Meritxell Huch

Meritxell Huch

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Meritxell Huch

Meritxell Huch

Publications by authors named "Meritxell Huch"

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Liver organoids: from basic research to therapeutic applications.

Gut 2019 Jul 12. Epub 2019 Jul 12.

Wellcome Trust-Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1136/gutjnl-2019-319256DOI Listing
July 2019

Disease modelling in human organoids.

Dis Model Mech 2019 Jul 29;12(7). Epub 2019 Jul 29.

The Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK

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http://dx.doi.org/10.1242/dmm.039347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679380PMC
July 2019

Lgr5 stem and progenitor cells reside at the apex of a heterogeneous embryonic hepatoblast pool.

Development 2019 Jun 12;146(12). Epub 2019 Jun 12.

The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK

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http://dx.doi.org/10.1242/dev.174557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602348PMC
June 2019

Definitions for adult stem cells debated.

Nature 2018 11;563(7731):328-329

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http://dx.doi.org/10.1038/d41586-018-07175-6DOI Listing
November 2018

Defining Lineage Potential and Fate Behavior of Precursors during Pancreas Development.

Dev Cell 2018 08 26;46(3):360-375.e5. Epub 2018 Jul 26.

Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK; The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK; Cavendish Laboratory, Department of Physics, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, UK. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2018.06.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085117PMC
August 2018

Universality of clone dynamics during tissue development.

Nat Phys 2018 May 26;14(5):469-474. Epub 2018 Feb 26.

Cavendish Laboratory, Department of Physics, JJ Thomson Avenue, University of Cambridge, Cambridge CB3 0HE, UK.

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http://dx.doi.org/10.1038/s41567-018-0055-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935228PMC
May 2018

Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation.

Dev Cell 2017 05 27;41(3):274-286.e5. Epub 2017 Apr 27.

Department of Oncology, University of Cambridge, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425251PMC
May 2017

Cancer: Tumours build their niche.

Nature 2017 05 10;545(7654):292-293. Epub 2017 May 10.

Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK. Both are also at the Wellcome Trust - Medical Research Council Stem Cell Institute, Cambridge.

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http://dx.doi.org/10.1038/nature22494DOI Listing
May 2017

The hope and the hype of organoid research.

Development 2017 03;144(6):938-941

Department of Genetics, University of Cambridge, Downing Site, Cambridge CB2 3EH, UK

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http://dx.doi.org/10.1242/dev.150201DOI Listing
March 2017

Organoids from adult liver and pancreas: Stem cell biology and biomedical utility.

Dev Biol 2016 Dec 27;420(2):251-261. Epub 2016 Jun 27.

Wellcome Trust/Cancer Research UK Gurdon Institute, Henry Wellcome Building of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK; Wellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00121606163027
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http://dx.doi.org/10.1016/j.ydbio.2016.06.039DOI Listing
December 2016

Organoids: A new in vitro model system for biomedical science and disease modelling and promising source for cell-based transplantation.

Dev Biol 2016 Dec 27;420(2):197-198. Epub 2016 Oct 27.

Wellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK; Wellcome Trust/Cancer Research UK Gurdon Institute, Henry Wellcome Building of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00121606163069
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http://dx.doi.org/10.1016/j.ydbio.2016.10.017DOI Listing
December 2016

Cellular plasticity in the adult liver and stomach.

J Physiol 2016 09 10;594(17):4815-25. Epub 2016 May 10.

Wellcome Trust/Cancer Research UK - Gurdon Institute, Henry Wellcome Building of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK.

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http://dx.doi.org/10.1113/JP271769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009796PMC
September 2016

Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation.

Nat Protoc 2016 09 25;11(9):1724-43. Epub 2016 Aug 25.

Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/nprot.2016.097DOI Listing
September 2016

The plastic cellular states of liver cells: Are EpCAM and Lgr5 fit for purpose?

Hepatology 2016 08 17;64(2):652-62. Epub 2016 Mar 17.

Laboratory of Liver Cell Biology, Department of Basic Biomedical Sciences, Faculty of Medicine and Pharmacy, Free University Brussels, Brussels, Belgium.

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http://dx.doi.org/10.1002/hep.28469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973669PMC
August 2016

Modeling mouse and human development using organoid cultures.

Development 2015 Sep;142(18):3113-25

Wellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK

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http://dx.doi.org/10.1242/dev.118570DOI Listing
September 2015

Building stomach in a dish.

Authors:
Meritxell Huch

Nat Cell Biol 2015 Aug;17(8):966-7

1] Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge CB2 1QN, UK [2] Wellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 1QR, UK [3] Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3DY, UK.

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http://dx.doi.org/10.1038/ncb3211DOI Listing
August 2015

In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.

Gastroenterology 2015 Jan 13;148(1):126-136.e6. Epub 2014 Oct 13.

Hubrecht Institute for Developmental Biology and Stem Cell Research and University Medical Centre Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1053/j.gastro.2014.09.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274199PMC
January 2015

Regenerative biology: The versatile and plastic liver.

Authors:
Meritxell Huch

Nature 2015 Jan;517(7533):155-6

Wellcome Trust/MRC Stem Cell Institute, in the Department of Physiology, Development and Neuroscience, and at the Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK.

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http://dx.doi.org/10.1038/517155aDOI Listing
January 2015

Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium.

Cell 2013 Oct;155(2):357-68

Hubrecht Institute for Developmental Biology and Stem Cell Research & University Medical Centre Utrecht, 3584 CT Utrecht, the Netherlands; Department of General, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, University of Dresden, 01307 Dresden, Germany.

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http://dx.doi.org/10.1016/j.cell.2013.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094146PMC
October 2013

Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5.

Cell Rep 2013 Jun;3(6):1885-92

Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.celrep.2013.06.009DOI Listing
June 2013

Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development.

Cell Rep 2012 Sep 20;2(3):540-52. Epub 2012 Sep 20.

Hubrecht Institute for Developmental Biology and Stem Cell Research/University Medical Centre Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.celrep.2012.08.018DOI Listing
September 2012

Controlled gene expression in primary Lgr5 organoid cultures.

Nat Methods 2011 Dec 4;9(1):81-3. Epub 2011 Dec 4.

Hubrecht Institute for Developmental Biology and Stem Cell Research, and University Medical Centre, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/nmeth.1802DOI Listing
December 2011

Sox9 marks adult organ progenitors.

Nat Genet 2011 Jan;43(1):9-10

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http://dx.doi.org/10.1038/ng0111-9DOI Listing
January 2011

Stem cells and cancer of the stomach and intestine.

Mol Oncol 2010 Oct 8;4(5):373-84. Epub 2010 Jun 8.

Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, Utrecht, Netherlands.

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http://doi.wiley.com/10.1016/j.molonc.2010.05.001
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http://dx.doi.org/10.1016/j.molonc.2010.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527927PMC
October 2010

Urokinase-type plasminogen activator receptor transcriptionally controlled adenoviruses eradicate pancreatic tumors and liver metastasis in mouse models.

Neoplasia 2009 Jun;11(6):518-28, 4 p following 528

Programa Gens i Malaltia, Centre de Regulació Genòmica-CRG, UPF, Parc de Recerca Biomèdica de Barcelona-PRBB, Barcelona, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685441PMC
http://dx.doi.org/10.1593/neo.81674DOI Listing
June 2009

Keratin 7 promoter selectively targets transgene expression to normal and neoplastic pancreatic ductal cells in vitro and in vivo.

FASEB J 2009 May 5;23(5):1366-75. Epub 2009 Jan 5.

Unitat de Biologia Cellular i Molecular, Institut Municipal d'Investigació Mèdica, Parc de Recerca Biomèdica de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1096/fj.08-115576DOI Listing
May 2009

RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: a potential pathogenic process in neurodegeneration.

Hum Mol Genet 2007 May 6;16(9):1039-50. Epub 2007 Mar 6.

Genes and Disease Program, Center for Genomic Regulation (CRG-UPF), Biomedical Research Park Building, E-08003 Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1093/hmg/ddm049DOI Listing
May 2007

RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: a potential pathogenic process in neurodegeneration.

Hum Mol Genet 2007 May 6;16(9):1039-50. Epub 2007 Mar 6.

Genes and Disease Program, Center for Genomic Regulation (CRG-UPF), Biomedical Research Park Building, E-08003 Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1093/hmg/ddm049DOI Listing
May 2007

Role of the putative heparan sulfate glycosaminoglycan-binding site of the adenovirus type 5 fiber shaft on liver detargeting and knob-mediated retargeting.

J Gen Virol 2006 Sep;87(Pt 9):2487-95

Translational Research Laboratory, IDIBELL-Institut Catala d'Oncologia, Av. Gran Via s/n Km 2.7, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.

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http://jgv.microbiologyresearch.org/content/journal/jgv/10.1
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http://dx.doi.org/10.1099/vir.0.81889-0DOI Listing
September 2006

Role of the putative heparan sulfate glycosaminoglycan-binding site of the adenovirus type 5 fiber shaft on liver detargeting and knob-mediated retargeting.

J Gen Virol 2006 Sep;87(Pt 9):2487-95

Translational Research Laboratory, IDIBELL-Institut Catala d'Oncologia, Av. Gran Via s/n Km 2.7, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.

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http://jgv.microbiologyresearch.org/content/journal/jgv/10.1
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http://dx.doi.org/10.1099/vir.0.81889-0DOI Listing
September 2006