Merit E Cudkowicz

Merit E Cudkowicz

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Merit E Cudkowicz

Publications by authors named "Merit E Cudkowicz"

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Selection design phase II trial of high dosages of tamoxifen and creatine in amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2019 Oct 14:1-9. Epub 2019 Oct 14.

Department of Neurology, Sean M Healey & AMG Center for ALS at Massachusetts General Hospital, Neurological Clinical Research Institute , Boston , MA , USA.

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http://dx.doi.org/10.1080/21678421.2019.1672750DOI Listing
October 2019

A phase III trial of as a potential treatment for amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2019 ;0(0):1-11

The Neurological Institute, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1080/21678421.2019.1612922DOI Listing
January 2019

Opinion and Special Articles: Challenges and opportunities in defining career identity in academic neurology.

Neurology 2018 10;91(14):670-672

From the Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000006284DOI Listing
October 2018

Respiratory measures in amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2018 08 23;19(5-6):321-330. Epub 2018 Mar 23.

f Eleanor and Lou Gehrig ALS Center, The Neurological Institute, Columbia University , New York , NY , USA.

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http://dx.doi.org/10.1080/21678421.2018.1452945DOI Listing
August 2018

Understanding the use of NIV in ALS: results of an international ALS specialist survey.

Amyotroph Lateral Scler Frontotemporal Degener 2018 08 16;19(5-6):331-341. Epub 2018 Apr 16.

k Department of Neurology, Brain Centre Rudolf Magnus , University Medical Centre Utrecht , Utrecht , The Netherlands.

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http://dx.doi.org/10.1080/21678421.2018.1457058DOI Listing
August 2018

Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis.

N Engl J Med 2018 08;379(9):846-855

From the Mellen Center for Multiple Sclerosis, Neurological Institute (R.J.F., S. Natarajan, R.A.B., D.O.), the Imaging Institute (X.H., M.J.L., K.E.S., X.Z.), and the Department of Biomedical Engineering (P.J., K.N., B. Thoomukuntla), Cleveland Clinic, Cleveland, Ohio State University, Columbus (M.R.), and University of Cincinnati, Cincinnati (A.Z.) - all in Ohio; the Data Coordinating Center, Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT), University of Iowa, Iowa City (C.S.C., J.B., D.E., E.K., M.K., J.D.L., J.Y.); the National Institute of Neurological Disorders and Stroke, Bethesda, MD (R.C.); the Clinical Coordinating Center, NeuroNEXT, Massachusetts General Hospital, Neurological Clinical Research Institute, Harvard Partners (M.E.C., M.M., A.A., B. Thornell), the Department of Neurology, Massachusetts General Hospital, Harvard Medical School (E.C.K.), and Brigham and Women's Hospital (C.S.), Boston; patient advocate (T.G.) and Swedish Medical Center at Seattle (P.R.), Seattle; University of Rochester Medical Center, Rochester (A.G.), Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai Medical Center (S.K.), Weill Cornell Medical College (J.S.P.), Columbia University Medical Center (C.S.R.), and Montefiore Medical Center, Albert Einstein College of Medicine (S.S.), New York, State University of New York (SUNY) at Stony Brook, Stony Brook (P.K.C.), SUNY Upstate Medical University, Syracuse (B.J.), and SUNY at Buffalo, Buffalo (B.W.-G.) - all in New York; MediciNova, La Jolla (K.M.), University of California at Davis, Sacramento (M.A.), and University of California at Los Angeles, Los Angeles (B.S.G.) - all in California; Washington University School of Medicine, St. Louis (R.T.N.); Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ (J.P.D.); NeuroRx Research, Montreal (S. Narayanan); the School of Health Sciences, College of Health and Human Sciences, Purdue University, West Lafayette, IN (X.Z.); University of Colorado Denver, Aurora (E.A.); University of Alabama at Birmingham, Birmingham (K.B.); Feinberg School of Medicine, Northwestern University, Chicago (B.A.C.); University of Miami Miller School of Medicine, Miami (S.D.); University of Utah, Salt Lake City (L.D.D.); University of Texas Southwestern Medical Center, Dallas (A.F.); University of Virginia at Charlottesville, Charlottesville (M.D.G.); Emory University, Atlanta (N.L.); University of Kansas Medical Center, Kansas City (S.G.L.); Vanderbilt University, Nashville (H.M.); University of Pittsburgh Medical Center, Pittsburgh (V.S.); and Oregon Health and Science University, Portland (V.Y.).

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http://dx.doi.org/10.1056/NEJMoa1803583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172944PMC
August 2018

Expanded autologous regulatory T-lymphocyte infusions in ALS: A phase I, first-in-human study.

Neurol Neuroimmunol Neuroinflamm 2018 Jul 18;5(4):e465. Epub 2018 May 18.

Houston Methodist Neurological Institute (J.R.T., D.R.B., W.Z., M.P., E.P.S., S.H.A.), Houston Methodist Hospital Research Institute, Stanley H. Appel Department of Neurology, Houston, TX; and Neurological Clinical Research Institute (J.D.B., M.E.C.), Massachusetts General Hospital, Boston, MA.

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http://dx.doi.org/10.1212/NXI.0000000000000465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961523PMC
July 2018

Imaging of glia activation in people with primary lateral sclerosis.

Neuroimage Clin 2018 25;17:347-353. Epub 2017 Oct 25.

Harvard Medical School, Department of Neurology, Neurological Clinical Research Institute (NCRI), Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.nicl.2017.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681341PMC
June 2018

Analysis of Participant Withdrawal in Huntington Disease Clinical Trials.

J Huntingtons Dis 2017 ;6(2):149-156

Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.3233/JHD-170246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565148PMC
March 2018

Serum urate at trial entry and ALS progression in EMPOWER.

Amyotroph Lateral Scler Frontotemporal Degener 2017 02 28;18(1-2):120-125. Epub 2016 Sep 28.

e Department of Epidemiology and Nutrition , Harvard TH Chan School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Harvard Medical School and Brigham and Women's Hospital , Boston , Massachusetts , USA.

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http://dx.doi.org/10.1080/21678421.2016.1214733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531275PMC
February 2017

Glial activation colocalizes with structural abnormalities in amyotrophic lateral sclerosis.

Neurology 2016 Dec 11;87(24):2554-2561. Epub 2016 Nov 11.

From A.A. Martinos Center for Biomedical Imaging, Department of Radiology (M.J.A., N.R.Z., M.L.L., D.B.C., D.I.G., C.C., B.R.R., J.M.H.), Neurological Clinical Research Institute, Department of Neurology (M.J.A., P.C., J.E.Y., M.E.C., N.A.), and Department of Anesthesiology (O.A.), Massachusetts General Hospital, Harvard Medical School, Charlestown.

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http://dx.doi.org/10.1212/WNL.0000000000003427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207001PMC
December 2016

Race/ethnicity, socioeconomic status, and ALS mortality in the United States.

Neurology 2016 Nov 14;87(22):2300-2308. Epub 2016 Oct 14.

From the Departments of Social and Behavioral Sciences (A.L.R., J.T.C.), Environmental Health (M.G.W.), and Epidemiology (M.G.W.), Harvard T.H. Chan School of Public Health, Boston, MA; United States Census Bureau (N.J.J.), Washington, DC; Harvard Medical School (M.E.C.); and MGH Neurological Clinical Research Institute (M.E.C.), Department of Neurology, Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000003298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135021PMC
November 2016

Job-related formaldehyde exposure and ALS mortality in the USA.

J Neurol Neurosurg Psychiatry 2016 07 13;87(7):786-8. Epub 2015 Jul 13.

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1136/jnnp-2015-310750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738165PMC
July 2016

The Role of Environmental Toxins in Amyotrophic Lateral Sclerosis Risk.

JAMA Neurol 2016 07;73(7):779-80

Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts3Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamaneurol.2016.1038DOI Listing
July 2016

A randomized trial of mexiletine in ALS: Safety and effects on muscle cramps and progression.

Neurology 2016 Apr 24;86(16):1474-81. Epub 2016 Feb 24.

From the Department of Neurology (M.D.W., J.B.D.), University of Washington Medical Center, Seattle; Biostatistics Center (E.A.M.), Massachusetts General Hospital and Harvard Medical School, Boston; Department of Neurology (Z.S.), Penn State Hershey Medical Center, Hershey, PA; Department of Neurology (A.S.K., N.A., M.E.C.), Neurological Clinical Research Institute, Massachusetts General Hospital, Boston; Program in Pharmacology and Experimental Therapeutics (D.J.G.), Tufts University School of Medicine, Boston, MA; Department of Neurology (M.G., N.P.), UCLA Medical Center, Los Angeles, CA; Department of Neurology (J.S.S., C.Q., R.H.B.), University of Massachusetts Memorial Medical Center, Worcester; Department of Neurology (J.T.), University of Texas Southwestern Medical Center, Dallas; Department of Neurology (J.M.S.), Barrow Neurological Institute, Phoenix, AZ; Department of Neurology (R.J.B.), University of Kansas Medical Center, Kansas City; Department of Neurology (A.P.), Washington University Medical Center, St. Louis, MO; and Department of Neurology (A.S.), University of Iowa Hospitals and Clinics, Iowa City.

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http://dx.doi.org/10.1212/WNL.0000000000002507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836879PMC
April 2016

Cortical Hyperexcitability in Amyotrophic Lateral Sclerosis: C9orf72 Repeats.

JAMA Neurol 2015 Nov;72(11):1235-6

Department of Neurology, Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1001/jamaneurol.2015.2197DOI Listing
November 2015

Military Service and Amyotrophic Lateral Sclerosis in a Population-based Cohort.

Epidemiology 2015 Nov;26(6):831-8

From the aDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA; bDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA; cDepartment of Neurology, Massachusetts General Hospital, Boston, MA; and dCenter for Administrative Records and Applications, US Bureau of the Census, Washington, DC.

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http://dx.doi.org/10.1097/EDE.0000000000000376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604116PMC
November 2015

Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: assessed with [(11)C]-PBR28.

Neuroimage Clin 2015 19;7:409-14. Epub 2015 Jan 19.

Neurological Clinical Research Institute (NCRI), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.nicl.2015.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310932PMC
September 2015

Clinical Trial Designs in Amyotrophic Lateral Sclerosis: Does One Design Fit All?

Neurotherapeutics 2015 Apr;12(2):376-83

Massachusetts General Hospital, Department of Neurology, Neurological Clinical Research Institute, 165 Cambridge Street, Suite 600, Boston, MA, 02114, USA,

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http://dx.doi.org/10.1007/s13311-015-0341-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404442PMC
April 2015

Neuroprotective agents target molecular mechanisms of disease in ALS.

Drug Discov Today 2015 Jan 6;20(1):65-75. Epub 2014 Sep 6.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2014.08.016DOI Listing
January 2015

Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice.

Ann Neurol 2015 Jan 27;77(1):75-99. Epub 2014 Nov 27.

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02112.

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http://dx.doi.org/10.1002/ana.24304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432483PMC
January 2015

Preclinical Rodent Toxicity Studies for Long Term Use of Ceftriaxone.

Toxicol Rep 2015;2:1396-1403

Neurological Clinical Research Institute (NCRI), Massachusetts General Hospital, Boston, MA, Massachusetts General Hospital, 165 Cambridge Street, Suite 600, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.toxrep.2015.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685718PMC
January 2015

Locked in, but not out?

Neurology 2014 May 30;82(21):1852-3. Epub 2014 Apr 30.

From the Neurotechnology Trials Unit and the Neurological Clinical Trial Institute (L.R.H., M.E.C.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; and the Center for Neurorestoration and Neurotechnology (L.R.H.), Rehabilitation Research and Development Service, Office of Research and Development, Department of Veterans Affairs, and Brown University School of Engineering and Institute for Brain Science, Providence, RI.

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http://dx.doi.org/10.1212/WNL.0000000000000460DOI Listing
May 2014

Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons.

Cell Rep 2014 Apr 3;7(1):1-11. Epub 2014 Apr 3.

FM Kirby Neurobiology Center, Boston Children's Hospital and Harvard Stem Cell Institute, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.03.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023477PMC
April 2014

Predicting success: optimizing phase II ALS trials for the transition to phase III.

Amyotroph Lateral Scler Frontotemporal Degener 2014 Mar;15(1-2):1-8

Massachusetts General Hospital, Neurological Clinical Research Center , Boston, Massachusetts.

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http://dx.doi.org/10.3109/21678421.2013.838969DOI Listing
March 2014

Analysis of start-up, retention, and adherence in ALS clinical trials.

Neurology 2013 Oct 4;81(15):1350-5. Epub 2013 Sep 4.

From the Neurological Clinical Research Institute, Department of Neurology (N.A., P.Y.-R., H.Y., M.K., D.G., J.D., M.L.-W., J.S., A.L., L.J., M.E.C.), and Biostatistics Center (J.S., E.A.M.), Massachusetts General Hospital, Boston; and Harvard Medical School (N.A., P.Y.-R., E.A.M., M.E.C.), Boston, MA.

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http://dx.doi.org/10.1212/WNL.0b013e3182a823e0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806927PMC
October 2013

The Combined Assessment of Function and Survival (CAFS): a new endpoint for ALS clinical trials.

Amyotroph Lateral Scler Frontotemporal Degener 2013 Apr 17;14(3):162-8. Epub 2013 Jan 17.

Massachusetts General Hospital, Neurological Clinical Research Institute, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.3109/21678421.2012.762930DOI Listing
April 2013

Developing normalized strength scores for neuromuscular research.

Muscle Nerve 2013 Feb 21;47(2):177-82. Epub 2012 Nov 21.

Neurology Clinical Trials Unit, Massachusetts General Hospital, 149 13th Street, Room 2274, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1002/mus.23516DOI Listing
February 2013

Dexpramipexole effects on functional decline and survival in subjects with amyotrophic lateral sclerosis in a Phase II study: subgroup analysis of demographic and clinical characteristics.

Amyotroph Lateral Scler Frontotemporal Degener 2013 Jan 17;14(1):44-51. Epub 2012 Sep 17.

Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

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http://dx.doi.org/10.3109/17482968.2012.723723DOI Listing
January 2013

Uric acid levels predict survival in men with amyotrophic lateral sclerosis.

J Neurol 2012 Sep 10;259(9):1923-8. Epub 2012 Feb 10.

Neurology Clinical Trials Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown Navy Yard, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1007/s00415-012-6440-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441749PMC
September 2012

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS.

J Clin Invest 2012 Sep 6;122(9):3063-87. Epub 2012 Aug 6.

Department of Neurology, Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1172/JCI62636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428086PMC
September 2012

Oral repeated-dose toxicity studies of coenzyme Q10 in beagle dogs.

Int J Toxicol 2012 Jan-Feb;31(1):58-69. Epub 2012 Jan 20.

Neurology Clinical Trials Unit, Massachusetts General Hospital, 13th Street, Building 149, Room 2274, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1177/1091581811425256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288259PMC
June 2012

Biochemical alterations associated with ALS.

Amyotroph Lateral Scler 2012 Jan 25;13(1):110-8. Epub 2011 Nov 25.

Metabolon Inc., North Carolina, USA.

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http://dx.doi.org/10.3109/17482968.2011.619197DOI Listing
January 2012

Validation of a new strength measurement device for amyotrophic lateral sclerosis clinical trials.

Muscle Nerve 2012 Jan;45(1):81-5

Neurology Clinical Trials Unit, Massachusetts General Hospital, 149 13th Street, Room 2274, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1002/mus.22253DOI Listing
January 2012

New considerations in the design of clinical trials for amyotrophic lateral sclerosis.

Clin Investig (Lond) 2011 Oct;1(10):1375-1389

Massachusetts General Hospital, Department of Neurology, Neurology Clinical Trials Unit, 149 Thirteenth Street, Suite 2274, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.4155/cli.11.127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335743PMC
October 2011

Profound muscle weakness and pain after one dose of actonel.

Case Rep Med 2009 11;2009:693014. Epub 2009 Oct 11.

Neurology Clinical Trials Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1155/2009/693014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760234PMC
July 2011

Body mass index, not dyslipidemia, is an independent predictor of survival in amyotrophic lateral sclerosis.

Muscle Nerve 2011 Jul 23;44(1):20-4. Epub 2011 May 23.

Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/mus.22114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441750PMC
July 2011

Gender-based effect of statins on functional decline in amyotrophic lateral sclerosis.

J Neurol Sci 2011 Jan 5;300(1-2):23-7. Epub 2010 Nov 5.

Department of Neurology and ALS Clinic, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

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http://dx.doi.org/10.1016/j.jns.2010.10.011DOI Listing
January 2011

Clinical significance in the change of decline in ALSFRS-R.

Amyotroph Lateral Scler 2010 ;11(1-2):178-80

Massachusetts General Hospital, Charlestown, 02129, USA.

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http://dx.doi.org/10.3109/17482960903093710DOI Listing
August 2010

The natural history of ALS is changing: improved survival.

Amyotroph Lateral Scler 2009 Oct-Dec;10(5-6):324-31

Neurology Clinical Trials Unit, Massachusetts General Hospital, Harvard Medical School, 13th Street, Boston, MA 02129, USA.

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http://dx.doi.org/10.3109/17482960903009054DOI Listing
February 2010

Lyme disease serology in amyotrophic lateral sclerosis.

Muscle Nerve 2009 Oct;40(4):626-8

Neurology Clinical Trials Unit, Massachusetts General Hospital, Harvard Medical School, 13th Street, Building 149, Room 2274, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1002/mus.21438DOI Listing
October 2009

Serum Nogo-A levels are not elevated in amyotrophic lateral sclerosis patients.

Biomarkers 2009 Sep;14(6):414-7

Department of Neurology, Yale University School of Medicine, New Haven, CT 06520-8018, USA.

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http://dx.doi.org/10.1080/13547500903056051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842187PMC
September 2009

Clinical trials in progressive neurological diseases. Recruitment, enrollment, retention and compliance.

Front Neurol Neurosci 2009 19;25:144-151. Epub 2009 Mar 19.

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http://dx.doi.org/10.1159/000209493DOI Listing
July 2009

Combined riluzole and sodium phenylbutyrate therapy in transgenic amyotrophic lateral sclerosis mice.

Amyotroph Lateral Scler 2009 Apr;10(2):85-94

Department of Neurology, Boston University School of Medicine, Boston, MA, USA.

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http://dx.doi.org/10.1080/17482960802226148DOI Listing
April 2009

Phase 2 study of sodium phenylbutyrate in ALS.

Amyotroph Lateral Scler 2009 Apr;10(2):99-106

Massachusetts General Hospital, Neurology Clinical Trials Unit, 13th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1080/17482960802320487DOI Listing
April 2009

Medications and laboratory parameters as prognostic factors in amyotrophic lateral sclerosis.

Amyotroph Lateral Scler 2008 Dec;9(6):369-74

Neurology Clinical Trials Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1080/17482960802163614DOI Listing
December 2008

Is it too soon for mesenchymal stem cell trials in people with ALS?

Amyotroph Lateral Scler 2008 Dec;9(6):321-2

Neurology Clinical Trials Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1080/17482960802425559DOI Listing
December 2008

Scrutinizing enrollment in ALS clinical trials: room for improvement?

Amyotroph Lateral Scler 2008 Oct;9(5):257-65

Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1080/17482960802195913DOI Listing
October 2008

Serum ferritin and metal levels as risk factors for amyotrophic lateral sclerosis.

Open Neurol J 2008 Sep 12;2:51-4. Epub 2008 Sep 12.

Neurology Clinical Trials Unit; Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.

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http://dx.doi.org/10.2174/1874205X00802010051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2627516PMC
September 2008

Arimoclomol at dosages up to 300 mg/day is well tolerated and safe in amyotrophic lateral sclerosis.

Muscle Nerve 2008 Jul;38(1):837-44

Neurology Clinical Trials Unit, Massachusetts General Hospital, 13th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1002/mus.21059DOI Listing
July 2008

Electrical impedance myography to assess outcome in amyotrophic lateral sclerosis clinical trials.

Clin Neurophysiol 2007 Nov 25;118(11):2413-8. Epub 2007 Sep 25.

Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.clinph.2007.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080665PMC
November 2007

Is erythropoietin a potential therapy for amyotrophic lateral sclerosis?

Exp Neurol 2007 Jul 11;206(1):11-5. Epub 2007 Apr 11.

Department of Neurology, Neurology Clinical Trials Unit, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.expneurol.2007.04.001DOI Listing
July 2007

Coenzyme Q treatment of neurodegenerative diseases of aging.

Mitochondrion 2007 Jun 27;7 Suppl:S146-53. Epub 2007 Mar 27.

National Institute of Neurological Disorders and Stroke, National Institutes of Health, 6001 Executive Blvd., Room 2225, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.mito.2007.01.004DOI Listing
June 2007

Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis.

Expert Opin Emerg Drugs 2007 May;12(2):229-52

Duke University Medical Center, Box 3333, Durham NC 27705, USA.

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http://dx.doi.org/10.1517/14728214.12.2.229 DOI Listing
May 2007

Translating preclinical insights into effective human trials in ALS.

Biochim Biophys Acta 2006 Nov-Dec;1762(11-12):1139-49. Epub 2006 Apr 4.

Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.

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http://dx.doi.org/10.1016/j.bbadis.2006.03.007DOI Listing
January 2007

Increased incidence of deep venous thrombosis in ALS.

Neurology 2007 Jan;68(1):76-7

Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1212/01.wnl.0000250444.30622.eeDOI Listing
January 2007

Analysis of factors that modify susceptibility and rate of progression in amyotrophic lateral sclerosis (ALS).

Amyotroph Lateral Scler 2006 Sep;7(3):173-82

Neurology Clinical Trials Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1080/14660820600640596DOI Listing
September 2006

Trial of celecoxib in amyotrophic lateral sclerosis.

Ann Neurol 2006 Jul;60(1):22-31

Neurology Clinical Trials Unit, Massachusetts General Hospital, Harvard Medical School, Boston, 02172, USA.

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http://doi.wiley.com/10.1002/ana.20903
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http://dx.doi.org/10.1002/ana.20903DOI Listing
July 2006

Combination therapy using minocycline and coenzyme Q10 in R6/2 transgenic Huntington's disease mice.

Biochim Biophys Acta 2006 Mar 5;1762(3):373-80. Epub 2005 Dec 5.

Geriatric Research Education and Clinical Center, Bedford VA Medical Center, Bedford, MA 01730, USA.

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http://dx.doi.org/10.1016/j.bbadis.2005.11.002DOI Listing
March 2006

Clinical trials in amyotrophic lateral sclerosis: the tenuous past and the promising future.

J Clin Pharmacol 2005 Dec;45(12):1334-44

Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, GRB 1256, Boston, MA 02114, USA.

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http://dx.doi.org/10.1177/0091270005282631DOI Listing
December 2005

Increased plasma levels of matrix metalloproteinase-9 in patients with Alzheimer's disease.

Neurochem Int 2003 Aug;43(3):191-6

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 525 East 68th Street, Room F-610, New York, NY 10021, USA.

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August 2003

Ciliary neurotrophic factor genotype does not influence clinical phenotype in amyotrophic lateral sclerosis.

Ann Neurol 2003 Jul;54(1):130-4

Department of Neurology, Academic Neuroscience Centre, Institute of Psychiatry, King's College London, London, United Kingdom.

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http://dx.doi.org/10.1002/ana.10638DOI Listing
July 2003

Mitochondrial DNA from platelets of sporadic ALS patients restores normal respiratory functions in rho(0) cells.

Exp Neurol 2003 Feb;179(2):229-35

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/s0014-4886(02)00022-5DOI Listing
February 2003

Comparison of incremental with multipoint MUNE methods in transgenic ALS mice.

Muscle Nerve 2002 Jan;25(1):39-42

Department of Neurology, Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, USA.

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http://dx.doi.org/10.1002/mus.10000DOI Listing
January 2002