Publications by authors named "Mete Civelek"

82Publications

A Platelet Function Modulator of Thrombin Activation Is Causally Linked to Cardiovascular Disease and Affects PAR4 Receptor Signaling.

Am J Hum Genet 2020 Aug 9;107(2):211-221. Epub 2020 Jul 9.

National Heart, Lung, and Blood Institute, Division of Intramural Research, Population Sciences Branch, The Framingham Heart Study, Framingham, MA 01702, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2020.06.008DOI Listing
August 2020

Transcription Factor KLF14 and Metabolic Syndrome.

Front Cardiovasc Med 2020 27;7:91. Epub 2020 May 27.

Center for Public Health Genomics, University of Virginia, Charlottesville, VA, United States.

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http://dx.doi.org/10.3389/fcvm.2020.00091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274157PMC
May 2020

Assessing exposure effects on gene expression.

Genet Epidemiol 2020 Jun 8. Epub 2020 Jun 8.

Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1002/gepi.22324DOI Listing
June 2020

Defining data-driven primary transcript annotations with primaryTranscriptAnnotation in R.

Bioinformatics 2020 May;36(9):2926-2928

Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1093/bioinformatics/btaa011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203734PMC
May 2020

Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Authors:
Rainer Malik Ganesh Chauhan Matthew Traylor Muralidharan Sargurupremraj Yukinori Okada Aniket Mishra Loes Rutten-Jacobs Anne-Katrin Giese Sander W van der Laan Solveig Gretarsdottir Christopher D Anderson Michael Chong Hieab H H Adams Tetsuro Ago Peter Almgren Philippe Amouyel Hakan Ay Traci M Bartz Oscar R Benavente Steve Bevan Giorgio B Boncoraglio Robert D Brown Adam S Butterworth Caty Carrera Cara L Carty Daniel I Chasman Wei-Min Chen John W Cole Adolfo Correa Ioana Cotlarciuc Carlos Cruchaga John Danesh Paul I W de Bakker Anita L DeStefano Marcel den Hoed Qing Duan Stefan T Engelter Guido J Falcone Rebecca F Gottesman Raji P Grewal Vilmundur Gudnason Stefan Gustafsson Jeffrey Haessler Tamara B Harris Ahamad Hassan Aki S Havulinna Susan R Heckbert Elizabeth G Holliday George Howard Fang-Chi Hsu Hyacinth I Hyacinth M Arfan Ikram Erik Ingelsson Marguerite R Irvin Xueqiu Jian Jordi Jiménez-Conde Julie A Johnson J Wouter Jukema Masahiro Kanai Keith L Keene Brett M Kissela Dawn O Kleindorfer Charles Kooperberg Michiaki Kubo Leslie A Lange Carl D Langefeld Claudia Langenberg Lenore J Launer Jin-Moo Lee Robin Lemmens Didier Leys Cathryn M Lewis Wei-Yu Lin Arne G Lindgren Erik Lorentzen Patrik K Magnusson Jane Maguire Ani Manichaikul Patrick F McArdle James F Meschia Braxton D Mitchell Thomas H Mosley Michael A Nalls Toshiharu Ninomiya Martin J O'Donnell Bruce M Psaty Sara L Pulit Kristiina Rannikmäe Alexander P Reiner Kathryn M Rexrode Kenneth Rice Stephen S Rich Paul M Ridker Natalia S Rost Peter M Rothwell Jerome I Rotter Tatjana Rundek Ralph L Sacco Saori Sakaue Michele M Sale Veikko Salomaa Bishwa R Sapkota Reinhold Schmidt Carsten O Schmidt Ulf Schminke Pankaj Sharma Agnieszka Slowik Cathie L M Sudlow Christian Tanislav Turgut Tatlisumak Kent D Taylor Vincent N S Thijs Gudmar Thorleifsson Unnur Thorsteinsdottir Steffen Tiedt Stella Trompet Christophe Tzourio Cornelia M van Duijn Matthew Walters Nicholas J Wareham Sylvia Wassertheil-Smoller James G Wilson Kerri L Wiggins Qiong Yang Salim Yusuf Joshua C Bis Tomi Pastinen Arno Ruusalepp Eric E Schadt Simon Koplev Johan L M Björkegren Veronica Codoni Mete Civelek Nicholas L Smith David A Trégouët Ingrid E Christophersen Carolina Roselli Steven A Lubitz Patrick T Ellinor E Shyong Tai Jaspal S Kooner Norihiro Kato Jiang He Pim van der Harst Paul Elliott John C Chambers Fumihiko Takeuchi Andrew D Johnson Dharambir K Sanghera Olle Melander Christina Jern Daniel Strbian Israel Fernandez-Cadenas W T Longstreth Arndt Rolfs Jun Hata Daniel Woo Jonathan Rosand Guillaume Pare Jemma C Hopewell Danish Saleheen Kari Stefansson Bradford B Worrall Steven J Kittner Sudha Seshadri Myriam Fornage Hugh S Markus Joanna M M Howson Yoichiro Kamatani Stephanie Debette Martin Dichgans

Nat Genet 2019 Jul;51(7):1192-1193

Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.

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http://dx.doi.org/10.1038/s41588-019-0449-0DOI Listing
July 2019

MicroRNAs and regulation of cardiometabolic phenotypes: novel insights into the complexity of genome-wide association studies loci.

Cardiovasc Res 2019 09;115(11):1570-1571

Institute for Cardiogenetics, University Heart Center Luebeck, University of Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1093/cvr/cvz120DOI Listing
September 2019

Genetic Regulation of Enoyl-CoA Hydratase Domain-Containing 3 in Adipose Tissue Determines Insulin Sensitivity in African Americans and Europeans.

Diabetes 2019 07 22;68(7):1508-1522. Epub 2019 Apr 22.

Section of Endocrinology and Metabolism, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC

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http://dx.doi.org/10.2337/db18-1229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609988PMC
July 2019

A systems-approach reveals human nestin is an endothelial-enriched, angiogenesis-independent intermediate filament protein.

Sci Rep 2018 10 2;8(1):14668. Epub 2018 Oct 2.

Science for Life Laboratory, School of Biotechnology, Kungliga Tekniska Högskolan (KTH) Royal Institute of Technology, SE-171 21, Stockholm, Sweden.

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http://www.nature.com/articles/s41598-018-32859-4
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http://dx.doi.org/10.1038/s41598-018-32859-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168570PMC
October 2018

A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism.

Cell Metab 2018 May;27(5):1138-1155.e6

Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935137PMC
May 2018

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Authors:
Rainer Malik Ganesh Chauhan Matthew Traylor Muralidharan Sargurupremraj Yukinori Okada Aniket Mishra Loes Rutten-Jacobs Anne-Katrin Giese Sander W van der Laan Solveig Gretarsdottir Christopher D Anderson Michael Chong Hieab H H Adams Tetsuro Ago Peter Almgren Philippe Amouyel Hakan Ay Traci M Bartz Oscar R Benavente Steve Bevan Giorgio B Boncoraglio Robert D Brown Adam S Butterworth Caty Carrera Cara L Carty Daniel I Chasman Wei-Min Chen John W Cole Adolfo Correa Ioana Cotlarciuc Carlos Cruchaga John Danesh Paul I W de Bakker Anita L DeStefano Marcel den Hoed Qing Duan Stefan T Engelter Guido J Falcone Rebecca F Gottesman Raji P Grewal Vilmundur Gudnason Stefan Gustafsson Jeffrey Haessler Tamara B Harris Ahamad Hassan Aki S Havulinna Susan R Heckbert Elizabeth G Holliday George Howard Fang-Chi Hsu Hyacinth I Hyacinth M Arfan Ikram Erik Ingelsson Marguerite R Irvin Xueqiu Jian Jordi Jiménez-Conde Julie A Johnson J Wouter Jukema Masahiro Kanai Keith L Keene Brett M Kissela Dawn O Kleindorfer Charles Kooperberg Michiaki Kubo Leslie A Lange Carl D Langefeld Claudia Langenberg Lenore J Launer Jin-Moo Lee Robin Lemmens Didier Leys Cathryn M Lewis Wei-Yu Lin Arne G Lindgren Erik Lorentzen Patrik K Magnusson Jane Maguire Ani Manichaikul Patrick F McArdle James F Meschia Braxton D Mitchell Thomas H Mosley Michael A Nalls Toshiharu Ninomiya Martin J O'Donnell Bruce M Psaty Sara L Pulit Kristiina Rannikmäe Alexander P Reiner Kathryn M Rexrode Kenneth Rice Stephen S Rich Paul M Ridker Natalia S Rost Peter M Rothwell Jerome I Rotter Tatjana Rundek Ralph L Sacco Saori Sakaue Michele M Sale Veikko Salomaa Bishwa R Sapkota Reinhold Schmidt Carsten O Schmidt Ulf Schminke Pankaj Sharma Agnieszka Slowik Cathie L M Sudlow Christian Tanislav Turgut Tatlisumak Kent D Taylor Vincent N S Thijs Gudmar Thorleifsson Unnur Thorsteinsdottir Steffen Tiedt Stella Trompet Christophe Tzourio Cornelia M van Duijn Matthew Walters Nicholas J Wareham Sylvia Wassertheil-Smoller James G Wilson Kerri L Wiggins Qiong Yang Salim Yusuf Joshua C Bis Tomi Pastinen Arno Ruusalepp Eric E Schadt Simon Koplev Johan L M Björkegren Veronica Codoni Mete Civelek Nicholas L Smith David A Trégouët Ingrid E Christophersen Carolina Roselli Steven A Lubitz Patrick T Ellinor E Shyong Tai Jaspal S Kooner Norihiro Kato Jiang He Pim van der Harst Paul Elliott John C Chambers Fumihiko Takeuchi Andrew D Johnson Dharambir K Sanghera Olle Melander Christina Jern Daniel Strbian Israel Fernandez-Cadenas W T Longstreth Arndt Rolfs Jun Hata Daniel Woo Jonathan Rosand Guillaume Pare Jemma C Hopewell Danish Saleheen Kari Stefansson Bradford B Worrall Steven J Kittner Sudha Seshadri Myriam Fornage Hugh S Markus Joanna M M Howson Yoichiro Kamatani Stephanie Debette Martin Dichgans

Nat Genet 2018 04 12;50(4):524-537. Epub 2018 Mar 12.

Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.

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http://dx.doi.org/10.1038/s41588-018-0058-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968830PMC
April 2018

A Smoking-Associated miRNA-mRNA Coexpression Network.

Authors:
Mete Civelek

Circ Cardiovasc Genet 2017 10;10(5)

From the Department of Biomedical Engineering, Center for Public Health Genomics, University of Virginia, Charlottesville.

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https://www.ahajournals.org/doi/10.1161/CIRCGENETICS.117.001
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http://dx.doi.org/10.1161/CIRCGENETICS.117.001914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679253PMC
October 2017

Identification of breast cancer associated variants that modulate transcription factor binding.

PLoS Genet 2017 Sep 28;13(9):e1006761. Epub 2017 Sep 28.

Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1006761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619690PMC
September 2017

Functional Characterization of the Coronary Artery Disease Risk Locus.

Circulation 2017 Aug 9;136(5):476-489. Epub 2017 May 9.

From Deutsches Herzzentrum München, Klinik für Herz-und Kreislauferkrankungen, Technische Universität München, Munich, Germany (T.K., J.W., B.W., B.V., S.V.A., T.A.D., H.B.S., P.M.R., A.K., H.S.); Sektion für Funktionelle Genetik am Institut für Humangenetik, Universität zu Lübeck, Germany (J. Eckhold, R.H., F.J.K.); Center for Public Health Genomics, Department of Biomedical Engineering, University of Virginia, Charlottesville (R.A., M.C.); DZHK e.V. (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany (A.K., H.S.); Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY (J.L.M.B.); Department of Physiology, Institute of Biomedicine and Translational Medicine, University of Tartu, Estonia (J.L.M.B.); Institut für Integrative und Experimentelle Genomik and Universitäres Herzzentrum Lübeck, Universität zu Lübeck, Germany (J. Erdmann); DZHK e.V. (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Lübeck, Germany (J. Erdmann, F.J.K.); and Departments of Human Genetics and Medicine, David Geffen School of Medicine, University of California, Los Angeles (A.J.L., M.C.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.024152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560301PMC
August 2017

Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits.

Am J Hum Genet 2017 Mar;100(3):428-443

Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029297173002
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http://dx.doi.org/10.1016/j.ajhg.2017.01.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339333PMC
March 2017

A Suite of Tools for Biologists That Improve Accessibility and Visualization of Large Systems Genetics Datasets: Applications to the Hybrid Mouse Diversity Panel.

Methods Mol Biol 2017 ;1488:153-188

Department of Medicine/Division of Cardiology, University of California, Campus - 167917, BH-307 CHS, 10833 Le Conte Ave., Los Angeles, CA, USA.

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http://link.springer.com/10.1007/978-1-4939-6427-7_7
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http://dx.doi.org/10.1007/978-1-4939-6427-7_7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615944PMC
January 2018

Knowledge of Primary Care Physicians About Breast-Cancer-Related Lymphedema: Turkish Perspective.

J Cancer Educ 2016 12;31(4):687-692

Department of Family Medicine, Dıskapı Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey.

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http://dx.doi.org/10.1007/s13187-015-0880-6DOI Listing
December 2016

Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function.

Cardiovasc Res 2016 12 30;112(3):702-713. Epub 2016 Sep 30.

Sorbonne Universités, UPMC, INSERM UMR_S 1166, ICAN, Genomics and Pathophysiology of Cardiovascular Diseases Team, 91 Bd de l'Hôpital, 75013 Paris, France

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http://dx.doi.org/10.1093/cvr/cvw217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157138PMC
December 2016

Preservation Analysis of Macrophage Gene Coexpression Between Human and Mouse Identifies PARK2 as a Genetically Controlled Master Regulator of Oxidative Phosphorylation in Humans.

G3 (Bethesda) 2016 10 13;6(10):3361-3371. Epub 2016 Oct 13.

Sorbonne Universités, Université Pierre et Marie Curie, Paris 06, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche en Santé 1166, F-75013 Paris, France Institute for Cardiometabolism and Nutrition, F-75013 Paris, France

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http://dx.doi.org/10.1534/g3.116.033894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068955PMC
October 2016

Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease.

Cell Syst 2016 03 3;2(3):196-208. Epub 2016 Mar 3.

Cardiovascular Genomics Group, Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden; Department of Physiology, Institute of Biomedicine and Translation Medicine, University of Tartu, 51014 Tartu, Estonia; Clinical Gene Networks AB, 114 44 Stockholm, Sweden; Department of Genetics & Genomic Sciences, Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Cardiovascular Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2016.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855300PMC
March 2016

Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains.

PLoS Genet 2015 Dec 22;11(12):e1005711. Epub 2015 Dec 22.

Departments of Medicine, Human Genetics, and Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1005711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687930PMC
December 2015

Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis.

J Exp Med 2015 Nov 9;212(12):2147-63. Epub 2015 Nov 9.

Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095 Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095

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http://dx.doi.org/10.1084/jem.20150603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647265PMC
November 2015

Prediction of Causal Candidate Genes in Coronary Artery Disease Loci.

Arterioscler Thromb Vasc Biol 2015 Oct 20;35(10):2207-17. Epub 2015 Aug 20.

From the Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Lübeck, Germany (I.B., B.R., J.E.); DZHK (German Research Centre for Cardiovascular Research), Partner Site Hamburg/Lübeck/Kiel, Lübeck, Germany (I.B., B.R., J.E.); University Heart Center Lübeck, Lübeck, Germany (I.B., B.R., J.E.); Departments of Medicine (M.C., A.J.L.) and Integrative Biology and Physiology (Y.Z., X.Y.), University of California, Los Angeles; Deutsches Herzzentrum München, Klinik für Herz-und Kreislauferkrankungen, Technische Universität München, Munich, Germany (B.V., L.Z., H.S.); Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY (A.D.N., K.H., E.E.S., J.L.M.B.); Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY (A.D.N., K.H., E.E.S., J.L.M.B.); Cardiovascular Epidemiology and Human Genomics Branch, National Heart, Lung, and Blood Institute, The Framingham Heart Study, Framingham, MA (A.D.J.); Unité Mixte de Recherche en Santé (UMR_S) 1166, Institut National pour la Santé et la Recherche Médicale (INSERM), Paris, France (V.C., D.-A.T.); UMR_S 1166, Team Genomics and Pathophysiology of Cardiovascular Diseases, Sorbonne Universités, Université Pierre et Marie Curie (UPMC Univ Paris 06), Paris, France (V.C., D.-A.T.); Institute for Cardiometabolism and Nutrition (ICAN), Paris, France (V.C., D.-A.T.); Department of Cardiovascular Sciences, University of Leicester, and NIHR Leicester Cardiovascular Biomedical Research Unit, BHF Cardiovascular Research Centre, Leicester, United Kingdom (T.R.W., S.E.H., N.J.S.); Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden (H.F.A., J.L.M.B.); and Department of Molecular and Experimental Medicine, Scripps Translational Science Institute, La Jolla, CA (E.J.T.).

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http://dx.doi.org/10.1161/ATVBAHA.115.306108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583353PMC
October 2015

Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo.

Cell 2015 Jul;162(1):33-44

Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://www.cell.com/cms/attachment/2035445924/2050997248/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S009286741500709
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http://dx.doi.org/10.1016/j.cell.2015.06.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493773PMC
July 2015

Genomic analysis of ADAR1 binding and its involvement in multiple RNA processing pathways.

Nat Commun 2015 Mar 9;6:6355. Epub 2015 Mar 9.

Department of Integrative Biology and Physiology and the Molecular Biology Institute, Los Angeles, California, 90095.

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http://www.nature.com/articles/ncomms7355
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http://dx.doi.org/10.1038/ncomms7355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355961PMC
March 2015

From hairballs to an understanding of transendothelial migration of monocytes in atherosclerosis.

Arterioscler Thromb Vasc Biol 2014 Sep;34(9):1809-10

From the Departments of Medicine (M.C., A.J.L.), Microbiology, Immunology and Molecular Genetics, and Human Genetics (A.J.L.), University of California, Los Angeles.

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http://dx.doi.org/10.1161/ATVBAHA.114.304151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142522PMC
September 2014

The WWOX gene modulates high-density lipoprotein and lipid metabolism.

Circ Cardiovasc Genet 2014 Aug 28;7(4):491-504. Epub 2014 May 28.

From the Cardiovascular Research Laboratories, Department of Biochemistry, Faculty of Medicine, Division of Cardiology, McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada (I.I., H.Y.C., I.R., Z.A., J.G.); Department of Human Genetics (M.V.P.L.R., D.W.-V., E.N., P.P.) and Department of Medicine (M.V.P.L.R., D.W.-V., E.N., P.P.), David Geffen School of Medicine at University of California at Los Angeles; Department of Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Smithville (H.K., J.L., C.M.A.); The Lautenberg Cancer Research Center, Department of Immunology and Cancer Research, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel (M.A.O., M.A.-R., R.I.A.); The Lautenberg Center for Immunology and Cancer Research, Department of Immunology and Cancer Research-IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel and Al-Quds-Bard College for Arts and Sciences, Al-Quds University, East Jerusalem-Abu Dis, Palestine (Z.S.); and Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus (M.C., C.M.C., R.I.A.).

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http://dx.doi.org/10.1161/CIRCGENETICS.113.000248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315188PMC
August 2014

Systems genetics approaches to understand complex traits.

Nat Rev Genet 2014 Jan 3;15(1):34-48. Epub 2013 Dec 3.

1] Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles. [2] Department of Human Genetics, University of California, Los Angeles. [3] Department of Medicine, A2-237 Center for Health Sciences, University of California, Los Angeles, California 90095-1679, USA.

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http://www.nature.com/articles/nrg3575
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http://dx.doi.org/10.1038/nrg3575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934510PMC
January 2014

The atherosusceptible endothelium: endothelial phenotypes in complex haemodynamic shear stress regions in vivo.

Cardiovasc Res 2013 Jul 25;99(2):315-27. Epub 2013 Apr 25.

Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1093/cvr/cvt101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695748PMC
July 2013

Coronary artery endothelial transcriptome in vivo: identification of endoplasmic reticulum stress and enhanced reactive oxygen species by gene connectivity network analysis.

Circ Cardiovasc Genet 2011 Jun 14;4(3):243-52. Epub 2011 Apr 14.

Department of Bioengineering, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1161/CIRCGENETICS.110.958926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116084PMC
June 2011

Discovery approaches to UPR in athero-susceptible endothelium in vivo.

Methods Enzymol 2011 ;489:109-26

Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1016/B978-0-12-385116-1.00007-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833809PMC
May 2011

Endoplasmic reticulum stress, redox, and a proinflammatory environment in athero-susceptible endothelium in vivo at sites of complex hemodynamic shear stress.

Antioxid Redox Signal 2011 Sep 25;15(5):1427-32. Epub 2011 May 25.

Institute for Medicine & Engineering, University of Pennsylvania, Philadelphia, PA 19041, USA.

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http://www.liebertpub.com/doi/10.1089/ars.2010.3741
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http://dx.doi.org/10.1089/ars.2010.3741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144426PMC
September 2011

MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro.

Proc Natl Acad Sci U S A 2010 Jul 12;107(30):13450-5. Epub 2010 Jul 12.

Institute for Medicine and Engineering, Center for Bioinformatics, and Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.1002120107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922125PMC
July 2010

Endothelial heterogeneity associated with regional athero-susceptibility and adaptation to disturbed blood flow in vivo.

Semin Thromb Hemost 2010 Apr 8;36(3):265-75. Epub 2010 Jun 8.

Institute for Medicine and Engineering, Department of Pathology & Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1055/s-0030-1253449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817717PMC
April 2010

Chronic endoplasmic reticulum stress activates unfolded protein response in arterial endothelium in regions of susceptibility to atherosclerosis.

Circ Res 2009 Aug 6;105(5):453-61. Epub 2009 Aug 6.

Institute for Medicine and Engineering, University of Pennsylvania, 1010 Vagelos Laboratories, 3340 Smith Walk, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.109.203711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746924PMC
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Smooth muscle cells contract in response to fluid flow via a Ca2+-independent signaling mechanism.

J Appl Physiol (1985) 2002 Dec 30;93(6):1907-17. Epub 2002 Aug 30.

Biomolecular Transport Dynamics Laboratory, Department of Chemical Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.

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http://dx.doi.org/10.1152/japplphysiol.00988.2001DOI Listing
December 2002

Intracellular calcium changes in rat aortic smooth muscle cells in response to fluid flow.

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Department of Chemical Engineering, The Pennsylvania State University, University Park 16802, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472337PMC
http://dx.doi.org/10.1114/1.1470179DOI Listing
March 2002