Publications by authors named "Mercedes Unzeta"

63 Publications

Proteasomal-Mediated Degradation of AKAP150 Accompanies AMPAR Endocytosis during cLTD.

eNeuro 2020 Mar/Apr;7(2). Epub 2020 Apr 16.

Institut de Neurociències and Dpt. Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Cerdanyola del Vallès 08193, Spain

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April 2020

Blood-brain barrier dysfunction underlying Alzheimer's disease is induced by an SSAO/VAP-1-dependent cerebrovascular activation with enhanced Aβ deposition.

Biochim Biophys Acta Mol Basis Dis 2019 09 30;1865(9):2189-2202. Epub 2019 Apr 30.

Biochemistry and Molecular Biology Department, Institute of Neurosciences (INc), Universitat Autònoma de Barcelona (UAB), Bellaterra, Barcelona, Spain. Electronic address:

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September 2019

Uric acid treatment after stroke modulates the Krüppel-like factor 2-VEGF-A axis to protect brain endothelial cell functions: Impact of hypertension.

Biochem Pharmacol 2019 06 4;164:115-128. Epub 2019 Apr 4.

Departament de Farmacologia, de Terapèutica i de Toxicologia, Facultat de Medicina, Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain. Electronic address:

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June 2019

Simvastatin blocks soluble SSAO/VAP-1 release in experimental models of cerebral ischemia: Possible benefits for stroke-induced inflammation control.

Biochim Biophys Acta Mol Basis Dis 2018 Feb 22;1864(2):542-553. Epub 2017 Nov 22.

Biochemistry and Molecular Biology Department, Institute of Neurosciences, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain. Electronic address:

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February 2018

In-vitro and in-vivo evaluation of the modulatory effects of the multitarget compound ASS234 on the monoaminergic system.

J Pharm Pharmacol 2017 Mar 30;69(3):314-324. Epub 2017 Jan 30.

Departament de Bioquímica i Biologia Molecular, Facultat de Medicina, Institute of Neurosciences, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain.

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March 2017

Monoaminergic and Histaminergic Strategies and Treatments in Brain Diseases.

Front Neurosci 2016 24;10:541. Epub 2016 Nov 24.

Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5293), Institut of Neurodegenerative Diseases Bordeaux Cedex, France.

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November 2016

The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease.

J Psychiatry Neurosci 2017 01;42(1):59-69

From the Neurovascular Research Group, Department of Translational Neurobiology, Cajal Institute (CSIC), Madrid, Spain (Serrano, Herrero-Labrador, Serrano, Fernandez, Martínez-Murillo); the Departament of Toxicology and Pharmacology, School of Veterinary, Complutense University of Madrid, Madrid, Spain (Romero); the Laboratory of Medicinal Chemistry, Institute of Organic Chemistry (CSIC), Madrid, Spain (Marco-Contelles); the College of Medicine, University of Florida, Gainesville, Florida. USA (Futch); the Departament de Bioquímica i Biología Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain (Unzeta); and the Department of Chemistry, United Arab Emirates University, Abu Dhabi, United Arab Emirates (Samadi).

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January 2017

ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy.

Front Neurosci 2016 28;10:294. Epub 2016 Jun 28.

Laboratoire de Chimie Organique et Thérapeutique, Neurosciences Intégratives et Cliniques EA 481, Université Franche-Comté, Université Bourgogne Franche-Comté, UFR SMP Besançon, France.

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July 2016

Design, synthesis and biological evaluation of N-methyl-N-[(1,2,3-triazol-4-yl)alkyl]propargylamines as novel monoamine oxidase B inhibitors.

Bioorg Med Chem 2016 10 28;24(20):4835-4854. Epub 2016 Jun 28.

Department of Nutrition, Food Science and Gastronomy, Faculty of Pharmacy and Institute of Biomedicine (IBUB), University of Barcelona, Av. Prat de la Riba 171, E-08921 Santa Coloma de Gramenet, Spain. Electronic address:

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October 2016

Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease.

Front Neurosci 2016 25;10:205. Epub 2016 May 25.

Laboratory of Medicinal Chemistry, Institute of General Organic Chemistry, Spanish National Research Council Madrid, Spain.

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June 2016

Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation.

Eur J Med Chem 2016 Oct 9;121:864-879. Epub 2015 Oct 9.

Laboratory of Medicinal Chemistry (IQOG, CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain. Electronic address:

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October 2016

Cross-talk between Aβ and endothelial SSAO/VAP-1 accelerates vascular damage and Aβ aggregation related to CAA-AD.

Neurobiol Aging 2015 Feb 13;36(2):762-75. Epub 2014 Oct 13.

Institut de Neurociències i Departament de Bioquímica i Biologia Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain.

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February 2015

Neuroprotective effects of the MAO-B inhibitor, PF9601N, in an in vivo model of excitotoxicity.

CNS Neurosci Ther 2014 Jul 28;20(7):641-50. Epub 2014 Apr 28.

Departament de Bioquimica i Biologia Molecular, Facultat de Medicina, Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain; Dipartimento di Neuroscienze, Psicologia Area del Farmaco e Salute del Bambino (NEUROFARBA), Università degli Studi di Firenze, Firenze, Italy.

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July 2014

Hepatocyte transplants improve liver function and encephalopathy in portacaval shunted rats.

CNS Neurosci Ther 2014 Jul 10;20(7):685-91. Epub 2014 Apr 10.

Department of Hormone Biochemistry, Medical University of Lodz, Lodz, Poland.

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July 2014

Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease.

Biochim Biophys Acta 2014 Jun 16;1844(6):1104-10. Epub 2014 Mar 16.

Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews KY16 8QP, UK. Electronic address:

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June 2014

Involvement of SSAO/VAP-1 in oxygen-glucose deprivation-mediated damage using the endothelial hSSAO/VAP-1-expressing cells as experimental model of cerebral ischemia.

Cerebrovasc Dis 2014 5;37(3):171-80. Epub 2014 Feb 5.

Institut de Neurociències i Departament de Bioquímica i Biologia Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain.

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October 2014

Multipotent, permeable drug ASS234 inhibits Aβ aggregation, possesses antioxidant properties and protects from Aβ-induced apoptosis in vitro.

Curr Alzheimer Res 2013 Oct;10(8):797-808

Departament de Bioquímica i Biología Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.

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October 2013

Analysis of the antioxidant properties of differently substituted 2- and 3-indolyl carbohydrazides and related derivatives.

Eur J Med Chem 2013 May 15;63:670-4. Epub 2013 Mar 15.

Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, 54124, Greece.

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May 2013

A comparison between radiometric and fluorimetric methods for measuring SSAO activity.

J Neural Transm (Vienna) 2013 Jun 12;120(6):1015-8. Epub 2013 Feb 12.

Department of Basic Sciences, Facultat de Medicina, Universitat Internacional de Catalunya, Sant Cugat del Vallès, Spain.

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June 2013

A therapeutic approach to cerebrovascular diseases based on indole substituted hydrazides and hydrazines able to interact with human vascular adhesion protein-1, monoamine oxidases (A and B), AChE and BuChE.

J Neural Transm (Vienna) 2013 Jun 21;120(6):911-8. Epub 2012 Dec 21.

Departament de Bioquímica i Biología Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, 08193, Barcelona, Spain.

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June 2013