Merit Cudkowicz

Merit Cudkowicz

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Merit Cudkowicz

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ALS/SURV: a modification of the CAFS statistic.

Amyotroph Lateral Scler Frontotemporal Degener 2019 Nov 23;20(7-8):576-583. Epub 2019 Jul 23.

Department of Neurology, University of Michigan , Ann Arbor , MI , USA.

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http://dx.doi.org/10.1080/21678421.2019.1643375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768708PMC
November 2019

Prospective natural history study of ALS clinical characteristics and biomarkers.

Neurology 2019 Oct 2. Epub 2019 Oct 2.

From the Department of Neurology (A.J.C., T.H., C.D., J.J.-B., A.M., S.B., A.S., T.J.E., C.C., T.M.M.), Washington University School of Medicine, St. Louis, MO; Department of Neurology (N.A., H.Y., A.V.S., M.C.), Neurological Clinical Research Institute, Massachusetts General Hospital, Boston; Department of Neurology (L.H.v.d.B., M.A.v.E., J.H.V., B.S.d.V.), Brain Center Rudolf Magnus, University Medical Center Utrecht, University Utrecht, the Netherlands; Department of Neurology (M.H.), Columbia University, New York, NY; Department of Neurology (R.H. Baloh), Cedars-Sinai Medical Center, Los Angeles, CA; Department of Neurology (R.H. Brown, N.W., D.M.-Y., M.A.O., C.D.), University of Massachusetts, Worcester; Department of Neurology (J.D.R.), Johns Hopkins University, Baltimore, MD; and Biogen Inc. (A.M., T.F.), Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000008359DOI Listing
October 2019

A phase III trial of as a potential treatment for amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2019 ;0(0):1-11

The Neurological Institute, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1080/21678421.2019.1612922DOI Listing
January 2019

A phase III trial of as a potential treatment for amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2019 ;0(0):1-11

The Neurological Institute, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1080/21678421.2019.1612922DOI Listing
January 2019

Opinion and Special Articles: Challenges and opportunities in defining career identity in academic neurology.

Neurology 2018 10;91(14):670-672

From the Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000006284DOI Listing
October 2018

Respiratory measures in amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2018 08 23;19(5-6):321-330. Epub 2018 Mar 23.

f Eleanor and Lou Gehrig ALS Center, The Neurological Institute, Columbia University , New York , NY , USA.

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http://dx.doi.org/10.1080/21678421.2018.1452945DOI Listing
August 2018

Understanding the use of NIV in ALS: results of an international ALS specialist survey.

Amyotroph Lateral Scler Frontotemporal Degener 2018 08 16;19(5-6):331-341. Epub 2018 Apr 16.

k Department of Neurology, Brain Centre Rudolf Magnus , University Medical Centre Utrecht , Utrecht , The Netherlands.

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http://dx.doi.org/10.1080/21678421.2018.1457058DOI Listing
August 2018

Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis.

N Engl J Med 2018 08;379(9):846-855

From the Mellen Center for Multiple Sclerosis, Neurological Institute (R.J.F., S. Natarajan, R.A.B., D.O.), the Imaging Institute (X.H., M.J.L., K.E.S., X.Z.), and the Department of Biomedical Engineering (P.J., K.N., B. Thoomukuntla), Cleveland Clinic, Cleveland, Ohio State University, Columbus (M.R.), and University of Cincinnati, Cincinnati (A.Z.) - all in Ohio; the Data Coordinating Center, Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT), University of Iowa, Iowa City (C.S.C., J.B., D.E., E.K., M.K., J.D.L., J.Y.); the National Institute of Neurological Disorders and Stroke, Bethesda, MD (R.C.); the Clinical Coordinating Center, NeuroNEXT, Massachusetts General Hospital, Neurological Clinical Research Institute, Harvard Partners (M.E.C., M.M., A.A., B. Thornell), the Department of Neurology, Massachusetts General Hospital, Harvard Medical School (E.C.K.), and Brigham and Women's Hospital (C.S.), Boston; patient advocate (T.G.) and Swedish Medical Center at Seattle (P.R.), Seattle; University of Rochester Medical Center, Rochester (A.G.), Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai Medical Center (S.K.), Weill Cornell Medical College (J.S.P.), Columbia University Medical Center (C.S.R.), and Montefiore Medical Center, Albert Einstein College of Medicine (S.S.), New York, State University of New York (SUNY) at Stony Brook, Stony Brook (P.K.C.), SUNY Upstate Medical University, Syracuse (B.J.), and SUNY at Buffalo, Buffalo (B.W.-G.) - all in New York; MediciNova, La Jolla (K.M.), University of California at Davis, Sacramento (M.A.), and University of California at Los Angeles, Los Angeles (B.S.G.) - all in California; Washington University School of Medicine, St. Louis (R.T.N.); Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ (J.P.D.); NeuroRx Research, Montreal (S. Narayanan); the School of Health Sciences, College of Health and Human Sciences, Purdue University, West Lafayette, IN (X.Z.); University of Colorado Denver, Aurora (E.A.); University of Alabama at Birmingham, Birmingham (K.B.); Feinberg School of Medicine, Northwestern University, Chicago (B.A.C.); University of Miami Miller School of Medicine, Miami (S.D.); University of Utah, Salt Lake City (L.D.D.); University of Texas Southwestern Medical Center, Dallas (A.F.); University of Virginia at Charlottesville, Charlottesville (M.D.G.); Emory University, Atlanta (N.L.); University of Kansas Medical Center, Kansas City (S.G.L.); Vanderbilt University, Nashville (H.M.); University of Pittsburgh Medical Center, Pittsburgh (V.S.); and Oregon Health and Science University, Portland (V.Y.).

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http://dx.doi.org/10.1056/NEJMoa1803583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172944PMC
August 2018

Expanded autologous regulatory T-lymphocyte infusions in ALS: A phase I, first-in-human study.

Neurol Neuroimmunol Neuroinflamm 2018 Jul 18;5(4):e465. Epub 2018 May 18.

Houston Methodist Neurological Institute (J.R.T., D.R.B., W.Z., M.P., E.P.S., S.H.A.), Houston Methodist Hospital Research Institute, Stanley H. Appel Department of Neurology, Houston, TX; and Neurological Clinical Research Institute (J.D.B., M.E.C.), Massachusetts General Hospital, Boston, MA.

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http://dx.doi.org/10.1212/NXI.0000000000000465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961523PMC
July 2018

Imaging of glia activation in people with primary lateral sclerosis.

Neuroimage Clin 2018 25;17:347-353. Epub 2017 Oct 25.

Harvard Medical School, Department of Neurology, Neurological Clinical Research Institute (NCRI), Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.nicl.2017.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681341PMC
June 2018

Long-term Phase 1/2 intraspinal stem cell transplantation outcomes in ALS.

Ann Clin Transl Neurol 2018 Jun 2;5(6):730-740. Epub 2018 May 2.

Department of Neurology University of Michigan 109 Zina Pitcher Place 5017 AAT-BSRB Ann Arbor Michigan 48109.

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http://doi.wiley.com/10.1002/acn3.567
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http://dx.doi.org/10.1002/acn3.567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989736PMC
June 2018

Analysis of Participant Withdrawal in Huntington Disease Clinical Trials.

J Huntingtons Dis 2017 ;6(2):149-156

Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.3233/JHD-170246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565148PMC
March 2018

Urate levels predict survival in amyotrophic lateral sclerosis: Analysis of the expanded Pooled Resource Open-Access ALS clinical trials database.

Muscle Nerve 2018 03 21;57(3):430-434. Epub 2017 Sep 21.

Department of Neurology, Neurological Clinical Research Institute, Massachusetts General Hospital, Harvard Medical School, 165 Cambridge St, Suite 600 Boston, Massachusetts, 02114.

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http://dx.doi.org/10.1002/mus.25950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812805PMC
March 2018

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Authors:
Aude Nicolas Kevin P Kenna Alan E Renton Nicola Ticozzi Faraz Faghri Ruth Chia Janice A Dominov Brendan J Kenna Mike A Nalls Pamela Keagle Alberto M Rivera Wouter van Rheenen Natalie A Murphy Joke J F A van Vugt Joshua T Geiger Rick A Van der Spek Hannah A Pliner Shankaracharya Bradley N Smith Giuseppe Marangi Simon D Topp Yevgeniya Abramzon Athina Soragia Gkazi John D Eicher Aoife Kenna Gabriele Mora Andrea Calvo Letizia Mazzini Nilo Riva Jessica Mandrioli Claudia Caponnetto Stefania Battistini Paolo Volanti Vincenzo La Bella Francesca L Conforti Giuseppe Borghero Sonia Messina Isabella L Simone Francesca Trojsi Fabrizio Salvi Francesco O Logullo Sandra D'Alfonso Lucia Corrado Margherita Capasso Luigi Ferrucci Cristiane de Araujo Martins Moreno Sitharthan Kamalakaran David B Goldstein Aaron D Gitler Tim Harris Richard M Myers Hemali Phatnani Rajeeva Lochan Musunuri Uday Shankar Evani Avinash Abhyankar Michael C Zody Julia Kaye Steven Finkbeiner Stacia K Wyman Alex LeNail Leandro Lima Ernest Fraenkel Clive N Svendsen Leslie M Thompson Jennifer E Van Eyk James D Berry Timothy M Miller Stephen J Kolb Merit Cudkowicz Emily Baxi Michael Benatar J Paul Taylor Evadnie Rampersaud Gang Wu Joanne Wuu Giuseppe Lauria Federico Verde Isabella Fogh Cinzia Tiloca Giacomo P Comi Gianni Sorarù Cristina Cereda Philippe Corcia Hannu Laaksovirta Liisa Myllykangas Lilja Jansson Miko Valori John Ealing Hisham Hamdalla Sara Rollinson Stuart Pickering-Brown Richard W Orrell Katie C Sidle Andrea Malaspina John Hardy Andrew B Singleton Janel O Johnson Sampath Arepalli Peter C Sapp Diane McKenna-Yasek Meraida Polak Seneshaw Asress Safa Al-Sarraj Andrew King Claire Troakes Caroline Vance Jacqueline de Belleroche Frank Baas Anneloor L M A Ten Asbroek José Luis Muñoz-Blanco Dena G Hernandez Jinhui Ding J Raphael Gibbs Sonja W Scholz Mary Kay Floeter Roy H Campbell Francesco Landi Robert Bowser Stefan M Pulst John M Ravits Daniel J L MacGowan Janine Kirby Erik P Pioro Roger Pamphlett James Broach Glenn Gerhard Travis L Dunckley Christopher B Brady Neil W Kowall Juan C Troncoso Isabelle Le Ber Kevin Mouzat Serge Lumbroso Terry D Heiman-Patterson Freya Kamel Ludo Van Den Bosch Robert H Baloh Tim M Strom Thomas Meitinger Aleksey Shatunov Kristel R Van Eijk Mamede de Carvalho Maarten Kooyman Bas Middelkoop Matthieu Moisse Russell L McLaughlin Michael A Van Es Markus Weber Kevin B Boylan Marka Van Blitterswijk Rosa Rademakers Karen E Morrison A Nazli Basak Jesús S Mora Vivian E Drory Pamela J Shaw Martin R Turner Kevin Talbot Orla Hardiman Kelly L Williams Jennifer A Fifita Garth A Nicholson Ian P Blair Guy A Rouleau Jesús Esteban-Pérez Alberto García-Redondo Ammar Al-Chalabi Ekaterina Rogaeva Lorne Zinman Lyle W Ostrow Nicholas J Maragakis Jeffrey D Rothstein Zachary Simmons Johnathan Cooper-Knock Alexis Brice Stephen A Goutman Eva L Feldman Summer B Gibson Franco Taroni Antonia Ratti Cinzia Gellera Philip Van Damme Wim Robberecht Pietro Fratta Mario Sabatelli Christian Lunetta Albert C Ludolph Peter M Andersen Jochen H Weishaupt William Camu John Q Trojanowski Vivianna M Van Deerlin Robert H Brown Leonard H van den Berg Jan H Veldink Matthew B Harms Jonathan D Glass David J Stone Pentti Tienari Vincenzo Silani Adriano Chiò Christopher E Shaw Bryan J Traynor John E Landers

Neuron 2018 03;97(6):1268-1283.e6

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867896PMC
March 2018

Randomized, double-blind, placebo-controlled trial of arimoclomol in rapidly progressive ALS.

Neurology 2018 02 24;90(7):e565-e574. Epub 2018 Jan 24.

From the Department of Neurology (M.B., J.W.), University of Miami, FL; Department of Pharmacology and Clinical Neuroscience (P.M.A.), Umeå University, Sweden; Department of Neurology (N.A., W.D., M.C.), Massachusetts General Hospital (D.S.), Harvard Medical School; and Department of Biostatistics (D.S.), Harvard Chan School of Public Health, Boston, MA.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000004960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818014PMC
February 2018

Motor, cognitive, and functional declines contribute to a single progressive factor in early HD.

Neurology 2017 Dec 15;89(24):2495-2502. Epub 2017 Nov 15.

From F. Hoffman-La Roche, Ltd (S.A.S., G.P., O.S.K., D.T., J.J.S.), Roche Innovation Center, Basel, Switzerland; University of Rochester (P.A., S.M., E.R.D., K.D.K.), NY; University of Iowa (J.D.L., D.R.L.), Iowa City; Massachusetts General Hospital and Harvard Medical School (M.C., S.H.), Boston; CHDI Management/Foundation (C.S.), Princeton, NJ; University of British Columbia, Vancouver, Canada (B.R.L.); and University College London (S.J.T.), UK.

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http://dx.doi.org/10.1212/WNL.0000000000004743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729794PMC
December 2017

Developing multidisciplinary clinics for neuromuscular care and research.

Muscle Nerve 2017 Nov 29;56(5):848-858. Epub 2017 Aug 29.

Harvard Medical School, Department of Neurology, Massachusetts General Hospital (MGH), Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/mus.25725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656914PMC
November 2017

Vitamin D levels are associated with gross motor function in amyotrophic lateral sclerosis.

Muscle Nerve 2017 Oct 5;56(4):726-731. Epub 2017 Apr 5.

Neurological Clinical Research Institute, Harvard Medical School, Massachusetts General Hospital, 165 Cambridge Street, Suite 600, Boston, Massachusetts, 02114, USA.

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http://doi.wiley.com/10.1002/mus.25555
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http://dx.doi.org/10.1002/mus.25555DOI Listing
October 2017

Functional Decline is Associated with Hopelessness in Amyotrophic Lateral Sclerosis (ALS).

J Neurol Neurophysiol 2017 Apr 29;8(2). Epub 2017 Apr 29.

Department of Neurology, Neurological Clinical Research Institute (NCRI), Massachusetts General Hospital; Harvard Medical School, USA.

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http://dx.doi.org/10.4172/2155-9562.1000423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548143PMC
April 2017

Serum urate at trial entry and ALS progression in EMPOWER.

Amyotroph Lateral Scler Frontotemporal Degener 2017 02 28;18(1-2):120-125. Epub 2016 Sep 28.

e Department of Epidemiology and Nutrition , Harvard TH Chan School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Harvard Medical School and Brigham and Women's Hospital , Boston , Massachusetts , USA.

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http://dx.doi.org/10.1080/21678421.2016.1214733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531275PMC
February 2017

A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease.

Neurology 2017 Jan 2;88(2):152-159. Epub 2016 Dec 2.

From Cooper University Healthcare at Rowan University (A.M.), Camden, NJ; University of Rochester (M.M., K.K., E.A.d.B., K.B., P.C.); Weill Cornell Medical Center (F.B.); Columbia Presbyterian Medical Center (K.M.), New York, NY; Johns Hopkins Medical Center (C.R.), Baltimore, MD; Georgetown University (I.S.), Washington, DC; NINDS (P.G.), Bethesda, MD; Hereditary Neurological Disease Center (W.M.M.), Wichita, KS; The Centre for Movement Disorders (M.G.), Toronto, Canada; Indiana University School of Medicine (J.W.), Indianapolis; Colorado Neurological Institute (R.K.), Englewood; University of Tennessee Health Science Center (M.S.L.), Memphis; London Health Sciences Centre (M.J.), Canada; Massachusetts General Hospital (H.D.R.), Boston; Struthers Parkinson's Center (M.N.), Minneapolis, MN; University of Kansas Medical Center (R.M.D.), Kansas City; Rush University Medical Center (K.M.S.), Chicago, IL; University of Texas Southwestern Medical Center (P.O.), Dallas; University of Michigan (K.C.), Ann Arbor; Wake Forest University (F.W.), Winston-Salem, NC; University of Alberta (W.M.), Edmonton, Canada; University of California Davis (V.L.W.), Sacramento; Westmead Hospital (E. McCusker), Westmead, Australia; Baylor College of Medicine (J.J.), Houston, TX; University of Miami Miller School of Medicine (C.S.), FL; University of South Florida (J.S.-R.), Tampa; Duke University (B.S.), Durham, NC; University of Calgary (O.S.), Canada; Emory University School of Medicine (S.A.F.), Atlanta, GA; Albany Medical College (D.S.H., Eric Molho), NY; University of Cincinnati (F.R.), OH; Mayo Clinic Arizona (J.N.C.), Scottsdale; Butler Hospital (J.H.F.), Providence, RI; Washington University (J.S.P.), St. Louis, MO; Feinstein Institute for Medical Research (A.F.), Manhasset, NY; Georgetown University (K.A.), Washington, DC; University of Florida (R.R., N.R.M.), Gainesville; Johns Hopkins University (R.L.M.), Baltimore, MD; University of Nevada School of Medicine (E.S.F.), Reno; University of British Columbia (L.A.R.), Vancouver, Canada; University of Pittsburgh (V.S.), PA; Ohio State University (S.K.), Columbus; The Cooper University Health System (A.C.), Camden, NJ; Idaho Elks Rehabilitation Hospital (L.S.), Boise, ID; University of Iowa (E.E.), Iowa City; North York General Hospital 1 (S.E.), Toronto, Canada; St. Luke's Hospital (N.D.), Allentown, PA; North York General Hospital 2 (W.L.A.F.), University of Toronto, Canada; Washington Regional Medical Center (A.D.), Fayetteville, AR; Beth-Israel Deaconess Medical Center (S.F.), Boston, MA; NJ Neuroscience Institute (P.H.), Edison; University of California Irvine (N.H.); The University of Alabama at Birmingham (L.S.D.); and Massachusetts General Hospital (M.C.), Harvard Medical School, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000003478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224719PMC
January 2017

Selecting Patients for Intra-Arterial Therapy in the Context of a Clinical Trial for Neuroprotection.

Stroke 2016 12 1;47(12):2979-2985. Epub 2016 Nov 1.

From the Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA (P.L.); ZZ Biotech, LLC, Houston, TX (S.W., H.L., K.P.); Department of Biostatistics, University of Iowa, Iowa City (C.C., S.O.); Neurological Clinical Research Institute, Massachusetts General Hospital, Boston (M.C., S.B.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (M.F.); Department of Neurology, University of Virginia, Charlottesville (E.C.H.); Department of Neurology and Rehabilitation Medicine, University of Cincinnati, OH (P.K.); Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles (J.S.); Department of Neurology, State University of New York Downstate Medical Center, Brooklyn (S.L.); Department of Neurology, University of Kansas Hospital, Kansas City (M.R.); Department of Neurology, University of Pittsburgh Medical School, PA (L.W., A.J.); and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD (E.M., S.W.).

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http://dx.doi.org/10.1161/STROKEAHA.116.013881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134840PMC
December 2016

Glial activation colocalizes with structural abnormalities in amyotrophic lateral sclerosis.

Neurology 2016 Dec 11;87(24):2554-2561. Epub 2016 Nov 11.

From A.A. Martinos Center for Biomedical Imaging, Department of Radiology (M.J.A., N.R.Z., M.L.L., D.B.C., D.I.G., C.C., B.R.R., J.M.H.), Neurological Clinical Research Institute, Department of Neurology (M.J.A., P.C., J.E.Y., M.E.C., N.A.), and Department of Anesthesiology (O.A.), Massachusetts General Hospital, Harvard Medical School, Charlestown.

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http://dx.doi.org/10.1212/WNL.0000000000003427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207001PMC
December 2016

Race/ethnicity, socioeconomic status, and ALS mortality in the United States.

Neurology 2016 Nov 14;87(22):2300-2308. Epub 2016 Oct 14.

From the Departments of Social and Behavioral Sciences (A.L.R., J.T.C.), Environmental Health (M.G.W.), and Epidemiology (M.G.W.), Harvard T.H. Chan School of Public Health, Boston, MA; United States Census Bureau (N.J.J.), Washington, DC; Harvard Medical School (M.E.C.); and MGH Neurological Clinical Research Institute (M.E.C.), Department of Neurology, Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000003298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135021PMC
November 2016

Quantitative strength testing in ALS clinical trials.

Neurology 2016 Aug 6;87(6):617-24. Epub 2016 Jul 6.

From the Department of Neurology (J.M.S.), Barrow Neurological Institute, Phoenix, AZ; Biogen (D.L., M.L.L., D.R.J., T.F.), Cambridge; and Department of Neurology (D.S., M.C.), Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000002941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977369PMC
August 2016

Job-related formaldehyde exposure and ALS mortality in the USA.

J Neurol Neurosurg Psychiatry 2016 07 13;87(7):786-8. Epub 2015 Jul 13.

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1136/jnnp-2015-310750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738165PMC
July 2016

The Role of Environmental Toxins in Amyotrophic Lateral Sclerosis Risk.

JAMA Neurol 2016 07;73(7):779-80

Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts3Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamaneurol.2016.1038DOI Listing
July 2016

Transplantation of spinal cord-derived neural stem cells for ALS: Analysis of phase 1 and 2 trials.

Neurology 2016 Jul 29;87(4):392-400. Epub 2016 Jun 29.

From the Departments of Neurology (J.D.G., M.P., J.B., C.F.) and Neurosurgery (N.M.B., J.R., T.F.), Emory University School of Medicine, Atlanta; Center for Nursing Data Science (V.S.H.), Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA; Neuralstem, Inc. (K.J., T.H.), Germantown, MD; Department of Neurology, Neurological Clinical Research Institute (M.C., N.A.), and Department of Neurosurgery (L.F.B.), Massachusetts General Hospital, Boston; Department of Neurology (S.B.R.), Beth Israel Hospital, Boston, MA; and Departments of Neurosurgery (P.G.P.) and Neurology (J.D., P.G.P., S.A.G., E.L.F.), University of Michigan, Ann Arbor, MI.

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http://dx.doi.org/10.1212/WNL.0000000000002889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977116PMC
July 2016

A randomized trial of mexiletine in ALS: Safety and effects on muscle cramps and progression.

Neurology 2016 Apr 24;86(16):1474-81. Epub 2016 Feb 24.

From the Department of Neurology (M.D.W., J.B.D.), University of Washington Medical Center, Seattle; Biostatistics Center (E.A.M.), Massachusetts General Hospital and Harvard Medical School, Boston; Department of Neurology (Z.S.), Penn State Hershey Medical Center, Hershey, PA; Department of Neurology (A.S.K., N.A., M.E.C.), Neurological Clinical Research Institute, Massachusetts General Hospital, Boston; Program in Pharmacology and Experimental Therapeutics (D.J.G.), Tufts University School of Medicine, Boston, MA; Department of Neurology (M.G., N.P.), UCLA Medical Center, Los Angeles, CA; Department of Neurology (J.S.S., C.Q., R.H.B.), University of Massachusetts Memorial Medical Center, Worcester; Department of Neurology (J.T.), University of Texas Southwestern Medical Center, Dallas; Department of Neurology (J.M.S.), Barrow Neurological Institute, Phoenix, AZ; Department of Neurology (R.J.B.), University of Kansas Medical Center, Kansas City; Department of Neurology (A.P.), Washington University Medical Center, St. Louis, MO; and Department of Neurology (A.S.), University of Iowa Hospitals and Clinics, Iowa City.

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http://dx.doi.org/10.1212/WNL.0000000000002507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836879PMC
April 2016

How common are ALS plateaus and reversals?

Neurology 2016 Mar 9;86(9):808-12. Epub 2015 Dec 9.

From the Department of Neurology (R.S.B.), Duke University and Durham VA Medical Center, Durham, NC; PatientsLikeMe (T.V., P.W., J.H.), Cambridge, MA; Massachusetts General Hospital (E.S., R.S., E.A.M., D.S., M.C., A.S.), Boston; and Harvard Medical School (E.A.M.), Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000002251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793781PMC
March 2016

Cortical Hyperexcitability in Amyotrophic Lateral Sclerosis: C9orf72 Repeats.

JAMA Neurol 2015 Nov;72(11):1235-6

Department of Neurology, Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1001/jamaneurol.2015.2197DOI Listing
November 2015

Military Service and Amyotrophic Lateral Sclerosis in a Population-based Cohort.

Epidemiology 2015 Nov;26(6):831-8

From the aDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA; bDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA; cDepartment of Neurology, Massachusetts General Hospital, Boston, MA; and dCenter for Administrative Records and Applications, US Bureau of the Census, Washington, DC.

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http://dx.doi.org/10.1097/EDE.0000000000000376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604116PMC
November 2015

Reply: To PMID 25900666.

Muscle Nerve 2015 Oct 19;52(4):691. Epub 2015 Aug 19.

Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1002/mus.24760DOI Listing
October 2015

Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: assessed with [(11)C]-PBR28.

Neuroimage Clin 2015 19;7:409-14. Epub 2015 Jan 19.

Neurological Clinical Research Institute (NCRI), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.nicl.2015.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310932PMC
September 2015

Pre-morbid type 2 diabetes mellitus is not a prognostic factor in amyotrophic lateral sclerosis.

Muscle Nerve 2015 Sep 1;52(3):339-43. Epub 2015 Jun 1.

Department of Neurology, Washington University School of Medicine, 115 Biotech Building, Box 8111, 660 South Euclid, Street, St. Louis, Missouri, 63110, USA.

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http://dx.doi.org/10.1002/mus.24688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536144PMC
September 2015

Transcranial magnetic stimulation of the brain: guidelines for pain treatment research.

Pain 2015 Sep;156(9):1601-14

aDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA bAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA cBerenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA dUS Food and Drug Administration, Center for Devices and Radiological Health, Division of Neurological and Physical Medicine Devices, Office of Device Evaluation, Bethesda, MD, USA eUS National Institutes of Health, National Institute on Mental Health, Experimental Therapeutics and Pathophysiology Branch, Bethesda, MD, USA fPain Research Institute, Neuroscience Research Centre, The Walton Centre NHS Foundation Trust, Liverpool, United Kingdom gDepartment of Neurosurgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA hDepartment of Physiology, Henri Mondor Hospital, Assistance Publique - Hôpitaux de Paris, Créteil, France, iEA 4391, Nerve Excitability and Therapeutic Team, Faculty of Medicine, Paris Est Créteil University, Créteil, France, jHuman Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA, kDepartments of Anesthesiology, Medicine, and Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, USA, lDepartment of Pathology (Neuropathology), Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1097/j.pain.0000000000000210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545735PMC
September 2015

Randomized phase 2 trial of NP001-a novel immune regulator: Safety and early efficacy in ALS.

Neurol Neuroimmunol Neuroinflamm 2015 Jun 9;2(3):e100. Epub 2015 Apr 9.

California Pacific Medical Center (R.G.M., J.S.K.), San Francisco, CA; Neuraltus Pharmaceuticals, Inc. (G.B., V.G., M.S.M., A.A.), Palo Alto, CA; University of Kansas (R.J.B.), Kansas City; Massachusetts General Hospital (M.C.), Boston; University of California, San Francisco (R.Z., M.S.M.); Agility Clinical, Inc. (E.L.), Carlsbad, CA; and The Methodist Hospital (S.H.A.), Houston, TX.

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http://dx.doi.org/10.1212/NXI.0000000000000100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396529PMC
June 2015

Clinical Trial Designs in Amyotrophic Lateral Sclerosis: Does One Design Fit All?

Neurotherapeutics 2015 Apr;12(2):376-83

Massachusetts General Hospital, Department of Neurology, Neurological Clinical Research Institute, 165 Cambridge Street, Suite 600, Boston, MA, 02114, USA,

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http://dx.doi.org/10.1007/s13311-015-0341-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404442PMC
April 2015

Neuroprotective agents target molecular mechanisms of disease in ALS.

Drug Discov Today 2015 Jan 6;20(1):65-75. Epub 2014 Sep 6.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2014.08.016DOI Listing
January 2015

Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice.

Ann Neurol 2015 Jan 27;77(1):75-99. Epub 2014 Nov 27.

Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02112.

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http://dx.doi.org/10.1002/ana.24304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432483PMC
January 2015

Preclinical Rodent Toxicity Studies for Long Term Use of Ceftriaxone.

Toxicol Rep 2015;2:1396-1403

Neurological Clinical Research Institute (NCRI), Massachusetts General Hospital, Boston, MA, Massachusetts General Hospital, 165 Cambridge Street, Suite 600, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.toxrep.2015.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685718PMC
January 2015

Disease burden in upper motor neuron syndromes: a survey of patient perspectives.

J Clin Neuromuscul Dis 2014 Dec;16(2):104-5

*Hospital for Special Care, New Britain, CT †University of Connecticut School of Medicine, Farmington, CT ‡Harvard Medical School, Department of Neurology, Neurological Clinical Research Institute (NCRI), Massachusetts General Hospital, Boston, MA §Harvard Medical School, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Charlestown, MA ¶VA Boston Healthcare System, Boston, MA ‖Spastic Paraplegia Foundation, Falls Church, VA.

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http://dx.doi.org/10.1097/CND.0000000000000051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243581PMC
December 2014

The PRO-ACT database: design, initial analyses, and predictive features.

Neurology 2014 Nov 8;83(19):1719-25. Epub 2014 Oct 8.

From the Neurological Clinical Research Institute (NCRI), Department of Neurology (N.A., J.B., A. Sherman, E.S., J.W., I.K., M.C.), and the Biostatistics Center (A. Shui, D.S.), Massachusetts General Hospital, Boston; and Prize4Life (N.Z., M.L.), Cambridge, MA.

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http://dx.doi.org/10.1212/WNL.0000000000000951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239834PMC
November 2014

Diagnostic timelines and delays in diagnosing amyotrophic lateral sclerosis (ALS).

Amyotroph Lateral Scler Frontotemporal Degener 2014 Sep 1;15(5-6):453-6. Epub 2014 Jul 1.

Department of Neurology, Harvard Medical School, Neurological Clinical Research Institute (NCRI), Massachusetts General Hospital , Boston, Massachusetts , USA.

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http://dx.doi.org/10.3109/21678421.2014.903974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433003PMC
September 2014

Seeking a measure of clinically meaningful change in ALS.

Amyotroph Lateral Scler Frontotemporal Degener 2014 Sep 15;15(5-6):398-405. Epub 2014 Aug 15.

New York State Psychiatric Institute , New York, NY.

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http://www.tandfonline.com/doi/full/10.3109/21678421.2014.94
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http://dx.doi.org/10.3109/21678421.2014.942668DOI Listing
September 2014

Opportunities for improving therapy development in ALS.

Amyotroph Lateral Scler Frontotemporal Degener 2014 Jun 29;15(3-4):169-73. Epub 2014 Jan 29.

ALS Association , Washington, D.C.

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http://dx.doi.org/10.3109/21678421.2013.872662DOI Listing
June 2014

Locked in, but not out?

Neurology 2014 May 30;82(21):1852-3. Epub 2014 Apr 30.

From the Neurotechnology Trials Unit and the Neurological Clinical Trial Institute (L.R.H., M.E.C.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; and the Center for Neurorestoration and Neurotechnology (L.R.H.), Rehabilitation Research and Development Service, Office of Research and Development, Department of Veterans Affairs, and Brown University School of Engineering and Institute for Brain Science, Providence, RI.

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http://dx.doi.org/10.1212/WNL.0000000000000460DOI Listing
May 2014

Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons.

Cell Rep 2014 Apr 3;7(1):1-11. Epub 2014 Apr 3.

FM Kirby Neurobiology Center, Boston Children's Hospital and Harvard Stem Cell Institute, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.03.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023477PMC
April 2014

Predicting success: optimizing phase II ALS trials for the transition to phase III.

Amyotroph Lateral Scler Frontotemporal Degener 2014 Mar;15(1-2):1-8

Massachusetts General Hospital, Neurological Clinical Research Center , Boston, Massachusetts.

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http://dx.doi.org/10.3109/21678421.2013.838969DOI Listing
March 2014

Outcome measures in amyotrophic lateral sclerosis clinical trials.

Clin Investig (Lond) 2014 ;4(7):605-618

Harvard Medical School, Department of Neurology, Neurological Clinical Research Institute (NCRI), Massachusetts Genera Hospital, MA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5305182PMC
January 2014

Post-lumbar puncture headache is reduced with use of atraumatic needles in ALS.

Amyotroph Lateral Scler Frontotemporal Degener 2013 Dec 8;14(7-8):632-4. Epub 2013 Jul 8.

Department of Neurology, University of Massachusetts, Memorial Medical Center , Worcester, Massachusetts.

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http://dx.doi.org/10.3109/21678421.2013.808227DOI Listing
December 2013

Analysis of start-up, retention, and adherence in ALS clinical trials.

Neurology 2013 Oct 4;81(15):1350-5. Epub 2013 Sep 4.

From the Neurological Clinical Research Institute, Department of Neurology (N.A., P.Y.-R., H.Y., M.K., D.G., J.D., M.L.-W., J.S., A.L., L.J., M.E.C.), and Biostatistics Center (J.S., E.A.M.), Massachusetts General Hospital, Boston; and Harvard Medical School (N.A., P.Y.-R., E.A.M., M.E.C.), Boston, MA.

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http://dx.doi.org/10.1212/WNL.0b013e3182a823e0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806927PMC
October 2013

7-T MRI of the spinal cord can detect lateral corticospinal tract abnormality in amyotrophic lateral sclerosis.

Muscle Nerve 2013 May 29;47(5):760-2. Epub 2013 Mar 29.

AA Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1002/mus.23720DOI Listing
May 2013

The Combined Assessment of Function and Survival (CAFS): a new endpoint for ALS clinical trials.

Amyotroph Lateral Scler Frontotemporal Degener 2013 Apr 17;14(3):162-8. Epub 2013 Jan 17.

Massachusetts General Hospital, Neurological Clinical Research Institute, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.3109/21678421.2012.762930DOI Listing
April 2013

Developing normalized strength scores for neuromuscular research.

Muscle Nerve 2013 Feb 21;47(2):177-82. Epub 2012 Nov 21.

Neurology Clinical Trials Unit, Massachusetts General Hospital, 149 13th Street, Room 2274, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1002/mus.23516DOI Listing
February 2013

Dexpramipexole effects on functional decline and survival in subjects with amyotrophic lateral sclerosis in a Phase II study: subgroup analysis of demographic and clinical characteristics.

Amyotroph Lateral Scler Frontotemporal Degener 2013 Jan 17;14(1):44-51. Epub 2012 Sep 17.

Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

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http://dx.doi.org/10.3109/17482968.2012.723723DOI Listing
January 2013

Enhancing clinical trials in neurodegenerative disorders: lessons from amyotrophic lateral sclerosis.

Curr Opin Neurol 2012 Dec;25(6):735-42

Department of Medicine, University of Toronto Medical School, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/WCO.0b013e32835a309dDOI Listing
December 2012

Uric acid levels predict survival in men with amyotrophic lateral sclerosis.

J Neurol 2012 Sep 10;259(9):1923-8. Epub 2012 Feb 10.

Neurology Clinical Trials Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown Navy Yard, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1007/s00415-012-6440-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441749PMC
September 2012

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS.

J Clin Invest 2012 Sep 6;122(9):3063-87. Epub 2012 Aug 6.

Department of Neurology, Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1172/JCI62636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428086PMC
September 2012

Oral repeated-dose toxicity studies of coenzyme Q10 in beagle dogs.

Int J Toxicol 2012 Jan-Feb;31(1):58-69. Epub 2012 Jan 20.

Neurology Clinical Trials Unit, Massachusetts General Hospital, 13th Street, Building 149, Room 2274, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1177/1091581811425256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288259PMC
June 2012

New considerations in the design of clinical trials for amyotrophic lateral sclerosis.

Clin Investig (Lond) 2011 Oct;1(10):1375-1389

Massachusetts General Hospital, Department of Neurology, Neurology Clinical Trials Unit, 149 Thirteenth Street, Suite 2274, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.4155/cli.11.127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335743PMC
October 2011