2,4-DCA > 2,4,6-TBA ~ 2,4,6-TCA > 2-CA, which might be explained by multiple factors including HP's dissociation degree, halogen atom's steric hindrance and specificity of HP O-methyltransferases. During the reaction, the microbial biomass dramatically increased 6.8-9.0 times in bulk water but dropped significantly on coupon biofilms. The effect of HPs significantly changed the bacterial communities on coupon in terms of composition and diversity, and declined the relative abundance of HA-producing bacteria, while fungi and their HA-producing genus showed better resistance ability towards HPs. By using Pearson correlation analysis, a significant correlation (p = 0.0003) was found between [HA] and initial coupon biofilm biomass. Finally, a linear relationship was established between initial total biomass and HA formation potential.
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http://dx.doi.org/10.1016/j.scitotenv.2019.04.329DOI Listing
August 2019

Recent Advances on the Molecular Mechanism of Cervical Carcinogenesis Based on Systems Biology Technologies.

Comput Struct Biotechnol J 2019 7;17:241-250. Epub 2019 Feb 7.

Departmant of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.

Cervical cancer is one of the common malignancies in women worldwide. Exploration of pathogenesis and molecular mechanism of cervical cancer is pivotal for development of effective treatment for this disease. Recently, systems biology approaches based on high-throughput technologies have been carried out to investigate the expression of some genes and proteins in genomics, transcriptomics, proteomics, and metabonomics of cervical cancer. Compared with traditional methods,systems biology technology has been shown to provide large of information regarding prognostic biomarkers and therapeutic targets for cervical cancer. These molecular signatures from system biology technology could be useful to understand the molecular mechanisms of cervical cancer development and progression, and help physicians to design targeted therapeutic strategies for patients with cervical cancer.
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http://dx.doi.org/10.1016/j.csbj.2019.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389684PMC
February 2019

The emerging role of WISP proteins in tumorigenesis and cancer therapy.

J Transl Med 2019 01 16;17(1):28. Epub 2019 Jan 16.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, No. 109 Xueyuan Xi Road, Wenzhou, 325027, Zhejiang, China.

Accumulated evidence has demonstrated that WNT1 inducible signaling pathway protein (WISP) genes, which belong to members of the CCN growth factor family, play a pivotal role in tumorigenesis and progression of a broad spectrum of human cancers. Mounting studies have identified that WISP proteins (WISP1-3) exert different biological functions in various human malignancies. Emerging evidence indicates that WISP proteins are critically involved in cell proliferation, apoptosis, invasion and metastasis in cancers. Because the understanding of a direct function of WISP proteins in cancer development and progression has begun to emerge, in this review article, we describe the physiological function of WISP proteins in a variety of human cancers. Moreover, we highlight the current understanding of how the WISP protein is involved in tumorigenesis and cancer progression. Furthermore, we discuss that targeting WISP proteins could be a promising strategy for the treatment of human cancers. Hence, the regulation of WISP proteins could improve treatments for cancer patients.
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http://dx.doi.org/10.1186/s12967-019-1769-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335850PMC
January 2019

Prognosis Analysis of Histone Deacetylases mRNA Expression in Ovarian Cancer Patients.

J Cancer 2018 11;9(23):4547-4555. Epub 2018 Nov 11.

Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.

Histone deacetylases modulate the dynamic balance of histone acetylation and deacetylation in cells, which participate in epigenetic regulations. Accumulated evidence has demonstrated that histone deacetylases are associated with angiogenesis, cell proliferation and survival in a variety of human cancers. However, the expression and distinct prognostic value of histone deacetylases in ovarian cancer have not been well elucidated. In the present study, we collected the overall survival (OS), progress free survival (PFS), and histone deacetylases (HDAC1-11) mRNA expression in ovarian cancer from the Kaplan-Meier plotter online database. We investigated the relationship between histone deacetylases mRNA level and the clinicopathological parameters of the ovarian cancer patients, such as histology subtypes, clinical stages, grades and TP53 mutation. Our analysis data showed that over-expression of HDAC1, HDAC2, HDAC4, HDAC5 and HDAC11 were correlated to poor overall survival and unfavorable progress free survival in all ovarian cancer patients. Notably, the higher level of HDAC11 was associated with the worse OS and PFS for serous/ stage III+IV/ grade III/ TP53 mutation ovarian cancer patients. In conclusion, HDACs may play a crucial role in the prognosis of ovarian cancer, but it is worth noting that HDAC11 may be a biomarker for poor prognosis in ovarian cancer patients.
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http://dx.doi.org/10.7150/jca.26780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277648PMC
November 2018

Prognostic value of microvessel density in cervical cancer.

Cancer Cell Int 2018 3;18:152. Epub 2018 Oct 3.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000 Zhejiang China.

Background: Several epidemiological researches have indicated that microvessel density (MVD), reflecting angiogenesis, was a negatively prognostic factor of cervical cancer. However, the results were inconsistent. Therefore, we performed a meta-analysis to evaluate the association between microvessel density and the survival probability of patients with cervical cancer.

Method: There was a comprehensive search of the PubMed, EMBASE and Cochrane databases up to August 31, 2017. Based on a fixed-effects or random-effects model, the hazard ratio (HR) and 95% confidence intervals (CIs) were calculated from researches on overall survival (OS) and disease-free survival (DFS).

Result: Totally, we included 13 observational researches, involving 1097 patients with cervical cancer. The results showed that high level of microvessel density was negatively correlated with OS (HR = 1.79, 95% CIs 1.31-2.44,  = 60.7%,  = 0.003) and DFS (HR = 1.47, 95% CIs 1.13-1.80,  = 0%,  = 0.423) of cervical cancer patients. In subgroup analysis, high counts of MVD were significantly associated with a poor survival (including OS and DFS) of the patients detected by anti-factor VIII antibodies or in European origin.

Conclusion: The present meta-analysis indicated that survival with high level of MVD was significant poorer than with low MVD in cervical cancer patient. Standardization of MVD assessment is needed.
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http://dx.doi.org/10.1186/s12935-018-0647-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169003PMC
October 2018

The prognostic values of the peroxiredoxins family in ovarian cancer.

Biosci Rep 2018 10 5;38(5). Epub 2018 Sep 5.

Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang, China

Peroxiredoxins (PRDXs) are a family of antioxidant enzymes with six identified mammalian isoforms (PRDX1-6). PRDX expression is up-regulated in various types of solid tumors; however, individual PRDX expression, and its impact on prognostic value in ovarian cancer patients, remains unclear. PRDXs family protein expression profiles in normal ovarian tissues and ovarian cancer tissues were examined using the Human Protein Atlas database. Then, the prognostic roles of PRDX family members in several sets of clinical data (histology, pathological grades, clinical stages, and applied chemotherapy) in ovarian cancer patients were investigated using the Kaplan-Meier plotter. PRDXs family protein expression in ovarian cancer tissues was elevated compared with normal ovarian tissues. Meanwhile, elevated expression of PRDX3, PRDX5, and PRDX6 mRNAs showed poorer overall survival (OS); PRDX5 and PRDX6 also predicted poor progression-free survival (PFS) for ovarian cancer patients. Furthermore, PRDX3 played significant prognostic roles, particularly in poor differentiation and late-stage serous ovarian cancer patients. Additionally, PRDX5 predicted a lower PFS in all ovarian cancer patients treated with Platin, Taxol, and Taxol+Platin chemotherapy. PRDX3 and PRDX6 also showed poor PFS in patients treated with Platin chemotherapy. Furthermore, PRDX3 and PRDX5 indicated lower OS in patients treated with these three chemotherapeutic agents. PRDX6 predicted a poorer OS in patients treated with Taxol and Taxol+Platin chemotherapy. These results suggest that there are distinct prognostic values of PRDX family members in patients with ovarian cancer, and that the expression of PRDX3, PRDX5, and PRDX6 mRNAs are a useful prognostic indicator in the effect of chemotherapy in ovarian cancer patients.
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http://dx.doi.org/10.1042/BSR20180667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123065PMC
October 2018

The prognostic value of HER2 in ovarian cancer: A meta-analysis of observational studies.

PLoS One 2018 30;13(1):e0191972. Epub 2018 Jan 30.

Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.

Background: The prognostic role of human epidermal growth factor receptor 2 (HER2) in ovarian cancer has been investigated in previous studies, but the results remain controversial. Here we present a meta-analysis to systematically review the association between HER2 expression and ovarian cancer prognosis.

Method: Observational studies published until July 2017 were searched in Pubmed, Embase, and Cochrane library databases. Hazard ratios (HRs) for survival with 95% confidence intervals (CIs), subgroup analyses, publication bias and sensitivity analyses were implemented under a standard manner. Estimates of overall survival (OS), progress-free survival (PFS) and disease-free survival (DFS) were weighted and pooled using Der Simonian-Laird random-effect model.

Result: Thirty-four studies that include 5180 ovarian cancer patients were collected for analysis. Expression of HER2 was negatively correlated with clinical prognosis of overall survival (HR = 1.57, 95% CI: 1.31 to 1.89, P < 0.001) and disease-free survival / progress-free survival (HR = 1.26, 95% CI = 1.06 to 1.49) in ovarian cancers. The association between HER2 expression and poor ovarian cancer prognosis in overall survival was also statistically significant in subgroups of unclassified ovarian cancer, Caucasian population and Asian population, while irrespective of detection method.

Conclusion: HER2 expression was related with poor prognosis in ovarian cancer patients and can be used as a predicting cancer prognostic biomarker in ovarian cancer patients.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0191972PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790275PMC
March 2018

Photothermal Catalyst Engineering: Hydrogenation of Gaseous CO with High Activity and Tailored Selectivity.

Adv Sci (Weinh) 2017 10 25;4(10):1700252. Epub 2017 Jul 25.

Materials Chemistry and Nanochemistry Research Group Solar Fuels Cluster Department of Chemistry University of Toronto 80 St. George Street Toronto Ontario M5S 3H6 Canada.

This study has designed and implemented a library of hetero-nanostructured catalysts, denoted as [email protected], comprised of size-controlled Pd nanocrystals interfaced with NbO nanorods. This study also demonstrates that the catalytic activity and selectivity of CO reduction to CO and CH products can be systematically tailored by varying the size of the Pd nanocrystals supported on the NbO nanorods. Using large Pd nanocrystals, this study achieves CO and CH production rates as high as 0.75 and 0.11 mol h g, respectively. By contrast, using small Pd nanocrystals, a CO production rate surpassing 18.8 mol h g is observed with 99.5% CO selectivity. These performance metrics establish a new milestone in the champion league of catalytic nanomaterials that can enable solar-powered gas-phase heterogeneous CO reduction. The remarkable control over the catalytic performance of [email protected] is demonstrated to stem from a combination of photothermal, electronic and size effects, which is rationally tunable through nanochemistry.
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http://dx.doi.org/10.1002/advs.201700252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644230PMC
October 2017

Adsorption behavior and mechanism of ibuprofen onto BiOCl microspheres with exposed {001} facets.

Environ Sci Pollut Res Int 2017 Apr 28;24(10):9556-9565. Epub 2017 Feb 28.

Zhejiang Key Laboratory of Drinking Water Safety and Distribution Technology, Zhejiang University, Hangzhou, 310058, People's Republic of China.

BiOCl microspheres with exposed {001} facets have been synthesized through a simple solvothermal method. The adsorption and photocatalytic activities of BiOCl microspheres were evaluated by removal of ibuprofen (IBP) as the model reaction. Parameters including IBP concentration, BiOCl dosage, and inorganic ions were investigated to reveal the role of adsorption in BiOCl-based photocatalysis. We found that the high IBP removal rate by BiOCl is not due to photocatalytic oxidation but to surface adsorption. The combination of ICP/MS, IC, XPS, and FT-IR results directly proved that anion exchange between dissociated IBP and Cl accompanied by the formation of surface complex (O-Bi-OOC-CH) onto the BiOCl surface is the main adsorption mechanism. In addition, we also demonstrated that organic compounds with carboxyl group (-COOH) such as diclofenac, benzoic acid, and p-phthalic acid can be adsorbed by BiOCl while organic compounds without carboxyl group such as carbamazepine, nitrobenzene, and p-chloronitrobenzene cannot be adsorbed. We believe that the BiOCl adsorption behavior and mechanism should be considered when discussing its photocatalytic mechanism.
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http://dx.doi.org/10.1007/s11356-017-8564-xDOI Listing
April 2017

Heterogeneous oxidation of diclofenac in the presence of α-MnO2 nanorods: influence of operating factors and mechanism.

Water Sci Technol 2015 ;71(9):1340-6

Institute of Municipal Engineering, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China E-mail:

Diclofenac (DCF), one of the pharmaceutical and personal care products that has been widely detected in water, was selected as a model pollutant to evaluate the oxidation activity of α-MnO2 nanorods. The results showed that the heterogeneous oxidation process is highly pH dependent, with higher degradation efficiency at lower pH values. The complete removal of DCF was obtained within 80 min at the solution pH value of 2.5. The oxidation kinetics of DCF can be modeled by Langmuir-Hinshelwood equation (R2>0.999). The effects of various operating parameters, including initial solution pH, α-MnO2 dosage, anions, and cations, on the oxidation efficiency were investigated in detail. A possible reaction pathway for DCF was proposed. In addition, it was demonstrated that the α-MnO2 nanorods can be recycled without decreasing their oxidation activity after 10 cycles.
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http://dx.doi.org/10.2166/wst.2015.068DOI Listing
November 2015

Nanocrystalline TiO₂-catalyzed photoreversible color switching.

Nano Lett 2014 Mar 20;14(3):1681-6. Epub 2014 Feb 20.

Department of Chemistry, University of California , Riverside, California 92521, United States.

We report a novel photoreversible color switching system based on the photocatalytic activity of TiO2 nanocrystals and the redox-driven color switching property of methylene blue (MB). This system rapidly changes from blue to colorless under UV irradiation and recovers its original blue color under visible light irradiation. We have identified four major competing reactions that contribute to the photoreversible switching, among which two are dominant: the decoloration process is mainly driven by the reduction of MB to leuco MB by photogenerated electrons from TiO2 nanocrystals under UV irradiation, and the recoloration process operates by the TiO2-induced self-catalyzed oxidation of LMB under visible irradiation. Compared with the conventional color switching systems based on photoisomerization of chromophores, our system has not only low toxicity but also significantly improved switching rate and cycling performance. It is envisioned that this photoreversible system may promise unique opportunities for many light-driven actuating or color switching applications.
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http://dx.doi.org/10.1021/nl500378kDOI Listing
March 2014

The adsorption of Sb(III) in aqueous solution by Fe2O3-modified carbon nanotubes.

Water Sci Technol 2013 ;68(3):658-64

Institute of Municipal Engineering, Zhejiang University, Hangzhou, China.

A novel kind of iron oxide supported on carbon nanotubes (CNTs) was prepared for adsorption of antimony (Sb)(III) in aqueous solution. The iron (III) oxide (Fe2O3)-modified CNTs were characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy, nitrogen adsorption-desorption and Fourier transform infrared spectrometer. Parameters affecting the adsorption efficiencies, including solution pH value, initial Sb(III) concentration, adsorbent dosage, adsorption time and temperature, were investigated. The results indicate that the removal rate of Sb(III) by Fe2O3-modified CNTs is 99.97% under the initial Sb(III) concentration of 1.5 mg/L, adsorbents dosage of 0.5 g/L, temperature of 25 (o)C and pH value of 7.00, which is 29.81% higher than that of the raw CNTs. The adsorption capacity increased correspondingly from 3.01 to 6.23 mg/g. The equilibrium adsorption data can be fitted to the Freundlich adsorption isotherm. In addition, it has been found that the solution pH values and adsorption temperatures have no significant influence on Sb(III) removal.
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http://dx.doi.org/10.2166/wst.2013.290DOI Listing
October 2013

Effect of calcination temperature on the catalytic activity of nanosized TiO(2) for ozonation of trace 4-chloronitrobenzene.

Water Sci Technol 2012 ;66(3):479-86

Institute of Municipal Engineering, Zhejiang University, Hangzhou, China.

Nanosized titanium dioxides were synthesized by hydrolysis of TiCl(4) followed by calcination at different temperatures ranging from 300 to 1,000 °C. The as-prepared samples were characterized by X-ray diffraction, N(2) adsorption-desorption, and zeta potential analysis. The catalytic activities of the TiO(2) nanoparticles were tested by catalytic ozonation of trace 4-chloronitrobenzene (4-CNB) in water. Moreover, the catalytic ozonation activity of a sample calcined at 400 °C (denoted as T400) was tested in aqueous solution using electron paramagnetic resonance (EPR) spin trapping technique with 5,5-dimethyl-1-pyrroline N-oxide (DMPO) spin trap. It was found that with increasing calcination temperatures, the average crystallite size and average pore size increased, in contrast the BET surface areas decreased. However, the isoelectric point (IEP) first increased, and then decreased. The ozone adsorption on the catalyst surface played an important role in determining their catalytic activity. Sample T400 with the IEP of 7.0, farthest away from the 4-CNB solution pH value (pH = 5.3), showed the best catalytic activity. The EPR experiments further confirmed that the hydroxyl radicals TiO(2)-catalyzed ozonation followed a radical-type mechanism.
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http://dx.doi.org/10.2166/wst.2012.181DOI Listing
August 2012