Mercedes Bonfill, PhD - Universitat de Barcelona - Professor

Mercedes Bonfill

PhD

Universitat de Barcelona

Professor

Barcelona, Catalunya | Spain

Main Specialties: Biotechnology

Additional Specialties: Plant Physiology/Biotechnology

ORCID logohttps://orcid.org/0000-0003-0664-3755


Top Author

Mercedes Bonfill, PhD - Universitat de Barcelona - Professor

Mercedes Bonfill

PhD

Introduction

Dr M Bonfill is Professor of Plant Physiology and Plant Biotechnology and a researcher of the Plant Biotechnology / Phytochemical Production Group at the Faculty of Pharmacy at the University of Barcelona (Spain).
She received the Pharmacy Degree at the University of Barcelona and the Master Degree in Pharmaceutical Science Research, at the Pharmacognosy Department of the same University.
She got her PhD at the Plant Physiology Department at Faculty of Pharmacy of the University of Barcelona in 1993 and performed post-doctoral research with Jacques Tempé and Jean Brevet at Centre National de la Recherche Scientifique (CNRS) at Gif sur Yvette (Paris, France) in 1995-1996.
Her research lines have covered, among others, the bioproduction of tropane alkaloids and the study of the rol genes of Agrobacterium rhizogenes in Solanaceae plants; the bioproduction of terpenes in Digitalis purpurea, the metabolism and ginsenoside production in Panax ginseng hairy roots, the production of triterpene saponines in cell cultures of Centella asiàtica, the improvement of the production of taxol and other taxanes of interest by in vitro cultures of Corylus avellana, etc.
Dr Bonfill’s current research is focused on the improvement of the production of taxol and other taxanes of interest by metabolic engineering of in vitro cultures of Taxus spp.


Primary Affiliation: Universitat de Barcelona - Barcelona, Catalunya , Spain

Specialties:

Additional Specialties:

Research Interests:


View Mercedes Bonfill’s Resume / CV

Education

Oct 1998
Spanish Nuclear Security Council at the Faculty of Biology, University of Barcelona.
Radioactivity Operator
May 1996
Centre National de la Recherche Scientifique (CNRS/ISV) Paris, France.
Post-doctoral position
Grant AFIRST, 7 months stay
May 1995
Centre National de la Recherche Scientifique (CNRS/ISV) Paris, France.
Post-doctoral position
Fellowship from the Commission of the European Communities, HCM Program (1 year stay).
Sep 1993
Faculty of Pharmacy, University of Barcelona (UB)
PhD
Plant Physiology Laboratory
Mar 1981
Faculty of Pharmacy, University of Barcelona (UB)
Pharmacy Degree

Experience

May 2014
Teaching a Plant Biotechnology course to master students of Coimbra ESAC
Visiting Professor
1-week stay at the ESAC-Politécnico de Coimbra (Portugal) on the framework of ERASMUS Program for University Professors,
Mar 2014
Collaboration between European and Egyptian Universities for high education in Egypt.
Project Member
Member of the TEMPUS Project entitled “Establish a New Joint Master Degree in Biotechnology Applied to Agri-Science, Environment and Pharmacology” from the EU (543865-TEMPUS-1-2013-1).
Feb 2012
Podophyllotoxin biosynthesis in Linum album in vitro cutures
Visiting Professor
6-month sabbatical stay at the Faculty of Health and Life Sciences at the De Montfort University, Leicester, United Kingdom.
Oct 2011
EU Project “Strengthening EU cooperation capacity of the National Institute of Medicinal and Aromatic Plants of Morocco: Towards Morocco’s integration into the ERA (FP7-INCO-2010-6-266575).
Project Member
Exploitation and valorization of medicinal and aromatic plants in Morocco
Sep 2004
Introducing on the hairy roots culture from Taxus spp. and somatic seeds from Centella asiatica.
Visiting Professor
1-month stay at the Faculty of Pharmacy at the Medical University of Warsaw, Poland
Jul 2003
Teaching and Research. Research member of the Plant Biotechnology/Phytochemical production Group.
Senior Lecturer
Plant Physiology Laboratory, Faculty of Pharmacy, University of Barcelona.
Apr 1992
Practical and theoretical classes of Plant Physiology, Plant Metabolism and Plant Biotechnology. Plant Physiology Coordinator. Research member of the Plant Biotechnology/Phytochemical production Group.
Part-time Lecturer
Plant Physiology Laboratory, Faculty of Pharmacy, University of Barcelona.
Jan 1989
Drug Monitoring in plasma, Chromatographic Separation Improvement and giving HPLC Basic and Specialized courses.
Research Assistant
Laboratory of Chromatography (HPLC) of the Pharmacology Department at the Faculty of Medicine at the Autonomous University of Barcelona (UAB) (3 years working)

Publications

31Publications

702Reads

12Profile Views

157PubMed Central Citations

Biotechnological production of ruscogenins in plant cell and organ cultures of Ruscus aculeatus.

Plant Physiol Biochem 2019 Aug 29;141:133-141. Epub 2019 May 29.

Secció de Fisiologia i Biotecnologia Vegetal, Departament de Biologia, Sanitat i Medi Ambient, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Joan XXIII 27-31, 08028, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.plaphy.2019.05.029DOI Listing
August 2019
6 Reads
2.756 Impact Factor

Physiological and anatomical studies of two wheat cultivars irrigated with magnetic water under drought stress conditions.

Plant Physiol Biochem 2019 Feb 14;135:480-488. Epub 2018 Nov 14.

Plant Physiology Department, Faculty of Pharmacy, University of Barcelona, E-08028, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.plaphy.2018.11.012DOI Listing
February 2019
37 Reads
2.756 Impact Factor

Advances in the Regulation of In Vitro Paclitaxel Production: Methylation of a Y-Patch Promoter Region Alters BAPT Gene Expression in Taxus Cell Cultures.

Plant Cell Physiol 2018 Nov;59(11):2255-2267

Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, E-08003 Barcelona, Spain.

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http://dx.doi.org/10.1093/pcp/pcy149DOI Listing
November 2018
8 Reads
4.931 Impact Factor

Biotechnological Production of Pharmaceuticals and Biopharmaceuticals in Plant Cell and Organ Cultures.

Curr Med Chem 2018 ;25(30):3577-3596

Laboratori de Fisiologia Vegetal, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.2174/0929867325666180309124317DOI Listing
October 2018
4 Reads
1 Citation
3.853 Impact Factor

Effect of in vitro morphogenesis on the production of podophyllotoxin derivatives in callus cultures of Linum album.

J Plant Physiol 2018 Sep 18;228:47-58. Epub 2018 May 18.

Sección de Fisiologia Vegetal, Facultad de Farmacia, Universidad de Barcelona, E-08028 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jplph.2018.05.007DOI Listing
September 2018
26 Reads
2.560 Impact Factor

Plant Anti-cancer Agents and their Biotechnological Production in Plant Cell Biofactories.

Curr Med Chem 2016 ;23(39):4418-4441

Laboratori de Fisiologia Vegetal, Facultat de Farmacia, Universitat de Barcelona, Av. Joan XXIII sn, 08028 Barcelona, Spain.

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http://dx.doi.org/10.2174/0929867323666161024145715DOI Listing
January 2017
3 Reads
1 Citation
3.853 Impact Factor

Genetic Transformation of Artemisia carvifolia Buch with rol Genes Enhances Artemisinin Accumulation.

PLoS One 2015 7;10(10):e0140266. Epub 2015 Oct 7.

Department of Biochemistry, Faculty of Biological sciences, Quaid-i-Azam University, Islamabad, Pakistan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140266PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596866PMC
June 2016
4 Reads
8 Citations
3.234 Impact Factor

Enhanced artemisinin yield by expression of rol genes in Artemisia annua.

Malar J 2015 Oct 29;14:424. Epub 2015 Oct 29.

Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

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http://dx.doi.org/10.1186/s12936-015-0951-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625606PMC
October 2015
26 Reads
8 Citations
3.110 Impact Factor

Changes in gene transcription and taxane production in elicited cell cultures of Taxus × media and Taxus globosa.

Phytochemistry 2015 Sep 16;117:174-184. Epub 2015 Jun 16.

Laboratori de Fisiologia Vegetal, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.phytochem.2015.06.013DOI Listing
September 2015
7 Reads
1 Citation
2.550 Impact Factor

Xanthomicrol: a comprehensive review of its chemistry, distribution, biosynthesis and pharmacological activity.

Mini Rev Med Chem 2014 ;14(9):725-33

Laboratori de Fisiologia Vegetal. Facultat de Farmacia, Universitat de Barcelona. Av. Joan XXIII sn. 08028 Barcelona. Spain.

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http://dx.doi.org/10.2174/1389557514666140820122818DOI Listing
June 2015
47 Reads
2.903 Impact Factor

Development of a hazel cell culture-based paclitaxel and baccatin III production process on a benchtop scale.

J Biotechnol 2015 Feb 3;195:93-102. Epub 2015 Jan 3.

Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Avda. Dr. Aiguader 80, E-08003 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jbiotec.2014.12.023DOI Listing
February 2015
51 Reads
4 Citations
2.871 Impact Factor

A rational approach to improving the biotechnological production of taxanes in plant cell cultures of Taxus spp.

Biotechnol Adv 2014 Nov 27;32(6):1157-67. Epub 2014 Mar 27.

Secció de Fisiologia Vegetal, Facultat de Farmacia, Universitat de Barcelona, Av. Joan XXIII sn., 08028 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.biotechadv.2014.03.002DOI Listing
November 2014
16 Reads
4 Citations
9.020 Impact Factor

Synergistic effect of cyclodextrins and methyl jasmonate on taxane production in Taxus x media cell cultures.

Plant Biotechnol J 2014 Oct 9;12(8):1075-84. Epub 2014 Jun 9.

Department of Plant Biology, Faculty of Biology, University of Murcia, Campus de Espinardo, Murcia, Spain.

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http://dx.doi.org/10.1111/pbi.12214DOI Listing
October 2014
7 Reads
6 Citations
5.752 Impact Factor

Bicyclic and tetracyclic diterpenes from a Trichoderma symbiont of Taxus baccata.

Phytochemistry 2014 Jan 21;97:55-61. Epub 2013 Nov 21.

Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles ICSN, Centre National de la Recherche Scientifique, CNRS, Avenue de la Terrasse 91198, Gif-sur-Yvette cedex, France. Electronic address:

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http://dx.doi.org/10.1016/j.phytochem.2013.10.016DOI Listing
January 2014
153 Reads
2 Citations
2.550 Impact Factor

Biosynthesis of panaxynol and panaxydol in Panax ginseng.

Molecules 2013 Jul 2;18(7):7686-98. Epub 2013 Jul 2.

Lehrstuhl für Biochemie, Technische Universität München, Lichtenbergstrasse 4, 85747 Garching, Germany.

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http://dx.doi.org/10.3390/molecules18077686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270202PMC
July 2013
30 Reads
2 Citations
2.420 Impact Factor

Living between two worlds: two-phase culture systems for producing plant secondary metabolites.

Crit Rev Biotechnol 2013 Mar 29;33(1):1-22. Epub 2012 Feb 29.

Department of Plant Biology, Institute of Biology, State University of Campinas, Campinas, Brazil.

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http://dx.doi.org/10.3109/07388551.2012.659173DOI Listing
March 2013
8 Reads
1 Citation
7.180 Impact Factor

Coronatine, a more powerful elicitor for inducing taxane biosynthesis in Taxus media cell cultures than methyl jasmonate.

J Plant Physiol 2013 Jan 23;170(2):211-9. Epub 2012 Oct 23.

Departament de Ciències Experimentals i de Salut, Universitat Pompeu Fabra, E-08003 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.jplph.2012.09.004DOI Listing
January 2013
7 Reads
7 Citations
2.560 Impact Factor

Isolation and characterization of Stemphylium sedicola SBU-16 as a new endophytic taxol-producing fungus from Taxus baccata grown in Iran.

FEMS Microbiol Lett 2012 Mar 10;328(2):122-9. Epub 2012 Jan 10.

Department of Agriculture, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Tehran, Iran.

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http://dx.doi.org/10.1111/j.1574-6968.2011.02488.xDOI Listing
March 2012
8 Reads
8 Citations
2.121 Impact Factor

Metabolic responses of Taxus media transformed cell cultures to the addition of methyl jasmonate.

Biotechnol Prog 2010 Jul-Aug;26(4):1145-53

Laboratorio de Fisiología Vegetal, Facultad de Farmacia, Universidad de Barcelona, Joan XXIII s/n, Barcelona, Spain.

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https://www.researchgate.net/profile/Mercedes_Bonfill/public
Web Search
http://dx.doi.org/10.1002/btpr.424DOI Listing
December 2010
28 Reads
6 Citations

Conversion of alpha-amyrin into centellosides by plant cell cultures of Centella asiatica.

Biotechnol Lett 2010 Feb 17;32(2):315-9. Epub 2009 Oct 17.

Laboratori de Fisiologia Vegetal, Facultat de Farmacia, Universitat de Barcelona, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1007/s10529-009-0143-xDOI Listing
February 2010
26 Reads
1 Citation
1.591 Impact Factor

Steroidal lactones from Withania somnifera, an ancient plant for novel medicine.

Molecules 2009 Jul 3;14(7):2373-93. Epub 2009 Jul 3.

Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin, Tehran, Iran.

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http://dx.doi.org/10.3390/molecules14072373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255378PMC
July 2009
16 Reads
60 Citations
2.420 Impact Factor

Effect of taxol feeding on taxol and related taxane production in Taxus baccata suspension cultures.

N Biotechnol 2009 Apr 3;25(4):252-9. Epub 2008 Dec 3.

Laboratorio de Fisiología vegetal, Facultad de Farmacia, Universidad de Barcelona, Avda. Diagonal 643, E-08028 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.nbt.2008.11.001DOI Listing
April 2009
6 Reads
2 Citations
2.900 Impact Factor

Triterpenoid saponin content and the expression level of some related genes in calli of Centella asiatica.

Biotechnol Lett 2008 Oct 25;30(10):1853-9. Epub 2008 Jun 25.

Laboratorio de Fisiología Vegetal, Facultad de Farmacia, Universidad de Barcelona, Avda. Diagonal 643, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1007/s10529-008-9766-6DOI Listing
October 2008
4 Reads
4 Citations
1.591 Impact Factor

Biotransformation of hyoscyamine into scopolamine in transgenic tobacco cell cultures.

J Plant Physiol 2007 Apr 10;164(4):521-4. Epub 2006 Aug 10.

Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Avda Dr Aiguader 80, E-08003 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.jplph.2006.06.012DOI Listing
April 2007
8 Reads
3 Citations
2.560 Impact Factor

Effect of organogenesis on steroidal saponin biosynthesis in calli cultures of Ruscus aculeatus.

Fitoterapia 2006 Apr 23;77(3):216-20. Epub 2006 Feb 23.

Laboratorio de Fisiología Vegetal, Facultad de Farmacia, Universidad de Barcelona, Avenida Diagonal 643, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.fitote.2006.02.005DOI Listing
April 2006
9 Reads
3 Citations
2.220 Impact Factor

Effects of immobilization by entrapment in alginate and scale-up on paclitaxel and baccatin III production in cell suspension cultures of Taxus baccata.

Biotechnol Bioeng 2005 Mar;89(6):647-55

Laboratorio de Fisiologia Vegetal, Facultad de Farmacia, Universidad de Barcelona, Avda. Diagonal 643, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1002/bit.20321DOI Listing
March 2005
13 Reads
4 Citations
4.130 Impact Factor

Engineering tropane biosynthetic pathway in Hyoscyamus niger hairy root cultures.

Proc Natl Acad Sci U S A 2004 Apr 14;101(17):6786-91. Epub 2004 Apr 14.

State Key Laboratory of Genetic Engineering, Morgan-Tan International Center for Life Sciences, School of Life Sciences, Fudan University, Shanghai 200433, China.

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http://dx.doi.org/10.1073/pnas.0401391101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC404123PMC
April 2004
69 Reads
17 Citations
9.810 Impact Factor

Inhibition of paclitaxel and baccatin III accumulation by mevinolin and fosmidomycin in suspension cultures of Taxus baccata.

J Biotechnol 2003 Mar;101(2):157-63

Laboratorio de Fisiologia Vegetal, Facultad de Farmacia, Universidad de Barcelona, Avda, Diagonal 643, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1016/s0168-1656(02)00318-8DOI Listing
March 2003
9 Reads
3 Citations
2.871 Impact Factor

Improved paclitaxel and baccatin III production in suspension cultures of Taxus media.

Biotechnol Prog 2002 May-Jun;18(3):418-23

Laboratorio de Fisiologia Vegetal, Facultad de Farmacia, Universidad de Barcelona, Avda. Diagonal 643, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1021/bp0101583DOI Listing
December 2002
58 Reads
1 Citation

Top co-authors

Elisabeth Moyano
Elisabeth Moyano

Universitat Pompeu Fabra

12
Javier Palazon
Javier Palazon

Laboratorio de Fisiología Vegetal

12
Javier Palazon
Javier Palazon

Laboratorio de Fisiología Vegetal

12
Rosa M Cusido
Rosa M Cusido

Universitat de Barcelona

11
Rosa M Cusido
Rosa M Cusido

Universitat de Barcelona

11
Miriam Onrubia
Miriam Onrubia

Universitat Pompeu Fabra

5
Elisabet Moyano
Elisabet Moyano

Universitat Pompeu Fabra

5
Liliana Lalaleo
Liliana Lalaleo

Technical University of Ambato

4
Regine Eibl
Regine Eibl

Institute of Biotechnology

3
Lidia Osuna
Lidia Osuna

Centro de Investigación Biomédica del Sur

3