Merrill J Egorin

Merrill J Egorin

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Merrill J Egorin

Merrill J Egorin

Publications by authors named "Merrill J Egorin"

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Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma.

PLoS One 2015 6;10(8):e0134426. Epub 2015 Aug 6.

Department of Neurological Surgery, University of Virginia, PO BOX 800212, Charlottesville, VA 22908, United States of America; Neuro-Oncology Branch, National Cancer Institute, NIH, 9030 Old Georgetown Rd, B82/Rm225, Bethesda, MD 20892, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134426PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527706PMC
May 2016

Characterization of the metabolism of benzaldehyde dimethane sulfonate (NSC 281612, DMS612).

Cancer Chemother Pharmacol 2015 Sep 21;76(3):537-46. Epub 2015 Jul 21.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Hillman Research Pavilion, Room G27E, 5117 Centre Avenue, Pittsburgh, PA, 15213-1863, USA.

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http://link.springer.com/content/pdf/10.1007%2Fs00280-015-28
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http://link.springer.com/10.1007/s00280-015-2828-2
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http://dx.doi.org/10.1007/s00280-015-2828-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545378PMC
September 2015

Calcium carbonate does not affect nilotinib pharmacokinetics in healthy volunteers.

Cancer Chemother Pharmacol 2013 Nov 14;72(5):1143-7. Epub 2013 Sep 14.

Molecular Therapeutics/Drug Discovery Program, University of Pittsburgh Cancer Institute, Hillman Research Pavilion, Room G27D, 5117 Centre Avenue, Pittsburgh, PA, 15213-1863, USA.

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http://dx.doi.org/10.1007/s00280-013-2283-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818249PMC
November 2013

Formation of active products of benzaldehyde dimethane sulfonate (NSC 281612, DMS612) in human blood and plasma and their activity against renal cell carcinoma lines.

Cancer Chemother Pharmacol 2013 Jan 5;71(1):73-83. Epub 2012 Oct 5.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1007/s00280-012-1980-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536923PMC
January 2013

The relationship of polymorphisms in ABCC2 and SLCO1B3 with docetaxel pharmacokinetics and neutropenia: CALGB 60805 (Alliance).

Pharmacogenet Genomics 2013 Jan;23(1):29-33

Sections of Clinical Pharmacology and Hematology/Oncology, Department of Medicine, The Geisel School of Medicine at Dartmouth, The Norris Cotton Cancer Center, Lebanon, NH 03756, USA.

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http://dx.doi.org/10.1097/FPC.0b013e32835b16d8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647228PMC
January 2013

Renal dysfunction in a renal transplant patient treated concurrently with cyclosporine and imatinib.

Invest New Drugs 2012 Dec 25;30(6):2400-2. Epub 2011 Nov 25.

Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1007/s10637-011-9769-3DOI Listing
December 2012

Application of a single-objective, hybrid genetic algorithm approach to pharmacokinetic model building.

J Pharmacokinet Pharmacodyn 2012 Aug 6;39(4):393-414. Epub 2012 Jul 6.

Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://dx.doi.org/10.1007/s10928-012-9258-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400037PMC
August 2012

Population pharmacokinetic analysis of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) in adult patients with solid tumors.

Cancer Chemother Pharmacol 2012 Jul 27;70(1):201-5. Epub 2012 Mar 27.

Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, 1001 W. 10th Street, WD W7123, Indianapolis, IN 46202, USA.

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http://link.springer.com/10.1007/s00280-012-1859-1
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http://dx.doi.org/10.1007/s00280-012-1859-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383947PMC
July 2012

Will imatinib compromise reproductive capacity?

Oncologist 2011 23;16(10):1422-7. Epub 2011 Sep 23.

UCSF Medical Center, Center for Reproductive Health, San Francisco, California, USA.

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http://dx.doi.org/10.1634/theoncologist.2011-0137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228060PMC
April 2012

Phase I study of vorinostat (suberoylanilide hydroxamic acid, NSC 701852) in combination with docetaxel in patients with advanced and relapsed solid malignancies.

Invest New Drugs 2012 Feb 5;30(1):249-57. Epub 2010 Aug 5.

Division of Hematology/Oncology, Department of Internal Medicine, Weill Cornell Medical College, 525 East 68th Street, 3rd floor, New York, NY 10065, USA.

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http://dx.doi.org/10.1007/s10637-010-9503-6DOI Listing
February 2012

Plasma pharmacokinetics and oral bioavailability of the 3,4,5,6-tetrahydrouridine (THU) prodrug, triacetyl-THU (taTHU), in mice.

Cancer Chemother Pharmacol 2011 Feb 5;67(2):421-30. Epub 2010 May 5.

Molecular Therapeutics/Drug Discovery Program, University of Pittsburgh Cancer Institute, Hillman Research Pavilion, Room G27D, 5117 Centre Avenue, Pittsburgh, PA 5213-1863, USA.

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http://dx.doi.org/10.1007/s00280-010-1337-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954253PMC
February 2011

In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max dimerization.

J Pharmacol Exp Ther 2010 Dec 26;335(3):715-27. Epub 2010 Aug 26.

Molecular Therapeutics/Drug Discovery Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1124/jpet.110.170555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993546PMC
December 2010

Liquid chromatography-tandem mass spectrometric assay for the quantitation in human plasma of the novel indenoisoquinoline topoisomerase I inhibitors, NSC 743400 and NSC 725776.

J Pharm Biomed Anal 2010 Sep 23;52(5):714-20. Epub 2010 Feb 23.

Molecular Therapeutics/Drug Discovery Program, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1016/j.jpba.2010.02.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865235PMC
September 2010

Safety, efficacy, pharmacokinetics, and pharmacodynamics of the combination of sorafenib and tanespimycin.

Clin Cancer Res 2010 Jul 4;16(14):3795-804. Epub 2010 Jun 4.

Barbara Ann Karmanos Cancer Institute, Department of Medicine, Wayne State University, Detroit, Michigan 48201, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-0503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909581PMC
July 2010

Embryonic stem cells lacking the epigenetic regulator Cfp1 are hypersensitive to DNA-damaging agents and exhibit decreased Ape1/Ref-1 protein expression and endonuclease activity.

DNA Repair (Amst) 2009 Dec 15;8(12):1411-23. Epub 2009 Oct 15.

Herman B Wells Center for Pediatric Research, Section of Pediatric Hematology/Oncology, Department of Pediatrics, Indiana University School of Medicine, 1044W. Walnut St. R4-W312, Indianapolis, IN 46202, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S156878640900252
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http://dx.doi.org/10.1016/j.dnarep.2009.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787775PMC
December 2009

Drug plasma monitoring in CML and GIST: A case-based discussion.

Clin Adv Hematol Oncol 2009 Nov;7(11):S1, S3-11

University of Pittsburgh Cancer Institute, PA, USA.

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November 2009

Imatinib mesylate pharmacokinetics before and after sleeve gastrectomy in a morbidly obese patient with chronic myeloid leukemia.

Pharmacotherapy 2009 Sep;29(9):1152-6

Division of Hematology, Angelica Ocampo Hospitalization and Clinical Research Center, FUNDALEU (Fundacion para Combatir la Leucemia), Buenos Aires, Argentina.

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http://dx.doi.org/10.1592/phco.29.9.1152DOI Listing
September 2009

Effect of a proton pump inhibitor on the pharmacokinetics of imatinib.

Br J Clin Pharmacol 2009 Sep;68(3):370-4

Molecular Therapeutics/Drug Discovery Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213-1863, USA.

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http://dx.doi.org/10.1111/j.1365-2125.2009.03466.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766475PMC
September 2009

A high-performance liquid chromatography-mass spectrometry assay for quantitation of the tyrosine kinase inhibitor nilotinib in human plasma and serum.

J Chromatogr B Analyt Technol Biomed Life Sci 2009 Jul 21;877(20-21):1894-900. Epub 2009 May 21.

Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1016/j.jchromb.2009.05.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759677PMC
July 2009

Disposition of temozolomide in a patient with glioblastoma multiforme after gastric bypass surgery.

J Neurooncol 2009 Jun 6;93(2):279-83. Epub 2009 Jan 6.

Department of Neurological Surgery, University of Pittsburgh School of Medicine, PA 15261, USA.

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http://dx.doi.org/10.1007/s11060-008-9773-4DOI Listing
June 2009

Interstitial continuous infusion therapy in a malignant glioma model in rats.

Childs Nerv Syst 2009 Jun 11;25(6):655-62. Epub 2009 Feb 11.

Division of Pediatric Neurosurgery, Children's Memorial Hospital, Chicago, IL 60614, USA.

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http://link.springer.com/10.1007/s00381-008-0805-3
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http://dx.doi.org/10.1007/s00381-008-0805-3DOI Listing
June 2009

Effect of antacid on imatinib absorption.

Cancer Chemother Pharmacol 2009 Feb 24;63(3):525-8. Epub 2008 May 24.

Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh School of Medicine, PA 15213, USA.

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http://dx.doi.org/10.1007/s00280-008-0778-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715160PMC
February 2009

Intraperitoneal gemcitabine pharmacokinetics: a pilot and pharmacokinetic study in patients with advanced adenocarcinoma of the pancreas.

Cancer Chemother Pharmacol 2008 Sep 27;62(4):647-53. Epub 2007 Nov 27.

Division of Surgical Oncology, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.

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http://dx.doi.org/10.1007/s00280-007-0647-9DOI Listing
September 2008

Liquid chromatography-mass spectrometric assay for the quantitation in human plasma of ABT-888, an orally available, small molecule inhibitor of poly(ADP-ribose) polymerase.

J Chromatogr B Analyt Technol Biomed Life Sci 2008 Sep 31;872(1-2):141-7. Epub 2008 Jul 31.

Molecular Therapeutics, Drug Discovery Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1016/j.jchromb.2008.07.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634284PMC
September 2008

Tumor, tissue, and plasma pharmacokinetic studies and antitumor response studies of docetaxel in combination with 9-nitrocamptothecin in mice bearing SKOV-3 human ovarian xenografts.

Cancer Chemother Pharmacol 2008 Aug 24;62(3):417-26. Epub 2007 Oct 24.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1007/s00280-007-0620-7DOI Listing
August 2008

Plasma pharmacokinetics and oral bioavailability of 3,4,5,6-tetrahydrouridine, a cytidine deaminase inhibitor, in mice.

Cancer Chemother Pharmacol 2008 Aug 15;62(3):457-64. Epub 2007 Nov 15.

Molecular Therapeutics/Drug Discovery Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1007/s00280-007-0625-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677692PMC
August 2008

Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU).

Cancer Chemother Pharmacol 2008 Jul 26;62(2):363-8. Epub 2007 Sep 26.

Molecular Therapeutics/Drug Discovery Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, 15213, USA.

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http://dx.doi.org/10.1007/s00280-007-0603-8DOI Listing
July 2008

Modulation of gemcitabine (2',2'-difluoro-2'-deoxycytidine) pharmacokinetics, metabolism, and bioavailability in mice by 3,4,5,6-tetrahydrouridine.

Clin Cancer Res 2008 Jun;14(11):3529-35

Molecular Therapeutics/Drug Discovery Program, University of Pittsburgh Cancer Institute, Room G.27d, Hillman Research Pavilion, 5117 Centre Avenue, Pittsburgh, PA 15213-1863, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-4885DOI Listing
June 2008

Quantitation of 5-fluorouracil (5-FU) in human plasma by liquid chromatography/electrospray ionization tandem mass spectrometry.

Rapid Commun Mass Spectrom 2008 ;22(2):224-30

Molecular Therapeutics/Drug Discovery Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1002/rcm.3362DOI Listing
April 2008

Population pharmacokinetc/pharmacodynamic modeling of paclitaxel and carboplatin in ovarian cancer.

Authors:
Merrill J Egorin

Clin Cancer Res 2008 Apr;14(8):2517; author reply 2517-8

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http://dx.doi.org/10.1158/1078-0432.CCR-07-5049DOI Listing
April 2008

Liquid chromatography-mass spectrometric assay for quantitation of the short-chain fatty acid, 2,2-dimethylbutyrate (NSC 741804), in rat plasma.

J Chromatogr B Analyt Technol Biomed Life Sci 2008 Feb 8;862(1-2):168-74. Epub 2007 Dec 8.

Molecular Therapeutics/Drug Discovery Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1016/j.jchromb.2007.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2254528PMC
February 2008

Pharmacology and antitumor activity of a quinolinedione Cdc25 phosphatase inhibitor DA3003-1 (NSC 663284).

Anticancer Res 2007 Sep-Oct;27(5A):3067-73

Departments of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, 15261, USA.

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November 2007

Phase I and pharmacokinetic study of imatinib mesylate (Gleevec) and gemcitabine in patients with refractory solid tumors.

Clin Cancer Res 2007 Oct;13(19):5876-82

The Cancer Institute of New Jersey, University of Medicine & Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-07-0883DOI Listing
October 2007

Quantitative determination of the cytidine deaminase inhibitor tetrahydrouridine (THU) in mouse plasma by liquid chromatography/electrospray ionization tandem mass spectrometry.

Rapid Commun Mass Spectrom 2007 ;21(13):1991-7

Molecular Therapeutics/Drug Discovery Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1002/rcm.3054DOI Listing
August 2007

Imatinib mesylate inhibits antigen-specific memory CD8 T cell responses in vivo.

J Immunol 2007 Feb;178(4):2028-37

Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.4049/jimmunol.178.4.2028DOI Listing
February 2007

Pharmacokinetics, metabolism, and oral bioavailability of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine in mice.

Clin Cancer Res 2006 Dec 30;12(24):7483-91. Epub 2006 Nov 30.

Molecular Therapeutics/Drug Discovery Program, University of Pittsburgh Cancer Institute, PA 15213-1863, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-1250DOI Listing
December 2006

Cisplatin preferentially binds mitochondrial DNA and voltage-dependent anion channel protein in the mitochondrial membrane of head and neck squamous cell carcinoma: possible role in apoptosis.

Clin Cancer Res 2006 Oct;12(19):5817-25

University of Maryland Marlene and Stewart Greenebaum Cancer Center, 22 South Greene Street, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-1037DOI Listing
October 2006

A mass balance and disposition study of the DNA methyltransferase inhibitor zebularine (NSC 309132) and three of its metabolites in mice.

Clin Cancer Res 2006 Oct;12(19):5826-33

Molecular Therapeutics/Drug Discovery Program, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-1234DOI Listing
October 2006

Disposition of 9-nitrocamptothecin and its 9-aminocamptothecin metabolite in relation to ABC transporter genotypes.

Invest New Drugs 2006 Sep;24(5):393-401

Hillman Cancer Research Center, Molecular Therapeutics Drug Discovery Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA.

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http://link.springer.com/10.1007/s10637-006-6335-5
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http://dx.doi.org/10.1007/s10637-006-6335-5DOI Listing
September 2006

A liquid chromatography-electrospray ionization tandem mass spectrometric assay for quantitation of the histone deacetylase inhibitor, vorinostat (suberoylanilide hydroxamicacid, SAHA), and its metabolites in human serum.

J Chromatogr B Analyt Technol Biomed Life Sci 2006 Aug 24;840(2):108-15. Epub 2006 May 24.

Molecular Therapeutics/Drug Discovery Program, University of Pittsburgh Cancer Institute, PA 15213, USA.

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http://dx.doi.org/10.1016/j.jchromb.2006.04.044DOI Listing
August 2006

Disposition of imatinib and its metabolite CGP74588 in a patient with chronic myelogenous leukemia and short-bowel syndrome.

Pharmacotherapy 2006 Jul;26(7):903-7

Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213-1863, USA.

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http://dx.doi.org/10.1592/phco.26.7.903DOI Listing
July 2006

Intermittent dosage of imatinib mesylate in CML patients with a history of significant hematologic toxicity after standard dosing.

Leuk Lymphoma 2006 Jun;47(6):1082-90

Department of Hemato-Oncology, University Hospital Olomouc and Faculty of Medicine, Palacky University in Olomouc, Olomouc, Czech Republic.

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http://dx.doi.org/10.1080/10428190600565057DOI Listing
June 2006

Case 4. Pulmonary stent migration and ingestion in a lung cancer patient.

J Clin Oncol 2006 Mar;24(9):1478-9

University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1200/JCO.2005.01.8218DOI Listing
March 2006

Quantitative determination of zebularine (NSC 309132), a DNA methyltransferase inhibitor, and three metabolites in murine plasma by high-performance liquid chromatography coupled with on-line radioactivity detection.

J Chromatogr B Analyt Technol Biomed Life Sci 2006 Feb 20;831(1-2):147-55. Epub 2005 Dec 20.

Molecular Therapeutics/Drug Discovery Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S157002320500897
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http://dx.doi.org/10.1016/j.jchromb.2005.11.048DOI Listing
February 2006