Meredith S Irwin

Meredith S Irwin

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Meredith S Irwin

Publications by authors named "Meredith S Irwin"

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The Role of Surgery in High-risk Neuroblastoma.

J Pediatr Hematol Oncol 2019 Oct 9. Epub 2019 Oct 9.

Department of Paediatrics, Division of Hematology/Oncology.

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http://dx.doi.org/10.1097/MPH.0000000000001607DOI Listing
October 2019

Long term outcomes after concurrent ipsilateral nephrectomy versus kidney-sparing surgery for high-risk, intraabdominal neuroblastoma.

J Pediatr Surg 2019 Aug 6;54(8):1632-1637. Epub 2018 Jul 6.

Division of General and Thoracic Surgery, Hospital for Sick Children, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.jpedsurg.2018.06.031DOI Listing
August 2019

An upfront immunomodulatory therapy protocol for pediatric opsoclonus-myoclonus syndrome.

Pediatr Blood Cancer 2019 Aug 29;66(8):e27776. Epub 2019 Apr 29.

Division of Neurology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.1002/pbc.27776DOI Listing
August 2019

Tandem Transplant for High-Risk Neuroblastoma: Next Steps in the Era of Precision Medicine.

JAMA 2019 08;322(8):729-731

Division of Hematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1001/jama.2019.11641DOI Listing
August 2019

The challenge of defining "ultra-high-risk" neuroblastoma.

Pediatr Blood Cancer 2019 Apr 26;66(4):e27556. Epub 2018 Nov 26.

Hospital for Sick Children and University of Toronto, Toronto, Canada.

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http://doi.wiley.com/10.1002/pbc.27556
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http://dx.doi.org/10.1002/pbc.27556DOI Listing
April 2019

Retrospective evaluation of a decision-support algorithm (MIPOGG) for genetic referrals for children with neuroblastic tumors.

Pediatr Blood Cancer 2018 12 16;65(12):e27390. Epub 2018 Aug 16.

Department of Medical Genetics, McGill University Health Centre, Montreal, Quebec, Canada.

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http://doi.wiley.com/10.1002/pbc.27390
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http://dx.doi.org/10.1002/pbc.27390DOI Listing
December 2018

Statistical Framework in Support of a Revised Children's Oncology Group Neuroblastoma Risk Classification System.

JCO Clin Cancer Inform 2018 12;2:1-15

Arlene Naranjo, University of Florida, Gainesville, FL; Meredith S. Irwin, Hospital for Sick Children, Toronto, ON, Canada; Michael D. Hogarty, University of Pennsylvania, Philadelphia, PA; Susan L. Cohn, The University of Chicago, Chicago, IL; Julie R. Park, University of Washington, Seattle, WA; and Wendy B. London, Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1200/CCI.17.00140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421832PMC
December 2018

Autologous stem cell transplantation for refractory opsoclonus myoclonus ataxia syndrome.

Pediatr Blood Cancer 2018 08 25;65(8):e27110. Epub 2018 Apr 25.

Division of Hematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.27110DOI Listing
August 2018

Characteristics and management of ganglioneuroma and ganglioneuroblastoma-intermixed in children and adolescents.

Pediatr Blood Cancer 2018 05 25;65(5):e26964. Epub 2018 Jan 25.

Division of Haematology & Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.26964DOI Listing
May 2018

Pediatric oncology enters an era of precision medicine.

Curr Probl Cancer 2017 May - Jun;41(3):194-200. Epub 2017 Feb 1.

Department of Pediatrics, Baylor College of Medicine, Houston, Texas; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1016/j.currproblcancer.2017.01.002DOI Listing
March 2018

Comprehensive Analysis of Hypermutation in Human Cancer.

Cell 2017 Nov 19;171(5):1042-1056.e10. Epub 2017 Oct 19.

Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.09.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849393PMC
November 2017

A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis.

Cancer Res 2017 02 29;77(3):696-706. Epub 2016 Nov 29.

Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-1502DOI Listing
February 2017

Heterogeneity of MYCN amplification in neuroblastoma at diagnosis, treatment, relapse, and metastasis.

Genes Chromosomes Cancer 2017 01 18;56(1):28-41. Epub 2016 Aug 18.

Department of Pediatric Laboratory Medicine, the Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.1002/gcc.22398DOI Listing
January 2017

Measuring primary tumor response in neuroblastoma: More than using a ruler.

Pediatr Blood Cancer 2017 01 20;64(1):11-12. Epub 2016 Oct 20.

Division of Haematology-Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.26274DOI Listing
January 2017

Response to treatment with azacitidine in children with advanced myelodysplastic syndrome prior to hematopoietic stem cell transplantation.

Haematologica 2016 12 18;101(12):1508-1515. Epub 2016 Aug 18.

Marrow Failure and Myelodysplasia Program, Division of Hematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada

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http://dx.doi.org/10.3324/haematol.2016.145821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479623PMC
December 2016

Transcript signatures that predict outcome and identify targetable pathways in MYCN-amplified neuroblastoma.

Mol Oncol 2016 11 18;10(9):1461-1472. Epub 2016 Aug 18.

Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada; James Birrell Laboratories, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.molonc.2016.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423212PMC
November 2016

Surveillance imaging and radiation exposure in the detection of relapsed neuroblastoma.

Pediatr Blood Cancer 2016 10 15;63(10):1786-93. Epub 2016 Jun 15.

Division of Haematology-Oncology, Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.26099DOI Listing
October 2016

The neuroblastoma and ganglion components of nodular ganglioneuroblastoma are genetically similar: evidence against separate clonal origins.

Mod Pathol 2015 Feb 1;28(2):166-76. Epub 2014 Aug 1.

1] Division of Pathology, The Hospital for Sick Children, Toronto, ON, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

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http://www.nature.com/articles/modpathol201490
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http://dx.doi.org/10.1038/modpathol.2014.90DOI Listing
February 2015

Neuroblastoma: paradigm for precision medicine.

Pediatr Clin North Am 2015 Feb;62(1):225-56

Division of Hematology-Oncology, Seattle Children's Hospital, University of Washington School of Medicine, Fred Hutchinson Cancer Research Center, 4800 Sandpoint Way NE, Seattle, WA 98105, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00313955140019
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http://dx.doi.org/10.1016/j.pcl.2014.09.015DOI Listing
February 2015

Isolated late CNS relapse in a young adult 10 years after initial treatment for neuroblastoma.

J Pediatr Hematol Oncol 2015 Jan;37(1):75-7

*Division of Hematology/Oncology The Hospital for Sick Children †Department of Radiation Oncology ‡Department of Medical Oncology Princess Margaret Cancer Centre, University of Toronto Canada.

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http://dx.doi.org/10.1097/MPH.0000000000000163DOI Listing
January 2015

Spy'ing on differentiation in neuroblastoma.

Oncotarget 2014 Aug;5(15):5848-9

Hospital for Sick Children Research Institute, Cell Biology Program.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171596PMC
http://dx.doi.org/10.18632/oncotarget.2325DOI Listing
August 2014

Metachronous neuroblastoma in an infant with germline translocation resulting in partial trisomy 2p: a role for ALK?

J Pediatr Hematol Oncol 2014 Apr;36(3):e193-6

*Department of Paediatrics, Division of Haematology/Oncology ‡Division of Molecular Genetics §Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON, Canada †Haematology/Oncology Service, KK Women's and Children's Hospital, Singapore, Singapore.

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http://dx.doi.org/10.1097/MPH.0b013e3182a8f25dDOI Listing
April 2014

Metastatic neuroblastoma confined to distant lymph nodes (stage 4N) predicts outcome in patients with stage 4 disease: A study from the International Neuroblastoma Risk Group Database.

J Clin Oncol 2014 Apr 24;32(12):1228-35. Epub 2014 Mar 24.

Daniel A. Morgenstern and Meredith S. Irwin, Hospital for Sick Children and University of Toronto; Derek Stephens, Hospital for Sick Children, Toronto, ON, Canada; Daniel A. Morgenstern, Great Ormond Street Hospital for Children National Health Service (NHS) Foundation Trust, London; Andrew D.J. Pearson, The Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom; Wendy B. London, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA; Samuel L. Volchenboum and Susan L. Cohn, University of Chicago, Chicago, IL; Barbara Hero, University Children's Hospital, Köln, Germany; Andrea Di Cataldo, University of Catania, Catania, Italy; Akira Nakagawara, Chiba University School of Medicine, Chiba, Japan; Hiroyuki Shimada, University of Southern California at Los Angeles, Los Angeles; Katherine K. Matthay, University of California at San Francisco, San Francisco, CA; and Peter F. Ambros, St. Anna Kinderkrebsforschung, Vienna, Austria.

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http://dx.doi.org/10.1200/JCO.2013.53.6342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876342PMC
April 2014

Diagnostic practices and disease surveillance in Canadian children with congenital central hypoventilation syndrome.

Can Respir J 2013 May-Jun;20(3):165-70

Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, M5G 1X8.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814263PMC
http://dx.doi.org/10.1155/2013/594859DOI Listing
January 2014

Eukaryotic translation elongation factor 1-alpha 1 inhibits p53 and p73 dependent apoptosis and chemotherapy sensitivity.

PLoS One 2013 14;8(6):e66436. Epub 2013 Jun 14.

Department of Paediatrics and Cell Biology Program, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0066436PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682968PMC
January 2014

Phase I study of vinblastine and sirolimus in pediatric patients with recurrent or refractory solid tumors.

Pediatr Blood Cancer 2014 Jan 17;61(1):128-33. Epub 2013 Aug 17.

Department of Paediatrics, University of Toronto and New Agent and Innovative Therapy Programme, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.24656DOI Listing
January 2014

Treatment with topotecan plus cyclophosphamide in children with first relapse of neuroblastoma.

Pediatr Blood Cancer 2013 Oct 3;60(10):1636-41. Epub 2013 May 3.

Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.24587DOI Listing
October 2013

Current and future strategies for relapsed neuroblastoma: challenges on the road to precision therapy.

J Pediatr Hematol Oncol 2013 Jul;35(5):337-47

Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/MPH.0b013e318299d637DOI Listing
July 2013

Inhibition of SRC corrects GM-CSF hypersensitivity that underlies juvenile myelomonocytic leukemia.

Cancer Res 2013 Apr 11;73(8):2540-50. Epub 2013 Feb 11.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-3425DOI Listing
April 2013

Propranolol as a novel adjunctive treatment for head and neck squamous cell carcinoma.

J Otolaryngol Head Neck Surg 2012 Oct;41(5):334-44

Department of Otolaryngology–Head and Neck Surgery, University of Toronto, Toronto, ON M5G 2N2.

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October 2012

Natural course of low risk neuroblastoma.

Pediatr Blood Cancer 2012 May 15;58(5):690-4. Epub 2011 Sep 15.

Institute of Pathology, Department of Medical Services, Ministry of Public Health, Bangkok, Thailand.

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http://dx.doi.org/10.1002/pbc.23325DOI Listing
May 2012

Characteristics and outcome of patients with ganglioneuroblastoma, nodular subtype: a report from the INRG project.

Eur J Cancer 2012 May 1;48(8):1185-91. Epub 2011 Dec 1.

Department of Paediatrics, Division of Haematology and Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S09598049110087
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http://dx.doi.org/10.1016/j.ejca.2011.10.037DOI Listing
May 2012

Long-term hepatic outcomes in survivors of stage 4S and 4 neuroblastoma in infancy.

Pediatr Blood Cancer 2012 Feb 2;58(2):283-8. Epub 2011 Mar 2.

Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.23077DOI Listing
February 2012

The ribosome-related protein, SBDS, is critical for normal erythropoiesis.

Blood 2011 Dec 30;118(24):6407-17. Epub 2011 Sep 30.

Cell Biology Program, Research Institute, Toronto, ON, Canada.

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http://dx.doi.org/10.1182/blood-2011-02-335190DOI Listing
December 2011

Special AT-rich binding protein-2 (SATB2) differentially affects disease-causing p63 mutant proteins.

J Biol Chem 2011 Nov 29;286(47):40671-80. Epub 2011 Sep 29.

Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.271189
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http://dx.doi.org/10.1074/jbc.M111.271189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220488PMC
November 2011

Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells.

Cancer Res 2011 Feb 8;71(4):1385-95. Epub 2011 Feb 8.

Cell Biology Program and James Birrell Laboratories, The Hospital for Sick Children, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-2484DOI Listing
February 2011

NEDD8 pathways in cancer, Sine Quibus Non.

Cancer Cell 2011 Feb;19(2):168-76

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.ccr.2011.01.002DOI Listing
February 2011

SATB2 augments ΔNp63α in head and neck squamous cell carcinoma.

EMBO Rep 2010 Oct 10;11(10):777-83. Epub 2010 Sep 10.

Department of Molecular Genetics, University of Toronto, Cell Biology Program, Hospital for Sick Children Research Institute, Department of Paediatrics, 555 University Avenue, Toronto, Ontario, M5G 1L7, Canada.

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http://embor.embopress.org/cgi/doi/10.1038/embor.2010.125
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http://dx.doi.org/10.1038/embor.2010.125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948183PMC
October 2010

In vivo antitumor and antimetastatic activity of sunitinib in preclinical neuroblastoma mouse model.

Neoplasia 2009 May;11(5):426-35

New Agent and Innovative Therapy Program, Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671855PMC
http://dx.doi.org/10.1593/neo.09166DOI Listing
May 2009

Regulation of endocytosis via the oxygen-sensing pathway.

Nat Med 2009 Mar 1;15(3):319-24. Epub 2009 Mar 1.

Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1038/nm.1922DOI Listing
March 2009

Overexpressed TP73 induces apoptosis in medulloblastoma.

BMC Cancer 2007 Jul 12;7:127. Epub 2007 Jul 12.

Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1186/1471-2407-7-127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1955450PMC
July 2007

Tissue microenvironment modulates CXCR4 expression and tumor metastasis in neuroblastoma.

Neoplasia 2007 Jan;9(1):36-46

New Agent and Innovative Therapy Program, The Hospital for Sick Children, Toronto, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1803034PMC
http://dx.doi.org/10.1593/neo.06670DOI Listing
January 2007

Analysis of needle versus open biopsy for the diagnosis of advanced stage pediatric neuroblastoma.

Pediatr Blood Cancer 2006 Dec;47(7):875-9

Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.20666DOI Listing
December 2006

Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function.

J Biol Chem 2006 Nov 14;281(45):34096-103. Epub 2006 Sep 14.

Cancer Research Program and Division of Haematology-Oncology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.

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http://dx.doi.org/10.1074/jbc.M603654200DOI Listing
November 2006

Ubiquitin and ubiquitin-like modifications of the p53 family.

Neoplasia 2006 Aug;8(8):655-66

Cancer Research Program and Division of Hematology-Oncology, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8.

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http://dx.doi.org/10.1593/neo.06439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1601941PMC
August 2006

DeltaNp73: misunderstood protein?

Authors:
Meredith S Irwin

Cancer Biol Ther 2006 Jul 14;5(7):804-7. Epub 2006 Jul 14.

Hospital for Sick Children Research Institute, Cancer Research Program University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.4161/cbt.5.7.3023DOI Listing
July 2006

Surgical challenges associated with intensive treatment protocols for high-risk neuroblastoma.

J Pediatr Surg 2006 May;41(5):960-5

Division of General Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8.

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http://dx.doi.org/10.1016/j.jpedsurg.2006.01.059DOI Listing
May 2006

Expression of p53 in renal carcinoma cells is independent of pVHL.

Mutat Res 2005 Oct 5;578(1-2):23-32. Epub 2005 Jul 5.

Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ont., Canada M5S 1A8.

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http://dx.doi.org/10.1016/j.mrfmmm.2005.02.016DOI Listing
October 2005

Family feud in chemosensitvity: p73 and mutant p53.

Authors:
Meredith S Irwin

Cell Cycle 2004 Mar 1;3(3):319-23. Epub 2004 Mar 1.

Hospital for Sick Children, University of Toronto, Department of Pediatrics, 555 University Avenue, Toronto, Ontario, Canada.

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March 2004

Chemosensitivity linked to p73 function.

Cancer Cell 2003 Apr;3(4):403-10

Dana-Farber Cancer Institute and Brigham and Womens Hospital, Harvard Medical School, Boston, MA 02115, USA.

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April 2003

Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis.

Mol Cell 2003 Jan;11(1):11-23

Signal Transduction, Cancer Research UK London Research Institue, 44 Lincoln's Inn Fields, London WC2A 3PX, United Kingdom.

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http://dx.doi.org/10.1016/s1097-2765(02)00776-1DOI Listing
January 2003