Merle G Paule

Merle G Paule

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Merle G Paule

Merle G Paule

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Mechanistic studies on ketamine-induced mitochondrial toxicity in zebrafish embryos.

Neurotoxicol Teratol 2018 Sep - Oct;69:63-72. Epub 2017 Dec 7.

Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ntt.2017.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992061PMC
October 2019

Cytotoxicity profile of pristine graphene on brain microvascular endothelial cells.

J Appl Toxicol 2019 Jul 19;39(7):966-973. Epub 2019 Feb 19.

Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR, USA.

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http://doi.wiley.com/10.1002/jat.3786
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http://dx.doi.org/10.1002/jat.3786DOI Listing
July 2019

An Alternative In Vitro Method for Examining Nanoparticle-Induced Cytotoxicity.

Int J Toxicol 2019 Sep/Oct;38(5):385-394. Epub 2019 Jun 24.

Nanotechnology Core Facility, Office of Scientific Coordination, NCTR, FDA, Jefferson, AR, USA.

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http://dx.doi.org/10.1177/1091581819859267DOI Listing
June 2019

Sevoflurane exposure has minimal effect on cognitive function and does not alter microglial activation in adult monkeys.

Neurotoxicology 2019 03 31;71:159-167. Epub 2018 Dec 31.

National Center for Toxicological Research (NCTR)/FDA, Division of Neurotoxicology, 3900 NCTR Road, Jefferson, AR, 72079, United States.

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http://dx.doi.org/10.1016/j.neuro.2018.12.008DOI Listing
March 2019

A randomized controlled laboratory study on the long-term effects of methylphenidate on cardiovascular function and structure in rhesus monkeys.

Pediatr Res 2019 02 17;85(3):398-404. Epub 2018 Dec 17.

Department of Pediatrics, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Oishei Children's Hospital, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14203, USA.

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http://dx.doi.org/10.1038/s41390-018-0256-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779032PMC
February 2019

Early life exposure to extended general anesthesia with isoflurane and nitrous oxide reduces responsivity on a cognitive test battery in the nonhuman primate.

Neurotoxicology 2019 01 14;70:80-90. Epub 2018 Nov 14.

Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, 72079, USA.

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http://dx.doi.org/10.1016/j.neuro.2018.11.005DOI Listing
January 2019

Lipidomics reveals a systemic energy deficient state that precedes neurotoxicity in neonatal monkeys after sevoflurane exposure.

Anal Chim Acta 2018 Dec 30;1037:87-96. Epub 2017 Nov 30.

Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, TX 78229, USA; Department of Medicine, Division of Diabetes, University of Texas Health Science Center at San Antonio, TX 78229, USA; Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, TX 78229, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00032670173133
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http://dx.doi.org/10.1016/j.aca.2017.11.052DOI Listing
December 2018

Electron microscopy techniques employed to explore mitochondrial defects in the developing rat brain following ketamine treatment.

Exp Cell Res 2018 12 18;373(1-2):164-170. Epub 2018 Oct 18.

NCTR/ORA Nanotechnology Core Facility, Office of Scientific Coordination, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2018.10.009DOI Listing
December 2018

Lipid profiling as an effective approach for identifying biomarkers/adverse events associated with pediatric anesthesia.

Toxicol Appl Pharmacol 2018 09 15;354:191-195. Epub 2018 Mar 15.

National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079, USA.

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http://dx.doi.org/10.1016/j.taap.2018.03.017DOI Listing
September 2018

Isolation and Culture of Brain Microvascular Endothelial Cells for In Vitro Blood-Brain Barrier Studies.

Methods Mol Biol 2018 ;1727:315-331

Division of Neurotoxicology, HFT-132, National Center for Toxicological Research/USFDA, Jefferson, AR, USA.

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http://dx.doi.org/10.1007/978-1-4939-7571-6_23DOI Listing
July 2018

Neuropsychological and Behavioral Outcomes after Exposure of Young Children to Procedures Requiring General Anesthesia: The Mayo Anesthesia Safety in Kids (MASK) Study.

Anesthesiology 2018 07;129(1):89-105

From the Departments of Anesthesiology and Perioperative Medicine (D.O.W., S.L.B., S.J.G., R.T.W., J.S., D.H., R.P.F.) Psychology (M.J.Z.) Health Sciences Research (S.K.K., D.R.S., A.C.H., P.J.S.) Mayo Clinic, Rochester, Minnesota the Department of Pediatric Medicine, Baylor College of Medicine, Houston, Texas (R.G.V.) National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas (M.G.P., J.J.C.).

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http://Insights.ovid.com/crossref?an=00000542-201807000-0001
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http://dx.doi.org/10.1097/ALN.0000000000002232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008202PMC
July 2018

Introduction to the special issue "Developmental neurotoxicity associated with pediatric general anesthesia: Preclinical findings".

Neurotoxicol Teratol 2017 Mar - Apr;60. Epub 2017 Feb 4.

Division of Neurotoxicology, National Center for Toxicological Research US FDA, 3900 NCTR Road, Jefferson, AR 72079, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08920362173003
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http://dx.doi.org/10.1016/j.ntt.2017.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771492PMC
June 2018

Characterization of uniaxial high-speed stretch as an in vitro model of mild traumatic brain injury on the blood-brain barrier.

Neurosci Lett 2018 04 16;672:123-129. Epub 2018 Feb 16.

Division of Neurotoxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR, 72079, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043940183009
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http://dx.doi.org/10.1016/j.neulet.2018.02.019DOI Listing
April 2018

Comparison of quantitative T and ADC mapping in the assessment of 3-nitropropionic acid-induced neurotoxicity in rats.

Neurotoxicology 2018 03 7;65:52-59. Epub 2018 Feb 7.

Center for Drug Evaluation and Research, US Food and Drug Administration, White Oak, MD, United States.

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http://dx.doi.org/10.1016/j.neuro.2018.02.004DOI Listing
March 2018

Review of preclinical studies on pediatric general anesthesia-induced developmental neurotoxicity.

Neurotoxicol Teratol 2017 Mar - Apr;60:2-23. Epub 2016 Nov 18.

National Center for Toxicological Research (NCTR)/FDA, Division of Neurotoxicology, 3900 NCTR Road, Jefferson, AR 72079, United States.

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http://dx.doi.org/10.1016/j.ntt.2016.11.005DOI Listing
January 2018

A Working Module for the Neurovascular Unit in the Sexually Dimorphic Nucleus of the Preoptic Area.

Mol Neurobiol 2018 01;55(1):156-163

Division of Neurotoxicology, HFT-132, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA.

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http://dx.doi.org/10.1007/s12035-017-0729-6DOI Listing
January 2018

Downregulation of 14-3-3 Proteins in a Kainic Acid-Induced Neurotoxicity Model.

Mol Neurobiol 2018 01;55(1):122-129

Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR, 72079, USA.

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http://dx.doi.org/10.1007/s12035-017-0724-yDOI Listing
January 2018

Characterization of Biaxial Stretch as an In Vitro Model of Traumatic Brain Injury to the Blood-Brain Barrier.

Mol Neurobiol 2018 01;55(1):258-266

Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, 72079, USA.

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http://dx.doi.org/10.1007/s12035-017-0738-5DOI Listing
January 2018

Decreased Mcl-1 protein level in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice.

Brain Res 2018 Jan 20;1678:432-439. Epub 2017 Nov 20.

Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, United States. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2017.11.014DOI Listing
January 2018

Cyclosporine exacerbates ketamine toxicity in zebrafish: Mechanistic studies on drug-drug interaction.

J Appl Toxicol 2017 Dec 1;37(12):1438-1447. Epub 2017 Jun 1.

Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079, USA.

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http://dx.doi.org/10.1002/jat.3488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859923PMC
December 2017

Positron emission tomography (PET) imaging of nicotine-induced dopamine release in squirrel monkeys using [F]Fallypride.

Drug Alcohol Depend 2017 10 8;179:254-259. Epub 2017 Aug 8.

Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, United States. Electronic address:

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http://dx.doi.org/10.1016/j.drugalcdep.2017.07.013DOI Listing
October 2017

Monoaminergic toxicity induced by cathinone phthalimide: An in vitro study.

Neurosci Lett 2017 Aug 3;655:76-81. Epub 2017 Jul 3.

Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Rd, HFT-132, Jefferson, AR, 72079, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043940173055
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http://dx.doi.org/10.1016/j.neulet.2017.06.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176714PMC
August 2017

Relationship between ketamine-induced developmental neurotoxicity and NMDA receptor-mediated calcium influx in neural stem cell-derived neurons.

Neurotoxicology 2017 May 27;60:254-259. Epub 2016 Apr 27.

Office of the Director, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079, USA.

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http://dx.doi.org/10.1016/j.neuro.2016.04.015DOI Listing
May 2017

Acetyl L-carnitine targets adenosine triphosphate synthase in protecting zebrafish embryos from toxicities induced by verapamil and ketamine: An in vivo assessment.

J Appl Toxicol 2017 02 18;37(2):192-200. Epub 2016 May 18.

Division of Neurotoxicology, National Center for Toxicological, Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA.

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http://dx.doi.org/10.1002/jat.3340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115992PMC
February 2017

Distinct effects of ketamine and acetyl L-carnitine on the dopamine system in zebrafish.

Neurotoxicol Teratol 2016 Mar-Apr;54:52-60. Epub 2016 Feb 16.

Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ntt.2016.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924529PMC
December 2016

Brain endothelial dysfunction following pyrithiamine induced thiamine deficiency in the rat.

Neurotoxicology 2016 12 28;57:298-309. Epub 2016 Oct 28.

Office of Testing & Research, CDER/FDA, White Oak, MD-20993, USA.

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http://dx.doi.org/10.1016/j.neuro.2016.10.014DOI Listing
December 2016

Single and repeated exposures to the volatile anesthetic isoflurane do not impair operant performance in aged rats.

Neurotoxicology 2016 09 3;56:159-169. Epub 2016 Aug 3.

National Center for Toxicological Research (NCTR)/FDA, Division of Neurotoxicology, 3900 NCTR Road, Jefferson, AR 72079, United States.

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http://dx.doi.org/10.1016/j.neuro.2016.07.012DOI Listing
September 2016

Longitudinal diffusion tensor imaging of the rat brain after hexachlorophene exposure.

Neurotoxicology 2016 09 20;56:225-232. Epub 2016 Aug 20.

Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, United States. Electronic address:

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http://dx.doi.org/10.1016/j.neuro.2016.08.011DOI Listing
September 2016

Protein Kinases and Parkinson's Disease.

Int J Mol Sci 2016 Sep 20;17(9). Epub 2016 Sep 20.

Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

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http://dx.doi.org/10.3390/ijms17091585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037850PMC
September 2016

Oral Administration of Thioflavin T Prevents Beta Amyloid Plaque Formation in Double Transgenic AD Mice.

Curr Alzheimer Res 2015 ;12(9):837-46

National Center for Toxicological Research/FDA, 3900 NCTR Road, HFT-132, Jefferson, AR-72079, USA.

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http://dx.doi.org/10.2174/156720501209151019105647DOI Listing
August 2016

In Vivo Monitoring of Sevoflurane-induced Adverse Effects in Neonatal Nonhuman Primates Using Small-animal Positron Emission Tomography.

Anesthesiology 2016 07;125(1):133-46

From the Divisions of Neurotoxicology (X.Z., S.L., G.D.N., M.G.P., F.L., T.A.P., C.W.) and Bioinformatics and Biostatistics (M.P.M.) and Priority One Services (R.C., J.T.), National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas; 3D Imaging, LLC, Little Rock, Arkansas (M.S.B., S.M.A., C.C.B.); and Center for Drug Evaluation and Research/U.S. Food and Drug Administration, Silver Spring, Maryland (J.P.H., W.S.).

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http://dx.doi.org/10.1097/ALN.0000000000001154DOI Listing
July 2016

The Reinforcing Effects of Nicotine in Humans and Nonhuman Primates: A Review of Intravenous Self-Administration Evidence and Future Directions for Research.

Nicotine Tob Res 2015 Nov 10;17(11):1297-310. Epub 2015 Feb 10.

National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR.

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http://dx.doi.org/10.1093/ntr/ntv002DOI Listing
November 2015

Estrogen Selectively Mobilizes Neural Stem Cells in the Third Ventricle Stem Cell Niche of Postnatal Day 21 Rats.

Mol Neurobiol 2015 Oct;52(2):927-33

HFT-132, Division of Neurotoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR, 72079, USA,

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http://dx.doi.org/10.1007/s12035-015-9244-9DOI Listing
October 2015

Ketamine-Induced Toxicity in Neurons Differentiated from Neural Stem Cells.

Mol Neurobiol 2015 Oct 9;52(2):959-69. Epub 2015 Jun 9.

Office of the Director, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR, 72079, USA,

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http://dx.doi.org/10.1007/s12035-015-9248-5DOI Listing
October 2015

Potential Adverse Effects of Prolonged Sevoflurane Exposure on Developing Monkey Brain: From Abnormal Lipid Metabolism to Neuronal Damage.

Toxicol Sci 2015 Oct 23;147(2):562-72. Epub 2015 Jul 23.

Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute at Lake Nona, Orlando, FL 32827; and.

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http://dx.doi.org/10.1093/toxsci/kfv150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707202PMC
October 2015

Pre- and postnatal bisphenol A treatment does not alter the number of tyrosine hydroxylase-positive cells in the anteroventral periventricular nucleus (AVPV) of weanling male and female rats.

Brain Res 2015 Oct 20;1624:1-8. Epub 2015 Jul 20.

Division of Neurotoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR 72079, United States. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2015.07.013DOI Listing
October 2015

Opposing effects of ketamine and acetyl L-carnitine on the serotonergic system of zebrafish.

Neurosci Lett 2015 Oct 10;607:17-22. Epub 2015 Sep 10.

Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2015.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955573PMC
October 2015

Quantitative Assessment of MRI T2 Response to Kainic Acid Neurotoxicity in Rats in vivo.

Toxicol Sci 2015 Jul 21;146(1):183-91. Epub 2015 Apr 21.

*Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas and Office of Testing and Research, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, White Oak, Maryland.

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http://dx.doi.org/10.1093/toxsci/kfv083DOI Listing
July 2015

Zebrafish model in drug safety assessment.

Curr Pharm Des 2014 ;20(34):5416-29

Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.

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http://dx.doi.org/10.2174/1381612820666140205145658DOI Listing
June 2015

Effects of silver nanoparticles on human and rat embryonic neural stem cells.

Front Neurosci 2015 8;9:115. Epub 2015 Apr 8.

Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration Jefferson, AR, USA.

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http://dx.doi.org/10.3389/fnins.2015.00115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389354PMC
April 2015

Developmental toxicity assay using high content screening of zebrafish embryos.

J Appl Toxicol 2015 Mar 28;35(3):261-72. Epub 2014 May 28.

Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079, USA.

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http://dx.doi.org/10.1002/jat.3029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957247PMC
March 2015

The use of MRI to assist the section selections for classical pathology assessment of neurotoxicity.

Regul Toxicol Pharmacol 2014 Dec 28;70(3):641-7. Epub 2014 Sep 28.

Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States.

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http://dx.doi.org/10.1016/j.yrtph.2014.09.010DOI Listing
December 2014

Positron Emission Tomography with [(18)F]FLT Revealed Sevoflurane-Induced Inhibition of Neural Progenitor Cell Expansion in vivo.

Front Neurol 2014 17;5:234. Epub 2014 Nov 17.

Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration , Jefferson, AR , USA.

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http://dx.doi.org/10.3389/fneur.2014.00234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233913PMC
December 2014

Acetyl L-carnitine protects motor neurons and Rohon-Beard sensory neurons against ketamine-induced neurotoxicity in zebrafish embryos.

Neurotoxicol Teratol 2013 Sep-Oct;39:69-76. Epub 2013 Jul 26.

Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.

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http://dx.doi.org/10.1016/j.ntt.2013.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467697PMC
November 2014

Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson's disease mouse model.

Neurotoxicology 2014 Sep 23;44:250-62. Epub 2014 Jul 23.

Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR 72079, United States.

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http://dx.doi.org/10.1016/j.neuro.2014.07.006DOI Listing
September 2014

In vitro detection of cytotoxicity using FluoroJade-C.

Toxicol In Vitro 2014 Jun 22;28(4):469-72. Epub 2014 Jan 22.

Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, United States.

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http://dx.doi.org/10.1016/j.tiv.2014.01.007DOI Listing
June 2014

Ketamine attenuates cytochrome p450 aromatase gene expression and estradiol-17β levels in zebrafish early life stages.

J Appl Toxicol 2014 May 20;34(5):480-8. Epub 2013 May 20.

Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR road, Jefferson, AR, 72079, USA; Toxicologic Pathology Associates, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR road, Jefferson, AR, 72079, USA.

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http://dx.doi.org/10.1002/jat.2888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474754PMC
May 2014

Protective effect of acetyl-L-carnitine on propofol-induced toxicity in embryonic neural stem cells.

Neurotoxicology 2014 May 2;42:49-57. Epub 2014 Apr 2.

Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuro.2014.03.011DOI Listing
May 2014

Comparison of delayed matching-to-sample performance in monkeys and children.

Behav Processes 2014 Mar 17;103:261-8. Epub 2014 Jan 17.

Division of Neurotoxicology, National Center for Toxicological Research, FDA, United States; Department of Psychology, Hendrix College, United States.

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http://dx.doi.org/10.1016/j.beproc.2014.01.002DOI Listing
March 2014

K114 inhibits A-beta aggregation and inflammation in vitro and in vivo in AD/Tg mice.

Curr Alzheimer Res 2014 Mar;11(3):299-308

Division of Neurotoxicology, National Center for Toxicological Research (NCTR)/FDA, Jefferson, AR 72079, USA.

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http://dx.doi.org/10.2174/1567205011666140220125324DOI Listing
March 2014

Neurovascular changes in acute, sub-acute and chronic mouse models of Parkinson's disease.

Curr Neurovasc Res 2014 Feb;11(1):48-61

Division of Neurotoxicology, National Center for Toxicological Research/FDA, Bldg. 53D, HFT-32, Jefferson-AR-72079, USA.

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http://dx.doi.org/10.2174/1567202610666131124234506DOI Listing
February 2014

Utilization of neural stem cell-derived models to study anesthesia-related toxicity and preventative approaches.

Mol Neurobiol 2013 Oct 12;48(2):302-7. Epub 2013 Jul 12.

Division of Neurotoxicology, National Center for Toxicological Research (NCTR)/FDA, Jefferson, AR, USA,

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http://dx.doi.org/10.1007/s12035-013-8501-zDOI Listing
October 2013

In situ demonstration of Fluoro-Turquoise conjugated gelatin for visualizing brain vasculature and endothelial cells and their characterization in normal and kainic acid exposed animals.

J Neurosci Methods 2013 Oct 14;219(2):276-84. Epub 2013 Aug 14.

Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR 72079, USA.

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http://dx.doi.org/10.1016/j.jneumeth.2013.07.020DOI Listing
October 2013

Application of microPET imaging approaches in the study of pediatric anesthetic-induced neuronal toxicity.

J Appl Toxicol 2013 Sep 11;33(9):861-8. Epub 2013 Feb 11.

Division of Neurotoxicology, National Center for Toxicological Research (NCTR)/FDA, Jefferson, AR 72079, USA.

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http://doi.wiley.com/10.1002/jat.2857
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http://dx.doi.org/10.1002/jat.2857DOI Listing
September 2013

Role of neural stem cell activity in postweaning development of the sexually dimorphic nucleus of the preoptic area in rats.

PLoS One 2013 30;8(1):e54927. Epub 2013 Jan 30.

Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054927PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559780PMC
July 2013

Ketamine induces motor neuron toxicity and alters neurogenic and proneural gene expression in zebrafish.

J Appl Toxicol 2013 Jun 2;33(6):410-7. Epub 2011 Nov 2.

Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.

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http://doi.wiley.com/10.1002/jat.1751
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http://dx.doi.org/10.1002/jat.1751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474752PMC
June 2013

Preclinical assessment of ketamine.

CNS Neurosci Ther 2013 Jun 6;19(6):448-53. Epub 2013 Mar 6.

Division of Neurotoxicology, National Center for Toxicological Research (NCTR)/FDA, Jefferson, AR 72079-9501, USA.

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http://dx.doi.org/10.1111/cns.12079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6493590PMC
June 2013

Chronic exposure to rotenone, a dopaminergic toxin, results in peripheral neuropathy associated with dopaminergic damage.

Neurosci Lett 2013 Apr 7;541:233-7. Epub 2013 Mar 7.

Division of Neurotoxicology, National Center for Toxicological Research/US FDA, Jefferson, AR 72079, United States.

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http://dx.doi.org/10.1016/j.neulet.2013.02.047DOI Listing
April 2013

Ketamine-induced neuronal damage and altered N-methyl-D-aspartate receptor function in rat primary forebrain culture.

Toxicol Sci 2013 Feb 11;131(2):548-57. Epub 2012 Oct 11.

Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079-0502, USA.

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http://dx.doi.org/10.1093/toxsci/kfs296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551423PMC
February 2013

Characterization of myelin pathology in the hippocampal complex of a transgenic mouse model of Alzheimer's disease.

Curr Alzheimer Res 2013 Jan;10(1):30-7

Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson AR 72079, USA.

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http://dx.doi.org/10.2174/1567205011310010005DOI Listing
January 2013

Inhalation Anesthesia-Induced Neuronal Damage and Gene Expression Changes in Developing Rat Brain.

Syst Pharmacol 2013 1;1:1-9. Epub 2013 Jan 1.

Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food & Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079 USA.

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http://dx.doi.org/10.2478/sph-2012-0001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755976PMC
January 2013

A pilot study of preemptive morphine analgesia in preterm neonates: effects on head circumference, social behavior, and response latencies in early childhood.

Neurotoxicol Teratol 2012 Jan-Feb;34(1):47-55. Epub 2011 Nov 7.

Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR, United States; Department of Pediatrics, Arkansas Children's Hospital, Little Rock, AR 72079, USA.

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http://dx.doi.org/10.1016/j.ntt.2011.10.008DOI Listing
October 2012

Low oral doses of bisphenol A increase volume of the sexually dimorphic nucleus of the preoptic area in male, but not female, rats at postnatal day 21.

Neurotoxicol Teratol 2012 May-Jun;34(3):331-7. Epub 2012 Apr 4.

Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA.

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http://dx.doi.org/10.1016/j.ntt.2012.03.004DOI Listing
October 2012

The use of an incremental repeated acquisition task to assess learning in children.

Behav Processes 2012 Sep 16;91(1):103-14. Epub 2012 Jun 16.

Department of Pediatrics, University of Arkansas for Medical Sciences-Arkansas Children's Hospital, Little Rock, AR 72202, United States.

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http://dx.doi.org/10.1016/j.beproc.2012.06.004DOI Listing
September 2012

Nicotine alters the expression of molecular markers of endocrine disruption in zebrafish.

Neurosci Lett 2012 Sep 24;526(2):133-7. Epub 2012 Aug 24.

Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.

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http://dx.doi.org/10.1016/j.neulet.2012.08.027DOI Listing
September 2012

Developmental origins of adult diseases and neurotoxicity: epidemiological and experimental studies.

Neurotoxicology 2012 Aug 10;33(4):810-6. Epub 2012 Jan 10.

University of Houston, College of Optometry, Houston, TX, USA.

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http://dx.doi.org/10.1016/j.neuro.2011.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657611PMC
August 2012

Effects of copper nanoparticles on rat cerebral microvessel endothelial cells.

Nanomedicine (Lond) 2012 Jun 16;7(6):835-46. Epub 2012 Feb 16.

Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR 72079, USA.

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http://dx.doi.org/10.2217/nnm.11.154DOI Listing
June 2012

One-step labeling of degenerative neurons in unfixed brain tissue samples using Fluoro-Jade C.

J Neurosci Methods 2012 Jun 23;208(1):40-3. Epub 2012 Apr 23.

Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, United States.

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http://dx.doi.org/10.1016/j.jneumeth.2012.04.012DOI Listing
June 2012

Ischemia-induced increase in microvascular phosphodiesterase 4D expression in rat hippocampus associated with blood brain barrier permeability: effect of age.

ACS Chem Neurosci 2012 Jun 27;3(6):428-32. Epub 2012 Feb 27.

Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Silver Spring, Maryland 20903, USA; Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.

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http://dx.doi.org/10.1021/cn2001156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400376PMC
June 2012

In vivo imaging and quantitative analysis of changes in axon length using transgenic zebrafish embryos.

Neurotoxicol Teratol 2011 Nov-Dec;33(6):618-23. Epub 2011 Aug 27.

Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S089203621100173
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http://dx.doi.org/10.1016/j.ntt.2011.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007021PMC
May 2012

Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on retinal dopaminergic system in mice.

Neurosci Lett 2012 May 4;515(2):107-10. Epub 2012 Mar 4.

Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/USFDA, Jefferson, AR 72079, USA.

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http://dx.doi.org/10.1016/j.neulet.2012.02.085DOI Listing
May 2012

L-Carnitine rescues ketamine-induced attenuated heart rate and MAPK (ERK) activity in zebrafish embryos.

Reprod Toxicol 2012 Apr 20;33(2):205-12. Epub 2011 Oct 20.

Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.

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http://dx.doi.org/10.1016/j.reprotox.2011.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470543PMC
April 2012

Inhalation anesthetic-induced neuronal damage in the developing rhesus monkey.

Neurotoxicol Teratol 2011 Sep-Oct;33(5):592-7. Epub 2011 Jun 25.

Division of Neurotoxicology, National Center for Toxicological Research/U.S. Food and Drug Administration, Jefferson, AR 72079, USA.

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http://dx.doi.org/10.1016/j.ntt.2011.06.003DOI Listing
January 2012

Brain microvessel endothelial cells responses to gold nanoparticles: In vitro pro-inflammatory mediators and permeability.

Nanotoxicology 2011 Dec 22;5(4):479-92. Epub 2010 Dec 22.

Neurochemistry Laboratory, Division of Neurotoxicology, National Center of Toxicological Research/FDA, Jefferson, Arkansas, USA.

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http://dx.doi.org/10.3109/17435390.2010.540356DOI Listing
December 2011

Current and future needs for developmental toxicity testing.

Birth Defects Res B Dev Reprod Toxicol 2011 Oct 15;92(5):384-94. Epub 2011 Sep 15.

U.S. Environmental Protection Agency, National Center for Environmental Assessment, Office of Research and Development, Washington, District of Columbia.

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http://dx.doi.org/10.1002/bdrb.20335DOI Listing
October 2011

Defining the phosphodiesterase superfamily members in rat brain microvessels.

ACS Chem Neurosci 2011 Oct 27;2(10):600-7. Epub 2011 Jun 27.

Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079,United States.

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http://dx.doi.org/10.1021/cn2000487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369711PMC
October 2011

Mechanistic toxicity evaluation of uncoated and PEGylated single-walled carbon nanotubes in neuronal PC12 cells.

ACS Nano 2011 Sep 7;5(9):7020-33. Epub 2011 Sep 7.

National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA.

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http://dx.doi.org/10.1021/nn2016259DOI Listing
September 2011

Disruption of blastomeric F-actin: a potential early biomarker of developmental toxicity in zebrafish.

Mol Cell Biochem 2011 Jul 3;353(1-2):283-90. Epub 2011 Apr 3.

Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.

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http://link.springer.com/10.1007/s11010-011-0797-2
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http://dx.doi.org/10.1007/s11010-011-0797-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441551PMC
July 2011

Assessing motivation in children using a progressive ratio task.

Behav Processes 2011 Jun 17;87(2):203-9. Epub 2011 Apr 17.

Division of Neurotoxicology, National Center for Toxicological Research, FDA, United States.

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http://linkinghub.elsevier.com/retrieve/pii/S037663571100076
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http://dx.doi.org/10.1016/j.beproc.2011.03.008DOI Listing
June 2011

Effect of methylphenidate on motivation in children with attention-deficit/hyperactivity disorder.

Exp Clin Psychopharmacol 2011 Apr;19(2):145-53

Division of Neurotoxicology, National Center for Toxicological Research.

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http://dx.doi.org/10.1037/a0022794DOI Listing
April 2011

Ketamine-induced neurotoxicity and changes in gene expression in the developing rat brain.

Curr Neuropharmacol 2011 Mar;9(1):256-61

Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food & Drug Administration, Jefferson, AR 72079, USA.

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http://dx.doi.org/10.2174/157015911795017155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137194PMC
March 2011

Silver nanoparticle induced blood-brain barrier inflammation and increased permeability in primary rat brain microvessel endothelial cells.

Toxicol Sci 2010 Nov 16;118(1):160-70. Epub 2010 Aug 16.

Neurochemistry Laboratory, Division of Neurotoxicology, National Center of Toxicological Research/Food and Drug Administration, Jefferson, Arkansas 72079, USA.

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http://dx.doi.org/10.1093/toxsci/kfq244DOI Listing
November 2010

Toxicity assessment of pramipexole in juvenile rhesus monkeys.

Toxicology 2010 Oct 10;276(3):164-71. Epub 2010 Aug 10.

Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food & Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079, USA.

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http://dx.doi.org/10.1016/j.tox.2010.08.002DOI Listing
October 2010

Preweaning behaviors, developmental landmarks, and acrylamide and glycidamide levels after pre- and postnatal acrylamide treatment in rats.

Neurotoxicol Teratol 2010 May-Jun;32(3):373-82. Epub 2010 Jan 29.

Division of Neurotoxicology, National Center for Toxicological Research/FDA, United States.

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http://dx.doi.org/10.1016/j.ntt.2010.01.010DOI Listing
July 2010

Anesthetic-induced oxidative stress and potential protection.

ScientificWorldJournal 2010 Jul 20;10:1473-82. Epub 2010 Jul 20.

National Center for Toxicological Research, U.S. Food & Drug Administration, Jefferson, AR, USA.

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http://dx.doi.org/10.1100/tsw.2010.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763762PMC
July 2010

Effects of chronic oral acrylamide exposure on incremental repeated acquisition (learning) task performance in Fischer 344 rats.

Neurotoxicol Teratol 2010 Mar-Apr;32(2):220-5. Epub 2009 Oct 19.

Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR 72211, United States.

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http://dx.doi.org/10.1016/j.ntt.2009.10.001DOI Listing
June 2010

On the early toxic effect of quinolinic acid: involvement of RAGE.

Neurosci Lett 2010 Apr 17;474(2):74-8. Epub 2010 Mar 17.

Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, S.S.A. Insurgentes Sur # 3877, México, D.F. 14269, Mexico.

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http://dx.doi.org/10.1016/j.neulet.2010.03.007DOI Listing
April 2010

A minimally invasive, translational biomarker of ketamine-induced neuronal death in rats: microPET Imaging using 18F-annexin V.

Toxicol Sci 2009 Oct 28;111(2):355-61. Epub 2009 Jul 28.

Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, USA.

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https://academic.oup.com/toxsci/article-lookup/doi/10.1093/t
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http://dx.doi.org/10.1093/toxsci/kfp167DOI Listing
October 2009